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Today, in NICUs all over the world, seizure treatment is started only when there is a strong clinical suspicion of seizures and/or there is confirmatory aEEG/cEEG evidence. Keywords: clinical trials; drug development; hypoxic-ischemic encephalopathy; seizures in newborns; treatment EN clinical trials drug development hypoxic-ischemic encephalopathy seizures in newborns treatment 1874 1879 6 07/15/22 20220701 NES 220701 INTRODUCTION Seizures present both diagnostic and therapeutic challenges in neonates who are admitted to neonatal intensive care units (NICUs) worldwide. Of course there is variability, as seizure onset depends on the time of occurrence of the primary injury.18 Seizures in HIE have a typical evolution, with a peak in seizure burden within the first 30 hours. Amplitude integrated EEG (aEEG) is more widely available for clinical management, but 20%-40% of seizures will be missed, in addition to a significant risk of false-positive detections.12 aEEG is not recommended for clinical trials of neonatal seizure treatment.13 WHAT DO WE KNOW ABOUT SEIZURES IN HIE?. [Extracted from the article]