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1. Putative TetR Family Transcriptional Regulator SCO1712 Encodes an Antibiotic Downregulator in Streptomyces coelicolor.

Author

Han-Na Lee, Jianqiang Huang, Jong-Hyuk Im, Seon-Hye Kim, Jun-Hee Noh, Cohen, Stanley N., and Eung-Soo Kim

Subjects
*MICROBIOLOGY, *ANTIBIOTICS, *STREPTOMYCES coelicolor, *GENES, *BIOSYNTHESIS, *NUCLEIC acids, *BIOCHEMISTRY, *MICROORGANISMS, *BACTERIA
Abstract

A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator. [ABSTRACT FROM AUTHOR]

Published
2010
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