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1. Interspecies DNA Microarray Analysis Identifies WblA as a Pleiotropic Down-Regulator of Antibiotic Biosynthesis in Streptomyces.

Author

Seung-Hoon Kang, Jianqiang Huang, Han-Na Lee, Yoon-Ah Hur, Cohen, Stanley N., and Eung-Soo Kim

Subjects
*STREPTOMYCES coelicolor, *GENE expression, *TRANSCRIPTION factors, *BIOSYNTHESIS, *ANTIBIOTICS, *DNA microarrays
Abstract

Using Streptomyces coelicolor microarrays to discover regulators of gene expression in other Streptomyces species, we identified wblA, a whiB-like gene encoding a putative transcription factor, as a down-regulator of doxorubicin biosynthesis in Streptomyces peucetius. Further analysis revealed that wblA functions pleiotropically to control antibiotic production and morphological differentiation in streptomycetes. Our results reveal a novel biological role for wblA and show the utility of interspecies microarray analysis for the investigation of streptomycete gene expression. [ABSTRACT FROM AUTHOR]

Published
2007
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