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Abstract: If the initial quantum state of the universe is a multiverse superposition over many different sets of values of the effective coupling ‘constants’ of physics, and if this quantum state collapses to an eigenstate of the set of coupling ‘constants’ with a probability purely proportional to the absolute square of the amplitude (with no additional factor for something like life or consciousness), then one should not expect that the coupling ‘constants’ would be so biophilic as they are observed to be. Therefore, the observed biophilic values (apparent fine tuning) of the coupling ‘constants’ is statistical evidence against such simple forms of wavefunction collapse. [Copyright &y& Elsevier]