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1. BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation.

Author

Mitsiadis, Thimios A., Graf, Daniel, Luder, Hansueli, Gridley, Thomas, and Bluteau, Gilles

Subjects
*DENTITION, *GROWTH factors, *BONE morphogenetic proteins, *FIBROBLAST growth factors, *MORPHOGENESIS
Abstract

The article offers information on a medical study which shows that bone morphogenetic proteins (BMP) and fibroblast growth factors (FGF) target Notch signalling via Jag 2 gene to regulate tooth morphogenesis and cytodifferentiation. The Notch signalling pathway is an evolutionarily intercellular signalling mechanism that is essential for cell fate and proper embryonic development. It is seen that Notch signalling is mediated by (Jag2) gene which is important for normal tooth development.

Published
2010
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