1. Four new compounds isolated from Psoralea corylifolia and their diacylglycerol acyltransferase (DGAT) inhibitory activity.
- Author
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Lin, Xin, Li, Ban-Ban, Zhang, Le, Li, Hao-Ze, Meng, Xiao, Jiang, Yi-Yu, Lee, Hyun-Sun, and Cui, Long
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ALTERNATIVE medicine , *PHYSICAL & theoretical chemistry , *DOSE-effect relationship in pharmacology , *ENZYME inhibitors , *MEDICINAL plants , *SPECTRUM analysis , *PLANT extracts , *DESCRIPTIVE statistics , *FLAVANONES , *IN vitro studies , *PHARMACODYNAMICS - Abstract
A new bakuchiol compound Δ 11 -12-hydroxy-12-dimethyl bakuchiol ( 1 ), a new flavanone compound 2( S )-6-methoxy-7- hydroxymethylene-4′-hydroxyl-flavanone ( 8 ), and two new isoflavanone compounds 4′,7-dihydroxy-3′-(6”β-hydroxy-3″,7″-dimethyl-,2″,7″-dibutenyl)-geranylisoflavone ( 9 ) and 4′,7-dihydroxy-3′-(7″-hydroxy-7″-methyl-2″,5″-dibutenyl)-geranylisoflavone ( 10 ) together with eight known compounds ( 2–7 , 11 , 12 ) were isolated from the P. corylifolia . Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 3 , 9 and 10 were found to exhibit selective inhibitory activity on DGAT1 with IC 50 values ranging from 93.7 ± 1.3 to 96.2 ± 1.1 μM. Compound 1 showed inhibition activity on DGAT1 with IC 50 values 73.4 ± 1.3 μM and inhibition of DGAT2 with IC 50 value 121.1 ± 1.3 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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