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3 results on '"zucker štakori"'

1. The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats

Author

Vukšić Antonija, Rašić Dubravka, Žunec Suzana, Božina Tamara, Konjevoda Paško, Lovrić Jasna, Bilušić Marinko, and Bradamante Vlasta

Subjects
lipid peroxidation, lipid-lowering drugs, oxidative stress, wistar rats, zucker rats, lijekovi za snižavanje lipida, oksidacijski stres, peroksidacija lipida, wistar štakori, zucker štakori, Toxicology. Poisons, RA1190-1270
Abstract

The objective of study was to investigate the effects of different doses of simvastatin and fenofibrate on malondialdehyde (MDA) and reduced glutathione (GSH) in the plasma, liver, and brain tissue of male normolipidaemic and hyperlipidaemic rats. Normolipidaemic (Wistar) rats were receiving 10 or 50 mg/kg a day of simvastatin or 30 or 50 mg/kg a day of fenofibrate. Hyperlipidaemic (Zucker) rats were receiving 50 mg/kg/day of simvastatin or 30 mg/kg/day of fenofibrate. Control normolipidaemic and hyperlipidaemic rats were receiving saline. Simvastatin, fenofibrate, and saline were administered by gavage for three weeks. In normolipidaemic rats simvastatin and fenofibrate showed similar and dose-independent effects on plasma and brain MDA and GSH concentrations. Generally, plasma and brain MDA decreased, while brain GSH concentration increased. In hyperlipidaemic rats simvastatin did not affect plasma and brain MDA and GSH concentrations but significantly decreased liver GSH. Fenofibrate decreased plasma and liver MDA but increased brain MDA. In both rat strains fenofibrate significantly decreased liver GSH concentrations, most likely because fenofibrate metabolites bind to GSH. Our findings suggest that simvastatin acts as an antioxidant only in normolipidaemic rats, whereas fenofibrate acts as an antioxidant in both rat strains.

Published
2023
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2. The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats.

Author

Vukšić, Antonija, Rašić, Dubravka, Žunec, Suzana, Božina, Tamara, Konjevoda, Paško, Lovrić, Jasna, Bilušić, Marinko, and Bradamante, Vlasta

Subjects
FENOFIBRATE, SIMVASTATIN, MALONDIALDEHYDE, GLUTATHIONE, RATS, LABORATORY rats, LIVER
Abstract

Copyright of Archives of Industrial Hygiene & Toxicology / Arhiv za Higijenu Rada I Toksikologiju is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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3. Učinci simvastatina i fenofibrata na aktivnost butirilkolinesteraze u mozgu, plazmi i jetri normolipidemičnih i hiperlipidemičnih štakora

Author

Antonija Vukšić, Vlasta Bradamante, Nina Blažević, Paško Konjevoda, Jasna Lovrić, and Marinko Bilušić

Subjects
0301 basic medicine, medicine.medical_specialty, Simvastatin, medicine.medical_treatment, Hyperlipidemias, Toxicology, acetylthiocoline, butyrylthiocholine, lipid-lowering drugs, Wistar rats, Zucker rats, Butyrylthiocholine, acetiltiokolin, antilipidni lijekovi, butiriltiokolin, Wistar štakori, Zucker štakori, 03 medical and health sciences, Plasma, 0302 clinical medicine, Fenofibrate, Internal medicine, medicine, Animals, Rats, Wistar, Saline, Butyrylcholinesterase, Hypolipidemic Agents, biology, Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area, Chemistry, Anticholesteremic Agents, Public Health, Environmental and Occupational Health, Brain, Basic Medical Sciences, Butyrylcholinesterase activity, Enzyme assay, Rats, 030104 developmental biology, Endocrinology, Liver, biology.protein, Cholinergic, 030217 neurology & neurosurgery, medicine.drug
Abstract

The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50 mg/kg of simvastatin a day or 30 mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Simvastatin and fenofibrate caused an increase in brain BuChE activity in both normo- and hyperlipidemic rats regardless of the substrate. The increase with BTCh as substrate was significant and practically the same in normolipidemic and hyperlipidemic rats after simvastatin treatment (14–17% vs controls). Simvastatin and fenofibrate also increased liver and plasma BuChE activity in both normolipidemic and hyperlipidemic rats regardless of the substrate. In most cases the increase was significant. Considering the important role of BuChE in cholinergic transmission as well as its pharmacological function, it is necessary to continue investigations of the effects of lipid-lowering drugs on BuChE activity., Cilj ispitivanja bio je u normolipidemičnih i hiperlipidemičnih štakora potvrditi pretpostavku da simvastatin (SIMV) I fenofibrat (FENO) ne uzrokuju samo povećanje aktivnosti butirilkolinesteraze (BuChE) u plazmi i jetri nego i povećavaju aktivnosti BuChE u mozgu. Katalitička aktivnost enzima mjerena je upotrebom acetiltiokolina (ATCh) i butiriltiokolina (BTCh) kao supstrata. Normolipidemični i hiperlipidemični štakori raspoređeni su u eksperimentalne skupine, koje su tri tjedna primale SIMV 50 mg/kg na dan ili FENO 30 mg/kg na dan, dok su kontrolne skupine primale fiziološku otopinu. I SIMV i FENO uglavnom su izazvali povećanje aktivnosti BuChE u mozgu obaju sojeva štakora bez obzira na korišteni supstrat. Aktivnosti BuChE mjerene BTCh kao supstratom bile su značajno veće u odnosu na kontrolne vrijednosti u mozgu normolipidemičih štakora nakon primjene SIMV te u mozgu hiperlipidemičnih štakora nakon primjene obaju agensa (14‒17%, p

Published
2019

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