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6. Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS):: A consensus document of the International Union of Phlebology (UIP), Australasian College of Phlebology (ACP), American Vein and Lymphatic Society (AVLS), American Venous Forum (AVF), European College of Phlebology (ECoP), European Venous Forum (EVF), Interventional Radiology Society of Australasia (IRSA), Latin American Venous Forum, Pan-American Society of Phlebology and Lymphology and the Venous Association of India (VAI)

Author

Parsi, Kurosh, van Rij, Andre M., Meissner, Mark H., Davies, Alun H., De Maeseneer, Marianne, Gloviczki, Peter, Benson, Stephen, Bottini, Oscar, Manuel Canata, Victor, Dinnen, Paul, Gasparis, Antonios, Gianesini, Sergio, Huber, David, Jenkins, David, Lal, Brajesh K., Kabnick, Lowell, Lim, Adrian, Marston, William, Granados, Alberto Martinez, Morrison, Nick, Nicolaides, Andrew, Paraskevas, Peter, Patel, Malay, Roberts, Stefania, Rogan, Christopher, Schul, Marlin W., Komlos, Pedro, Stirling, Andrew, Thibault, Simon, Varghese, Roy, Welch, Harold J., and Wittens, Cees H.A.

Published
2020
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8. Publisher Correction: Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease

Author

Neale, Joshua P. H., Pearson, James T., Thomas, Kate N., Tsuchimochi, Hirotsugu, Hosoda, Hiroshi, Kojima, Masayasu, Sato, Takahiro, Jones, Gregory T., Denny, Adam P., Daniels, Lorna J., Chandrasekera, Dhananjie, Liu, Ping, van Rij, Andre M., Katare, Rajesh, and Schwenke, Daryl O.

Published
2020
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12. Corrigendum to “European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. [Eur J Vasc Endovasc Surg (2022) 63, 184-267]”

Author

De Maeseneer, Marianne G., primary, Kakkos, Stavros K., additional, Aherne, Thomas, additional, Baekgaard, Niels, additional, Black, Stephen, additional, Blomgren, Lena, additional, Giannoukas, Athanasios, additional, Gohel, Manjit, additional, de Graaf, Rick, additional, Hamel-Desnos, Claudine, additional, Jawien, Arkadiusz, additional, Jaworucka-Kaczorowska, Aleksandra, additional, Lattimer, Christopher R., additional, Mosti, Giovanni, additional, Noppeney, Thomas, additional, Josee van Rijn, Marie, additional, Stansby, Gerry, additional, Kolh, Philippe, additional, Goncalves, Frederico Bastos, additional, Chakfé, Nabil, additional, Coscas, Raphael, additional, de Borst, Gert J., additional, Dias, Nuno V., additional, Hinchliffe, Robert J., additional, Koncar, Igor B., additional, Lindholt, Jes S., additional, Trimarchi, Santi, additional, Tulamo, Riikka, additional, Twine, Christopher P., additional, Vermassen, Frank, additional, Wanhainen, Anders, additional, Björck, Martin, additional, Labropoulos, Nicos, additional, Lurie, Fedor, additional, Mansilha, Armando, additional, Nyamekye, Isaac K., additional, Ortega, Marta Ramirez, additional, Ulloa, Jorge H., additional, Urbanek, Tomasz, additional, van Rij, Andre M., additional, and Vuylsteke, Marc E., additional

Published
2022
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14. European society for vascular surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs

Author

De Maeseneer, Marianne G., Kakkos, Stavros K., Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R., Mosti, Giovanni, Noppeney, Thomas, Josee van Rijn, Marie, Stansby, Gerry, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfe, Nabil, Coscas, Raphael, de Borst, Gert J., Dias, Nuno, V, Hinchliffe, Robert J., Koncar, Igor B., Lindholt, Jes S., Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P., Vermassen, Frank, Wanhainen, Anders, Bjorck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K., Ramirez Ortega, Marta, Ulloa, Jorge H., Urbanek, Tomasz, van Rij, Andre M., Vuylsteke, Marc E., De Maeseneer, Marianne G., Kakkos, Stavros K., Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R., Mosti, Giovanni, Noppeney, Thomas, Josee van Rijn, Marie, Stansby, Gerry, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfe, Nabil, Coscas, Raphael, de Borst, Gert J., Dias, Nuno, V, Hinchliffe, Robert J., Koncar, Igor B., Lindholt, Jes S., Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P., Vermassen, Frank, Wanhainen, Anders, Bjorck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K., Ramirez Ortega, Marta, Ulloa, Jorge H., Urbanek, Tomasz, van Rij, Andre M., and Vuylsteke, Marc E.

Published
2022
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15. Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs

Author

Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, De Maeseneer, Marianne G, Kakkos, Stavros K, Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R, Mosti, Giovanni, Noppeney, Thomas, van Rijn, Marie Josee, Stansby, Gerry, Esvs Guidelines Committee, Guidelines Committee, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfé, Nabil, Coscas, Raphael, de Borst, Gert J, Dias, Nuno V, Hinchliffe, Robert J, Koncar, Igor B, Lindholt, Jes S, Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P, Vermassen, Frank, Wanhainen, Anders, Document Reviewers, Reviewers, Björck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K, Ramirez Ortega, Marta, Ulloa, Jorge H, Urbanek, Tomasz, van Rij, Andre M, Vuylsteke, Marc E, Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, De Maeseneer, Marianne G, Kakkos, Stavros K, Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R, Mosti, Giovanni, Noppeney, Thomas, van Rijn, Marie Josee, Stansby, Gerry, Esvs Guidelines Committee, Guidelines Committee, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfé, Nabil, Coscas, Raphael, de Borst, Gert J, Dias, Nuno V, Hinchliffe, Robert J, Koncar, Igor B, Lindholt, Jes S, Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P, Vermassen, Frank, Wanhainen, Anders, Document Reviewers, Reviewers, Björck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K, Ramirez Ortega, Marta, Ulloa, Jorge H, Urbanek, Tomasz, van Rij, Andre M, and Vuylsteke, Marc E

Published
2022

16. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Author

Jones, Gregory T., Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F., Giusti, Betti, Strauss, Ewa, van‘t Hof, Femke N.G., Webb, Thomas R., Erdman, Robert, Ritchie, Marylyn D., Elmore, James R., Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J., Ye, Zi, Peissig, Peggy L., Gottesman, Omri, Verma, Shefali S., Malinowski, Jennifer, Rasmussen-Torvik, Laura J., Borthwick, Kenneth M., Smelser, Diane T., Crosslin, David R., de Andrade, Mariza, Ryer, Evan J., McCarty, Catherine A., Böttinger, Erwin P., Pacheco, Jennifer A., Crawford, Dana C., Carrell, David S., Gerhard, Glenn S., Franklin, David P., Carey, David J., Phillips, Victoria L., Williams, Michael J.A., Wei, Wenhua, Blair, Ross, Hill, Andrew A., Vasudevan, Thodor M., Lewis, David R., Thomson, Ian A., Krysa, Jo, Hill, Geraldine B., Roake, Justin, Merriman, Tony R., Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R., Bumpstead, Suzannah, Badger, Stephen A., Clough, Rachel E., Cockerill, Gillian, Hafez, Hany, Scott, D. Julian A., Futers, T. Simon, Romaine, Simon P.R., Bridge, Katherine, Griffin, Kathryn J., Bailey, Marc A., Smith, Alberto, Thompson, Matthew M., van Bockxmeer, Frank M., Matthiasson, Stefan E., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D., Teijink, Joep A.W., Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A., Lindholt, Jes S., Hughes, Anne, Bradley, Declan T., Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E., Powell, Janet T., Humphries, Steve E., Hamby, Stephen E., Goodall, Alison H., Nelson, Christopher P., Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E., Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D., Johnson, Andrew D., Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E., Björkegren, Johan L.M., Lipovich, Leonard, Drolet, Anne M., Verhoeven, Eric L., Zeebregts, Clark J., Geelkerken, Robert H., van Sambeek, Marc R., van Sterkenburg, Steven M., de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R., de Bakker, Paul I.W., Deloukas, Panos, Sayers, Robert D., Harrison, Seamus C., van Rij, Andre M., Samani, Nilesh J., and Bown, Matthew J.

Published
2017
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17. European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs

Author

De Maeseneer, Marianne G, Kakkos, Stavros K, Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R, Mosti, Giovanni, Noppeney, Thomas, Josee van Rijn, Marie, Stansby, Gerry, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfe, Nabil, Coscas, Raphael, de Borst, Gert J, Dias, Nuno, Hinchliffe, Robert J, Koncar, Igor B, Lindholt, Jes S, Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P, Vermassen, Frank, Wanhainen, Anders, Bjorck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K, Ramirez Ortega, Marta, Ulloa, Jorge H, Urbanek, Tomasz, van Rij, Andre M, and Vuylsteke, Marc E

Subjects
Science & Technology, ELASTIC COMPRESSION STOCKINGS, STRAIN-GAUGE PLETHYSMOGRAPHY, Kirurgi, RANDOMIZED CONTROLLED-TRIAL, HEAT-INDUCED THROMBOSIS, GUIDED FOAM SCLEROTHERAPY, RECURRENT VARICOSE-VEINS, TRANSILLUMINATED POWERED PHLEBECTOMY, Peripheral Vascular Disease, QUALITY-OF-LIFE, GREAT SAPHENOUS-VEIN, Cardiovascular System & Cardiology, Surgery, ENDOVENOUS LASER-ABLATION, Life Sciences & Biomedicine
Abstract

ispartof: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY vol:63 issue:2 pages:184-267 ispartof: location:England status: published

Published
2022

22. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Author

Thorgeirsson, Thorgeir E., Geller, Frank, Sulem, Patrick, Rafnar, Thorunn, Wiste, Anna, Magnusson, Kristinn P., Manolescu, Andrei, Thorleifsson, Gudmar, Stefansson, Hreinn, Ingason, Andres, Stacey, Simon N., Bergthorsson, Jon T., Thorlacius, Steinunn, Gudmundsson, Julius, Jonsson, Thorlakur, Jakobsdottir, Margret, Saemundsdottir, Jona, Olafsdottir, Olof, Gudmundsson, Larus J., Bjornsdottir, Gyda, Kristjansson, Kristleifur, Skuladottir, Halla, Isaksson, Helgi J., Gudbjartsson, Tomas, Jones, Gregory T., Mueller, Thomas, Gottsäter, Anders, Flex, Andrea, Aben, Katja K. H., de Vegt, Femmie, Mulders, Peter F. A., Isla, Dolores, Vidal, Maria J., Asin, Laura, Saez, Berta, Murillo, Laura, Blondal, Thorsteinn, Kolbeinsson, Halldor, Stefansson, Jon G., Hansdottir, Ingunn, Runarsdottir, Valgerdur, Pola, Roberto, Lindblad, Bengt, van Rij, Andre M., Dieplinger, Benjamin, Haltmayer, Meinhard, Mayordomo, Jose I., Kiemeney, Lambertus A., Matthiasson, Stefan E., Oskarsson, Hogni, Tyrfingsson, Thorarinn, Gudbjartsson, Daniel F., Gulcher, Jeffrey R., Jonsson, Steinn, Thorsteinsdottir, Unnur, Kong, Augustine, and Stefansson, Kari

Published
2008
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25. Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm : A Meta-analysis

Author

Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., Humphries, Steve E., Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., and Humphries, Steve E.

Published
2018

26. Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis

Author

Team Medisch, Circulatory Health, Genetica Klinische Genetica, CMM Groep Kaaij, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., Humphries, Steve E., Team Medisch, Circulatory Health, Genetica Klinische Genetica, CMM Groep Kaaij, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., and Humphries, Steve E.

Published
2018

29. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Author

Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J, Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, and Bown, Matthew J

Published
2017

30. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Author

Genetica Klinische Genetica, Circulatory Health, CMM Groep Kaaij, Brain, Infection & Immunity, Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J, Genetica Klinische Genetica, Circulatory Health, CMM Groep Kaaij, Brain, Infection & Immunity, Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, and Bown, Matthew J

Published
2017

31. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Author

Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, J.P.P.M., Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J, Surgery, ICaR - Ischemia and repair, ACS - Microcirculation, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Cardiac & Cardiovascular Systems, aortic aneurysm abdominal, computational biology, Cardiac and Cardiovascular Systems, genetics, Aortic Aneurysm, Abdominal/diagnosis, genome-wide association study, matrix metalloproteinases, meta-analysis, Aortic Aneurysm, Abdominal, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Physiology, Cardiology and Cardiovascular Medicine, Kardiologi, Hematology, C-REACTIVE PROTEIN, TRANSCRIPTION FACTORS, Genetic Variation/genetics, DENSITY-LIPOPROTEIN CHOLESTEROL, Genetic Loci/genetics, Genome-Wide Association Study/methods, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, abdominal, cardiovascular system, CORONARY-ARTERY-DISEASE, aortic aneurysm, Life Sciences & Biomedicine, aortic aneurysm, abdominal, SUSCEPTIBILITY LOCI, 1102 Cardiovascular Medicine And Haematology, Article, SDG 3 - Good Health and Well-being, Genetic Predisposition to Disease/epidemiology, Journal Article, CANDIDATE GENE ASSOCIATION, Hematologi, cardiovascular diseases, Science & Technology, genome-wide association study ■ matrix metalloproteinases, ELECTRONIC MEDICAL-RECORDS, HUMAN PREFRONTAL CORTEX, 1103 Clinical Sciences, Atherosclerosis, Peripheral Vascular Disease, Cardiovascular System & Hematology, SEQUENCE VARIANT, RECEPTOR-RELATED PROTEIN-1, Cardiovascular System & Cardiology, Clinical Track
Abstract

Supplemental Digital Content is available in the text., Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.

Published
2016
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32. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms

Author

van 't Hof, Femke N G, Ruigrok, Ynte M, Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F, Blankensteijn, Jan D, Böttinger, Erwin P, Bown, Matthew J, Broderick, Joseph, Bijlenga, Philippe, Carrell, David S, Crawford, Dana C, Crosslin, David R, Ebeling, Christian, Eriksson, Johan G, Fornage, Myriam, Foroud, Tatiana, von Und Zu Fraunberg, Mikael, Friedrich, Christoph M, Gaál, Emília I, Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C, Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jääskeläinen, Juha E, Jones, Gregory T, Kiemeney, Lambertus A L M, Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J, Kuivaniemi, Helena, Kurki, Mitja I, Laakso, Aki, Lai, Dongbing, Leal, Suzanne M, Lehto, Hanna, LeMaire, Scott A, Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A, Milewicz, Dianna M, Mosley, Thomas H, Nakamura, Yusuke, Nakaoka, Hirofumi, Niemelä, Mika, Pacheco, Jennifer, Peissig, Peggy L, Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D, Rivadeneira, Fernando, van Rij, Andre M, Santos-Cortez, Regie Lyn P, Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, André G, Verma, Shefali S, Vermeulen, Sita H, Wang, Gao T, Han, Buhm, Rinkel, Gabriël J E, de Bakker, Paul I W, Aneurysm Consortium; Vascular Research Consortium of New Zealand, van 't Hof, Femke N G, Ruigrok, Ynte M, Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F, Blankensteijn, Jan D, Böttinger, Erwin P, Bown, Matthew J, Broderick, Joseph, Bijlenga, Philippe, Carrell, David S, Crawford, Dana C, Crosslin, David R, Ebeling, Christian, Eriksson, Johan G, Fornage, Myriam, Foroud, Tatiana, von Und Zu Fraunberg, Mikael, Friedrich, Christoph M, Gaál, Emília I, Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C, Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jääskeläinen, Juha E, Jones, Gregory T, Kiemeney, Lambertus A L M, Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J, Kuivaniemi, Helena, Kurki, Mitja I, Laakso, Aki, Lai, Dongbing, Leal, Suzanne M, Lehto, Hanna, LeMaire, Scott A, Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A, Milewicz, Dianna M, Mosley, Thomas H, Nakamura, Yusuke, Nakaoka, Hirofumi, Niemelä, Mika, Pacheco, Jennifer, Peissig, Peggy L, Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D, Rivadeneira, Fernando, van Rij, Andre M, Santos-Cortez, Regie Lyn P, Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, André G, Verma, Shefali S, Vermeulen, Sita H, Wang, Gao T, Han, Buhm, Rinkel, Gabriël J E, de Bakker, Paul I W, and Aneurysm Consortium; Vascular Research Consortium of New Zealand

Published
2016

33. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms

Author

University of Helsinki, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Neurokirurgian yksikkö, van't Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F., Blankensteijn, Jan D., Bottinger, Erwin P., Bown, Matthew J., Broderick, Joseph, Bijlenga, Philippe, Carrell, David S., Crawford, Dana C., Crosslin, David R., Ebeling, Christian, Eriksson, Johan G., Fornage, Myriam, Foroud, Tatiana, von und zu Fraunberg, Mikael, Friedrich, Christoph M., Gaal, Emilia I., Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C., Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jaaskelainen, Juha E., Jones, Gregory T., Kiemeney, Lambertus A. L. M., Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J., Kuivaniemi, Helena, Kurki, Mitja I., Laakso, Aki, Lai, Dongbing, Leal, Suzanne M., Lehto, Hanna, LeMaire, Scott A., Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A., Milewicz, Dianna M., Mosley, Thomas H., Nakamura, Yusuke, Nakaoka, Hirofumi, Niemela, Mika, Pacheco, Jennifer, Peissig, Peggy L., Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D., Rivadeneira, Fernando, van Rij, Andre M., Santos-Cortez, Regie Lyn P., Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, Andre G., Verma, Shefali S., Vermeulen, Sita H., Wang, Gao T., Han, Buhm, Rinkel, Gabriel J. E., de Bakker, Paul I. W., Aneurysm Consortium, Vasc Res Consortium New Zealand, University of Helsinki, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Neurokirurgian yksikkö, van't Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F., Blankensteijn, Jan D., Bottinger, Erwin P., Bown, Matthew J., Broderick, Joseph, Bijlenga, Philippe, Carrell, David S., Crawford, Dana C., Crosslin, David R., Ebeling, Christian, Eriksson, Johan G., Fornage, Myriam, Foroud, Tatiana, von und zu Fraunberg, Mikael, Friedrich, Christoph M., Gaal, Emilia I., Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C., Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jaaskelainen, Juha E., Jones, Gregory T., Kiemeney, Lambertus A. L. M., Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J., Kuivaniemi, Helena, Kurki, Mitja I., Laakso, Aki, Lai, Dongbing, Leal, Suzanne M., Lehto, Hanna, LeMaire, Scott A., Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A., Milewicz, Dianna M., Mosley, Thomas H., Nakamura, Yusuke, Nakaoka, Hirofumi, Niemela, Mika, Pacheco, Jennifer, Peissig, Peggy L., Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D., Rivadeneira, Fernando, van Rij, Andre M., Santos-Cortez, Regie Lyn P., Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, Andre G., Verma, Shefali S., Vermeulen, Sita H., Wang, Gao T., Han, Buhm, Rinkel, Gabriel J. E., de Bakker, Paul I. W., Aneurysm Consortium, and Vasc Res Consortium New Zealand

Abstract

Background-Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. Methods and Results-We performed a mega-analysis of 1000 Genomes Project-imputed genome-wide association study (GWAS) data of 4 previously published aneurysm cohorts: 2 IA cohorts (in total 1516 cases, 4305 controls), 1 AAA cohort (818 cases, 3004 controls), and 1 TAA cohort (760 cases, 2212 controls), and observed associations of 4 known IA, AAA, and/or TAA risk loci (9p21, 18q11, 15q21, and 2q33) with consistent effect directions in all 4 cohorts. We calculated polygenic scores based on IA-, AAA-, and TAA-associated SNPs and tested these scores for association to case-control status in the other aneurysm cohorts; this revealed no shared polygenic effects. Similarly, linkage disequilibrium-score regression analyses did not show significant correlations between any pair of aneurysm subtypes. Last, we evaluated the evidence for 14 previously published aneurysm risk single-nucleotide polymorphisms through collaboration in extended aneurysm cohorts, with a total of 6548 cases and 16 843 controls (IA) and 4391 cases and 37 904 controls (AAA), and found nominally significant associations for IA risk locus 18q11 near RBBP8 to AAA (odds ratio [OR]= 1.11; P=4.1 x 10(-5)) and for TAA risk locus 15q21 near FBN1 to AAA (OR=1.07; P=1.1 x 10(-3)). Conclusions-Although there was no evidence for polygenic overlap between IAs, AAAs, and TAAs, we found nominally significant effects of two established risk loci for IAs and TAAs in AAAs. These two loci will require further replication.

Published
2016

34. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease

Author

Nioi, Paul, Sigurdsson, Asgeir, Thorleifsson, Gudmar, Helgason, Hannes, Agustsdottir, Arna B, Norddahl, Gudmundur L, Helgadottir, Anna, Magnusdottir, Audur, Jonasdottir, Aslaug, Gretarsdottir, Solveig, Jonsdottir, Ingileif, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Swinkels, Dorine W, Galesloot, Tessel E, Grarup, Niels, Jørgensen, Torben, Vestergaard, Henrik, Hansen, Torben, Lauritzen, Torsten, Linneberg, Allan, Friedrich, Nele, Krarup, Nikolaj T, Fenger, Mogens, Abildgaard, Ulrik, Hansen, Peter R, Galløe, Anders M, Braund, Peter S, Nelson, Christopher P, Hall, Alistair S, Williams, Michael J A, van Rij, Andre M, Jones, Gregory T, Patel, Riyaz S, Levey, Allan I, Hayek, Salim, Shah, Svati H, Reilly, Muredach, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Olafsson, Isleifur, Kiemeney, Lambertus A, Quyyumi, Arshed A, Rader, Daniel J, Kraus, William E, Samani, Nilesh J, Pedersen, Oluf, Thorgeirsson, Gudmundur, Masson, Gisli, Holm, Hilma, Gudbjartsson, Daniel, Sulem, Patrick, Thorsteinsdottir, Unnur, Stefansson, Kari, Nioi, Paul, Sigurdsson, Asgeir, Thorleifsson, Gudmar, Helgason, Hannes, Agustsdottir, Arna B, Norddahl, Gudmundur L, Helgadottir, Anna, Magnusdottir, Audur, Jonasdottir, Aslaug, Gretarsdottir, Solveig, Jonsdottir, Ingileif, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Swinkels, Dorine W, Galesloot, Tessel E, Grarup, Niels, Jørgensen, Torben, Vestergaard, Henrik, Hansen, Torben, Lauritzen, Torsten, Linneberg, Allan, Friedrich, Nele, Krarup, Nikolaj T, Fenger, Mogens, Abildgaard, Ulrik, Hansen, Peter R, Galløe, Anders M, Braund, Peter S, Nelson, Christopher P, Hall, Alistair S, Williams, Michael J A, van Rij, Andre M, Jones, Gregory T, Patel, Riyaz S, Levey, Allan I, Hayek, Salim, Shah, Svati H, Reilly, Muredach, Eyjolfsson, Gudmundur I, Sigurdardottir, Olof, Olafsson, Isleifur, Kiemeney, Lambertus A, Quyyumi, Arshed A, Rader, Daniel J, Kraus, William E, Samani, Nilesh J, Pedersen, Oluf, Thorgeirsson, Gudmundur, Masson, Gisli, Holm, Hilma, Gudbjartsson, Daniel, Sulem, Patrick, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

Background Several sequence variants are known to have effects on serum levels of non-high-density lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. Methods We sequenced the genomes of 2636 Icelanders and found variants that we then imputed into the genomes of approximately 398,000 Icelanders. We tested for association between these imputed variants and non-HDL cholesterol levels in 119,146 samples. We then performed replication testing in two populations of European descent. We assessed the effects of an implicated loss-of-function variant on the risk of coronary artery disease in 42,524 case patients and 249,414 controls from five European ancestry populations. An augmented set of genomes was screened for additional loss-of-function variants in a target gene. We evaluated the effect of an implicated variant on protein stability. Results We found a rare noncoding 12-base-pair (bp) deletion (del12) in intron 4 of ASGR1, which encodes a subunit of the asialoglycoprotein receptor, a lectin that plays a role in the homeostasis of circulating glycoproteins. The del12 mutation activates a cryptic splice site, leading to a frameshift mutation and a premature stop codon that renders a truncated protein prone to degradation. Heterozygous carriers of the mutation (1 in 120 persons in our study population) had a lower level of non-HDL cholesterol than noncarriers, a difference of 15.3 mg per deciliter (0.40 mmol per liter) (P=1.0×10(-16)), and a lower risk of coronary artery disease (by 34%; 95% confidence interval, 21 to 45; P=4.0×10(-6)). In a larger set of sequenced samples from Icelanders, we found another loss-of-function ASGR1 variant (p.W158X, carried by 1 in 1850 persons) that was also associated with lower levels of non-HDL cholesterol (P=1.8×10(-3)). Conclusions ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease. (Funded by the National Institutes of Health a

Published
2016

38. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Author

Gretarsdottir, Solveig, Baas, Annette F., Thorleifsson, Gudmar, Holm, Hilma, den Heijer, Martin, de Vries, Jean-Paul P. M., Kranendonk, Steef E., Zeebregts, Clark J. A. M., van Sterkenburg, Steven M., Geelkerken, Robert H., van Rij, Andre M., Williams, Michael J. A., Boll, Albert P. M., Kostic, Jelena P., Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Walters, G. Bragi, Masson, Gisli, Sulem, Patrick, Saemundsdottir, Jona, Mouy, Magali, Magnusson, Kristinn P., Tromp, Gerard, Elmore, James R., Sakalihasan, Natzi, Limet, Raymond, Defraigne, Jean-Olivier, Ferrell, Robert E., Ronkainen, Antti, Ruigrok, Ynte M., Wijmenga, Cisca, Grobbee, Diederick E., Shah, Svati H., Granger, Christopher B., Quyyumi, Arshed A., Vaccarino, Viola, Patel, Riyaz S., Zafari, A. Maziar, Levey, Allan I., Austin, Harland, Girelli, Domenico, Pignatti, Pier Franco, Olivieri, Oliviero, Martinelli, Nicola, Malerba, Giovanni, Trabetti, Elisabetta, Becker, Lewis C., Becker, Diane M., Reilly, Muredach P., Rader, Daniel J., Mueller, Thomas, Dieplinger, Benjamin, Haltmayer, Meinhard, Urbonavicius, Sigitas, Lindblad, Bengt, Gottsater, Anders, Gaetani, Eleonora, Pola, Roberto, Wells, Philip, Rodger, Marc, Forgie, Melissa, Langlois, Nicole, Corral, Javier, Vicente, Vicente, Fontcuberta, Jordi, Espana, Francisco, Grarup, Niels, Jorgensen, Torben, Witte, Daniel R., Hansen, Torben, Pedersen, Oluf, Aben, Katja K., de Graaf, Jacqueline, Holewijn, Suzanne, Folkersen, Lasse, Franco-Cereceda, Anders, Eriksson, Per, Collier, David A., Stefansson, Hreinn, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Valdimarsson, Einar M., Magnadottir, Hulda B., Sveinbjornsdottir, Sigurlaug, Olafsson, Isleifur, Magnusson, Magnus Karl, Palmason, Robert, Haraldsdottir, Vilhelmina, Andersen, Karl, Onundarson, Pall T., Thorgeirsson, Gudmundur, Kiemeney, Lambertus A., Powell, Janet T., Carey, David J., Kuivaniemi, Helena, Lindholt, Jes S., Jones, Gregory T., Kong, Augustine, Blankensteijn, Jan D., Matthiasson, Stefan E., Thorsteinsdottir, Unnur, and Stefansson, Kari

Published
2010

39. A gene-centric study of common carotid artery remodelling

Author

Harrison, Seamus C., Zabaneh, Delilah, Asselbergs, Folkert W., Drenos, Fotios, Jones, Gregory T., Shah, Sonia, Gertow, Karl, Sennblad, Bengt, Strawbridge, Rona J., Gigante, Bruna, Holewijn, Suzanne, De Graaf, Jacqueline, Vermeulen, Sita, Folkersen, Lasse, van Rij, Andre M., Baldassarre, Damiano, Veglia, Fabrizio, Talmud, Philippa J., Deanfield, John E., Agu, Obi, Kivimaki, Mika, Kumari, Meena, Bown, Matthew J., Nyyssonen, Kristiina, Rauramaa, Rainer, Smit, Andries J., Franco-Cereceda, Anders, Giral, Philippe, Mannarino, Elmo, Silveira, Angela, Syvänen, Ann-Christine, de Borst, Gert J., van der Graaf, Yolanda, de Faire, Ulf, Baas, Annette F., Blankensteijn, Jan D., Wareham, Nicholas J., Fowkes, Gerry, Tzoulaki, Ionna, Price, Jacqueline F., Tremoli, Elena, Hingorani, Aroon D., Eriksson, Per, Hamsten, Anders, Humphries, Steve E., Harrison, Seamus C., Zabaneh, Delilah, Asselbergs, Folkert W., Drenos, Fotios, Jones, Gregory T., Shah, Sonia, Gertow, Karl, Sennblad, Bengt, Strawbridge, Rona J., Gigante, Bruna, Holewijn, Suzanne, De Graaf, Jacqueline, Vermeulen, Sita, Folkersen, Lasse, van Rij, Andre M., Baldassarre, Damiano, Veglia, Fabrizio, Talmud, Philippa J., Deanfield, John E., Agu, Obi, Kivimaki, Mika, Kumari, Meena, Bown, Matthew J., Nyyssonen, Kristiina, Rauramaa, Rainer, Smit, Andries J., Franco-Cereceda, Anders, Giral, Philippe, Mannarino, Elmo, Silveira, Angela, Syvänen, Ann-Christine, de Borst, Gert J., van der Graaf, Yolanda, de Faire, Ulf, Baas, Annette F., Blankensteijn, Jan D., Wareham, Nicholas J., Fowkes, Gerry, Tzoulaki, Ionna, Price, Jacqueline F., Tremoli, Elena, Hingorani, Aroon D., Eriksson, Per, Hamsten, Anders, and Humphries, Steve E.

Abstract

Background: Expansive remodelling is the process of compensatory arterial enlargement in response to atherosclerotic stimuli. The genetic determinants of this process are poorly characterized. Methods: Genetic association analyses of inter-adventitial common carotid artery diameter (ICCAD) in the IMPROVE study (n = 3427) using the Illumina 200k Metabochip was performed. Single nucleotide polymorphisms (SNPs) that met array-wide significance were taken forward for analysis in three further studies (n = 5704), and tested for association with Abdominal Aortic Aneurysm (AAA). Results: rs3768445 on Chromosome 1q24.3, in a cluster of protein coding genes (DNM3, PIGC, C1orf105) was associated with larger ICCAD in the IMPROVE study. For each copy of the rare allele carried, ICCAD was on average 0.13 mm greater (95% CI 0.08-0.18 mm, P = 8.2 x 10(-8)). A proxy SNP (rs4916251, R-2 = 0.99) did not, however, show association with ICCAD in three follow-up studies (P for replication = 0.29). There was evidence of interaction between carotid intima-media thickness (CIMT) and rs4916251 on ICCAD in two of the cohorts studies suggesting that it plays a role in the remodelling response to atherosclerosis. In meta-analysis of 5 case-control studies pooling data from 5007 cases and 43,630 controls, rs4916251 was associated with presence of AAA 1.10, 95% CI 1.03-1.17, p = 2.8 x 10(-3), I-2 = 18.8, Q = 0.30). A proxy SNP, rs4916251 was also associated with increased expression of PIGC in aortic tissue, suggesting that this may the mechanism by which this locus affects vascular remodelling. Conclusions: Common variation at 1q24.3 is associated with expansive vascular remodelling and risk of AAA. These findings support a hypothesis that pathways involved in systemic vascular remodelling play a role in AAA development.

Published
2013
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40. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Author

Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Holm, Hilma, Patel, Riyaz S, Gudnason, Thorarinn, Jones, Gregory T, van Rij, Andre M, Eapen, Danny J, Baas, Annette F, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel, Emmerich, Joseph, Lindblad, Bengt, Gottsäter, Anders, Kiemeny, Lambertus A, Lindholt, Jes S., Sakalihasan, Natzi, Ferrell, Robert E, Carey, David J, Elmore, James R, Tsao, Philip S, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Pola, Roberto, Gaetani, Eleonora, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Ronkainen, Antti, Ruigrok, Ynte M, Blankensteijn, Jan D, Mueller, Thomas, Wells, Philip S, Corral, Javier, Soria, Jose Manuel, Souto, Juan Carlos, Peden, John F, Jalilzadeh, Shapour, Mayosi, Bongani M, Keavney, Bernard, Strawbridge, Rona J, Sabater-Lleal, Maria, Gertow, Karl, Baldassarre, Damiano, Nyyssönen, Kristiina, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, de Faire, Ulf, Humphries, Steve E, Hamsten, Anders, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Magnusson, Magnus K, Samani, Nilesh J, Levey, Allan I, Markus, Hugh S, Kostulas, Konstantinos, Dichgans, Martin, Berger, Klaus, Kuhlenbäumer, Gregor, Ringelstein, E Bernd, Stoll, Monika, Seedorf, Udo, Rothwell, Peter M, Powell, Janet T, Kuivaniemi, Helena, Onundarson, Pall T, Valdimarsson, Einar, Matthiasson, Stefan E, Gudbjartsson, Daniel F, Thorgeirsson, Guðmundur, Quyyumi, Arshed A, Watkins, Hugh, Farrall, Martin, Thorsteinsdottir, Unnur, Stefansson, Kari, Helgadottir, Anna, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Holm, Hilma, Patel, Riyaz S, Gudnason, Thorarinn, Jones, Gregory T, van Rij, Andre M, Eapen, Danny J, Baas, Annette F, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel, Emmerich, Joseph, Lindblad, Bengt, Gottsäter, Anders, Kiemeny, Lambertus A, Lindholt, Jes S., Sakalihasan, Natzi, Ferrell, Robert E, Carey, David J, Elmore, James R, Tsao, Philip S, Grarup, Niels, Jørgensen, Torben, Witte, Daniel R, Hansen, Torben, Pedersen, Oluf, Pola, Roberto, Gaetani, Eleonora, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Ronkainen, Antti, Ruigrok, Ynte M, Blankensteijn, Jan D, Mueller, Thomas, Wells, Philip S, Corral, Javier, Soria, Jose Manuel, Souto, Juan Carlos, Peden, John F, Jalilzadeh, Shapour, Mayosi, Bongani M, Keavney, Bernard, Strawbridge, Rona J, Sabater-Lleal, Maria, Gertow, Karl, Baldassarre, Damiano, Nyyssönen, Kristiina, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, de Faire, Ulf, Humphries, Steve E, Hamsten, Anders, Haraldsdottir, Vilhelmina, Olafsson, Isleifur, Magnusson, Magnus K, Samani, Nilesh J, Levey, Allan I, Markus, Hugh S, Kostulas, Konstantinos, Dichgans, Martin, Berger, Klaus, Kuhlenbäumer, Gregor, Ringelstein, E Bernd, Stoll, Monika, Seedorf, Udo, Rothwell, Peter M, Powell, Janet T, Kuivaniemi, Helena, Onundarson, Pall T, Valdimarsson, Einar, Matthiasson, Stefan E, Gudbjartsson, Daniel F, Thorgeirsson, Guðmundur, Quyyumi, Arshed A, Watkins, Hugh, Farrall, Martin, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components.

Published
2012

41. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Author

Gudbjartsson, Daniel F., Bjornsdottir, Unnur S., Halapi, Eva, Helgadottir, Anna, Sulem, Patrick, Jonsdottir, Gudrun M., Thorleifsson, Gudmar, Helgadottir, Hafdis, Steinthorsdottir, Valgerdur, Stefansson, Hreinn, Williams, Carolyn, Hui, Jennie, Beilby, John, Warrington, Nicole M., James, Alan, Palmer, Lyle J., Koppelman, Gerard H., Heinzmann, Andrea, Krueger, Marcus, Boezen, H. Marike, Wheatley, Amanda, Altmuller, Janine, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Gislason, David, Park, Choon-Sik, Rasmussen, Linda M., Porsbjerg, Celeste, Hansen, Jakob W., Backer, Vibeke, Werge, Thomas, Janson, Christer, Jönsson, Ulla-Britt, Ng, Maggie C. Y., Chan, Juliana, So, Wing Yee, Ma, Ronald, Shah, Svati H., Granger, Christopher B., Quyyumi, Arshed A., Levey, Allan I., Vaccarino, Viola, Reilly, Muredach P., Rader, Daniel J., Williams, Michael J. A., van Rij, Andre M., Jones, Gregory T., Trabetti, Elisabetta, Malerba, Giovanni, Pignatti, Pier Franco, Boner, Attilio, Pescollderungg, Lydia, Girelli, Domenico, Olivieri, Oliviero, Martinelli, Nicola, Ludviksson, Bjorn R., Ludviksdottir, Dora, Eyjolfsson, Gudmundur I., Arnar, David, Thorgeirsson, Gudmundur, Deichmann, Klaus, Thompson, Philip J., Wjst, Matthias, Hall, Ian P., Postma, Dirkje S., Gislason, Thorarinn, Gulcher, Jeffrey, Kong, Augustine, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Stefansson, Kari, Gudbjartsson, Daniel F., Bjornsdottir, Unnur S., Halapi, Eva, Helgadottir, Anna, Sulem, Patrick, Jonsdottir, Gudrun M., Thorleifsson, Gudmar, Helgadottir, Hafdis, Steinthorsdottir, Valgerdur, Stefansson, Hreinn, Williams, Carolyn, Hui, Jennie, Beilby, John, Warrington, Nicole M., James, Alan, Palmer, Lyle J., Koppelman, Gerard H., Heinzmann, Andrea, Krueger, Marcus, Boezen, H. Marike, Wheatley, Amanda, Altmuller, Janine, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Gislason, David, Park, Choon-Sik, Rasmussen, Linda M., Porsbjerg, Celeste, Hansen, Jakob W., Backer, Vibeke, Werge, Thomas, Janson, Christer, Jönsson, Ulla-Britt, Ng, Maggie C. Y., Chan, Juliana, So, Wing Yee, Ma, Ronald, Shah, Svati H., Granger, Christopher B., Quyyumi, Arshed A., Levey, Allan I., Vaccarino, Viola, Reilly, Muredach P., Rader, Daniel J., Williams, Michael J. A., van Rij, Andre M., Jones, Gregory T., Trabetti, Elisabetta, Malerba, Giovanni, Pignatti, Pier Franco, Boner, Attilio, Pescollderungg, Lydia, Girelli, Domenico, Olivieri, Oliviero, Martinelli, Nicola, Ludviksson, Bjorn R., Ludviksdottir, Dora, Eyjolfsson, Gudmundur I., Arnar, David, Thorgeirsson, Gudmundur, Deichmann, Klaus, Thompson, Philip J., Wjst, Matthias, Hall, Ian P., Postma, Dirkje S., Gislason, Thorarinn, Gulcher, Jeffrey, Kong, Augustine, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).

Published
2009
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42. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Author

Gudbjartsson, Daniel F, Bjornsdottir, Unnur S, Halapi, Eva, Helgadottir, Anna, Sulem, Patrick, Jonsdottir, Gudrun M, Thorleifsson, Gudmar, Helgadottir, Hafdis, Steinthorsdottir, Valgerdur, Stefansson, Hreinn, Williams, Carolyn, Hui, Jennie, Beilby, John, Warrington, Nicole M, James, Alan, Palmer, Lyle J, Koppelman, Gerard H, Heinzmann, Andrea, Krueger, Marcus, Boezen, H Marike, Wheatley, Amanda, Altmuller, Janine, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Gislason, David, Park, Choon-Sik, Rasmussen, Linda M, Porsbjerg, Celeste, Hansen, Jakob W, Backer, Vibeke, Werge, Thomas, Janson, Christer, Jönsson, Ulla-Britt, Ng, Maggie C Y, Chan, Juliana, So, Wing Yee, Ma, Ronald, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Levey, Allan I, Vaccarino, Viola, Reilly, Muredach P, Rader, Daniel J, Williams, Michael J A, van Rij, Andre M, Jones, Gregory T, Trabetti, Elisabetta, Malerba, Giovanni, Pignatti, Pier Franco, Boner, Attilio, Pescollderungg, Lydia, Girelli, Domenico, Olivieri, Oliviero, Martinelli, Nicola, Ludviksson, Bjorn R, Ludviksdottir, Dora, Eyjolfsson, Gudmundur I, Arnar, David, Thorgeirsson, Gudmundur, Deichmann, Klaus, Thompson, Philip J, Wjst, Matthias, Hall, Ian P, Postma, Dirkje S, Gislason, Thorarinn, Gulcher, Jeffrey, Kong, Augustine, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Stefansson, Kari, Gudbjartsson, Daniel F, Bjornsdottir, Unnur S, Halapi, Eva, Helgadottir, Anna, Sulem, Patrick, Jonsdottir, Gudrun M, Thorleifsson, Gudmar, Helgadottir, Hafdis, Steinthorsdottir, Valgerdur, Stefansson, Hreinn, Williams, Carolyn, Hui, Jennie, Beilby, John, Warrington, Nicole M, James, Alan, Palmer, Lyle J, Koppelman, Gerard H, Heinzmann, Andrea, Krueger, Marcus, Boezen, H Marike, Wheatley, Amanda, Altmuller, Janine, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Gislason, David, Park, Choon-Sik, Rasmussen, Linda M, Porsbjerg, Celeste, Hansen, Jakob W, Backer, Vibeke, Werge, Thomas, Janson, Christer, Jönsson, Ulla-Britt, Ng, Maggie C Y, Chan, Juliana, So, Wing Yee, Ma, Ronald, Shah, Svati H, Granger, Christopher B, Quyyumi, Arshed A, Levey, Allan I, Vaccarino, Viola, Reilly, Muredach P, Rader, Daniel J, Williams, Michael J A, van Rij, Andre M, Jones, Gregory T, Trabetti, Elisabetta, Malerba, Giovanni, Pignatti, Pier Franco, Boner, Attilio, Pescollderungg, Lydia, Girelli, Domenico, Olivieri, Oliviero, Martinelli, Nicola, Ludviksson, Bjorn R, Ludviksdottir, Dora, Eyjolfsson, Gudmundur I, Arnar, David, Thorgeirsson, Gudmundur, Deichmann, Klaus, Thompson, Philip J, Wjst, Matthias, Hall, Ian P, Postma, Dirkje S, Gislason, Thorarinn, Gulcher, Jeffrey, Kong, Augustine, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).

Published
2009

43. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Author

Helgadottir, Anna, Thorleifsson, Gudmar, Magnusson, Kristinn P, Grétarsdottir, Solveig, Steinthorsdottir, Valgerdur, Manolescu, Andrei, Jones, Gregory T, Rinkel, Gabriel J E, Blankensteijn, Jan D, Ronkainen, Antti, Jääskeläinen, Juha E, Kyo, Yoshiki, Lenk, Guy M, Sakalihasan, Natzi, Kostulas, Konstantinos, Gottsäter, Anders, Flex, Andrea, Stefansson, Hreinn, Hansen, Torben, Andersen, Gitte, Weinsheimer, Shantel, Borch-Johnsen, Knut, Jørgensen, Torben, Shah, Svati H, Quyyumi, Arshed A, Granger, Christopher B, Reilly, Muredach P, Austin, Harland, Levey, Allan I, Vaccarino, Viola, Palsdottir, Ebba, Walters, G Bragi, Jonsdottir, Thorbjorg, Snorradottir, Steinunn, Magnusdottir, Dana, Gudmundsson, Gudmundur, Ferrell, Robert E, Sveinbjornsdottir, Sigurlaug, Hernesniemi, Juha, Niemelä, Mika, Limet, Raymond, Andersen, Karl, Sigurdsson, Gunnar, Benediktsson, Rafn, Verhoeven, Eric L G, Teijink, Joep A W, Grobbee, Diederick E, Rader, Daniel J, Collier, David A, Pedersen, Oluf, Pola, Roberto, Hillert, Jan, Lindblad, Bengt, Valdimarsson, Einar M, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Baas, Annette F, Ruigrok, Ynte M, van Rij, Andre M, Kuivaniemi, Helena, Powell, Janet T, Matthiasson, Stefan E, Gulcher, Jeffrey R, Thorgeirsson, Gudmundur, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, Helgadottir, Anna, Thorleifsson, Gudmar, Magnusson, Kristinn P, Grétarsdottir, Solveig, Steinthorsdottir, Valgerdur, Manolescu, Andrei, Jones, Gregory T, Rinkel, Gabriel J E, Blankensteijn, Jan D, Ronkainen, Antti, Jääskeläinen, Juha E, Kyo, Yoshiki, Lenk, Guy M, Sakalihasan, Natzi, Kostulas, Konstantinos, Gottsäter, Anders, Flex, Andrea, Stefansson, Hreinn, Hansen, Torben, Andersen, Gitte, Weinsheimer, Shantel, Borch-Johnsen, Knut, Jørgensen, Torben, Shah, Svati H, Quyyumi, Arshed A, Granger, Christopher B, Reilly, Muredach P, Austin, Harland, Levey, Allan I, Vaccarino, Viola, Palsdottir, Ebba, Walters, G Bragi, Jonsdottir, Thorbjorg, Snorradottir, Steinunn, Magnusdottir, Dana, Gudmundsson, Gudmundur, Ferrell, Robert E, Sveinbjornsdottir, Sigurlaug, Hernesniemi, Juha, Niemelä, Mika, Limet, Raymond, Andersen, Karl, Sigurdsson, Gunnar, Benediktsson, Rafn, Verhoeven, Eric L G, Teijink, Joep A W, Grobbee, Diederick E, Rader, Daniel J, Collier, David A, Pedersen, Oluf, Pola, Roberto, Hillert, Jan, Lindblad, Bengt, Valdimarsson, Einar M, Magnadottir, Hulda B, Wijmenga, Cisca, Tromp, Gerard, Baas, Annette F, Ruigrok, Ynte M, van Rij, Andre M, Kuivaniemi, Helena, Powell, Janet T, Matthiasson, Stefan E, Gulcher, Jeffrey R, Thorgeirsson, Gudmundur, Kong, Augustine, Thorsteinsdottir, Unnur, and Stefansson, Kari

Abstract

Udgivelsesdato: 2008-Feb, Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.

Published
2008

45. Correction: Elderly Men Have Low Levels of Anti-Müllerian Hormone and Inhibin B, but with High Interpersonal Variation: A Cross-Sectional Study of the Sertoli Cell Hormones in 615 Community-Dwelling Men

Author

Chong, Yih Harng, primary, Dennis, Nicola A., additional, Connolly, Martin J., additional, Teh, Ruth, additional, Jones, Gregory T., additional, van Rij, Andre M., additional, Farrand, Stephanie, additional, Campbell, A. John, additional, and McLennan, Ian S., additional

Published
2013
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46. Elderly Men Have Low Levels of Anti-Müllerian Hormone and Inhibin B, but with High Interpersonal Variation: A Cross-Sectional Study of the Sertoli Cell Hormones in 615 Community-Dwelling Men

Author

Chong, Yih Harng, primary, Dennis, Nicola A., additional, Connolly, Martin J., additional, Teh, Ruth, additional, Jones, Gregory T., additional, van Rij, Andre M., additional, Farrand, Stephanie, additional, Campbell, A. John, additional, and MLennan, Ian S., additional

Published
2013
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49. Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism

Author

Helgadottir, Anna, primary, Gretarsdottir, Solveig, additional, Thorleifsson, Gudmar, additional, Holm, Hilma, additional, Patel, Riyaz S., additional, Gudnason, Thorarinn, additional, Jones, Gregory T., additional, van Rij, Andre M., additional, Eapen, Danny J., additional, Baas, Annette F., additional, Tregouet, David-Alexandre, additional, Morange, Pierre-Emmanuel, additional, Emmerich, Joseph, additional, Lindblad, Bengt, additional, Gottsäter, Anders, additional, Kiemeny, Lambertus A., additional, Lindholt, Jes S., additional, Sakalihasan, Natzi, additional, Ferrell, Robert E., additional, Carey, David J., additional, Elmore, James R., additional, Tsao, Philip S., additional, Grarup, Niels, additional, Jørgensen, Torben, additional, Witte, Daniel R., additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Pola, Roberto, additional, Gaetani, Eleonora, additional, Magnadottir, Hulda B., additional, Wijmenga, Cisca, additional, Tromp, Gerard, additional, Ronkainen, Antti, additional, Ruigrok, Ynte M., additional, Blankensteijn, Jan D., additional, Mueller, Thomas, additional, Wells, Philip S., additional, Corral, Javier, additional, Soria, Jose Manuel, additional, Souto, Juan Carlos, additional, Peden, John F., additional, Jalilzadeh, Shapour, additional, Mayosi, Bongani M., additional, Keavney, Bernard, additional, Strawbridge, Rona J., additional, Sabater-Lleal, Maria, additional, Gertow, Karl, additional, Baldassarre, Damiano, additional, Nyyssönen, Kristiina, additional, Rauramaa, Rainer, additional, Smit, Andries J., additional, Mannarino, Elmo, additional, Giral, Philippe, additional, Tremoli, Elena, additional, de Faire, Ulf, additional, Humphries, Steve E., additional, Hamsten, Anders, additional, Haraldsdottir, Vilhelmina, additional, Olafsson, Isleifur, additional, Magnusson, Magnus K., additional, Samani, Nilesh J., additional, Levey, Allan I., additional, Markus, Hugh S., additional, Kostulas, Konstantinos, additional, Dichgans, Martin, additional, Berger, Klaus, additional, Kuhlenbäumer, Gregor, additional, Ringelstein, E. Bernd, additional, Stoll, Monika, additional, Seedorf, Udo, additional, Rothwell, Peter M., additional, Powell, Janet T., additional, Kuivaniemi, Helena, additional, Onundarson, Pall T., additional, Valdimarsson, Einar, additional, Matthiasson, Stefan E., additional, Gudbjartsson, Daniel F., additional, Thorgeirsson, Guðmundur, additional, Quyyumi, Arshed A., additional, Watkins, Hugh, additional, Farrall, Martin, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2012
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