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2. Safety and infectivity of female cercariae in Schistosoma-naïve, healthy participants: a controlled human Schistosoma mansoni infection study

Author

Koopman, Jan Pieter R., Houlder, Emma L., Janse, Jacqueline J., Casacuberta-Partal, Miriam, Lamers, Olivia A.C., Sijtsma, Jeroen C., de Dood, Claudia, Hilt, Stan T., Ozir-Fazalalikhan, Arifa, Kuiper, Vincent P., Roozen, Geert V.T., de Bes-Roeleveld, Laura M., Kruize, Yvonne C.M., Wammes, Linda J., Smits, Hermelijn H., van Lieshout, Lisette, van Dam, Govert J., van Amerongen-Westra, Inge M., Meij, Pauline, Corstjens, Paul L.A.M., Jochems, Simon P., van Diepen, Angela, Yazdanbakhsh, Maria, Hokke, Cornelis H., and Roestenberg, Meta

Published
2023
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3. Flow-S: A Field-Deployable Device with Minimal Hands-On Effort to Concentrate and Quantify Schistosoma Circulating Anodic Antigen (CAA) from Large Urine Volumes

Author

de Jong, Daniëlle, primary, Carrell, Cody, additional, Maganga, Jane K., additional, Mhango, Loyce, additional, Shigella, Peter S., additional, Gill, Maddy, additional, Shogren, Ryan, additional, Mullins, Brianna, additional, Warrick, Jay W., additional, Changalucha, John M., additional, van Dam, Govert J., additional, Pham, Khanh, additional, Downs, Jennifer A., additional, and Corstjens, Paul L. A. M., additional

Published
2024
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4. Clinical and demographic factors associated with Kaposi’s sarcoma-associated herpesvirus shedding in saliva or cervical secretions in a cohort of Tanzanian women

Author

Mertelsmann, Anna M, primary, Mukerebe, Crispin, additional, Miyaye, Donald, additional, Shigella, Peter, additional, Mhango, Loyce, additional, Lutonja, Peter, additional, Corstjens, Paul L A M, additional, de Dood, Claudia, additional, van Dam, Govert J, additional, Colombe, Soledad, additional, Maganga, Jane, additional, Aristide, Christine, additional, Kalluvya, Samuel E, additional, Ward, Maureen M, additional, Cordeiro, Alexandra A, additional, Lee, Myung Hee, additional, Changalucha, John M, additional, and Downs, Jennifer A, additional

Published
2024
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5. Cervicovaginal bacterial communities in reproductive-aged Tanzanian women with Schistosoma mansoni, Schistosoma haematobium, or without schistosome infection

Author

Bullington, Brooke W., Lee, Myung Hee, Mlingi, Jane, Paul, Ndalloh, Aristide, Christine, Fontana, Emily, Littmann, Eric R., Mukerebe, Crispin, Shigella, Peter, Kashangaki, Philibert, Kalluvya, Samuel E., de Dood, Claudia J., van Dam, Govert J., Corstjens, Paul L.A.M., Fitzgerald, Daniel W., Pamer, Eric G., and Downs, Jennifer A.

Published
2021
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6. Schistosome infection among pregnant women in the rural highlands of Madagascar: A cross-sectional study calling for public health interventions in vulnerable populations.

Author

Rakotozandrindrainy, Raphäel, Rakotoarivelo, Rivo Andry, Kislaya, Irina, Marchese, Valentina, Rasamoelina, Tahimandranto, Solonirina, Jeannine, Ratiaharison, Elveric Fesia, Razafindrakoto, Ravo, Razafindralava, Nantenaina Matthieu, Rakotozandrindrainy, Njary, Radomanana, Mickael, Andrianarivelo, Mala Rakoto, Klein, Philipp, Lorenz, Eva, Jaeger, Anna, Hoekstra, Pytsje T., Corstjens, Paul L. A. M., Schwarz, Norbert Georg, van Dam, Govert J., and May, Jürgen

Subjects
PREGNANT women, RURAL women, PARASITIC diseases, PUBLIC health, CROSS-sectional method
Abstract

Introduction: Schistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa (SSA) with Madagascar being among the countries with highest burden of the disease worldwide. Despite WHO recommendations, suggesting treatment of pregnant women after the first trimester, this group is still excluded from Mass Drug Administration programs. Our study, had the objective to measure the prevalence of schistosome infection among pregnant women in Madagascar in order to inform public health policies for treatment in this vulnerable population. Methods: Women were recruited for this cross-sectional study between April 2019 and February 2020 when attending Antenatal Care Services (ANCs) at one of 42 included Primary Health Care Centers. The urine-based upconverting reporter particle, lateral flow (UCP-LF) test detecting circulating anodic antigen was used for the detection of schistosome infections. To identify factors associated with the prevalence of schistosome infection crude and adjusted prevalence ratios and 95% CIs were estimated using mixed-effect Poisson regression. Results: Among 4,448 participating women aged between 16 and 47 years, the majority (70.4%, 38 n = 3,133) resided in rural settings. Overall, the prevalence of schistosome infection was 55.9% (n = 2486, CI 95%: 53.3–58.5). A statistically significant association was found with age group (increased prevalence in 31–47 years old, compared to 16–20 years old (aPR = 1.15, CI 95%: 1.02–1.29) and with uptake of antimalaria preventive treatment (decreased prevalence, aPR = 0.85, CI 95%: 0.77–0.95). No other associations of any personal characteristics or contextual factors with schistosome infection were found in our multivariate regression analysis. Discussion and conclusion: The high prevalence of schistosome infection in pregnant women supports the consideration of preventive schistosomiasis treatment in ANCs of the Malagasy highlands. We strongly advocate for adapting schistosomiasis programs in highly endemic contexts. This, would contribute to both the WHO and SDGs agendas overall to improving the well-being of women and consequently breaking the vicious cycle of poverty perpetuated by schistosomiasis. Author summary: Schistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa and in Madagascar, where pregnant women are systematically excluded from prevention and control strategies. Our study shows the urgency for adapting public health strategies. We report a high prevalence of schistosome infection among pregnant women in Madagascar. The lack of systematic treatment for this vulnerable group can have a direct impact on the well-being of women and their offspring contributing to the vicious cycle of poverty perpetuated by schistosomiasis. [ABSTRACT FROM AUTHOR]

Published
2024
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7. A cluster randomized controlled trial for assessing POC-CCA test based praziquantel treatment for schistosomiasis control in pregnant women and their young children: study protocol of the freeBILy clinical trial in Madagascar

Author

Fusco, Daniela, Rakotozandrindrainy, Raphäel, Rakotoarivelo, Rivo Andry, Andrianarivelo, Mala Rakoto, Rakotozandrindrainy, Njary, Rasamoelina, Tahinamandranto, Puradiredja, Dewi Ismajani, Klein, Philipp, Stahlberg, Karl, Dechenaud, Marie, Lorenz, Eva, Jaeger, Anna, Kreidenweiss, Andrea, Hoekstra, Pytsje T., Adegnika, Akim Ayola, Sicuri, Elisa, Corstjens, Paul L. A. M., van Dam, Govert J., May, Jürgen, and Schwarz, Norbert Georg

Published
2021
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9. Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

Author

Amaral, Murilo Sena, Santos, Daisy Woellner, Pereira, Adriana S. A., Tahira, Ana Carolina, Malvezzi, João V. M., Miyasato, Patrícia Aoki, Freitas, Rafaela de Paula, Kalil, Jorge, Tjon Kon Fat, Elisa M., de Dood, Claudia J., Corstjens, Paul L. A. M., van Dam, Govert J., Nakano, Eliana, Castro, Simone de Oliveira, Mattaraia, Vânia Gomes de Moura, Augusto, Ronaldo de Carvalho, Grunau, Christoph, Wilson, R. Alan, and Verjovski-Almeida, Sergio

Published
2021
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10. A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics

Author

Langenberg, Marijke C. C., Hoogerwerf, Marie-Astrid, Koopman, Jan Pieter R., Janse, Jacqueline J., Kos-van Oosterhoud, Janneke, Feijt, Carola, Jochems, Simon P., de Dood, Claudia J., van Schuijlenburg, Roos, Ozir-Fazalalikhan, Arifa, Manurung, Mikhael D., Sartono, Erliyani, van der Beek, Martha T., Winkel, Béatrice M. F., Verbeek-Menken, Petra H., Stam, Koen A., van Leeuwen, Fijs W. B., Meij, Pauline, van Diepen, Angela, van Lieshout, Lisette, van Dam, Govert J., Corstjens, Paul L. A. M., Hokke, Cornelis H., Yazdanbakhsh, Maria, Visser, Leo G., and Roestenberg, Meta

Published
2020
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11. Reproducibility matters: intra- and inter-sample variation of the point-of-care circulating cathodic antigen test in two Schistosoma mansoni endemic areas in Uganda

Author

Kabbas-Piñango, Elías, primary, Arinaitwe, Moses, additional, van Dam, Govert J., additional, Moses, Adriko, additional, Namukuta, Annet, additional, Nankasi, Andrina Barungi, additional, Mwima, Nicholas Khayinja, additional, Besigye, Fred, additional, Prada, Joaquin M., additional, and Lamberton, Poppy H. L., additional

Published
2023
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12. Establishing a Single-Sex Controlled Human Schistosoma mansoni Infection Model for Uganda: Protocol for Safety and Dose-Finding Trial

Author

Abaasa, Andrew, primary, Egesa, Moses, additional, Driciru, Emmanuella, additional, Koopman, Jan Pieter R, additional, Kiyemba, Ronald, additional, Sanya, Richard E, additional, Nassuuna, Jacent, additional, Ssali, Agnes, additional, Kimbugwe, Geofrey, additional, Wajja, Anne, additional, van Dam, Govert J, additional, Corstjens, Paul L A M, additional, Cose, Stephen, additional, Seeley, Janet, additional, Kamuya, Dorcas, additional, Webb, Emily L, additional, Yazdanbakhsh, Maria, additional, Kaleebu, Pontiano, additional, Siddiqui, Afzal A, additional, Kabatereine, Narcis, additional, Tukahebwa, Edridah, additional, Roestenberg, Meta, additional, and Elliott, Alison M, additional

Published
2023
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13. Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses

Author

Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Kyosiimire-Lugemwa, Jacqueline, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Matthew, additional, Connors, Jennifer, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K., additional

Published
2023
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14. Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis

Author

Calvo-Urbano, Beatriz, primary, Léger, Elsa, additional, Gabain, Isobel, additional, De Dood, Claudia J., additional, Diouf, Nicolas D., additional, Borlase, Anna, additional, Rudge, James W., additional, Corstjens, Paul L. A. M., additional, Sène, Mariama, additional, Van Dam, Govert J., additional, Walker, Martin, additional, and Webster, Joanne P., additional

Published
2023
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19. Limited efficacy of repeated praziquantel treatment in Schistosoma mansoni infections as revealed by highly accurate diagnostics, PCR and UCP-LF CAA (RePST trial)

Author

Hoekstra, Pytsje T., primary, Casacuberta-Partal, Miriam, additional, van Lieshout, Lisette, additional, Corstjens, Paul L. A. M., additional, Tsonaka, Roula, additional, Assaré, Rufin K., additional, Silué, Kigbafori D., additional, N’Goran, Eliézer K., additional, N’Gbesso, Yves K., additional, Brienen, Eric A. T., additional, Roestenberg, Meta, additional, Knopp, Stefanie, additional, Utzinger, Jürg, additional, Coulibaly, Jean T., additional, and van Dam, Govert J., additional

Published
2022
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20. The Presence of Hemoglobin in Cervicovaginal Lavage Is Not Associated With Genital Schistosomiasis in Zambian Women From the BILHIV Study

Author

Sturt, Amy S, primary, Webb, Emily L, additional, Phiri, Comfort R, additional, Mapani, Joyce, additional, Mudenda, Maina, additional, Himschoot, Lisa, additional, Kjetland, Eyrun F, additional, Mweene, Tobias, additional, Levecke, Bruno, additional, van Dam, Govert J, additional, Corstjens, Paul L A M, additional, Ayles, Helen, additional, Hayes, Richard J, additional, Francis, Suzanna C, additional, van Lieshout, Lisette, additional, Cools, Piet, additional, Hansingo, Isaiah, additional, and Bustinduy, Amaya L, additional

Published
2022
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22. Sensitive Diagnosis and Post-Treatment Follow-Up of Schistosoma mansoni Infections in Asymptomatic Eritrean Refugees by Circulating Anodic Antigen Detection and Polymerase Chain Reaction

Author

Hoekstra, Pytsje T., primary, Chernet, Afona, additional, de Dood, Claudia J., additional, Brienen, Eric A. T., additional, Corstjens, Paul L. A. M., additional, Labhardt, Niklaus D., additional, Nickel, Beatrice, additional, Wammes, Linda J., additional, van Dam, Govert J., additional, Neumayr, Andreas, additional, and van Lieshout, Lisette, additional

Published
2022
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23. Female Genital Schistosomiasis Lesions Explored Using Circulating Anodic Antigen as an Indicator for Live Schistosoma Worms

Author

Nemungadi, Takalani Girly, primary, Kleppa, Elisabeth, additional, van Dam, Govert J., additional, Corstjens, Paul L. A. M., additional, Galappaththi-Arachchige, Hashini Nilushika, additional, Pillay, Pavitra, additional, Gundersen, Svein Gunnar, additional, Vennervald, Birgitte J., additional, Ndhlovu, Patricia, additional, Taylor, Myra, additional, Naidoo, Saloshni, additional, and Kjetland, Eyrun F., additional

Published
2022
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24. Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures

Author

Casacuberta-Partal, Miriam, primary, van Lieshout, Lisette, additional, van Diepen, Angela, additional, Sijtsma, Jeroen, additional, Ozir-Fazalalikhan, Arifa, additional, Koopman, Jan Pieter R., additional, de Dood, Claudia J., additional, Corstjens, Paul L.A.M., additional, van Dam, Govert J., additional, Hokke, Cornelis H., additional, and Roestenberg, Meta, additional

Published
2021
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28. Female Genital Schistosomiasis and HIV-1 Incidence in Zambian Women: A Retrospective Cohort Study

Author

Sturt, Amy S, Webb, Emily L, Phiri, Comfort R, Mudenda, Maina, Mapani, Joyce, Kosloff, Barry, Cheeba, Maina, Shanaube, Kwame, Bwalya, Justin, Kjetland, Eyrun F, Francis, Suzanna C, Corstjens, Paul LAM, van Dam, Govert J, van Lieshout, Lisette, Hansingo, Isaiah, Ayles, Helen, Hayes, Richard J, and Bustinduy, Amaya L

Abstract

BACKGROUND: Female genital schistosomiasis (FGS) has been associated with prevalent HIV-1. We estimated the incidence of HIV-1 infection in Zambian women with and without FGS. METHODS: Women (aged 18-31, nonpregnant, sexually active) were invited to participate in this study in January-August 2018 at the final follow-up of the HPTN 071 (PopART) Population Cohort. HIV-1-negative participants at enrollment (n = 492) were included in this analysis, with testing to confirm incident HIV-1 performed in HPTN 071 (PopART). The association of incident HIV-1 infection with FGS (Schistosoma DNA detected by polymerase chain reaction [PCR] in any genital specimen) was assessed with exact Poisson regression. RESULTS: Incident HIV-1 infections were observed in 4.1% (20/492) of participants. Women with FGS were twice as likely to seroconvert as women without FGS but with no statistical evidence for a difference (adjusted rate ratio, 2.16; 95% CI, 0.21-12.30; P = .33). Exploratory analysis suggested an association with HIV-1 acquisition among women with ≥2 positive genital PCR specimens (rate ratio, 6.02; 95% CI, 0.58-34.96; P = .13). CONCLUSIONS: Despite higher HIV seroconversion rates in women with FGS, there was no statistical evidence of association, possibly due to low power. Further longitudinal studies should investigate this association in a setting with higher schistosomiasis endemicity.

Published
2021

29. Accuracy of Two Circulating Antigen Tests for the Diagnosis and Surveillance of Schistosoma mansoni Infection in Low-Endemicity Settings of Côte d’Ivoire

Author

Assaré, Rufin K., primary, Tra-Bi, Mathieu I., additional, Coulibaly, Jean T., additional, Corstjens, Paul L. A. M., additional, Ouattara, Mamadou, additional, Hürlimann, Eveline, additional, van Dam, Govert J., additional, Utzinger, Jürg, additional, and N’Goran, Eliézer K., additional

Published
2021
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30. Association of Female Genital Schistosomiasis With the Cervicovaginal Microbiota and Sexually Transmitted Infections in Zambian Women

Author

Sturt, Amy S, primary, Webb, Emily L, additional, Himschoot, Lisa, additional, Phiri, Comfort R, additional, Mapani, Joyce, additional, Mudenda, Maina, additional, Kjetland, Eyrun F, additional, Mweene, Tobias, additional, Levecke, Bruno, additional, van Dam, Govert J, additional, Corstjens, Paul L A M, additional, Ayles, Helen, additional, Hayes, Richard J, additional, van Lieshout, Lisette, additional, Hansingo, Isaiah, additional, Francis, Suzanna C, additional, Cools, Piet, additional, and Bustinduy, Amaya L, additional

Published
2021
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33. Sensitive diagnosis and post-treatment follow-up of Schistosoma mansoni infections in asymptomatic Eritrean refugees by Circulating Anodic Antigen (CAA) detection and PCR

Author

Hoekstra, Pytsje T., Chernet, Afona, de Dood, Claudia J., Brienen, Eric A. T., Corstjens, Paul L. A. M., Labhardt, Niklaus D., Nickel, Beatrice, Wammes, Linda, van Dam, Govert J., Neumayr, Andreas, and van Lieshout, Lisette

Abstract

The increasing number of refugees coming from or passing through Schistosoma-endemic areas and arriving in Europe highlights the importance of screening for schistosomiasis on arrival, and focuses attention on the choice of diagnostic test. We evaluate the diagnostic performance of circulating anodic antigen (CAA) detection in 92 asymptomatic refugees from Eritrea. Results were compared with already-available stool microscopy, serology, and urine point-of-care circulating cathodic antigen (POC-CCA) data. For a full diagnostic comparison, real-time polymerase chain reaction (PCR) and the POC-CCA were included. All outcomes were compared against a composite reference standard. Urine and serum samples were subjected to the ultra-sensitive and highly specific up-converting particle lateral flow CAA test, Schistosoma spp. real-time PCR was performed on urine and stool, and the POC-CCA was used on urine using the G-score method. CAA was detected in 43% of urine and in 40% of serum samples. Urine PCR was negative in all 92 individuals, whereas 25% showed Schistosoma DNA in stool. POC-CCA was positive in 30% of individuals. The CAA test confirmed all microscopy positives, except for two cases that were also negative by all other diagnostic procedures. Post-treatment, a significant reduction in the number of positives and infection intensity was observed, in particular regarding CAA levels. Our findings confirm that microscopy, serology, and POC-CCA lack the sensitivity to detect all active Schistosoma infections. Accuracy of stool PCR was similar to microscopy, indicating that this method also lacks sensitivity. The CAA test appeared to be the most accurate method for screening active Schistosoma infections and for monitoring treatment efficacy.

Published
2021

34. High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study.

Author

Mulindwa, Julius, Namulondo, Joyce, Kitibwa, Anna, Nassuuna, Jacent, Nyangiri, Oscar Asanya, Kimuda, Magambo Phillip, Boobo, Alex, Nerima, Barbara, Busingye, Fred, Candia, Rowel, Namukuta, Annet, Ssenyonga, Ronald, Ukumu, Noah, Ajal, Paul, Adriko, Moses, Noyes, Harry, de Dood, Claudia J., Corstjens, Paul L. A. M., van Dam, Govert J., and Elliott, Alison M.

Subjects
STUNTED growth, SCHOOL children, SCHISTOSOMA mansoni, SHORELINES, CHILD nutrition, FRESH water, GIRLS
Abstract

Background: Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease. Methods: We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10–15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status. Results: The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83–87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI<18.5), and most notably, boys had significantly lower height for age (stunting) than girls in the same age range (p < 0.0001), but this was not directly associated with S. mansoni infection. Conclusion: High prevalence of S. mansoni infection in the region calls for more frequent mass drug administration with praziquantel. We observed high levels of stunting which was not associated with schistosomiasis. There is a need for improved nutrition among the children in the area. Author summary: Schistosomiasis is a neglected but frequent disease that is caused by schistosomes, with over 290 million people worldwide at risk of infection. The major mode of transmission is through contact with fresh water sources infested with infected snails (the intermediate host). In this study, using the point of care test (POC-CCA), we screened 914 school aged children (10–15 years) living in the rural communities along the Lake Albert- River Nile shores of Pakwach district in Northern Uganda. We observed a very high prevalence of S. mansoni infections (over 80%) although the prevalence dropped to 40% in communities that were further from the lake shores. This high prevalence was also coupled with Kato Katz light schistosome infection intensities as categorised by WHO guidelines. We further compared the POC-CCA and Kato Katz tests to the more sensitive CAA assay and this revealed that even though both tests gave good probability of positive prediction, the POC-CCA had higher sensitivity in screening for S. mansoni infections than Kato Katz assay. The study also revealed high levels of stunting within the children, more so amongst boys. Frequent screening and mass treatment of these communities with praziquantel will reduce on the infection rates. But in addition, improved hygiene and sanitation will be required for a sustainable reduction in the prevalence and morbidity of schistosomiasis in the Albert-Nile communities along with dietary intervention for optimal child health. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Female Genital Schistosomiasis and HIV-1 Incidence in Zambian Women: A Retrospective Cohort Study

Author

Sturt, Amy S, primary, Webb, Emily L, additional, Phiri, Comfort R, additional, Mudenda, Maina, additional, Mapani, Joyce, additional, Kosloff, Barry, additional, Cheeba, Maina, additional, Shanaube, Kwame, additional, Bwalya, Justin, additional, Kjetland, Eyrun F, additional, Francis, Suzanna C, additional, Corstjens, Paul L A M, additional, van Dam, Govert J, additional, van Lieshout, Lisette, additional, Hansingo, Isaiah, additional, Ayles, Helen, additional, Hayes, Richard J, additional, and Bustinduy, Amaya L, additional

Published
2021
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36. Specificity of the Point-of-Care Urine Strip Test for Schistosoma Circulating Cathodic Antigen (POC-CCA) Tested in Non-Endemic Pregnant Women and Young Children

Author

Casacuberta-Partal, Miriam, primary, Beenakker, Margreet, additional, de Dood, Claudia J., additional, Hoekstra, Pytsje T., additional, Kroon, Lisa, additional, Kornelis, Dieuwke, additional, Corstjens, Paul, additional, Hokke, Cornelis H., additional, van Dam, Govert J., additional, Roestenberg, Meta, additional, and van Lieshout, Lisette, additional

Published
2021
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40. Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis

Author

Sturt, Amy S., primary, Webb, Emily L., additional, Patterson, Catriona, additional, Phiri, Comfort R., additional, Mweene, Tobias, additional, Kjetland, Eyrun F., additional, Mudenda, Maina, additional, Mapani, Joyce, additional, Mutengo, Mable M., additional, Chipeta, James, additional, van Dam, Govert J., additional, Corstjens, Paul L. A. M., additional, Ayles, Helen, additional, Hayes, Richard J., additional, Hansingo, Isaiah, additional, Cools, Piet, additional, van Lieshout, Lisette, additional, Helmby, Helena, additional, McComsey, Grace A., additional, Francis, Suzanna C., additional, and Bustinduy, Amaya L., additional

Published
2021
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41. Genital self-sampling compared with cervicovaginal lavage for the diagnosis of female genital schistosomiasis in Zambian women: The BILHIV study

Author

Sturt, Amy S., Webb, Emily L., Phiri, Comfort R., Mweene, Tobias, Chola, Namakau, van Dam, Govert J., Corstjens, Paul L. A. M., Wessels, Els, Stothard, Russell, Hayes, Richard, Ayles, Helen, Hansingo, Isaiah, van Lieshout, Lisette, and Bustinduy, Amaya L.

Subjects
wj_140, wj_100, wa_395, wa_309, wc_810, wp_141
Abstract

Background: Given the potentially causal association of female genital schistosomiasis (FGS) with HIV-1 infection, improved diagnostics are urgently needed to scale-up FGS surveillance. The BILHIV (bilharzia and HIV) study assessed the performance of home-based self-collection methods (cervical and vaginal swabs) compared to cervicovaginal lavage (CVL) for the detection of Schistosoma DNA by real-time polymerase chain reaction (PCR). Methods: Between January and August 2018, a consecutive series of female participants from the Population-Cohort of the previous HIV prevention trial HPTN 071 (PopART), resident in Livingstone, Zambia were invited to take part in BILHIV if they were 18–31 years old, non-pregnant and sexually active. Genital self-collected swabs and a urine specimen were obtained and a questionnaire completed at home visits. CVL was obtained at clinic follow-up. Results: 603 women self-collected genital swabs. Of these, 527 women had CVL performed by a mid-wife during clinic follow-up. Schistosoma DNA was more frequently detected in genital self-collected specimens (24/603, 4.0%) compared to CVL (14/527, 2.7%). Overall, 5.0% (30/603) women had female genital schistosomiasis, defined as a positive PCR by any genital sampling method (cervical swab PCR, vaginal swab PCR, or CVL PCR) and 95% (573/603) did not have a positive genital PCR. The sensitivity of any positive genital self-collected swab against CVL was 57.1% (95% CI 28.9–82.3%), specificity 97.3% (95.5–98.5%). In a subset of participants with active schistosome infection, determined by detectable urine Circulating Anodic Antigen (CAA) (15.1%, 91/601), positive PCR (4.3%, 26/601), or positive microscopy (5.5%, 33/603), the sensitivity of any positive self-collected specimen against CVL was 88.9% (51.8–99.7%). Conclusions: Genital self-sampling increased the overall number of PCR-based FGS diagnoses in a field setting, compared with CVL. Home-based sampling may represent a scalable alternative method for FGS community-based diagnosis in endemic resource limited settings.

Published
2020

42. Schistosomiasis and HIV in rural Zimbabwe: efficacy of treatment of schistosomiasis in individuals with HIV coinfection

Author

Kallestrup, Per, Zinyama, Rutendo, Gomo, Exnevia, Butterworth, Anthony E., van Dam, Govert J., Gerstoft, Jan, Erikstrup, Christian, and Ullum, Henrik

Subjects
Schistosomiasis -- Care and treatment, HIV infection -- Care and treatment, Comorbidity -- Management, Praziquantel -- Dosage and administration, Praziquantel -- Research, Company business management, Health, Health care industry
Published
2006

43. The burden of HIV, syphilis and schistosome infection and associated factors among adults in the fishing communities in northwestern Tanzania

Author

Kapiga, Saidi, primary, Hansen, Christian H., additional, Downs, Jennifer A., additional, Sichalwe, Simon, additional, Hashim, Ramadhan, additional, Mngara, Julius, additional, van Dam, Govert J., additional, Corstjens, Paul L. A. M., additional, Kingery, Justin R., additional, Peck, Robert N., additional, and Grosskurth, Heiner, additional

Published
2020
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44. Genital self-sampling compared with cervicovaginal lavage for the diagnosis of female genital schistosomiasis in Zambian women: The BILHIV study

Author

Sturt, Amy S., primary, Webb, Emily L., additional, Phiri, Comfort R., additional, Mweene, Tobias, additional, Chola, Namakau, additional, van Dam, Govert J., additional, Corstjens, Paul L. A. M., additional, Wessels, Els, additional, Stothard, J. Russell, additional, Hayes, Richard, additional, Ayles, Helen, additional, Hansingo, Isaiah, additional, van Lieshout, Lisette, additional, and Bustinduy, Amaya L., additional

Published
2020
Full Text
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45. Circulating Anodic Antigen (CAA): A Highly Sensitive Diagnostic Biomarker to Detect Active Schistosoma Infections—Improvement and Use during SCORE

Author

Corstjens, Paul L. A. M., primary, de Dood, Claudia J., additional, Knopp, Stefanie, additional, Clements, Michelle N., additional, Ortu, Giuseppina, additional, Umulisa, Irenee, additional, Ruberanziza, Eugene, additional, Wittmann, Udo, additional, Kariuki, Thomas, additional, LoVerde, Philip, additional, Secor, William Evan, additional, Atkins, Lydia, additional, Kinung’hi, Safari, additional, Binder, Sue, additional, Campbell, Carl H., additional, Colley, Daniel G., additional, and van Dam, Govert J., additional

Published
2020
Full Text
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46. Nationwide Remapping of Schistosoma mansoni Infection in Rwanda Using Circulating Cathodic Antigen Rapid Test: Taking Steps toward Elimination

Author

Ruberanziza, Eugene, primary, Wittmann, Udo, additional, Mbituyumuremyi, Aimable, additional, Mutabazi, Alphonse, additional, Campbell, Carl H., additional, Colley, Daniel G., additional, Fleming, Fiona M., additional, Ortu, Giuseppina, additional, van Dam, Govert J., additional, Umulisa, Irenee, additional, Tallant, Jamie, additional, Kabera, Michee, additional, Semakula, Muhammed, additional, Corstjens, Paul L. A. M., additional, Munyaneza, Tharcisse, additional, Lancaster, Warren, additional, Mbonigaba, Jean Bosco, additional, and Clements, Michelle N., additional

Published
2020
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47. Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals

Author

Zinsou, Jeannot F., primary, Janse, Jacqueline J., additional, Honpkehedji, Yabo Y., additional, Dejon-Agobé, Jean Claude, additional, García-Tardón, Noemí, additional, Hoekstra, Pytsje T., additional, Massinga-Loembe, Marguerite, additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Giera, Martin, additional, Kremsner, Peter G., additional, Yazdanbakhsh, Maria, additional, Adegnika, Ayola A., additional, and Guigas, Bruno, additional

Published
2020
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50. Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST)

Author

Hoekstra, Pytsje T., primary, Casacuberta-Partal, Miriam, additional, van Lieshout, Lisette, additional, Corstjens, Paul L. A. M., additional, Tsonaka, Roula, additional, Assaré, Rufin K., additional, Silué, Kigbafori D., additional, Meité, Aboulaye, additional, N’Goran, Eliézer K., additional, N’Gbesso, Yves K., additional, Amoah, Abena S., additional, Roestenberg, Meta, additional, Knopp, Stefanie, additional, Utzinger, Jürg, additional, Coulibaly, Jean T., additional, and van Dam, Govert J., additional

Published
2020
Full Text
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