Search

Your search keyword '"van Beijsterveldt, C. E. M."' showing total 44 results
Start Over Author "van Beijsterveldt, C. E. M." Search Limiters Full Text
44 results on '"van Beijsterveldt, C. E. M."'

12. Comparing the genetic architecture of childhood behavioral problems across socioeconomic strata in the Netherlands and the United Kingdom

Author

Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Hendriks, A M, Finkenauer, C, Nivard, M G, Van Beijsterveldt, C E M, Plomin, R J, Boomsma, D I, Bartels, M, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Hendriks, A M, Finkenauer, C, Nivard, M G, Van Beijsterveldt, C E M, Plomin, R J, Boomsma, D I, and Bartels, M

Published
2020

13. Genetic and environmental variation in educational attainment : an individual-based analysis of 28 twin cohorts

Author

Silventoinen, K., Jelenkovic, A., Sund, R., Latvala, A., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Rebato, E., Busjahn, A., Tyler, J., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Medda, E., Nisticò, L., Toccaceli, V., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Duncan, G. E., Buchwald, D., Tynelius, P., Rasmussen, F., Tan, Q., Zhang, D., Pang, Z., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., Hwang, A. E., Mack, T. M., Krueger, R. F., McGue, M., Pahlen, S., Brandt, I., Nilsen, T. S., Harris, J. R., Martin, N. G., Medland, S. E., Montgomery, G. W., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Franz, C. E., Kremen, W. S., Lyons, M. J., Silberg, J. L., Maes, H. H., Kandler, C., Nelson, T. L., Whitfield, K. E., Corley, R. P., Huibregtse, B. M., Gatz, M., Butler, D. A., Tarnoki, A. D., Tarnoki, D. L., Park, H. A., Lee, J., Lee, S. J., Sung, J., Yokoyama, Y., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J., Silventoinen, K., Jelenkovic, A., Sund, R., Latvala, A., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Rebato, E., Busjahn, A., Tyler, J., Hopper, J. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Medda, E., Nisticò, L., Toccaceli, V., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Duncan, G. E., Buchwald, D., Tynelius, P., Rasmussen, F., Tan, Q., Zhang, D., Pang, Z., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., Hwang, A. E., Mack, T. M., Krueger, R. F., McGue, M., Pahlen, S., Brandt, I., Nilsen, T. S., Harris, J. R., Martin, N. G., Medland, S. E., Montgomery, G. W., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Franz, C. E., Kremen, W. S., Lyons, M. J., Silberg, J. L., Maes, H. H., Kandler, C., Nelson, T. L., Whitfield, K. E., Corley, R. P., Huibregtse, B. M., Gatz, M., Butler, D. A., Tarnoki, A. D., Tarnoki, D. L., Park, H. A., Lee, J., Lee, S. J., Sung, J., Yokoyama, Y., Sørensen, T. I. A., Boomsma, D. I., and Kaprio, J.

Abstract

We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural–geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability: a2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30–0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900–1949 (a2 = 0.44; 0.41–0.46) than in the later cohorts born in 1950–1989 (a2 = 0.38; 0.36–0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29–0.33 and c2 = 0.34; 0.32–0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.

Published
2020
Full Text
View/download PDF

20. Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting

Author

Slof-Op ‘t Landt, M. C. T., Meulenbelt, I., Bartels, M., Suchiman, E., Middeldorp, C. M., Houwing-Duistermaat, J. J., van Trier, J., Onkenhout, E. J., Vink, J. M., van Beijsterveldt, C. E. M., Brandys, M. K., Sanders, N., Zipfel, S., Herzog, W., Herpertz-Dahlmann, B., Klampfl, K., Fleischhaker, C., Zeeck, A., de Zwaan, M., Herpertz, S., Ehrlich, S., van Elburg, A. A., Adan, R. A. H., Scherag, S., Hinney, A., Hebebrand, J., Boomsma, D. I., van Furth, E. F., and Slagboom, P. E.

Published
2011
Full Text
View/download PDF

25. The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

Author

Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Bogl, L. H., Freitas, D. L., Maia, J. A., Hjelmborg, J. v. B., Aaltonen, S., Piirtola, M., Latvala, A., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Ji, F., Ning, F., Pang, Z., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Martin, N. G., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Oncel, S. Y., Aliev, F., Medda, E., Nistico, L., Toccaceli, V., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Jeong, H. -U., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Gao, W., Yu, C., Li, L., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Silberg, J. L., Maes, H. H., Cutler, T. L., Hopper, J. L., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Ullemar, V., Almqvist, C., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Rasmussen, F., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Harris, J. R., Sung, J., Park, H. A., Lee, J., Lee, S. J., Willemsen, G., Bartels, M., Van Beijsterveldt, C. E. M., Llewellyn, C. H., Fisher, A., Rebato, E., Busjahn, A., Tomizawa, R., Inui, F., Watanabe, M., Honda, C., Sakai, N., Hur, Y. -M., Sørensen, T. I. A., Boomsma, D. I., Kaprio, J., Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Bogl, L. H., Freitas, D. L., Maia, J. A., Hjelmborg, J. v. B., Aaltonen, S., Piirtola, M., Latvala, A., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Ji, F., Ning, F., Pang, Z., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Martin, N. G., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Oncel, S. Y., Aliev, F., Medda, E., Nistico, L., Toccaceli, V., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Jeong, H. -U., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Gao, W., Yu, C., Li, L., Bayasgalan, G., Narandalai, D., Harden, K. P., Tucker-Drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Silberg, J. L., Maes, H. H., Cutler, T. L., Hopper, J. L., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Ullemar, V., Almqvist, C., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Rasmussen, F., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Harris, J. R., Sung, J., Park, H. A., Lee, J., Lee, S. J., Willemsen, G., Bartels, M., Van Beijsterveldt, C. E. M., Llewellyn, C. H., Fisher, A., Rebato, E., Busjahn, A., Tomizawa, R., Inui, F., Watanabe, M., Honda, C., Sakai, N., Hur, Y. -M., Sørensen, T. I. A., Boomsma, D. I., and Kaprio, J.

Published
2019

28. Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : An individual-based pooled analysis of 40 twin cohorts

Author

Silventoinen, K., Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y. -M, Cozen, W., Hwang, A. E., Mack, T. M., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Tomizawa, R., Pietilainen, K. H., Rissanen, A., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Piirtola, M., Aaltonen, S., Oncel, S. Y., Aliev, F., Rebato, E., Hjelmborg, J. B., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Cutler, T. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Song, Y. -M, Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. -U, Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Spector, T. D., Mangino, M., Lachance, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Huibregtse, B. M., Bartels, M., Van Beijsterveldt, C. E. M., Willemsen, G., Goldberg, J. H., Rasmussen, F., Tarnoki, A. D., Tarnoki, D. L., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Hopper, J. L., Sung, J., Maes, H. H., Turkheimer, E., Boomsma, D. I., Sørensen, T. I. A., Kaprio, J., Silventoinen, K., Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y. -M, Cozen, W., Hwang, A. E., Mack, T. M., Honda, C., Inui, F., Iwatani, Y., Watanabe, M., Tomizawa, R., Pietilainen, K. H., Rissanen, A., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Tan, Q., Zhang, D., Pang, Z., Piirtola, M., Aaltonen, S., Oncel, S. Y., Aliev, F., Rebato, E., Hjelmborg, J. B., Christensen, K., Skytthe, A., Kyvik, K. O., Silberg, J. L., Eaves, L. J., Cutler, T. L., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Song, Y. -M, Yang, S., Lee, K., Franz, C. E., Kremen, W. S., Lyons, M. J., Busjahn, A., Nelson, T. L., Whitfield, K. E., Kandler, C., Jang, K. L., Gatz, M., Butler, D. A., Stazi, M. A., Fagnani, C., D'Ippolito, C., Duncan, G. E., Buchwald, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Jeong, H. -U, Swan, G. E., Krasnow, R., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, Anna K., McAdams, T. A., Eley, T. C., Gregory, A. M., Tynelius, P., Baker, L. A., Tuvblad, C., Bayasgalan, G., Narandalai, D., Spector, T. D., Mangino, M., Lachance, G., Burt, S. A., Klump, K. L., Harris, J. R., Brandt, I., Nilsen, T. S., Krueger, R. F., McGue, M., Pahlen, S., Corley, R. P., Huibregtse, B. M., Bartels, M., Van Beijsterveldt, C. E. M., Willemsen, G., Goldberg, J. H., Rasmussen, F., Tarnoki, A. D., Tarnoki, D. L., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Hopper, J. L., Sung, J., Maes, H. H., Turkheimer, E., Boomsma, D. I., Sørensen, T. I. A., and Kaprio, J.

Abstract

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20-29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.

Published
2017
Full Text
View/download PDF

29. Cost-effectiveness of embryo transfer strategies : a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF

Author

van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, Dirksen, C D, van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, and Dirksen, C D

Published
2016

30. Cost-effectiveness of embryo transfer strategies: a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF

Author

Geboortecentrum voorzitterschap, Other research (not in main researchprogram), MS Neonatologie, Brain, Fertiliteitartsen, Child Health, van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, Dirksen, C D, Geboortecentrum voorzitterschap, Other research (not in main researchprogram), MS Neonatologie, Brain, Fertiliteitartsen, Child Health, van Heesch, M M J, van Asselt, A D I, Evers, J L H, van der Hoeven, M A H B M, Dumoulin, J C M, van Beijsterveldt, C E M, Bonsel, G J, Dykgraaf, R H M, van Goudoever, J B, Koopman-Esseboom, C, Nelen, W L D M, Steiner, K, Tamminga, P, Tonch, N, Torrance, H L, and Dirksen, C D

Published
2016

31. Hospital costs during the first 5 years of life for multiples compared with singletons born after IVF or ICSI

Author

Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., Dirksen, C. D., Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., and Dirksen, C. D.

Published
2015

32. Hospital costs during the first 5 years of life for multiples compared with singletons born after IVF or ICSI

Author

Fertiliteitartsen, Child Health, CTI Leusen, Geboortecentrum voorzitterschap, MS Neonatologie, Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., Dirksen, C. D., Fertiliteitartsen, Child Health, CTI Leusen, Geboortecentrum voorzitterschap, MS Neonatologie, Van Heesch, M. M J, Evers, J. L H, Van Der Hoeven, M. A H B M, Dumoulin, J. C M, Van Beijsterveldt, C. E M, Bonsel, G. J., Dykgraaf, R. H M, Van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L D M, Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., and Dirksen, C. D.

Published
2015

36. Cost-effectiveness of embryo transfer strategies: a decision analytic model using long-term costs and consequences of singletons and multiples born as a consequence of IVF.

Author

van Heesch, M. M. J., van Asselt, A. D. I, Evers, J. L. H., van der Hoeven, M. A. H. B. M., Dumoulin, J. C. M., van Beijsterveldt, C. E. M., Bonsel, G. J., Dykgraaf, R. H. M., van Goudoever, J. B., Koopman-Esseboom, C., Nelen, W. L. D. M., Steiner, K., Tamminga, P., Tonch, N., Torrance, H. L., and Dirksen, C. D.

Subjects
EMBRYO transfer, FERTILIZATION in vitro, COST effectiveness, MEDICAL decision making, QUALITY of life, BIRTH rate, DECISION making, MULTIPLE pregnancy, RETROSPECTIVE studies, QUALITY-adjusted life years, STATISTICAL models, ECONOMICS
Abstract

Study Question: What is the cost-effectiveness of elective single embryo transfer (eSET) versus double embryo transfer (DET) strategies from a societal perspective, when applying a time horizon of 1, 5 and 18 years?Summary Answer: From a short-term perspective (1 year) it is cost-effective to replace DET with single embryo transfer; however when intermediate- (5 years) and long-term (18 years) costs and consequences are incorporated, DET becomes the most cost-effective strategy, given a ceiling ratio of €20 000 per quality-adjusted life years (QALY) gained.What Is Already Known: According to previous cost-effectiveness research into embryo transfer strategies, DET is considered cost-effective if society is willing to pay around €20 000 for an extra live birth. However, interpretation of those studies is complicated, as those studies fail to incorporate long-term costs and outcomes and used live birth as a measure of effectiveness instead of QALYs. With this outcome, both multiple and singletons were valued as one live birth, whereas costs of all children of a multiple were incorporated.Study Design, Size, Duration: A Markov model (cycle length: 1 year; time horizon: 1, 5 and 18 years) was developed comparing a maximum of: (i) three cycles of eSET in all patients; (ii) four cycles of eSET in all patients; (iii) five cycles of eSET in all patients; (iv) three cycles of standard treatment policy (STP), i.e. eSET in women <38 years with a good quality embryo, and DET in all other women; and (v) three cycles of DET in all patients.Participants/materials, Setting, Methods: Expected life years (LYs), child QALYs and costs were estimated for all comparators. Input parameters were derived from a retrospective cohort study, in which hospital resource data were collected (n=580) and a parental questionnaire was sent out (431 respondents). Probabilistic sensitivity analysis (5000 iterations) was performed.Main Results and the Role Of Chance: With a time horizon of 18 years, DETx3 is most effective (0.54 live births, 10.2 LYs and 9.8 QALYs) and expensive (€37 871) per couple starting IVF. Three cycles of eSET are least effective (0.43 live births, 7.1 LYs and 6.8 QALYs) and expensive (€25 563). We assumed that society is willing to pay €20 000 per QALY gained. With a time horizon of 1 year, eSETx3 was the most cost-effective embryo transfer strategy with a probability of being cost-effective of 99.9%. With a time horizon of 5 or 18 years, DETx3 was most cost-effective, with probabilities of being cost-effective of 77.3 and 93.2%, respectively.Limitations, Reasons For Caution: This is the first study to use QALYs generated by the children in the economic evaluation of embryo transfer strategies. There remains some disagreement on whether QALYs generated by new life should be used in economic evaluations of fertility treatment. A further limitation is that treatment ends when it results in live birth and that only child QALYs were considered as measure of effectiveness. The results for the time horizon of 18 years might be less solid, as the data beyond the age of 8 years are based on extrapolation.Wider Implications Of the Findings: The current Markov model indicates that when child QALYs are used as measure of outcome it is not cost-effective on the long term to replace DET with single embryo transfer strategies. However, for a balanced approach, a family-planning perspective would be preferable, including additional treatment cycles for couples who wish to have another child. Furthermore, the analysis should be extended to include QALYs of family members.Study Funding/competing Interests: This study was supported by a research grant (grant number 80-82310-98-09094) from the Netherlands Organization for Health Research and Development (ZonMw). There are no conflicts of interest in connection with this article.Trial Registration Number: Not applicable. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

38. Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting

Author

Slof-Op ‘t Landt, M. C. T., primary, Meulenbelt, I., additional, Bartels, M., additional, Suchiman, E., additional, Middeldorp, C. M., additional, Houwing-Duistermaat, J. J., additional, van Trier, J., additional, Onkenhout, E. J., additional, Vink, J. M., additional, van Beijsterveldt, C. E. M., additional, Brandys, M. K., additional, Sanders, N., additional, Zipfel, S., additional, Herzog, W., additional, Herpertz-Dahlmann, B., additional, Klampfl, K., additional, Fleischhaker, C., additional, Zeeck, A., additional, de Zwaan, M., additional, Herpertz, S., additional, Ehrlich, S., additional, van Elburg, A. A., additional, Adan, R. A. H., additional, Scherag, S., additional, Hinney, A., additional, Hebebrand, J., additional, Boomsma, D. I., additional, van Furth, E. F., additional, and Slagboom, P. E., additional

Published
2010
Full Text
View/download PDF

40. The heritability of general cognitive ability increases linearly from childhood to young adulthood

Author

Haworth, C M A, primary, Wright, M J, additional, Luciano, M, additional, Martin, N G, additional, de Geus, E J C, additional, van Beijsterveldt, C E M, additional, Bartels, M, additional, Posthuma, D, additional, Boomsma, D I, additional, Davis, O S P, additional, Kovas, Y, additional, Corley, R P, additional, DeFries, J C, additional, Hewitt, J K, additional, Olson, R K, additional, Rhea, S-A, additional, Wadsworth, S J, additional, Iacono, W G, additional, McGue, M, additional, Thompson, L A, additional, Hart, S A, additional, Petrill, S A, additional, Lubinski, D, additional, and Plomin, R, additional

Published
2009
Full Text
View/download PDF

41. Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins

Author

Hur, Y-M, primary, Kaprio, J, additional, Iacono, W G, additional, Boomsma, D I, additional, McGue, M, additional, Silventoinen, K, additional, Martin, N G, additional, Luciano, M, additional, Visscher, P M, additional, Rose, R J, additional, He, M, additional, Ando, J, additional, Ooki, S, additional, Nonaka, K, additional, Lin, C C H, additional, Lajunen, H R, additional, Cornes, B K, additional, Bartels, M, additional, van Beijsterveldt, C E M, additional, Cherny, S S, additional, and Mitchell, K, additional

Published
2008
Full Text
View/download PDF

43. Secular trends in gestational age and birthweight in twins.

Author

Gielen, M., van Beijsterveldt, C. E. M., Derom, C., Vlietinck, R., Nijhuis, J. G., Zeegers, M. P. A., and Boomsma, D. I.

Subjects
*SECULAR changes (Child development), *GESTATIONAL age, *BIRTH weight, *TWINS, *PREMATURE labor, *CESAREAN section, *CROSS-sectional method, *MULTIPLE regression analysis, *PHYSIOLOGY
Abstract

BACKGROUND: In recent decades, the overall rate of preterm births has increased. The aim of the present study was to examine whether this trend is also seen for multiple gestations. More specifically, we examined if there has been a decrease in gestational age for live born monozygotic (MZ) and dizygotic (DZ) twins and if there has been a simultaneous change in birthweight. The contributions of fertility treatments and Caesarean sections were taken into consideration. All analyses were carried out in two large European twin cohorts. METHODS: Cross-sectional study of 6310 live born twin pairs, born between 1964-2007, from the Belgian East Flanders Prospective Twin Survey and 14 712 twin pairs, born between 1990-2006, from the Netherlands Twin Register. Multiple regression analyses were performed with gestational age as outcome variable, and multilevel analysis with birthweight as outcome variable. All analyses were performed with and without adjustment for zygosity, parity, maternal age, mode of conception and delivery and, for the analyses of birthweight, gestational age. RESULTS: Gestational age decreased in a linear fashion from 1964 to 2007 with a decrease of 0.25 days per year in a similar way for MZ and DZ twins. Changes in birthweight depended on gestational age: up to 32 weeks, birthweight decreased and after 32 weeks birthweight increased. The frequency of infertility treatment and Caesarean sections, primiparity and advanced maternal age increased over the years, but none of these factors influenced the secular trends in gestational age and birthweight. CONCLUSIONS: The decrease in gestational age and change in birthweight in twins are sources of concern, especially for very preterm twins, for whom birthweight decreased. For twins born after 32 weeks, an increase in birthweight was observed and this is very likely the explanation for the decrease in gestational age. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

44. Body composition, smoking, and spontaneous dizygotic twinning.

Author

Hoekstra C, Willemsen G, van Beijsterveldt CE, Lambalk CB, Montgomery GW, and Boomsma DI

Subjects
Adolescent, Adult, Educational Status, Female, Gravidity, Humans, Maternal Age, Middle Aged, Netherlands epidemiology, Pregnancy, Prevalence, Registries, Retrospective Studies, Risk Factors, Twins, Monozygotic, Young Adult, Body Composition, Pregnancy Complications epidemiology, Smoking epidemiology, Twins, Dizygotic
Abstract

Objective: To examine differences in body composition and smoking between mothers of spontaneous monozygotic and dizygotic twins, while taking into account maternal age, gravidity, and educational attainment., Design: Retrospective cohort study., Setting: The Netherlands Twin Register., Patient(s): Mothers of twins (n = 19,357) registered with the Netherlands Twin Register. Data were selected from mothers of spontaneous monozygotic twins (MZ; n = 5663) and mothers of spontaneous dizygotic twins (DZ; n = 8515)., Intervention(s): None., Main Outcome Measure(s): The odds of having spontaneous DZ twins versus spontaneous MZ twins as a function of height, body mass index (BMI), and smoking before pregnancy, after accounting for age, gravidity, and educational attainment., Result(s): Compared with spontaneous MZ twinning, spontaneous DZ twinning is significantly associated with increasing height (odds ratio, 1.6; 95% confidence interval [CI], 1.5-1.8 for the tallest versus the shortest height quartile), an increased BMI (odds ratio, 1.3; 95% CI, 1.1-1.4 for overweight vs. normal weight), and smoking before the twin pregnancy (odds ratio, 1.4; 95% CI, 1.3-1.5 for smoker vs. nonsmoker). Maternal age and gravidity, but not educational attainment, had to be included in the model., Conclusion(s): Spontaneous dizygotic twinning is associated with body composition and smoking., (Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results