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Spinal muscular atrophy (SMA) is caused by a deficiency of the ubiquitously expressed survival motor neuron (SMN) protein. The main pathological hallmark of SMA is the degeneration of lower motor neurons (MNs) with subsequent denervation and atrophy of skeletal muscle. However, increasing evidence indicates that low SMN levels not only are detrimental to the central nervous system (CNS) but also directly affect other peripheral tissues and organs, including skeletal muscle. To better understand the potential primary impact of SMN deficiency in muscle, we explored the cellular, ultrastructural, and molecular basis of SMA myopathy in the SMNΔ7 mouse model of severe SMA at an early postnatal period (P0-7) prior to muscle denervation and MN loss (preneurodegenerative [PND] stage). This period contrasts with the neurodegenerative (ND) stage (P8-14), in which MN loss and muscle atrophy occur. At the PND stage, we found that SMN∆7 mice displayed early signs of motor dysfunction with overt myofiber alterations in the absence of atrophy. We provide essential new ultrastructural data on focal and segmental lesions in the myofibrillar contractile apparatus. These lesions were observed in association with specific myonuclear domains and included abnormal accumulations of actin-thin myofilaments, sarcomere disruption, and the formation of minisarcomeres. The sarcoplasmic reticulum and triads also exhibited ultrastructural alterations, suggesting decoupling during the excitation–contraction process. Finally, changes in intermyofibrillar mitochondrial organization and dynamics, indicative of mitochondrial biogenesis overactivation, were also found. Overall, our results demonstrated that SMN deficiency induces early and MN loss-independent alterations in myofibers that essentially contribute to SMA myopathy. This strongly supports the growing body of evidence indicating the existence of intrinsic alterations in the skeletal muscle in SMA and further reinforces the relevance of this peripheral tissue as a key therapeutic target for the disease. [ABSTRACT FROM AUTHOR]

In spectral wave models, the nonlinear triad source term accounts for the transfer of energy to the bound higher harmonics. This paper presents an extension to commonly used spectral models that resolves the evolution of the bound wave energy by keeping track of the energy that has been bound by the triad interactions. This extension is referred to as the bound wave evolution (BWE) model. From this, the spatial evolution of the bound wave height is obtained, which serves as a proxy for the nonlinear wave shape. The accuracy of these bound wave heights, and thus wave shape predictions, is highly dependent on the accuracy of the triad source term. Therefore, in this study, the capability of the LTA and SPB triad formulations to capture the growth of the bound wave height is evaluated. For both of these formulations, it is found that slope dependent calibration parameters are required. Overall, despite being computationally more expensive, the SPB method proves to be significantly more accurate in predicting the bound wave evolution. In the shoaling zone, where the bound wave energy is dominated by triads, the BWE model is well capable of predicting the nonlinear wave's shape. In the surf zone, however, where a combination of triads and wave breaking control the spectral evolution, the BWE model over-predicts the bound wave height. Nevertheless, this paper shows the promising capabilities of spectral models to predict the nonlinear wave shape. [ABSTRACT FROM AUTHOR]

Hydrogen is troublesome in any periodic table classification. This being so it may as well be placed in a position that confers desirable attributes to the arrangement of the elements, while notionally recognising its lineage to the group 1 alkali metals and the group 17 halogens. Since the noble gases bridge the halogens and the alkali metals, and hydrogen encompasses the transition from the alkali metals to the halogens, there is more to the idea of hydrogen over helium. Hydrogen...seems to claim an exceptional position (Meyer 1870, p. 357) The real voyage of discovery consists not in seeking new lands but in seeing with new eyes (Proust 1927, p. 559) [ABSTRACT FROM AUTHOR]

The mafias, opening up from their territories of origin, have opened up to profound global transformations, also rethinking their own hierarchies of values, their own purposes and their own rules. In particular, in this paper the author deals with the Chinese mafia and its presence on Italian and European territory. In a transnational dimension, the Chinese underworld operates, with the native and foreign criminal cliques present in the territories, in carrying out illicit business and does this with a "mafia-style" methodology. Triad is the name given in the West to a secret society, founded in China in the 17th century and which has today become a dangerous mafia criminal organisation. It has its bases in Hong Kong and the island of Taiwan, but today it is increasingly widespread not only in the United States of America, but also in Italy and Europe [ABSTRACT FROM AUTHOR]

In spectral wave models, the nonlinear triad source term accounts for the transfer of energy to the bound higher harmonics. This paper presents an extension to commonly used spectral models that resolves the evolution of the bound wave energy by keeping track of the energy that has been bound by the triad interactions. This extension is referred to as the bound wave evolution (BWE) model. From this, the spatial evolution of the bound wave height is obtained, which serves as a proxy for the nonlinear wave shape. The accuracy of these bound wave heights, and thus wave shape predictions, is highly dependent on the accuracy of the triad source term. Therefore, in this study, the capability of the LTA and SPB triad formulations to capture the growth of the bound wave height is evaluated. For both of these formulations, it is found that slope dependent calibration parameters are required. Overall, despite being computationally more expensive, the SPB method proves to be significantly more accurate in predicting the bound wave evolution. In the shoaling zone, where the bound wave energy is dominated by triads, the BWE model is well capable of predicting the nonlinear wave’s shape. In the surf zone, however, where a combination of triads and wave breaking control the spectral evolution, the BWE model over-predicts the bound wave height. Nevertheless, this paper shows the promising capabilities of spectral models to predict the nonlinear wave shape.

The outcome-oriented e-education concept is one of the current international advanced education concepts, and its generation and development fit with the development of information technology and the social demand for the quality of talent cultivation. In this paper, a knowledge mapping system for university English courses based on the concept of outcome-orientated education is investigated to enable the integration of university English course knowledge and its visualization in the form of web pages. Knowledge points, concepts, definitions, and other information about the university English subject are extracted, and various data sources, which contain structured, semi-structured, and unstructured data, are collected, integrated, and extracted in the form of English knowledge triads. The system testing results indicate that, in comparison to the traditional DistMult method, this paper’s method enhances the classification accuracy of the three English course datasets by 0.93%, 1.68%, and 0.85%, respectively. The experimental results validate the effectiveness and superiority of the system. Meanwhile, the questionnaire survey found that the system can effectively help learners improve their confidence, interest, and initiative in learning, enhance their learning effectiveness, improve their learning efficiency, and provide them with high-quality learning resources that have good application value.

Humans subtly synchronize body movement during face-to-face conversation. In this context, bodily synchrony has been linked to affiliation and social bonding, task success and comprehension, and potential conflict. Almost all studies of conversational synchrony involve dyads, and relatively less is known about the structure of synchrony in groups larger than two. We conducted an optic flow analysis of body movement in triads engaged in face-to-face conversation, and explored a common measure of synchrony: time-aligned bodily covariation. We correlated this measure of synchrony with a diverse set of covariates related to the outcome of interactions. Triads showed higher maximum cross-correlation relative to a surrogate baseline, and 'meta-synchrony', in that composite dyads in a triad tended to show correlated structure. A windowed analysis also revealed that synchrony varies widely across an interaction. As in prior studies, average synchrony was low but statistically reliable in just a few minutes of interaction. In an exploratory analysis, we investigated the potential function of body synchrony by predicting it from various covariates, such as linguistic style matching, liking, laughter and cooperative play in a behavioural economic game. Exploratory results do not reveal a clear function for synchrony, though colaughter within triads was associated with greater body synchrony, and is consistent with an earlier analysis showing a positive connection between colaughter and cooperation. We end by discussing the importance of expanding and codifying analyses of synchrony and assessing its function.

Abstract Motifs represent local subgraphs that are overrepresented in networks. Several disciplines document multiple instances in which motifs appear in graphs and provide insight into the structure and processes of these networks. In the current paper, we focus on social networks and examine the prevalence of dyad, triad, and symmetric tetrad motifs among 24 networks that represent six types of social interactions: friendship, legislative co-sponsorship, Twitter messages, advice seeking, email communication, and terrorist collusion. Given that the correct control distribution for detecting motifs is a matter of continuous debate, we propose a novel approach that compares the local patterns of observed networks to random graphs simulated from exponential random graph models. Our proposed technique can produce conditional distributions that control for multiple, lower-level structural patterns simultaneously. We find evidence for five motifs using our approach, including the reciprocated dyad, three triads, and one symmetric tetrad. Results highlight the importance of mutuality, hierarchy, and clustering across multiple social interactions, and provide evidence of “structural signatures” within different genres of graph. Similarities also emerge between our findings and those in other disciplines, such as the preponderance of transitive triads.

The article begins with a response to a recent contribution by Jensen, in which he has criticized several aspects of the use of triads of elements, including Döbereiner's original introduction of the concept and the modern use of atomic number triads by some authors including myself. Such triads are groups of three elements, one of which has approximately the average atomic weight of the other two elements, as well as having intermediate chemical reactivity. I also examine Jensen's attempted reconstruction Mendeleev's use of triads in predicting the atomic weights of three hitherto unknown elements, that were subsequently named gallium, germanium and scandium. The present article then considers the use of atomic number triads, in conjunction with the phenomenon of first member anomaly, in order to offer support for Janet's left-step periodic table, in which helium is relocated into group 2 of the table. Such a table features triads in which the 2nd and third elements of each group, without fail, fall into periods of equal length, a feature that is absent in the conventional 18-column or the conventional 32-column table. The dual sense of the term element, which is the source of much discussion in the philosophy of chemistry, is alluded to in further support of such a relocation of helium that may at first appear to contradict chemical intuition. [ABSTRACT FROM AUTHOR]

Abstract The relationship between a firm and its supply chain has been well studied, however, the association between the position of firms in complex supply chain networks and their performance has not been adequately investigated. This is primarily due to insufficient availability of empirical data on large-scale networks. To addresses this gap in the literature, we investigate the relationship between embeddedness patterns of individual firms in a supply network and their performance using empirical data from the automotive industry. In this study, we devise three measures that characterize the embeddedness of individual firms in a supply network. These are namely: centrality, tier position, and triads. Our findings caution us that centrality impacts individual performance through a diminishing returns relationship. The second measure, tier position, allows us to investigate the concept of tiers in supply networks because we find that as networks emerge, the boundaries between tiers become unclear. Performance of suppliers degrade as they move away from the focal firm (i.e., Toyota). The final measure, triads, investigates the effect of buying and selling to firms that supply the same customer, portraying the level of competition and cooperation in a supplier’s network. We find that increased coopetition (i.e., cooperative competition) is a performance enhancer, however, excessive complexity resulting from being involved in both upstream and downstream coopetition results in diminishing performance. These original insights help understand the drivers of firm performance from a network perspective and provide a basis for further research.

Introduction. Long before the creation of a national writing system, the Oirats (Kalmyks) had developed a unique oral poetic tradition. By the late 17th century, there appeared a large number of translated poetic works distinguished by genre and artistic diversity. Oirat scholars would insistently turn to the rich oral poetic heritage. And triads were one such most ancient type of aphoristic poetry, their genre characteristics still remaining a matter of debate: some classify them as riddles, others as proverbs — but it is universally accepted that triads hold a special place in the oral poetic tradition. Triads were used not only by medieval authors but have also been turned to by modern Kalmyk writers. Goals. The article introduces into scientific discourse a text of the Oirat version of The Story of Usun Debeskertu Khan which contains triads and quatrains; analyzes didactic contents of the literary triads and compares them to oral (folk) ones. Materials and Methods. The work primarily employs the comparative analysis method. Despite triads have been published in a number of folklore collections (along with proverbs and riddles), their contents have never been investigated in the context of written monuments. Results. The wide use of triads in ancient oral poetic traditions of Mongolic peoples is evidenced by works of researchers from Mongolia, Russia, and China. So, it has been revealed that triads are not identical to riddles, constituting a separate Mongolic poetic genre and having been explicitly used in didactic written monuments as a special form of homilies. Conclusions. The Story of Usun Debeskertu Khan is a didactic composition containing triads and quatrains, the latter — judging from their contents and functions attributed — being essentially edifying (moralistic), which thus makes it possible to finally distinguish them from riddles as such.

Characterizing judgments of similarity within a perceptual or semantic domain, and making inferences about the underlying structure of this domain from these judgments, has an increasingly important role in cognitive and systems neuroscience. We present a new framework for this purpose that makes limited assumptions about how perceptual distances are converted into similarity judgments. The approach starts from a dataset of empirical judgments of relative similarities: the fraction of times that a subject chooses one of two comparison stimuli to be more similar to a reference stimulus. These empirical judgments provide Bayesian estimates of underling choice probabilities. From these estimates, we derive indices that characterize the set of judgments in three ways: compatibility with a symmetric dis-similarity, compatibility with an ultrametric space, and compatibility with an additive tree. Each of the indices is derived from rank-order relationships among the choice probabilities that, as we show, are necessary and sufficient for local consistency with the three respective characteristics. We illustrate this approach with simulations and example psychophysical datasets of dis-similarity judgments in several visual domains and provide code that implements the analyses at https://github.com/jvlab/simrank.

Recent research has shown that action knowledgeinfluences categorical decisions (Borghi, Flumini, Natraj &Wheaton, 2012; Chao & Martin, 2000; Iachini, Borghi &Senese, 2008; Kalénine, Shapiro, Flumini, Borghi &Buxbaum, 2013). Shipp, Vallée-Tourangeau, and Anthony,(2014) showed that action influences categorisation in aforced-choice triad task when combined with taxonomicinformation and presented within a functional context. Thepresent experiment examined whether participants wouldbe more likely to match items in a triad task based onshared actions following priming with the functionalactions of the objects. Participants engaged in the triad taskused in Shipp et al. after a priming phase where they eitherinteracted with a series of objects for their functionalcapacity (Action Priming), grouped them into categories(Taxonomic Priming) or moved them from one table toanother (Movement Priming). Items within the triads werepresented as an image either on a white background(context-lean condition) or as a functional scene with theobject being used by an agent (context-rich condition).Consistent with Shipp et al. the results showed that actionwas primarily used to base choices on the triad task whenthe action choice also shared a taxonomic relation, and waspresented in context. Additionally, participants were morelikely to select the action related item when they had beenprimed with the functional action of the objects. The resultsare discussed in terms of the transfer effect from the objectinteraction task that facilitates how the objects aresimulated (Barsalou, 1999, 2003; Yeh & Barsalou, 2006).

The forced-choice triad task has become increasinglypopular in use over recent years. While it is seen as beinga categorisation task (Lin & Murphy, 2001) variation intask instructions often leads to different results. Shipp,Vallée-Tourangeau, and Anthony (2014) used the triadtask to show that when participants are asked to choosean option that ‘goes best with the target’, they are morelikely to select the choice that shares an action relationwhen it also shares taxonomic information. Howeverusing the instruction to select the item that “goes best” isvague and might encourage a strategy other than acategorical decision. The present experiment used thesame triads as in Shipp et al. to test whether participantswould match items based on shared actions or sharedtaxonomic relations when given specific categorisationinstructions. The task instructions were manipulated sothat participants either selected the item that “goes best”,“goes best to form a category” or is “most similar” to thetarget. The results found instances where the instructionsof “goes best to form a category” led to a higherprobability that participants would select the actionchoices over the instructions of “goes best”. Howeverwhen participants were encouraged to use similarityoverall action choices were lower. Therefore the triadtask does encourage a natural categorisation strategy anddifferences in task instructions across research are aresult of the stimuli used.

The reuniens nucleus (RE) is situated at the most ventral position of the midline thalamus. In rats and mice RE is distinguished by bidirectional connections with the hippocampus and medial prefrontal cortex (mPFC) and a role in memory and cognition. In primates, many foundational questions pertaining to RE remain unresolved. We addressed these issues by investigating the composition of the rhesus monkey RE in both sexes by labeling for GABA, a marker of inhibitory neurons, and for the calcium-binding proteins parvalbumin (PV), calbindin (CB), and calretinin (CR), which label thalamic excitatory neurons that project to cortex. As in rats and mice, the macaque RE was mostly populated by CB and CR neurons, characteristic of matrix-dominant nuclei, and had bidirectional connections with hippocampus and mPFC area 25 (A25). Unlike rodents, we found GABAergic neurons in the monkey RE and a sparser but consistent population of core-associated thalamocortical PV neurons. RE had stronger connections with the basal amygdalar complex than in rats or mice. Amygdalar terminations were enriched with mitochondria and frequently formed successive synapses with the same postsynaptic structures, suggesting an active and robust pathway to RE. Significantly, hippocampal pathways formed multisynaptic complexes that uniquely involved excitatory projection neurons and dendrites of local inhibitory neurons in RE, extending this synaptic principle beyond sensory to high-order thalamic nuclei. Convergent pathways from hippocampus, A25, and amygdala in RE position it to flexibly coordinate activity for memory, cognition, and emotional context, which are disrupted in several psychiatric and neurologic diseases in humans. [ABSTRACT FROM AUTHOR]

Junctin is a transmembrane protein of striated muscles, located at the junctional sarcoplasmic reticulum (SR). It is characterized by a luminal C-terminal tail, through which it functionally interacts with calsequestrin and the ryanodine receptor (RyR). Interaction with calsequestrin was ascribed to the presence of stretches of charged amino acids (aa). However, the regions able to bind calsequestrin have not been defined in detail. We report here that, in non-muscle cells, junctin and calsequestrin assemble in long linear regions within the endoplasmic reticulum, mirroring the formation of calsequestrin polymers. In differentiating myotubes, the two proteins colocalize at triads, where they assemble with other proteins of the junctional SR. By performing GST pull-down assays with distinct regions of the junctin tail, we identified two KEKE motifs that can bind calsequestrin. In addition, stretches of charged aa downstream these motifs were found to also bind calsequestrin and the RyR. Deletion of even one of these regions impaired the ability of junctin to localize at the junctional SR, suggesting that interaction with other proteins at this site represents a key element in junctin targeting.0 [ABSTRACT FROM AUTHOR]

Our study investigates how collaboration from a triadic perspective affects the development of operational capabilities through a practice-adoption process. This research conducted a multiple case study in three triads in Brazil. The results imply that inter-organizational collaboration plays a positive role by moderating the relationship between information technology practices and the development of customization, responsiveness, and cooperation capabilities. Moreover, sharing information emerges as a critical factor for these three capabilities when collaboration is present. In addition, collaboration enables the development of improvement-thinking, dyadic-diffused relationships between buyer-supplier or supplier-supplier in an open triad. In this triadic structure, the first-tier supplier plays a unique role in information sharing and capabilities development. On the other hand, to ensure the development of other capabilities, such as responsiveness, the buyer and second-tier supplier must expand their connection to form at least a transitional structure.

The goal of the research is twofold. First, it aims to reveal the basic modes of governance run by the manufacturer across the examined triadic supply chains. Secondly, the paper compares the groups of triadic supply chains, applying certain modes of governance, including network governance, in terms of the relational benefits and supply chain performance. To investigate the relationship between network governance and the supply chain performance, the Principal Component Analysis (PCA) with Varimax Rotation was used, followed by the cluster analysis and non-parametric tests. The study showed that the triadic supply chains significantly differentiate in terms of the modes of governance. Further findings also indicated that the triadic supply chains that follow the network governance mode consider their performance to be significantly higher in comparison to the supply chains that do not run this type of governance mechanism. Firstly, the research showed that it is difficult to unequivocally reveal the pure mechanisms of governance, undistorted by the influence of another distinct mode in the triadic supply chains. On the contrary, they are more or less influenced by other modes of governance distinguished in the literature. Likewise, it is also important to highlight that the mechanism of governance is inseparably bound with a certain dyadic relationship established between two actors in the wider structure of supply chains. The study also showed that incorporating a clan as a social mechanism of governance together with a market and hierarchy results in increasing the relational benefits and overall performance for both dyads in the triadic supply chains.

Peer review is viewed as a valid quality assurance mechanism in higher education. Peer review of teaching is common practice at universities in Australia. However, peer review of assessment is a relatively new innovation in tertiary education. Peer review of assessment in a Triad structure utilised data, via interviews with academics and students, to develop a peer review of assessment framework. This project was modelled on a Triad based peer review of teaching process at a major university in Brisbane Australia. A 10 question framework was used initially to facilitate conversations between assessors in a range of undergraduate courses (teacher education, business, visual arts, occupational therapy, outdoor education). The benefits for all stakeholders were widespread and significant, impacting students and assessors and provided a response to sector wide, national and international criticisms of tertiary assessment by students, who are driven by successful assessment experiences and shaped by the clarity of assessment rubrics. [ABSTRACT FROM AUTHOR]

For over a century, neurons have been considered the basic functional units of the brain while glia only elements of support. Activation of glia has been long regarded detrimental for survival of neurons but more it appears that this is not the case in all circumstances. In this review, we report and discuss the recent literature on the alterations of astrocytes and microglia during inflammaging, the low-grade, slow, chronic inflammatory response that characterizes normal brain aging, and in acute inflammation. Becoming reactive, astrocytes and microglia undergo transcriptional, functional, and morphological changes that transform them into cells with different properties and functions, such as A1 and A2 astrocytes, and M1 and M2 microglia. This classification of microglia and astrocytes in two different, all-or-none states seems too simplistic, and does not correspond to the diverse variety of phenotypes so far found in the brain. Different interactions occur among the many cell populations of the central nervous system in health and disease conditions. Such interactions give rise to networks of morphological and functional reciprocal reliance and dependency. Alterations affecting one cell population reverberate to the others, favoring or dysregulating their activities. In the last part of this review, we present the modifications of the interplay between neurons and glia in rat models of brain aging and acute inflammation, focusing on the differences between CA1 and CA3 areas of the hippocampus, one of the brain regions most susceptible to different insults. With triple labeling fluorescent immunohistochemistry and confocal microscopy (TIC), it is possible to evaluate and compare quantitatively the morphological and functional alterations of the components of the neuron-astrocyte-microglia triad. In the contiguous and interconnected regions of rat hippocampus, CA1 and CA3 Stratum Radiatum, astrocytes and microglia show a different, finely regulated, and region-specific reactivity, demonstrating that glia responses vary in a significant manner from area to area. It will be of great interest to verify whether these differential reactivities of glia explain the diverse vulnerability of the hippocampal areas to aging or to different damaging insults, and particularly the higher sensitivity of CA1 pyramidal neurons to inflammatory stimuli.

Eye gaze plays an important role in communication but understanding of its actual function or functions and the methods used to elucidate this have varied considerably. This systematized review was undertaken to summarize both the proposed functions of eye gaze in conversations of healthy adults and the methodological approaches employed. The eligibility criteria were restricted to a healthy adult population and excluded studies that manipulated eye gaze behavior. A total of 29 articles—quantitative, qualitative and mixed methods were returned, with a wide range of methodological designs. The main areas of variability related to number of conversants, their familiarity and status, conversation topic, data collection tools—video and eye tracking—and definitions of eye gaze. The findings confirm that eye gaze facilitates turn yielding, plays a role in speech monitoring, prevents and repairs conversation breakdowns and facilitates intentional and unintentional speech interruptions. These findings were remarkably consistent given the variability in methods across the 29 articles. However, in relation to turn initiation, the results were less consistent, requiring further investigation. This review provides a starting point for future studies to make informed decisions about study methods for examining eye gaze and selecting variables of interest.

Eye gaze plays an important role in communication but understanding of its actual function or functions and the methods used to elucidate this have varied considerably. This systematized review was undertaken to summarize both the proposed functions of eye gaze in conversations of healthy adults and the methodological approaches employed. The eligibility criteria were restricted to a healthy adult population and excluded studies that manipulated eye gaze behavior. A total of 29 articles—quantitative, qualitative and mixed methods were returned, with a wide range of methodological designs. The main areas of variability related to number of conversants, their familiarity and status, conversation topic, data collection tools—video and eye tracking—and definitions of eye gaze. The findings confirm that eye gaze facilitates turn yielding, plays a role in speech monitoring, prevents and repairs conversation breakdowns and facilitates intentional and unintentional speech interruptions. These findings were remarkably consistent given the variability in methods across the 29 articles. However, in relation to turn initiation, the results were less consistent, requiring further investigation. This review provides a starting point for future studies to make informed decisions about study methods for examining eye gaze and selecting variables of interest. [ABSTRACT FROM AUTHOR]

For over a century, neurons have been considered the basic functional units of the brain while glia only elements of support. Activation of glia has been long regarded detrimental for survival of neurons but more it appears that this is not the case in all circumstances. In this review, we report and discuss the recent literature on the alterations of astrocytes and microglia during inflammaging, the low-grade, slow, chronic inflammatory response that characterizes normal brain aging, and in acute inflammation. Becoming reactive, astrocytes and microglia undergo transcriptional, functional, and morphological changes that transform them into cells with different properties and functions, such as A1 and A2 astrocytes, and M1 and M2 microglia. This classification of microglia and astrocytes in two different, all-or-none states seems too simplistic, and does not correspond to the diverse variety of phenotypes so far found in the brain. Different interactions occur among the many cell populations of the central nervous system in health and disease conditions. Such interactions give rise to networks of morphological and functional reciprocal reliance and dependency. Alterations affecting one cell population reverberate to the others, favoring or dysregulating their activities. In the last part of this review, we present the modifications of the interplay between neurons and glia in rat models of brain aging and acute inflammation, focusing on the differences between CA1 and CA3 areas of the hippocampus, one of the brain regions most susceptible to different insults. With triple labeling fluorescent immunohistochemistry and confocal microscopy (TIC), it is possible to evaluate and compare quantitatively the morphological and functional alterations of the components of the neuron-astrocyte-microglia triad. In the contiguous and interconnected regions of rat hippocampus, CA1 and CA3 Stratum Radiatum, astrocytes and microglia show a different, finely regulated, and region-specific reactivity, demonstrating that glia responses vary in a significant manner from area to area. It will be of great interest to verify whether these differential reactivities of glia explain the diverse vulnerability of the hippocampal areas to aging or to different damaging insults, and particularly the higher sensitivity of CA1 pyramidal neurons to inflammatory stimuli. [ABSTRACT FROM AUTHOR]

The author, Maurizio Catino, has undertaken a meticulous examination of criminal organizations that dominate the illicit marketplace throughout the world. The Mafia, Cosa Nostra, Camorra, ‘Ndrangheta, Triads, Yakuza, and the South American cartels are dissected and their respective nomenclatures compared and contrasted. Catino addresses their relationship to the illicit markets that they operate within and organize in order to minimize risks and maximize profits. Relying upon electronic surveillances, investigative reports, and intelligence sources, Catino takes this ethnographic data and molds it into a series of principles that govern each criminal organization. His research has profoundly advanced our understanding of criminal organizations and the illicit markets they supply. It will likely go down as the most seminal piece of research in the past thirty or more years.

Neurons have been long regarded as the basic functional cells of the brain, whereas astrocytes and microglia have been regarded only as elements of support. However, proper intercommunication among neurons–astrocytes–microglia is of fundamental importance for the functional organization of the brain. Perturbation in the regulation of brain energy metabolism not only in neurons but also in astrocytes and microglia may be one of the pathophysiological mechanisms of neurodegeneration, especially in hypoxia/ischemia. Glial activation has long been considered detrimental for survival of neurons, but recently it appears that glial responses to an insult are not equal but vary in different brain areas. In this review, we first take into consideration the modifications of the vascular unit of the glymphatic system and glial metabolism in hypoxic conditions. Using the method of triple-labeling fluorescent immunohistochemistry coupled with confocal microscopy (TIC), we recently studied the interplay among neurons, astrocytes, and microglia in chronic brain hypoperfusion. We evaluated the quantitative and morpho-functional alterations of the neuron–astrocyte–microglia triads comparing the hippocampal CA1 area, more vulnerable to ischemia, to the CA3 area, less vulnerable. In these contiguous and interconnected areas, in the same experimental hypoxic conditions, astrocytes and microglia show differential, finely regulated, region-specific reactivities. In both areas, astrocytes and microglia form triad clusters with apoptotic, degenerating neurons. In the neuron–astrocyte–microglia triads, the cell body of a damaged neuron is infiltrated and bisected by branches of astrocyte that create a microscar around it while a microglial cell phagocytoses the damaged neuron. These coordinated actions are consistent with the scavenging and protective activities of microglia. In hypoxia, the neuron–astrocyte–microglia triads are more numerous in CA3 than in CA1, further indicating their protective effects. These data, taken from contiguous and interconnected hippocampal areas, demonstrate that glial response to the same hypoxic insult is not equal but varies significantly. Understanding the differences of glial reactivity is of great interest to explain the differential susceptibility of hippocampal areas to hypoxia/ischemia. Further studies may evidence the differential reactivity of glia in different brain areas, explaining the higher or lower sensitivity of these areas to different insults and whether glia may represent a target for future therapeutic interventions.

Humans subtly synchronize body movement during face-to-face conversation. In this context, bodily synchrony has been linked to affiliation and social bonding, task success and comprehension, and potential conflict. Almost all studies of conversational synchrony involve dyads, and relatively less is known about the structure of synchrony in groups larger than two. We conducted an optic flow analysis of body movement in triads engaged in face-to-face conversation, and explored a common measure of synchrony: time-aligned bodily covariation. We correlated this measure of synchrony with a diverse set of covariates related to the outcome of interactions. Triads showed higher maximum cross-correlation relative to a surrogate baseline, and ‘meta-synchrony’, in that composite dyads in a triad tended to show correlated structure. A windowed analysis also revealed that synchrony varies widely across an interaction. As in prior studies, average synchrony was low but statistically reliable in just a few minutes of interaction. In an exploratory analysis, we investigated the potential function of body synchrony by predicting it from various covariates, such as linguistic style matching, liking, laughter and cooperative play in a behavioural economic game. Exploratory results do not reveal a clear function for synchrony, though colaughter within triads was associated with greater body synchrony, and is consistent with an earlier analysis showing a positive connection between colaughter and cooperation. We end by discussing the importance of expanding and codifying analyses of synchrony and assessing its function.

The article examines the character of interaction of folklore elements and their functional load within the idiostyle of poet Gary Davaev on material of the poem «Altma». The author revealed that these elements perform several functions: compositional, textual and others, and also enrich the language of artistic work, creating nationaloriginal colour.

Neurons have been long regarded as the basic functional cells of the brain, whereas astrocytes and microglia have been regarded only as elements of support. However, proper intercommunication among neurons–astrocytes–microglia is of fundamental importance for the functional organization of the brain. Perturbation in the regulation of brain energy metabolism not only in neurons but also in astrocytes and microglia may be one of the pathophysiological mechanisms of neurodegeneration, especially in hypoxia/ischemia. Glial activation has long been considered detrimental for survival of neurons, but recently it appears that glial responses to an insult are not equal but vary in different brain areas. In this review, we first take into consideration the modifications of the vascular unit of the glymphatic system and glial metabolism in hypoxic conditions. Using the method of triple-labeling fluorescent immunohistochemistry coupled with confocal microscopy (TIC), we recently studied the interplay among neurons, astrocytes, and microglia in chronic brain hypoperfusion. We evaluated the quantitative and morpho-functional alterations of the neuron–astrocyte–microglia triads comparing the hippocampal CA1 area, more vulnerable to ischemia, to the CA3 area, less vulnerable. In these contiguous and interconnected areas, in the same experimental hypoxic conditions, astrocytes and microglia show differential, finely regulated, region-specific reactivities. In both areas, astrocytes and microglia form triad clusters with apoptotic, degenerating neurons. In the neuron–astrocyte–microglia triads, the cell body of a damaged neuron is infiltrated and bisected by branches of astrocyte that create a microscar around it while a microglial cell phagocytoses the damaged neuron. These coordinated actions are consistent with the scavenging and protective activities of microglia. In hypoxia, the neuron–astrocyte–microglia triads are more numerous in CA3 than in CA1, further indicating their protective effects. These data, taken from contiguous and interconnected hippocampal areas, demonstrate that glial response to the same hypoxic insult is not equal but varies significantly. Understanding the differences of glial reactivity is of great interest to explain the differential susceptibility of hippocampal areas to hypoxia/ischemia. Further studies may evidence the differential reactivity of glia in different brain areas, explaining the higher or lower sensitivity of these areas to different insults and whether glia may represent a target for future therapeutic interventions. [ABSTRACT FROM AUTHOR]

This essay presents a theory of musical and verbal double entendre inspired by and applicable to the late-period music of Milton Babbitt. Rather than assuming the appropriateness of any single method (which might tend toward singularity of meaning), a number of approaches are applied to three late works: primarily his Whirled Series (1987), and secondarily his Canonical Form (1983) and Gloss on 'Round Midnight (2001). These are interpreted through various kinds of analysis, not only serial, but also tonal (chordal and voice-leading), associational, pitch-permeational, and form-functional. Connections to Tin-Pan-Alley song lyrics, jazz improvisation, hermeneutics, and Gibsonian affordances are discussed in relation to these musical analyses. All this is done to infer and cultivate connections (represented as a conceptual integration networks) between Babbitt7s extratheoretic verbal expression and extra-dodecaphonic aspects of his music, connections that suggest an underlying poetics (a tacit motivational philosophy implicitly fueling his creativity) that provides pragmatic benefit to the artistic ambitions of diverse personal identities. [ABSTRACT FROM AUTHOR]

Despite the common knowledge that there is something "Pythagorean" about Charles Peirce's phenomenology and classification of signs there is a manifest lack of inquiries into the matter. Perhaps there is too little to go on, as Pythagoras himself did not leave us any writings to consult. Nevertheless, much of ancient Greek philosophy bears an unmistakable Pythagorean stamp, and Iamblichus' bio - graphy of Pythagoras provides us with enough to get such inquiries started. This paper examines the development of triads, beginning with the Pythagorean one (body, soul, and intellect) and proceeds to those of Immanuel Kant (Experience, Understanding, and Reason) and Peirce's compatriot and family acquaintance Pliny Earle Chase (Motivity, Spontaneity, and Rationality). The article concludes with an examination of the various triads in Peirce's early writings, especially around the time of his discovery of Chase's "Intellectual symbolism". [ABSTRACT FROM AUTHOR]

Homans' insights that interaction and sentiment are in a feedback loop that includes clique formation, social ranking and leadership are formalized and derived from a set of limited assumptions and propositions. Freeman's model of groups is used to detect pure informal groups, those that are not consequential upon anything else than sheer hanging around. It produces a system of cliques and rankings based purely on the rates of transitive triads that may include a third who is only weakly connected to the other two. Two assumptions about motivation in networks – the need for safety and efficacy are then combined with Gould's modeling of asymmetric relations in which members are valued for either intrinsic or extrinsic merits. The ratings tend to cascade according to the "Matthew Effect." Finally, people like to choose others who are more attractive than they are, subject to the condition that too much unrequited love is painful. Gould's Formalization of these ideas for the case of small groups produces, among other results, the consequence that those who are chosen more often than others also tend to direct interaction more towards others with lesser rank, a non-intuitive result observed by Homans, but explained by him in substantive rather than formal terms. The logic of rank further dictates that groups become segmented by structural equivalence. Other results are also summarized.

Using a variety of technical approaches, we have detected the presence of continuous triads that cover the entire length of T tubules in the main white body muscles of several small fish. This is in contrast to the discontinuous association of SR with T tubules in the red muscles from the same fish as well as in all other previously described muscles in a large variety of skeletal muscles. We suggest that continuous triads are permissible only in muscle fibers that are not normally subject to significant changes in sarcomere length during normal in vivo activity, as is the case for white muscles in the trunk of fish.

The reactions between the bis(1,10-phenantro[5,6-b])tetrathiafulvalene triad (L) and the metallo-precursors Yb(hfac)3(H2O)2 (hfac− = 1,1,1,5,5,5-hexafluoroacetylacetonato anion) and Dy(facam)3 (facam− = 3-trifluoro-acetyl-(+)-camphorato anion) lead to the formation of two dinuclear complexes of formula [Yb2(hfac)6(L)]·2(C7H16) ((1)·2(C7H16)) and [Dy2((+)facam)6(L)]·2(C6H14) ((2)·2(C6H14)). The X-ray structures reveal that the L triad bridges two terminal Yb(hfac)3 or Dy(facam)3 units. (1)·2(C7H16) behaved as a near infrared YbIII centered emitter and a field-induced Single-Molecule Magnet (SMM) while (2)·2(C6H14) displayed SMM behavior in both zero- and in-dc field. The magnetization mainly relaxes through a Raman process for both complexes under an optimal applied magnetic field.

Using a variety of technical approaches, we have detected the presence of continuous triads that cover the entire length of T tubules in the main white body muscles of several small fish. This is in contrast to the discontinuous association of SR with T tubules in the red muscles from the same fish as well as in all other previously described muscles in a large variety of skeletal muscles. We suggest that continuous triads are permissible only in muscle fibers that are not normally subject to significant changes in sarcomere length during normal in vivo activity, as is the case for white muscles in the trunk of fish. [ABSTRACT FROM AUTHOR]

The paper presents the Triads Geometric Consistency Index ( T - G C I ), a measure for evaluating the inconsistency of the pairwise comparison matrices employed in the Analytic Hierarchy Process (AHP). Based on the Saaty’s definition of consistency for AHP, the new measure works directly with triads of the initial judgements, without having to previously calculate the priority vector, and therefore is valid for any prioritisation procedure used in AHP. The T - G C I is an intuitive indicator defined as the average of the log quadratic deviations from the unit of the intensities of all the cycles of length three. Its value coincides with that of the Geometric Consistency Index ( G C I ) and this allows the utilisation of the inconsistency thresholds as well as the properties of the G C I when using the T - G C I . In addition, the decision tools developed for the G C I can be used when working with triads ( T - G C I ), especially the procedure for improving the inconsistency and the consistency stability intervals of the judgements used in group decision making. The paper further includes a study of the computational complexity of both measures ( T - G C I and G C I ) which allows selecting the most appropriate expression, depending on the size of the matrix. Finally, it is proved that the generalisation of the proposed measure to cycles of any length coincides with the T - G C I . It is not therefore necessary to consider cycles of length greater than three, as they are more complex to obtain and the calculation of their associated measure is more difficult.