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3. Distinct T cell responsiveness to different COVID-19 vaccines and cross-reactivity to SARS-CoV-2 variants with age and CMV status

Author

Brummelman, Jolanda, primary, Suárez-Hernández, Sara, additional, de Rond, Lia, additional, Bogaard-van Maurik, Marjan, additional, Molenaar, Petra, additional, van Wijlen, Emma, additional, Oomen, Debbie, additional, Beckers, Lisa, additional, Rots, Nynke Y., additional, van Beek, Josine, additional, Nicolaie, Mioara A., additional, van Els, Cécile A. C. M., additional, Boer, Mardi C., additional, Kaaijk, Patricia, additional, Buisman, Anne-Marie, additional, and de Wit, Jelle, additional

Published
2024
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4. Humoral and cellular immunogenicity, effectiveness and safety of COVID-19 mRNA vaccination in patients with pediatric rheumatic diseases: A prospective cohort study

Author

Immuno/reuma onderzoek 7 (Swart), Infection & Immunity, Immuno/reuma onderzoek 1 (Vastert), Child Health, MMB Medische Staf, Immuno/reuma patientenzorg, CTI Van Loosdregt, Immunologie/Reumatologie, Cluster B, Geneeskunde, Immuno/reuma ERN, Hamad Saied, Mohamad, van Straalen, Joeri W, de Roock, Sytze, Verduyn Lunel, Frans M, de Wit, Jelle, de Rond, Lia G H, Van Nieuwenhove, Erika, Vastert, Bas J, van Montfrans, Joris M, van Royen-Kerkhof, Annet, de Joode-Smink, Gerrie C J, Swart, Joost F, Wulffraat, Nico M, Jansen, Marc H A, Immuno/reuma onderzoek 7 (Swart), Infection & Immunity, Immuno/reuma onderzoek 1 (Vastert), Child Health, MMB Medische Staf, Immuno/reuma patientenzorg, CTI Van Loosdregt, Immunologie/Reumatologie, Cluster B, Geneeskunde, Immuno/reuma ERN, Hamad Saied, Mohamad, van Straalen, Joeri W, de Roock, Sytze, Verduyn Lunel, Frans M, de Wit, Jelle, de Rond, Lia G H, Van Nieuwenhove, Erika, Vastert, Bas J, van Montfrans, Joris M, van Royen-Kerkhof, Annet, de Joode-Smink, Gerrie C J, Swart, Joost F, Wulffraat, Nico M, and Jansen, Marc H A

Published
2024

5. Contribution of SARS-CoV-2 infection preceding COVID-19 mRNA vaccination to generation of cellular and humoral immune responses in children

Author

Verheul, Marije K., primary, Vos, Martijn, additional, de Rond, Lia, additional, De Zeeuw-Brouwer, Mary-Lène, additional, Nijhof, Kim H., additional, Smit, Debbie, additional, Oomen, Debbie, additional, Molenaar, Petra, additional, Bogaard, Marjan, additional, van Bergen, Rianne, additional, Middelhof, Irene, additional, Beckers, Lisa, additional, Wijmenga-Monsuur, Alienke J., additional, Buisman, Anne-Marie, additional, Boer, Mardi C., additional, van Binnendijk, Rob, additional, de Wit, Jelle, additional, and Guichelaar, Teun, additional

Published
2023
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6. Booster Immunization Improves Memory B Cell Responses in Older Adults Unresponsive to Primary SARS-CoV-2 Immunization

Author

Verheul, Marije K., primary, Nijhof, Kim H., additional, de Zeeuw-Brouwer, Mary-lène, additional, Duijm, Geraly, additional, ten Hulscher, Hinke, additional, de Rond, Lia, additional, Beckers, Lisa, additional, Eggink, Dirk, additional, van Tol, Sophie, additional, Reimerink, Johan, additional, Boer, Mardi, additional, van Beek, Josine, additional, Rots, Nynke, additional, van Binnendijk, Rob, additional, and Buisman, Anne-Marie, additional

Published
2023
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8. Contribution of SARS-CoV-2 infection preceding COVID-19 mRNA vaccination to generation of cellular and humoral immune responses in children.

Author

Verheul, Marije K., Vos, Martijn, de Rond, Lia, De Zeeuw-Brouwer, Mary-Lène, Nijhof, Kim H., Smit, Debbie, Oomen, Debbie, Molenaar, Petra, Bogaard, Marjan, van Bergen, Rianne, Middelhof, Irene, Beckers, Lisa, Wijmenga-Monsuur, Alienke J., Buisman, Anne-Marie, Boer, Mardi C., van Binnendijk, Rob, de Wit, Jelle, and Guichelaar, Teun

Subjects
HUMORAL immunity, COVID-19 vaccines, SARS-CoV-2, VACCINATION of children, T cells, COVID-19 pandemic
Abstract

Primary COVID-19 vaccination for children, 5-17 years of age, was offered in the Netherlands at a time when a substantial part of this population had already experienced a SARS-CoV-2 infection. While vaccination has been shown effective, underlying immune responses have not been extensively studied. We studied immune responsiveness to one and/or two doses of primary BNT162b2 mRNA vaccination and compared the humoral and cellular immune response in children with and without a preceding infection. Antibodies targeting the original SARS-CoV-2 Spike or Omicron Spike were measured by multiplex immunoassay. B-cell and Tcell responses were investigated using enzyme-linked immunosorbent spot (ELISpot) assays. The activation of CD4+ and CD8+ T cells was studied by flowcytometry. Primary vaccination induced both a humoral and cellular adaptive response in naive children. These responses were stronger in those with a history of infection prior to vaccination. A second vaccine dose did not further boost antibody levels in those who previously experienced an infection. Infection-induced responsiveness prior to vaccination was mainly detected in CD8+ T cells, while vaccineinduced T-cell responses were mostly by CD4+ T cells. Thus, SARS-CoV-2 infection prior to vaccination enhances adaptive cellular and humoral immune responses to primary COVID-19 vaccination in children. As most children are now expected to contract infection before the age of five, the impact of infection-induced immunity in children is of high relevance. Therefore, considering natural infection as a priming immunogen that enhances subsequent vaccine-responsiveness may help decision-making on the number and timing of vaccine doses. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Kuijpers, Yunus, Picavet, H Susan J, de Rond, Lia, de Zeeuw-Brouwer, Mary-Lène, Rutkens, Ryanne, Gijsbers, Esther, Slits, Irene, Engelfriet, Peter, Buisman, Anne-Marie, Verschuren, W M Monique, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Kuijpers, Yunus, Picavet, H Susan J, de Rond, Lia, de Zeeuw-Brouwer, Mary-Lène, Rutkens, Ryanne, Gijsbers, Esther, Slits, Irene, Engelfriet, Peter, Buisman, Anne-Marie, and Verschuren, W M Monique

Published
2023

10. Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands

Author

van den Hoogen, Lotus Leonie, primary, Boer, Mardi, additional, Postema, Abigail, additional, de Rond, Lia, additional, de Zeeuw-Brouwer, Mary-lène, additional, Pronk, Inge, additional, Wijmenga-Monsuur, Alienke Jentien, additional, Bijvank, Elske, additional, Kruiper, Caitlyn, additional, Beckers, Lisa, additional, Maurik, Marjan Bogaard-van, additional, Zutt, Ilse, additional, van Vliet, Jeffrey, additional, van Bergen, Rianne, additional, Kuijer, Marjan, additional, Smits, Gaby, additional, Verschuren, W. M. Monique, additional, Picavet, H. Susan J., additional, van der Klis, Fiona Regina Maria, additional, den Hartog, Gerco, additional, van Binnendijk, Robert Samuel, additional, and Buisman, Anne-Marie, additional

Published
2022
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11. Characterization of the early cellular immune response induced by HPV vaccines

Author

Pasmans, Hella, primary, Berkowska, Magdalena A., additional, Diks, Annieck M., additional, de Mooij, Bas, additional, Groenland, Rick J., additional, de Rond, Lia, additional, Nicolaie, M. Alina, additional, van der Burg, Sjoerd H., additional, van Dongen, Jacques J. M., additional, van der Klis, Fiona R. M., additional, and Buisman, Anne-Marie, additional

Published
2022
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12. Memory B Cell Activation Induced by Pertussis Booster Vaccination in Four Age Groups of Three Countries.

Author

Versteegen, Pauline, Barkoff, Alex-Mikael, Valente Pinto, Marta, van de Kasteele, Jan, Knuutila, Aapo, Bibi, Sagida, de Rond, Lia, Teräsjärvi, Johanna, Sanders, Katherine, de Zeeuw-Brouwer, Mary-lène, Luoto, Raakel, ten Hulscher, Hinke, Clutterbuck, Elizabeth A., Sanders, Elisabeth A. M., Mertsola, Jussi, Berbers, Guy A. M., He, Qiushui, Kelly, Dominic F., and Buisman, Anne-Marie

Subjects
IMMUNOLOGIC memory, BOOSTER vaccines, WHOOPING cough vaccines, AGE groups, PERTUSSIS toxin, PSYCHONEUROIMMUNOLOGY, AUTOBIOGRAPHICAL memory
Abstract

Background: Immunogenicity of acellular pertussis (aP) vaccines is conventionally assessed by measuring antibody responses but antibody concentrations wane quickly after vaccination. Memory B cells, however, are critical in sustaining long-term protection and therefore may be an important factor when assessing pertussis immunity after vaccination. Aim: We studied pertussis specific memory B cell (re)activation induced by an aP booster vaccination in four different age groups within three countries. Materials and methods: From a phase IV longitudinal interventional study, 268 participants across Finland, the Netherlands and the United Kingdom were included and received a 3-component pertussis booster vaccine: children (7-10y, n=53), adolescents (11-15y, n=66), young adults (20-34y, n=74), and older adults (60-70y, n=75). Memory B cells at baseline, day 28, and 1 year post-vaccination were measured by a pertussis toxin (Ptx), filamentous haemagglutinin (FHA), and pertactin (Prn) specific ELISpot assay. Antibody results measured previously were available for comparison. Furthermore, study participants were distributed into groups based on their baseline memory B cell frequencies, vaccine responses were monitored between these groups. Results: Geometric mean (GM) memory B cell frequencies for pertussis antigens at baseline were low. At 28 days post-vaccination, these frequencies increased within each age group and were still elevated one year post-booster compared to baseline. Highest frequencies at day 28 were found within adolescents (GM: 5, 21, and 13, for Ptx, FHA and Prn, respectively) and lowest within older adults (GM: 2, 9, and 3, respectively). Moderate to strong correlations between memory B cell frequencies at day 28 and antibody concentrations at day 28 and 1 year were observed for Prn. Memory B cell frequencies > 1 per 100,000 PBMCs at baseline were associated with significantly higher memory responses after 28 days and 1 year. Conclusions: An aP booster vaccine (re)activated memory B cells in all age groups. Still elevated memory B cell frequencies after one year indicates enhanced immunological memory. However, antigen specific memory B cell activation seems weaker in older adults, which might reflect immunosenescence. Furthermore, the presence of circulating memory B cells at baseline positively affects memory B cell responses. This study was registered at www.clinicaltrialsregister.eu : No. 2016-003678-42. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study

Author

CTI Borghans, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, CTI Research, Samson, Leonard Daniel, van den Berg, Sara P. H., Engelfriet, Peter, Boots, Annemieke M. H., Hendriks, Marion, de Rond, Lia G. H., de Zeeuw-Brouwer, Mary-Iene, Verschuren, W. M. Monique, Borghans, Jose A. M., Buisman, Anne-Marie, van Baarle, Debbie, CTI Borghans, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, CTI Research, Samson, Leonard Daniel, van den Berg, Sara P. H., Engelfriet, Peter, Boots, Annemieke M. H., Hendriks, Marion, de Rond, Lia G. H., de Zeeuw-Brouwer, Mary-Iene, Verschuren, W. M. Monique, Borghans, Jose A. M., Buisman, Anne-Marie, and van Baarle, Debbie

Published
2020

15. Elevated Immune Response Among Children 4 Years Of Age With Pronounced Local Adverse Events After The Fifth Dtap Vaccination

Author

van der Lee, Saskia, Kemmeren, Jeanet M, de Rond, Lia G H, Öztürk, Kemal, Westerhof, Anneke, de Melker, Hester E, Sanders, Elisabeth A M, Berbers, Guy A M, van der Maas, Nicoline A T, Rümke, Hans C, Buisman, Anne-Marie, van der Lee, Saskia, Kemmeren, Jeanet M, de Rond, Lia G H, Öztürk, Kemal, Westerhof, Anneke, de Melker, Hester E, Sanders, Elisabeth A M, Berbers, Guy A M, van der Maas, Nicoline A T, Rümke, Hans C, and Buisman, Anne-Marie

Published
2017

16. Elevated Immune Response Among Children 4 Years Of Age With Pronounced Local Adverse Events After The Fifth Dtap Vaccination

Author

Immuno/reuma onderzoek 7 (Montfrans), Infection & Immunity, Child Health, Immuno/reuma patientenzorg, van der Lee, Saskia, Kemmeren, Jeanet M, de Rond, Lia G H, Öztürk, Kemal, Westerhof, Anneke, de Melker, Hester E, Sanders, Elisabeth A M, Berbers, Guy A M, van der Maas, Nicoline A T, Rümke, Hans C, Buisman, Anne-Marie, Immuno/reuma onderzoek 7 (Montfrans), Infection & Immunity, Child Health, Immuno/reuma patientenzorg, van der Lee, Saskia, Kemmeren, Jeanet M, de Rond, Lia G H, Öztürk, Kemal, Westerhof, Anneke, de Melker, Hester E, Sanders, Elisabeth A M, Berbers, Guy A M, van der Maas, Nicoline A T, Rümke, Hans C, and Buisman, Anne-Marie

Published
2017

19. Identification of pertussis-specific effector memory T cells in preschool children

Author

De Rond, Lia, Van Els, Cecile A C M C.A.C.M., Smits, Kaatje, Buisman, Anne-Marie, Schure, Rose Minke, Öztürk, Kemal, Berbers, Guy, Sanders, Elisabeth A M, Twillert, Inonge Van, Carollo, Maria, Mascart, Françoise, Ausiello, Clara Maria, De Rond, Lia, Van Els, Cecile A C M C.A.C.M., Smits, Kaatje, Buisman, Anne-Marie, Schure, Rose Minke, Öztürk, Kemal, Berbers, Guy, Sanders, Elisabeth A M, Twillert, Inonge Van, Carollo, Maria, Mascart, Françoise, and Ausiello, Clara Maria

Abstract

Whooping cough remains a problem despite vaccination, and worldwide resurgence of pertussis is evident. Since cellular immunity plays a role in long-term protection against pertussis, we studied pertussis-specific T-cell responses. Around the time of the preschool acellular pertussis (aP) booster dose at 4 years of age, T-cell memory responses were compared in children who were primed during infancy with either a whole-cell pertussis (wP) or an aP vaccine. Peripheral blood mononuclear cells (PBMCs) were isolated and stimulated with pertussis vaccine antigens for 5 days. T cells were characterized by flow-based analysis of carboxyfluorescein succinimidyl ester (CFSE) dilution and CD4, CD3, CD45RA, CCR7, gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α) expression. Before the aP preschool booster vaccination, both the proliferated pertussis toxin (PT)-specific CD4+ and CD8+ T-cell fractions (CFSEdim) were higher in aP-than in wP-primed children. Post-booster vaccination, more pertussis-specific CD4+ effector memory cells (CD45RA- CCR7-) were induced in aP-primed children than in those primed with wP. The booster vaccination did not appear to significantly affect the T-cell memory subsets and functionality in aP-primed or wP-primed children. Although the percentages of Th1 cytokine-producing cells were alike in aP- and wP-primed children pre-booster vaccination, aP-primed children produced more Th1 cytokines due to higher numbers of proliferated pertussis-specific effector memory cells. At present, infant vaccinations with four aP vaccines in the first year of life result in pertussis-specific CD4+ and CD8+ effector memory T-cell responses that persist in children until 4 years of age and are higher than those in wP-primed children. The booster at 4 years of age is therefore questionable; this may be postponed to 6 years of age., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

20. Identification of pertussis-specific effector memory T cells in preschool children

Author

de Rond, Lia C G H, Schure, Rose Minke, Öztürk, Kemal, Berbers, Guy A M, Sanders, Elisabeth, Van Twillert, Inonge, Carollo, Maria, Mascart, Françoise, Ausiello, Clara M., Van Els, Cecile A.C.M., Smits, Kaat, Buisman, Anne-Marie, de Rond, Lia C G H, Schure, Rose Minke, Öztürk, Kemal, Berbers, Guy A M, Sanders, Elisabeth, Van Twillert, Inonge, Carollo, Maria, Mascart, Françoise, Ausiello, Clara M., Van Els, Cecile A.C.M., Smits, Kaat, and Buisman, Anne-Marie

Published
2015

21. Identification of pertussis-specific effector memory T cells in preschool children

Author

Immuno/reuma patientenzorg, Infection & Immunity, Child Health, Immuno/reuma onderzoek 7 (Montfrans), de Rond, Lia C G H, Schure, Rose Minke, Öztürk, Kemal, Berbers, Guy A M, Sanders, Elisabeth, Van Twillert, Inonge, Carollo, Maria, Mascart, Françoise, Ausiello, Clara M., Van Els, Cecile A.C.M., Smits, Kaat, Buisman, Anne-Marie, Immuno/reuma patientenzorg, Infection & Immunity, Child Health, Immuno/reuma onderzoek 7 (Montfrans), de Rond, Lia C G H, Schure, Rose Minke, Öztürk, Kemal, Berbers, Guy A M, Sanders, Elisabeth, Van Twillert, Inonge, Carollo, Maria, Mascart, Françoise, Ausiello, Clara M., Van Els, Cecile A.C.M., Smits, Kaat, and Buisman, Anne-Marie

Published
2015

22. Identification of Pertussis-Specific Effector Memory T Cells in Preschool Children

Author

de Rond, Lia, primary, Schure, Rose-Minke, additional, Öztürk, Kemal, additional, Berbers, Guy, additional, Sanders, Elisabeth, additional, van Twillert, Inonge, additional, Carollo, Maria, additional, Mascart, Françoise, additional, Ausiello, Clara M., additional, van Els, Cecile A. C. M., additional, Smits, Kaat, additional, and Buisman, Anne-Marie, additional

Published
2015
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23. Differences in CD4 and CD8 memory T-cell populations in Dutch children after vaccination with various pertussis vaccines.

Author

European Congress of Immunology (September 5th-8th 2012: Glasgow, Scotland), De Rond, Lia, Schure, Rose Minke, Öztürk, Kemal, Twillert, Inonge Van, Carollo, Maria, Mascart, Françoise, Ausiello, Clara Maria, Smits, Kaatje, Van Els, Cecile A C M C.A.C.M., Buisman, Anne-Marie, European Congress of Immunology (September 5th-8th 2012: Glasgow, Scotland), De Rond, Lia, Schure, Rose Minke, Öztürk, Kemal, Twillert, Inonge Van, Carollo, Maria, Mascart, Françoise, Ausiello, Clara Maria, Smits, Kaatje, Van Els, Cecile A C M C.A.C.M., and Buisman, Anne-Marie

Abstract

info:eu-repo/semantics/nonPublished

Published
2012

24. Evaluation of Bordetella pertussis-specific immune responses after infection or after different vaccination programs in the framework of the FP7 Child-INNOVAC program.

Author

9th International Bordetella Symposium (September 2010: Washington, USA), Smits, Kaatje, De Smet, J., Twillert, Inonge Van, Stenger, R., Van, Chau, Carollo, Maria, Palazzo, Raffaella, Ausiello, Clara Maria, Schure, Rose Minke, De Rond, Lia, Buisman, Anne-Marie, Locht, Camille, Mascart, Françoise, 9th International Bordetella Symposium (September 2010: Washington, USA), Smits, Kaatje, De Smet, J., Twillert, Inonge Van, Stenger, R., Van, Chau, Carollo, Maria, Palazzo, Raffaella, Ausiello, Clara Maria, Schure, Rose Minke, De Rond, Lia, Buisman, Anne-Marie, Locht, Camille, and Mascart, Françoise

Abstract

info:eu-repo/semantics/nonPublished

Published
2010

30. Gene Expression Differences in Lungs of Mice during Secondary Immune Responses to Respiratory Syncytial Virus Infection

Author

Schuurhof, Annemieke, primary, Bont, Louis, additional, Pennings, Jeroen L. A., additional, Hodemaekers, Hennie M., additional, Wester, Piet W., additional, Buisman, Annemarie, additional, de Rond, Lia C. G. H., additional, Widjojoatmodjo, Myra N., additional, Luytjes, Willem, additional, Kimpen, Jan L. L., additional, and Janssen, Riny, additional

Published
2010
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32. Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study.

Author

Samson LD, van den Berg SP, Engelfriet P, Boots AM, Hendriks M, de Rond LG, de Zeeuw-Brouwer ML, Verschuren WM, Borghans JA, Buisman AM, and van Baarle D

Abstract

Objectives: Cytomegalovirus infection is thought to affect the immune system and to impact general health during ageing. Higher CMV-specific antibody levels in the elderly are generally assumed to reflect experienced viral reactivation during life. Furthermore, high levels of terminally differentiated and CMV-specific T cells are hallmarks of CMV infection, which are thought to expand over time, a process also referred to as memory inflation., Methods: We studied CMV-specific antibody levels over ~ 27 years in 268 individuals (aged 60-89 years at study endpoint), and to link duration of CMV infection to T-cell numbers, CMV-specific T-cell functions, frailty and cardiovascular disease at study endpoint., Results: In our study, 136/268 individuals were long-term CMV seropositive and 19 seroconverted during follow-up (seroconversion rate: 0.56%/year). CMV-specific antibody levels increased slightly over time. However, we did not find an association between duration of CMV infection and CMV-specific antibody levels at study endpoint. No clear association between duration of CMV infection and the size and function of the memory T-cell pool was observed. Elevated CMV-specific antibody levels were associated with the prevalence of cardiovascular disease but not with frailty. Age at CMV seroconversion was positively associated with CMV-specific antibody levels, memory CD4 + T-cell numbers and frailty., Conclusion: Cytomegalovirus-specific memory T cells develop shortly after CMV seroconversion but do not seem to further increase over time. Age-related effects other than duration of CMV infection seem to contribute to CMV-induced changes in the immune system. Although CMV-specific immunity is not evidently linked to frailty, it tends to associate with higher prevalence of cardiovascular disease., Competing Interests: The authors declare no conflict of interest., (© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)

Published
2020
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