120 results on '"de Hoog M"'
Search Results
2. Trends in community response and long-term outcomes from pediatric cardiac arrest:A retrospective observational study
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Albrecht, M, de Jonge, R C J, Dulfer, K, Van Gils-Frijters, A P J M, de Hoog, M, Hunfeld, M, Kammeraad, J A E, Moors, X R J, Nadkarni, V M, Buysse, C M P, Albrecht, M, de Jonge, R C J, Dulfer, K, Van Gils-Frijters, A P J M, de Hoog, M, Hunfeld, M, Kammeraad, J A E, Moors, X R J, Nadkarni, V M, and Buysse, C M P
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AIM: This study aimed to investigate trends over time in pre-hospital factors for pediatric out-of-hospital cardiac arrest (pOHCA) and long-term neurological and neuropsychological outcomes. These have not been described before in large populations.METHODS: Non-traumatic arrest patients, 1 day-17 years old, presented to the Sophia Children's Hospital from January 2002 to December 2020, were eligible for inclusion. Favorable neurological outcome was defined as Pediatric Cerebral Performance Categories (PCPC) 1-2 or no difference with pre-arrest baseline. The trend over time was tested with multivariable logistic and linear regression models with year of event as independent variable.FINDINGS: Over a nineteen-year study period, the annual rate of long-term favorable neurological outcome, assessed at a median 2·5 years follow-up, increased significantly (OR 1·10, 95%-CI 1·03-1·19), adjusted for confounders. Concurrently, annual automated external defibrillator (AED) use and, among adolescents, initial shockable rhythm increased significantly (OR 1·21, 95% CI 1·10-1·33 and OR 1·15, 95% CI 1·02-1·29, respectively), adjusted for confounders. For generalizability purposes, only the total intelligence quotient (IQ) was considered for trend analysis of all tested domains. Total IQ scores and bystander basic life support (BLS) rate did not change significantly over time.INTERPRETATION: Long-term favorable neurological outcome, assessed at a median 2·5 years follow-up, improved significantly over the study period. Total IQ scores did not significantly change over time. Furthermore, AED use (OR 1·21, 95%CI 1.10-1·33) and shockable rhythms among adolescents (OR1·15, 95%CI 1·02-1·29) increased over time.
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- 2024
3. SARS-CoV-2 incidence in secondary schools;: the role of national and school-initiated COVID-19 measures
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Jonker, L, Linde, K J, de Boer, A R, Ding, E, Zhang, D, de Hoog, M L A, Herfst, S, Heederik, D J J, Fraaij, P L A, Bluyssen, P M, Wouters, I M, Bruijning-Verhagen, P C J L, IRAS OH Epidemiology Microbial Agents, and Faculteit Diergeneeskunde
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Schools ,SARS-CoV-2 ,Incidence ,Communicable Disease Control ,Humans ,Dust ,Carbon Dioxide ,COVID-19/epidemiology - Abstract
INTRODUCTION: Our aim was to gain insight into the effect of COVID-19 measures on SARS-CoV-2 incidence in secondary schools and the association with classroom CO 2 concentration and airborne contamination. METHODS: Between October 2020-June 2021, 18 schools weekly reported SARS-CoV-2 incidence and completed surveys on school-initiated COVID-19 measures (e.g. improving hygiene or minimizing contacts). CO 2 was measured in occupied classrooms twice, and SARS-CoV-2 air contamination longitudinally using electrostatic dust collectors (EDC) and analyzed using RT-qPCR. National COVID-19 policy measures varied during pre-lockdown, lockdown and post-lockdown periods. During the entire study, schools were recommended to improve ventilation. SARS-CoV-2 incidence rate ratios (IRR) were estimated by Generalized Estimating Equation (GEE) models. RESULTS: During 18 weeks follow-up (range: 10-22) SARS-CoV-2 school-incidence decreased during national lockdown (adjusted IRR: 0.41, 95%CI: 0.21-0.80) and post-lockdown (IRR: 0.60, 0.39-0.93) compared to pre-lockdown. School-initiated COVID-19 measures had no additional effect. Pre-lockdown, IRRs per 10% increase in time CO 2 exceeded 400, 550 and 800 ppm above outdoor level respectively, were 1.08 (1.00-1.16), 1.10 (1.02-1.19), and 1.08 (0.95-1.22). Post-lockdown, CO 2-concentrations were considerably lower and not associated with SARS-CoV-2 incidence. No SARS-CoV-2 RNA was detected in any of the EDC samples. CONCLUSION: During a period with low SARS-CoV-2 population immunity and increased attention to ventilation, with CO 2 levels most of the time below acceptable thresholds, only the national policy during and post-lockdown of reduced class-occupancy, stringent quarantine, and contact testing reduced SARS-CoV-2 incidence in Dutch secondary schools. Widespread SARS-CoV-2 air contamination could not be demonstrated in schools under the prevailing conditions during the study.
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- 2023
4. PB0254 Factor XI and XII in Children Undergoing Extracorporeal Membrane Oxygenation (ECMO)
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Drop, J., primary, Letunica, N., additional, Van Den Helm, S., additional, Wildschut, E., additional, De Hoog, M., additional, Barton, R., additional, Yaw, H., additional, Newall, F., additional, Horton, S., additional, Chiletti, R., additional, Johansen, A., additional, Best, D., additional, McKittrick, J., additional, Butt, W., additional, D'Udekem, Y., additional, MacLaren, G., additional, Ignjatovic, V., additional, Attard, C., additional, Van Ommen, C., additional, and Monagle, P., additional
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- 2023
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5. SARS-CoV-2 incidence in secondary schools: the role of national and school-initiated COVID-19 measures
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IRAS OH Epidemiology Microbial Agents, Faculteit Diergeneeskunde, IRAS – One Health Microbial, Jonker, L, Linde, K J, de Boer, A R, Ding, E, Zhang, D, de Hoog, M L A, Herfst, S, Heederik, D J J, Fraaij, P L A, Bluyssen, P M, Wouters, I M, Bruijning-Verhagen, P C J L, IRAS OH Epidemiology Microbial Agents, Faculteit Diergeneeskunde, IRAS – One Health Microbial, Jonker, L, Linde, K J, de Boer, A R, Ding, E, Zhang, D, de Hoog, M L A, Herfst, S, Heederik, D J J, Fraaij, P L A, Bluyssen, P M, Wouters, I M, and Bruijning-Verhagen, P C J L
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- 2023
6. SARS-CoV-2 incidence in secondary schools; the role of national and school-initiated COVID-19 measures
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Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Jonker, L, Linde, K J, de Boer, A R, Ding, E, Zhang, D, de Hoog, M L A, Herfst, S, Heederik, D J J, Fraaij, P L A, Bluyssen, P M, Wouters, I M, Bruijning-Verhagen, P C J L, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Jonker, L, Linde, K J, de Boer, A R, Ding, E, Zhang, D, de Hoog, M L A, Herfst, S, Heederik, D J J, Fraaij, P L A, Bluyssen, P M, Wouters, I M, and Bruijning-Verhagen, P C J L
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- 2023
7. Physician exhaustion and work engagement during the COVID-19 pandemic: A longitudinal survey into the role of resources and support interventions
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Solms, L., van Vianen, A.E.M., Koen, J., Kan, K.-J., de Hoog, M., de Pagter, A.P.J., Geriatrics, APH - Aging & Later Life, APH - Quality of Care, Psychology Other Research (FMG), Arbeids- en Organisatie Psychologie (Psychologie, FMG), Methods and Statistics (RICDE, FMG), and Research Institute for Child Development and Education
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Multidisciplinary - Abstract
Background Physicians increasingly show symptoms of burnout due to the high job demands they face, posing a risk for the quality and safety of care. Job and personal resources as well as support interventions may function as protective factors when demands are high, specifically in times of crisis such as the COVID-19 pandemic. Based on the Job Demands-Resources theory, this longitudinal study investigated how monthly fluctuations in job demands and job and personal resources relate to exhaustion and work engagement and how support interventions are associated with these outcomes over time. Methods A longitudinal survey consisting of eight monthly measures in the period 2020–2021, completed by medical specialists and residents in the Netherlands. We used validated questionnaires to assess job demands (i.e., workload), job resources (e.g., job control), personal resources (e.g., psychological capital), emotional exhaustion, and work engagement. Additionally, we measured the use of specific support interventions (e.g., professional support). Multilevel modeling and longitudinal growth curve modeling were used to analyze the data. Results 378 medical specialists and residents were included in the analysis (response rate: 79.08%). Workload was associated with exhaustion (γ = .383, p < .001). All job resources, as well as the personal resources psychological capital and self-judgement were associated with work engagement (γs ranging from -.093 to .345, all ps < .05). Job control and psychological capital attenuated the workload-exhaustion relationship while positive feedback and peer support strengthened it (all ps < .05). The use of professional support interventions (from a mental health expert or coach) was related to higher work engagement (estimate = .168, p = .032) over time. Participation in organized supportive group meetings was associated with higher exhaustion over time (estimate = .274, p = .006). Conclusions Job and personal resources can safeguard work engagement and mitigate the risk of emotional exhaustion. Professional support programs are associated with higher work engagement over time, whereas organized group support meetings are associated with higher exhaustion. Our results stress the importance of professional individual-level interventions to counteract a loss of work engagement in times of crisis.
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- 2023
8. Additional file 1 of SARS-CoV-2 incidence in secondary schools; the role of national and school-initiated COVID-19 measures
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Jonker, L., Linde, K. J., de Boer, A. R., Ding, E., Zhang, D., de Hoog, M. L. A., Herfst, S., Heederik, D. J. J., Fraaij, P. L. A., Bluyssen, P. M., Wouters, I. M., and Bruijning-Verhagen, P. C. J. L.
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Additional file 1: Box S1. Survey baseline characteristics school. Box S2. Survey school-initiated COVID-19 measures. Table S1. National COVID-19 policy during the study period (October 2020 – June 2021) for each lockdown period. Table S2. School-initiated COVID-19 measures and corresponding scores. Box S3. Laboratory analysis of settling dust samples. Table S3. Results of SARS-CoV-2 RT-PCR in settling dust samples in secondary schools.
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- 2023
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9. Coagulation in pediatric extracorporeal membrane oxygenation: A systematic review of studies shows lack of standardized reporting.
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Drop, J, Van Den Helm, S, Monagle, P, Wildschut, E, de Hoog, M, Gunput, STG, Newall, F, Dalton, HJ, MacLaren, G, Ignjatovic, V, van Ommen, CH, Drop, J, Van Den Helm, S, Monagle, P, Wildschut, E, de Hoog, M, Gunput, STG, Newall, F, Dalton, HJ, MacLaren, G, Ignjatovic, V, and van Ommen, CH
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OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) involves complex coagulation management and frequent hemostatic complications. ECMO practice between centers is variable. To compare results between coagulation studies, standardized definitions and clear documentation of ECMO practice is essential. We assessed how study population, outcome definitions, and ECMO-, coagulation-, and transfusion-related parameters were described in pediatric ECMO studies. DATA SOURCES: Embase, Medline, Web of Science, Cochrane Library and Google Scholar. STUDY SELECTION: English original studies of pediatric ECMO patients describing hemostatic tests or outcome. DATA EXTRACTION: Eligibility was assessed following PRISMA guidelines. Study population, outcome and ECMO-, coagulation, and transfusion parameters were summarized. DATA SYNTHESIS: A total of 107 of 1312 records were included. Study population parameters most frequently included (gestational) age (79%), gender (60%), and (birth) weight (59%). Outcomes, including definitions of bleeding (29%), thrombosis (15%), and survival (43%), were described using various definitions. Description of pump type, oxygenator and cannulation mode occurred in 49%, 45%, and 36% of studies, respectively. The main coagulation test (53%), its reference ranges (49%), and frequency of testing (24%) were the most prevalent reported coagulation parameters. The transfusion thresholds for platelets, red blood cells, and fibrinogen were described in 27%, 18%, and 18% of studies, respectively. CONCLUSIONS: This systematic review demonstrates a widespread lack of detail or standardization of several parameters in coagulation research of pediatric ECMO patients. We suggest several parameters that might be included in future coagulation studies. We encourage the ECMO community to adopt and refine this list of parameters and to use standardized definitions in future research.
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- 2022
10. Epidemiology and Etiology of Severe Childhood Encephalitis in The Netherlands
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De Blauw, D., Bruning, A. H.L., Busch, C. B.E., Kolodziej, Lisa M., Jansen, N. J.G., Van Woensel, J. B.M., Pajkrt, Dasja, Kneijber, M. C.J., Lemson, J., Van Heerde, M., Van Dam, N. A.M., Bekker, V., De Hoog, M., Wolfs, T. F.W., Visser, I. H.E., Van Waardenburg, D. A., Kolodziej, L. M., Pajkrt, D., Wolthers, K. W., Pediatric surgery, ACS - Diabetes & metabolism, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), Pediatrics, Graduate School, Medical Microbiology and Infection Prevention, Paediatric Intensive Care, and Paediatric Infectious Diseases / Rheumatology / Immunology
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Microbiology (medical) ,Herpes simplex virus infection ,Infectious Encephalitis ,Male ,medicine.medical_specialty ,Pediatrics ,encephalitis ,Intensive Care Units, Pediatric ,Severity of Illness Index ,Original Studies ,03 medical and health sciences ,0302 clinical medicine ,children ,030225 pediatrics ,Intensive care ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Encephalitis, Viral ,Child ,Netherlands ,Retrospective Studies ,business.industry ,Infant ,Decreased consciousness ,medicine.disease ,Hospitalization ,Infectious Diseases ,pediatric intensive care ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Etiology ,outcome ,epidemiology ,Female ,business ,Lower mortality ,Encephalitis - Abstract
Background: Limited data are available on childhood encephalitis. Our study aimed to increase insight on clinical presentation, etiology, and clinical outcome of children with severe encephalitis in the Netherlands. Methods: We identified patients through the Dutch Pediatric Intensive Care Evaluation database and included children diagnosed with encephalitis
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- 2020
11. The Pharmacokinetics of Beta-Lactam Antibiotics Using Scavenged Samples in Pediatric Intensive Care Patients: The EXPAT Kids Study Protocol
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Schouwenburg, Stef, primary, Wildschut, Enno D., additional, de Hoog, M., additional, Koch, Birgit C.P., additional, and Abdulla, Alan, additional
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- 2021
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12. Association between shockable rhythms and long-term outcome after pediatric out-of-hospital cardiac arrest in Rotterdam, the Netherlands: An 18-year observational study
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Albrecht, M., de Jonge, R. C.J., Nadkarni, V. M., de Hoog, M., Hunfeld, M., Kammeraad, J. A.E., van Zellem, L., Moors, X. R.J., Buysse, C. M.P., Pediatric Surgery, Pediatrics, Neurology, Anesthesiology, and Erasmus MC other
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Male ,Emergency Medical Services ,medicine.medical_specialty ,Adolescent ,Emergency Nursing ,Return of spontaneous circulation ,Out of hospital cardiac arrest ,Cohort Studies ,Rhythm ,medicine ,Humans ,Child ,Netherlands ,Retrospective Studies ,Pediatric intensive care unit ,business.industry ,Shockable rhythm ,Emergency department ,Cardiopulmonary Resuscitation ,Child, Preschool ,Emergency medicine ,Cohort ,Emergency Medicine ,Observational study ,Cardiology and Cardiovascular Medicine ,business ,Out-of-Hospital Cardiac Arrest - Abstract
Introduction Shockable rhythm following pediatric out-of-hospital cardiac arrest (pOHCA) is consistently associated with hospital and short-term survival. Little is known about the relationship between shockable rhythm and long-term outcomes (>1 year) after pOHCA. The aim was to investigate the association between first documented rhythm and long-term outcomes in a pOHCA cohort over 18 years. Methods All children aged 1 day–18 years who experienced non-traumatic pOHCA between 2002–2019 and were subsequently admitted to the emergency department (ED) or pediatric intensive care unit (PICU) of Erasmus MC-Sophia Children’s Hospital were included. Data was abstracted retrospectively from patient files, (ground) ambulance and Helicopter Emergency Medical Service (HEMS) records, and follow-up clinics. Long-term outcome was determined using a Pediatric Cerebral Performance Category (PCPC) score at the longest available follow-up interval through august 2020. The primary outcome measure was survival with favorable neurologic outcome, defined as PCPC 1–2 or no difference between pre- and post-arrest PCPC. The association between first documented rhythm and the primary outcome was calculated in a multivariable regression model. Results 369 children were admitted, nine children were lost to follow-up. Median age at arrest was age 3.4 (IQR 0.8–9.9) years, 63% were male and 14% had a shockable rhythm (66% non-shockable, 20% unknown or return of spontaneous circulation (ROSC) before emergency medical service (EMS) arrival). In adolescents (aged 12–18 years), 39% had shockable rhythm. 142 (39%) of children survived to hospital discharge. On median follow-up interval of 25 months (IQR 5.1–49.6), 115/142 (81%) of hospital survivors had favorable neurologic outcome. In multivariable analysis, shockable rhythm was associated with survival with favorable long-term neurologic outcome (OR 8.9 [95%CI 3.1–25.9]). Conclusion In children with pOHCA admitted to ED or PICU shockable rhythm had significantly higher odds of survival with long-term favorable neurologic outcome compared to non-shockable rhythm. Survival to hospital discharge after pOHCA was 39% over the 18-year study period. Of survivors to discharge, 81% had favorable long-term (median 25 months, IQR 5.1–49.6) neurologic outcome. Efforts for improving outcome of pOHCA should focus on early recognition and treatment of shockable pOHCA at scene.
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- 2021
13. The Pharmacokinetics of Beta-Lactam Antibiotics Using Scavenged Samples in Pediatric Intensive Care Patients:The EXPAT Kids Study Protocol
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Schouwenburg, Stef, Wildschut, Enno D., de Hoog, M., Koch, Birgit C.P., Abdulla, Alan, Schouwenburg, Stef, Wildschut, Enno D., de Hoog, M., Koch, Birgit C.P., and Abdulla, Alan
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Background: Emerging evidence supports the importance of optimized antibiotic exposure in pediatric intensive care unit (PICU) patients. Traditional antibiotic dosing is not designed for PICU patients, as the extreme pharmacokinetic (PK) behavior of drugs threatens the achievement of optimal antibiotic treatment outcomes. Scavenged sampling is a sampling strategy which may have positive implications for routine TDM and PK research, as well as monitoring other biomarkers. EXPAT Kids study was designed to analyze whether current empiric dosing regimens of frequently used beta-lactam antibiotics achieve defined therapeutic target concentrations in PICU patients. Methods: A mono-centre, exploratory pharmacokinetic and pharmacodynamic study was designed to assess target attainment of beta-lactam antibiotics. One hundred forty patients will be included within 24 months after start of inclusion. At various time points serum concentration of the study antibiotic (cefotaxime, ceftazidime, ceftriaxone, cefuroxime, flucloxacillin, and meropenem) are determined. In parallel with these sampling moments, residual material is collected to validate the use of blood of scavenged heparinized astrup syringes for the quantification of antibiotic exposure. The primary outcome is the time that the free (unbound) concentration of the study antibiotic remains above one to four the minimal inhibitory concentration during a dosing interval (100%ƒT > MIC and 100%ƒT>4xMIC). Other included outcomes are disease severity, safety, length of stay, and inflammatory biomarkers. Discussion: Potentially, scavenged sampling may enrich the EXPAT Kids dataset, and reduce additional blood sampling and workload for clinical personnel. The findings from the EXPAT Kids study will lead to new insights in the PK parameters of beta-lactams and consecutive effects on target attainment and clinical outcomes. Is there a need for more precision in dosing? Netherlands Trial Register
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- 2021
14. Association between shockable rhythms and long-term outcome after pediatric out-of-hospital cardiac arrest in Rotterdam, the Netherlands:An 18-year observational study
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Albrecht, M., de Jonge, R. C.J., Nadkarni, V. M., de Hoog, M., Hunfeld, M., Kammeraad, J. A.E., van Zellem, L., Moors, X. R.J., Buysse, C. M.P., Albrecht, M., de Jonge, R. C.J., Nadkarni, V. M., de Hoog, M., Hunfeld, M., Kammeraad, J. A.E., van Zellem, L., Moors, X. R.J., and Buysse, C. M.P.
- Abstract
Introduction: Shockable rhythm following pediatric out-of-hospital cardiac arrest (pOHCA) is consistently associated with hospital and short-term survival. Little is known about the relationship between shockable rhythm and long-term outcomes (>1 year) after pOHCA. The aim was to investigate the association between first documented rhythm and long-term outcomes in a pOHCA cohort over 18 years. Methods: All children aged 1 day–18 years who experienced non-traumatic pOHCA between 2002–2019 and were subsequently admitted to the emergency department (ED) or pediatric intensive care unit (PICU) of Erasmus MC-Sophia Children's Hospital were included. Data was abstracted retrospectively from patient files, (ground) ambulance and Helicopter Emergency Medical Service (HEMS) records, and follow-up clinics. Long-term outcome was determined using a Pediatric Cerebral Performance Category (PCPC) score at the longest available follow-up interval through august 2020. The primary outcome measure was survival with favorable neurologic outcome, defined as PCPC 1–2 or no difference between pre- and post-arrest PCPC. The association between first documented rhythm and the primary outcome was calculated in a multivariable regression model. Results: 369 children were admitted, nine children were lost to follow-up. Median age at arrest was age 3.4 (IQR 0.8–9.9) years, 63% were male and 14% had a shockable rhythm (66% non-shockable, 20% unknown or return of spontaneous circulation (ROSC) before emergency medical service (EMS) arrival). In adolescents (aged 12–18 years), 39% had shockable rhythm. 142 (39%) of children survived to hospital discharge. On median follow-up interval of 25 months (IQR 5.1–49.6), 115/142 (81%) of hospital survivors had favorable neurologic outcome. In multivariable analysis, shockable rhythm was associated with survival with favorable long-term neurologic outcome (OR 8.9 [95%CI 3.1–25.9]). Conclusion: In children with pOHCA admitted to ED or PICU shockable r
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- 2021
15. Sevoflurane therapy for life-threatening asthma in children
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Schutte, D., Zwitserloot, A. M., Houmes, R., de Hoog, M., Draaisma, J. M., and Lemson, J.
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- 2013
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16. Human bocavirus infection as a cause of severe acute respiratory tract infection in children
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Moesker, F.M., van Kampen, J.J.A., van der Eijk, A.A., van Rossum, A.M.C., de Hoog, M., Schutten, M., Smits, S.L., Bodewes, R., Osterhaus, A.D.M.E., and Fraaij, P.L.A.
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- 2015
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17. Finger-Prick Blood Sampling for Therapeutic Drug Monitoring: Be Aware of Skin Contamination by Nebulized Drugs
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Winter, B.C.M. (Brenda) de, de Hoog, M., Vet, N.J. (Nienke), Dunk-Craaijo, J.H., Koch, B.C.P., Wildt, S.N. (Saskia) de, Winter, B.C.M. (Brenda) de, de Hoog, M., Vet, N.J. (Nienke), Dunk-Craaijo, J.H., Koch, B.C.P., and Wildt, S.N. (Saskia) de
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- 2020
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18. Ethnic differences in maternal underestimation of offspringʼs weight: the ABCD study
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de Hoog, M LA, Stronks, K, van Eijsden, M, Gemke, R JBJ, and Vrijkotte, T GM
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- 2012
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19. Essential knowledge for junior doctors regarding infectious disease control: a modified Delphi study
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van den Berg, N M, primary, de Hoog, M L A, primary, Seeleman, M C, primary, and Jambroes, M, primary
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- 2019
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20. Epidemiology and Outcome of Critically Ill Pediatric Cancer and Hematopoietic Stem Cell Transplant Patients Requiring Continuous Renal Replacement Therapy: A Retrospective Nationwide Cohort Study
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Raymakers-Janssen, P., Lilien, M. (Marc), Tibboel, D. (Dick), Kneyber, M.C.J., Dijkstra, S., Woensel, J.B. (Job) van, Lemson, J. (J.), Cransberg, K. (Karlien), Heuvel-Eibrink, M.M. (Marry) van den, Wösten-van Asperen, R.M. (Roelie), van Woensel, J., Bem, R., van Heerden, M., Riedijk, M.A. (Maaike), de Hoog, M., Verbruggen, S.C.A.T. (Sascha), Kneyber, M., Van Waardenburg, D, Roeleveld, N. (Nel), Raymakers-Janssen, P., Lilien, M. (Marc), Tibboel, D. (Dick), Kneyber, M.C.J., Dijkstra, S., Woensel, J.B. (Job) van, Lemson, J. (J.), Cransberg, K. (Karlien), Heuvel-Eibrink, M.M. (Marry) van den, Wösten-van Asperen, R.M. (Roelie), van Woensel, J., Bem, R., van Heerden, M., Riedijk, M.A. (Maaike), de Hoog, M., Verbruggen, S.C.A.T. (Sascha), Kneyber, M., Van Waardenburg, D, and Roeleveld, N. (Nel)
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Objective: Acute kidney injury requiring continuous renal replacement therapy is a serious treatment-related complication in pediatric cancer and hematopoietic stem cell transplant patients. The purpose of this study was to assess epidemiology and outcome of these patients requiring continuous renal replacement therapy in the PICU. Design: A nationwide, multicenter, retrospective, observational study. Setting: Eight PICUs of a tertiary care hospitals in the Netherlands. Patients: Pediatric cancer and hematopoietic stem cell transplant
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- 2019
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21. Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations
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Colin, P.J., Allegaert, K.M. (Karel), Thomson, A.H., Touw, D.J. (Daan), Dolton, M., de Hoog, M., Roberts, JA, Adane, E.D., Yamamoto, M. (Masayuki), Santos-Buelga, D., Martin-Suarez, A., Simon, N., Taccone, F.S. (Fabio), Lo, Y.L., Barcia, E., Struys, M., Eleveld, D.J., Colin, P.J., Allegaert, K.M. (Karel), Thomson, A.H., Touw, D.J. (Daan), Dolton, M., de Hoog, M., Roberts, JA, Adane, E.D., Yamamoto, M. (Masayuki), Santos-Buelga, D., Martin-Suarez, A., Simon, N., Taccone, F.S. (Fabio), Lo, Y.L., Barcia, E., Struys, M., and Eleveld, D.J.
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Background and Objectives Uncertainty exists regarding the optimal dosing regimen for vancomycin in diferent patient populations, leading to a plethora of subgroup-specifc pharmacokinetic models and derived dosing regimens. We aimed to investigate whether a single model for vancomycin could be developed based on a broad dataset covering the extremes of patient characteristics. Furthermore, as a benchmark for current dosing recommendations, we evaluated and optimised the expected vancomycin exposure throughout life and for specifc patient subgroups. Methods A pooled population-pharmacokinetic model was built in NONMEM based on data from 14 diferent studies in diferent patient populations. Steady-state exposure was simulated and compared across patient subgro
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- 2019
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22. Endocrine and Metabolic Responses in Children with Meningoccocal Sepsis: Striking Differences between Survivors and Nonsurvivors
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Joosten, K F. M, de Kleijn, E D, Westerterp, M, de Hoog, M, v Eijck, F C, Hop, W C. J, vd Voort, E, Hazelzet, J A, and Hokken-Koelega, A C. S
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- 2000
23. In situ observations of wintertime low-altitude clouds over the Southern Ocean
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Ahn, E, Huang, Y, Chubb, TH, Baumgardner, D, Isaac, P, de Hoog, M, Siems, ST, Manton, MJ, Ahn, E, Huang, Y, Chubb, TH, Baumgardner, D, Isaac, P, de Hoog, M, Siems, ST, and Manton, MJ
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- 2017
24. Viruses as sole causative agents of severe acute respiratory tract infections in children
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Moesker, F.M. (Fleur), Kampen, J.J.A. (Jeroen) van, Rossum, A.M.C. (Annemarie) van, De Hoog, M. (Matthijs), Koopmans D.V.M., M.P.G. (Marion), Osterhaus, A.D.M.E. (Albert), Fraaij, P.L.A. (Pieter), Moesker, F.M. (Fleur), Kampen, J.J.A. (Jeroen) van, Rossum, A.M.C. (Annemarie) van, De Hoog, M. (Matthijs), Koopmans D.V.M., M.P.G. (Marion), Osterhaus, A.D.M.E. (Albert), and Fraaij, P.L.A. (Pieter)
- Abstract
Background: Respiratory syncytial virus (RSV) and influenza A viruses are known to cause severe acute respiratory tract infections (SARIs) in children. For other viruses like human rhinoviruses (HRVs) this is less well established. Viral or bacterial co-infections are often considered essential for severe manifestations of these virus infections. Objective: The study aims at identifying viruses that may cause SARI in children in the absence of viral and bacterial co-infections, at identifying disease characteristics associated with these single virus infections, and at identifying a possible correlation between viral loads and disease severities. Study Design: Between April 2007 and March 2012, we identified children (<18 year) with or without a medical history, admitted to our paediatric intensive care unit (PICU) with SARI or to the medium care (MC) with an acute respiratory tract infection (ARTI) (controls). Data were extracted from the clinical and laboratory databases of our tertiary care paediatric hospital. Patient specimens were tested for fifteen respiratory viruses with real-time reverse transcriptase PCR assays and we selected patients with a single virus infection only. Typical bacterial co-infections were considered unlikely to have contributed to the PICU or MC admission based on C-reactive protein-levels or bacteriological test results if performed. Results: We identified 44 patients admitted to PICU with SARI and 40 patients admitted to MC with ARTI. Twelve viruses were associated with SARI, ten of which were also associated with ARTI in the absence of typical bacterial and viral co-infections, with RSV and HRV being the most frequent causes. Viral loads were not different between PICU-SARI patients and MCARTI patients. Conclusion: Bo
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- 2016
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25. Welkom! Investeren in Cultuur
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de Hoog, M., Vermeulen, R., and Urban Planning (AISSR, FMG)
- Abstract
Eind negentiende eeuw investeerde Amsterdam rond het Museumplein in haar culturele infrastructuur. Sinds het 700-jarig bestaan in 1975 is de stad ook een festivalstad geworden met bijzondere evenementen als Sail, het voetbaltoernooi Amsterdam Tournament en de Marathon. Vanaf de jaren negentig heeft het stadstoerisme een enorme groei doorgemaakt en zijn verschillende culturele hotspots ontstaan. Toch is het behoud van de positie van Amsterdam als toeristisch centrum niet vanzelfsprekend. Om succesvol te blijven zijn kwalitatieve investeringen noodzakelijk: in de openbare ruimte, in de toegankelijkheid en in de diversiteit van de verschillende toeristische en uitgaansgebieden in de stad.
- Published
- 2011
26. Mechanical circulatory support in the Dutch National Paediatric Heart Transplantation Programme
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van der Meulen, M. H., primary, Dalinghaus, M., additional, Maat, A. P. W. M., additional, van de Woestijne, P. C., additional, van Osch, M., additional, de Hoog, M., additional, Kraemer, U. S., additional, and Bogers, A. J. J. C., additional
- Published
- 2015
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27. 273 * MECHANICAL CIRCULATORY SUPPORT IN THE DUTCH NATIONAL PAEDIATRIC HEART TRANSPLANTATION PROGRAM
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Van Der Meulen, M., primary, Dalinghaus, M., additional, Maat, A., additional, Van De Woestijne, P., additional, Van Osch, L., additional, De Hoog, M., additional, Kraemer, U., additional, and Bogers, A. J. J. C., additional
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- 2014
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28. BOSS Studytour 2002. Mexico City
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van der Voordt, D.J.M, van Meel, J.J., de Hoog, M., and Zorge, M.
- Published
- 2002
29. A baby with meningococcemia and septic shock
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Leeuwenburg-Pronk, W.G., Smith, P.J., van Vught, A.J., Lantos, J.D., Tibboel, D., de Hoog, M, Buysse, C., Leeuwenburg-Pronk, W.G., Smith, P.J., van Vught, A.J., Lantos, J.D., Tibboel, D., de Hoog, M, and Buysse, C.
- Published
- 2012
30. A baby with meningococcemia and septic shock
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Other research (not in main researchprogram), Intensive care, Leeuwenburg-Pronk, W.G., Smith, P.J., van Vught, A.J., Lantos, J.D., Tibboel, D., de Hoog, M, Buysse, C., Other research (not in main researchprogram), Intensive care, Leeuwenburg-Pronk, W.G., Smith, P.J., van Vught, A.J., Lantos, J.D., Tibboel, D., de Hoog, M, and Buysse, C.
- Published
- 2012
31. Assessment of opioid and benzodiazepine withdrawal symptoms in critically ill children:Current state of the art
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Ista, E., Van Dijk, M., Tibboel, D., De Hoog, M., Ista, E., Van Dijk, M., Tibboel, D., and De Hoog, M.
- Abstract
Prolonged administration of benzodiazepines and/or opioids to children in a paediatric intensive care unit (PICU) may induce physiological dependence and withdrawal symptoms. We reviewed the literature for relevant contributions on the nature of these withdrawal symptoms and on availability of valid scoring systems to assess the extent of symptoms in children. Symptoms of benzodiazepine and opioid withdrawal can be classified into three groups: central nervous system (CNS) overstimulation, gastrointestinal dysregulation and autonomic dysfunction. In children, symptoms associated with CNS overstimulation and autonomic dysfunction may overlap after long-term use of benzodiazepines or opioids. Symptoms of gastrointestinal dysfunction in the PICU population have only been described for opioid withdrawal. Four scoring systems for use in children have been described. Two of these provided good reliability and validity to determine withdrawal symptoms: the Withdrawal Assessment Tool version 1 (WAT-1) and the Sophia Observation withdrawal Symptoms-scale (SOS).
- Published
- 2009
32. Ethnic differences in maternal underestimation of offspring's weight: the ABCD study
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de Hoog, M L A, primary, Stronks, K, additional, van Eijsden, M, additional, Gemke, R J B J, additional, and Vrijkotte, T G M, additional
- Published
- 2011
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33. BOSS Studytour 2002. Mexico City
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van der Voordt, D.J.M (author), van Meel, J.J. (author), de Hoog, M. (author), Zorge, M. (author), van der Voordt, D.J.M (author), van Meel, J.J. (author), de Hoog, M. (author), and Zorge, M. (author)
- Published
- 2002
34. Fatal neonatal parechovirus encephalitis
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van Zwol, A. L, primary, Lequin, M., additional, Aarts-Tesselaar, C., additional, van der Eijk, A. A, additional, Driessen, G. A, additional, de Hoog, M., additional, and Govaert, P., additional
- Published
- 2009
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35. Local vasoconstriction in spinal cord-injured and able-bodied individuals
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Kooijman, M., primary, de Hoog, M., additional, Rongen, G. A., additional, van Kuppevelt, H. J. M., additional, Smits, P., additional, and Hopman, M. T. E., additional
- Published
- 2007
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36. Assessment in nonverbal populations (infants, mentally impaired, etc.)
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Prins, S., primary, Van Dijk, M., additional, Houmes, R., additional, de Hoog, M., additional, Van den Boogaart, L., additional, and Tibboel, D., additional
- Published
- 2004
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37. DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis
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Merkus, P.J.F.M., primary, de Hoog, M., additional, van Gent, R., additional, and de Jongste, J.C., additional
- Published
- 2001
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38. Serial measurements of energy expenditure in critically ill children: optimizing nutritional therapy?
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de Klerk, G, primary, Hop, WCJ, additional, de Hoog, M, additional, and Joosten, KFM, additional
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- 2001
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39. Hypocalcemia in children with septic shock
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Buysse, CMP, primary, van der Kaay, DCM, additional, van der Voort, E, additional, de Hoog, M, additional, Hazelzet, JA, additional, and Joosten, KFM, additional
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- 2001
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40. Treatment of status asthmaticus in children: is there a place for sodium bicarbonate?
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Buysse, CMP and de Hoog, M
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Meeting Abstract - Published
- 2002
41. Overweight at age two years in a multi-ethnic cohort (ABCD study): the role of prenatal factors, birth outcomes and postnatal factors
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Stronks Karien, van Eijsden Manon, de Hoog Marieke LA, Gemke Reinoud JBJ, and Vrijkotte Tanja GM
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body mass index (BMI) ,childhood ,ethnicity ,overweight ,weight gain ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Childhood overweight/obesity is a major public health problem worldwide which disproportionally affects specific ethnic groups. Little is known about whether such differences already exist at an early age and which factors contribute to these ethnic differences. Therefore, the present study assessed possible ethnic differences in overweight at age 2 years, and the potential explanatory role of prenatal factors, birth outcomes and postnatal factors. Methods Data were derived from a multi-ethnic cohort in the Netherlands (the ABCD study). Weight and height data of 3,156 singleton infants at age 2 years were used. Five ethnic populations were distinguished: Dutch native (n = 1,718), African descent (n = 238), Turkish (n = 162), Moroccan (n = 245) and other non-Dutch (n = 793). Overweight status was defined by the International Obesity Task Force guidelines. The explanatory role of prenatal factors, birth outcomes and postnatal factors in ethnic disparities in overweight (including obesity) was assessed by logistic regression analysis. Results Compared to the native Dutch (7.1%), prevalence of overweight was higher in the Turkish (19.8%) and Moroccan (16.7%) group, whereas the prevalence was not increased in the African descent (9.2%) and other non-Dutch (8.8%) group. Although maternal pre-pregnancy body mass index partly explained the ethnic differences, the odds ratio (OR) of being overweight remained higher in the Turkish (OR: 2.66; 95%CI: 1.56-4.53) and Moroccan (OR: 2.11; 95%CI: 1.31-3.38) groups after adjusting for prenatal factors. The remaining differences were largely accounted for by weight gain during the first 6 months of life (postnatal factor). Maternal height, birth weight and gender were independent predictors for overweight at age 2 years, but did not explain the ethnic differences. Conclusion Turkish and Moroccan children in the Netherlands have 2- to 3-fold higher odds for being overweight at age 2 years, which is largely attributed to maternal pre-pregnancy BMI and weight gain during the first 6 months of life. Further study on the underlying factors of this early weight gain is required to tackle ethnic differences in overweight among these children.
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- 2011
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42. Healthcare costs related to respiratory syncytial virus in paediatric intensive care units in the Netherlands: a nationwide prospective observational study (the BRICK study).
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Phijffer EWEM, Wildenbeest JG, Brouwer CNM, de Hoog M, Kneyber MCJ, Maebe S, Nusmeier A, Riedijk MA, Wösten-van Asperen RM, van Woensel JBM, Bont LJ, and Frederix GJW
- Abstract
Background: The implementation of the approved respiratory syncytial virus (RSV) preventive interventions in immunisation programmes is advancing rapidly. Insight into healthcare costs of RSV-related paediatric intensive care unit (PICU) admissions is lacking, but of great importance to evaluate the impact of implementation. Therefore, this study aimed to determine the total annual RSV-related paediatric intensive care healthcare costs in the Netherlands., Methods: A nationwide prospective, observational, multicenter study was performed from September 2021 until June 2023. The total annual RSV-related healthcare costs on PICUs in the Netherlands were calculated using RSV-related costs (subgroup I) and consequential costs (subgroup II and III). Subgroup I comprised all PICU admitted infants ≤12 months of age with laboratory-confirmed RSV infection. Subgroup II and III consisted of postponed elective PICU admissions and refused acute PICU admissions due to RSV-related lack of PICU capacity., Findings: A total of 424 infants with RSV-related PICU admission were included. Median age at PICU admission was 46 days (IQR 25-89). The median length of PICU admission was 5 days (IQR 3-8). The total RSV-related PICU costs are € 3,826,386 in 2021-2022, and € 3,183,888 in 2022-2023. Potential costs averted by RSV preventive interventions is € 1.9 to € 2.6 million depending on season, and the duration of protection., Interpretation: RSV-related PICU admissions cost €3.1 to €3.8 million in the Netherlands during one season. The introduction of new RSV preventive interventions into the Dutch immunisation programme will generate significant cost-savings on PICUs and decreases the admission burden of PICUs., Funding: None., Competing Interests: EP, CB, MH, MK, SM, AN, MR, RWA, JvW and GF have no competing interests to declare. LB has regular interaction with pharmaceutical and other industrial partners. He has not received personal fees or other personal benefits. UMCU has received major funding (>€100,000 per industrial partner) for investigator initiated studies from AstraZeneca, Sanofi, Janssen, Pfizer, MSD and MeMed Diagnostics. UMCU has received major funding from the Bill and Melinda Gates Foundation. UMCU has received major funding as part of the public private partnership IMI-funded RESCEU and PROMISE projects with partners GSK, Novavax, Janssen, AstraZeneca, Pfizer and Sanofi. UMCU has received major funding by Julius Clinical for participating in clinical studies sponsored by AstraZeneca, Merck and Pfizer. UMCU received minor funding (€1000–25,000 per industrial partner) for consultation, DSMB membership or invited lectures by Ablynx, Bavaria Nordic, GSK, Novavax, Pfizer, Moderna, Astrazeneca, MSD, Sanofi, Janssen. LB is the founding chairman of the ReSViNET Foundation. JGW has been an investigator for clinical trials sponsored by pharmaceutical companies including AstraZeneca, Merck, Pfizer, Sanofi, and Janssen and an investigator for clinical trials funded by IMI/Horizon2020 and ZonMw. All funds have been paid to the institution (UMCU). JGW participated in advisory boards of Janssen and Sanofi and was a speaker at a Sanofi sponsored symposium with fees paid to the institution (UMCU)., (© 2024 The Author(s).)
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- 2024
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43. Lifelong development in medicine: a thematic analysis of coaching goals throughout medical careers.
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Stojanović A, Fris DAH, Solms L, van Hooft EAJ, De Hoog M, and de Pagter APJ
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- Humans, Female, Netherlands, Male, Qualitative Research, Physicians psychology, Adult, Internship and Residency, Career Choice, Specialization, Burnout, Professional prevention & control, Mentoring, Goals, Students, Medical psychology
- Abstract
Objectives: Healthcare grapples with staff shortages and rising burnout rates for medical students, residents and specialists. To prioritise both their well-being and the delivery of high-quality patient care, it becomes imperative to deepen our understanding of physicians' developmental aims and needs. Our first aim is, therefore, to gain comprehensive insights into the specific developmental aims physicians prioritise by examining the coaching goals they set at the beginning of coaching. Since physicians face distinct roles as they advance in their careers, our second aim is to highlight similarities and differences in developmental aims and needs among individuals at various medical career stages., Design: We conducted a qualitative analysis of 2571 coaching goals. We performed an inductive thematic analysis to code one-half of coaching goals and a codebook thematic analysis for the other half. Our interpretation of the findings was grounded in a critical realist approach., Setting: Sixteen hospitals in the Netherlands., Participants: A total of 341 medical clerkship students, 336 medical residents, 122 early-career specialists, 82 mid-career specialists and 57 late-career specialists provided their coaching goals at the start of coaching., Results: The findings revealed that coachees commonly set goals about their career and future, current job and tasks, interpersonal work relations, self-insight and development, health and well-being, nonwork aspects and the coaching process. Furthermore, the findings illustrate how the diversity of coaching goals increases as physicians advance in their careers., Conclusions: Our findings underscore the significance of recognising distinct challenges at various career stages and the necessity for tailoring holistic support for physicians. This insight holds great relevance for healthcare organisations, enabling them to better align system interventions with physicians' needs and enhance support. Moreover, our classification of coaching goals serves as a valuable foundation for future research, facilitating a deeper exploration of how these goals influence coaching outcomes., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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44. An 18-year, single centre, retrospective study of long-term neurological outcomes in paediatric submersion-related cardiac arrests.
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Scharink D, Hunfeld M, Albrecht M, Dulfer K, de Hoog M, van Gils A, de Jonge R, and Buysse C
- Abstract
Aim: Investigate long-term outcome in paediatric submersion-related cardiac arrests (CA)., Methods: Children (age one day-17 years) were included if admitted to the Erasmus MC Sophia Children's Hospital, after drowning with CA, between 2002 and 2019. Primary outcome was survival with favourable neurological outcome, defined as a Paediatric Cerebral Performance Category (PCPC) score of 1-3 at longest available follow-up. Secondary outcome were age-appropriate neuropsychological assessments at longest available follow-up., Results: Upon hospital admission, 99 children were included (median age at time of CA 3.2 years [IQR 2.0-5.9] and 65% males). Forty children died in-hospital (no return of circulation (45%) or withdrawal of life sustaining therapies (55%)) and 4 children deceased after hospital discharge due to complications following the drowning-incident. Among survivors, with a median follow-up of 2.3 years [IQR 0.2-5.5], 47 children had favourable neurological outcome (i.e. PCPC 1-3) and 8 children unfavourable (unfavourable outcome group total n = 52, i.e. PCPC 4-5 or deceased). Twenty-six (47%) children participated in a neuropsychological assessment (median follow-up 4.0 years [IQR 2.3-8.7]). Compared with normative test data, participants obtained worse general ( p = 0.008) and performance ( p = 0.003) intelligence scores, processing speed ( p = 0.002) and visual motor integration scores ( p = 0.0012)., Conclusions: Although overall outcome in survivors was favourable at longest available follow-up, significant deficits in neuropsychological assessments were found. This study underlines the need for a standardized long term follow-up program as standard of care in paediatric drowning with CA., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)
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- 2024
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45. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study.
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van Boven M, van Dorp CH, Westerhof I, Jaddoe V, Heuvelman V, Duijts L, Fourie E, Sluiter-Post J, van Houten MA, Badoux P, Euser S, Herpers B, Eggink D, de Hoog M, Boom T, Wildenbeest J, Bont L, Rozhnova G, Bonten MJ, Kretzschmar ME, and Bruijning-Verhagen P
- Subjects
- Adult, Adolescent, Humans, SARS-CoV-2, Prospective Studies, Family Characteristics, COVID-19 epidemiology, Epidemics
- Abstract
Household studies provide an efficient means to study transmission of infectious diseases, enabling estimation of susceptibility and infectivity by person-type. A main inclusion criterion in such studies is usually the presence of an infected person. This precludes estimation of the hazards of pathogen introduction into the household. Here we estimate age- and time-dependent household introduction hazards together with within household transmission rates using data from a prospective household-based study in the Netherlands. A total of 307 households containing 1,209 persons were included from August 2020 until March 2021. Follow-up of households took place between August 2020 and August 2021 with maximal follow-up per household mostly limited to 161 days. Almost 1 out of 5 households (59/307) had evidence of an introduction of SARS-CoV-2. We estimate introduction hazards and within-household transmission rates in our study population with penalized splines and stochastic epidemic models, respectively. The estimated hazard of introduction of SARS-CoV-2 in the households was lower for children (0-12 years) than for adults (relative hazard: 0.62; 95%CrI: 0.34-1.0). Estimated introduction hazards peaked in mid October 2020, mid December 2020, and mid April 2021, preceding peaks in hospital admissions by 1-2 weeks. Best fitting transmission models included increased infectivity of children relative to adults and adolescents, such that the estimated child-to-child transmission probability (0.62; 95%CrI: 0.40-0.81) was considerably higher than the adult-to-adult transmission probability (0.12; 95%CrI: 0.057-0.19). Scenario analyses indicate that vaccination of adults can strongly reduce household infection attack rates and that adding adolescent vaccination offers limited added benefit., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 van Boven et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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46. Career coach preferences of medical students: coaching specialist or specialistic coach?
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Fris DAH, van Vianen AEM, van Hooft EAJ, de Hoog M, and de Pagter APJ
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- Humans, Communication, Specialization, Mentoring, Students, Medical
- Abstract
Background: Medical students' demand for career coaching is growing. However, little is known about what type of career coach they prefer. Using the Warmth-Competence Framework, we investigated if and why medical students prefer physician coaches compared to career psychologist coaches. We also examined whether students' coach choice related to coaches' amount of experience with medical students., Methods: In a two-by-two between participants vignette study (n = 147), we manipulated coach occupational background (physician vs. psychologist) and experience with coaching medical students (limited vs. considerable). Participants read one coach description, rated the likelihood that they would choose the coach, and rated the coach on dimensions of warmth and competence., Results: Students who evaluated a physician career coach were more likely to choose the coach than students who evaluated a psychologist career coach. Students expected that a physician career coach would better understand their situation and be better able to provide career information, while they expected a psychologist career coach to have better conversation skills, all of which were relevant to choosing a coach. Coaches' experience with coaching medical students was unrelated to students' coach choice and their assessment of the coach's warmth and competence., Conclusions: Our findings highlight the relevance of coaches' occupational background and have implications for the implementation of career coach interventions. Medical schools could help students choose a career coach by providing information about the coach qualities that students value. Future studies could investigate whether career coaches with different occupational backgrounds differ in coach behaviors and coaching effectiveness., (© 2023. The Author(s).)
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- 2023
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47. Acquired von Willebrand disease in children undergoing extracorporeal membrane oxygenation: a prospective observational study.
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Drop JG, Wildschut ED, de Maat MPM, van Rosmalen J, de Boode WP, de Hoog M, and Heleen van Ommen C
- Subjects
- Child, Humans, Collagen, Hemorrhage complications, von Willebrand Factor metabolism, Prospective Studies, Extracorporeal Membrane Oxygenation adverse effects, von Willebrand Diseases diagnosis, von Willebrand Diseases epidemiology
- Abstract
Background: Extracorporeal membrane oxygenation (ECMO) provides cardiopulmonary support for children with severe cardiac and/or pulmonary failure. The incidence of bleeding complications during ECMO support is high. Acquired von Willebrand disease (AVWD) might contribute to the development of bleeding complications., Objective: To study the incidence and longitudinal profile of AVWD during the first 14 days of ECMO support in children and to investigate the association between AVWD and bleeding complications., Methods: This prospective observational study included pediatric patients (0-17 years) receiving ECMO. Blood was sampled prior to and after ECMO start, daily and 12 to 24 hours after stopping ECMO. von Willebrand factor (VWF) parameters and multimer patterns were determined. Clinical data were collected for each patient. AVWD was defined as loss of high-molecular weight multimers (ie, decreased compared with baseline) or a VWF:collagen binding/VWF: antigen (Ag) ratio or VWF:activity/VWF:Ag ratio below 0.7., Results: All of 50 (100%) patients developed AVWD during ECMO. The VWF:collagen binding /VWF:Ag ratio, VWF:activity/VWF:Ag ratio, and high-molecular weight multimers decreased during the initial days and recovered to baseline level within 24 hours after stopping ECMO. The incidence and longitudinal profile of AVWD were similar in patients with and without major bleeding complications., Conclusion: Children receiving ECMO support commonly develop AVWD. AVWD develops rapidly after ECMO initiation and recovers quickly after ECMO cessation. Importantly, AVWD appears to be independent of major bleeding., Competing Interests: Declaration of competing interests There are no competing interests to disclose., (Copyright © 2023 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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48. Factors XI and XII in extracorporeal membrane oxygenation: longitudinal profile in children.
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Drop J, Letunica N, Van Den Helm S, Heleen van Ommen C, Wildschut E, de Hoog M, van Rosmalen J, Barton R, Yaw HP, Newall F, Horton SB, Chiletti R, Johansen A, Best D, McKittrick J, Butt W, d'Udekem Y, MacLaren G, Linden MD, Ignjatovic V, Attard C, and Monagle P
- Abstract
Background: Extracorporeal membrane oxygenation (ECMO) is used in children with cardiopulmonary failure. While the majority of ECMO centers use unfractionated heparin, other anticoagulants, including factor XI and factor XII inhibitors are emerging, which may prove suitable for ECMO patients. However, before these anticoagulants can be applied in these patients, baseline data of FXI and FXII changes need to be acquired., Objectives: This study aimed to describe the longitudinal profile of FXI and FXII antigenic levels and function before, during, and after ECMO in children., Methods: This is a prospective observational study in neonatal and pediatric patients with ECMO (<18 years). All patients with venoarterial ECMO and with sufficient plasma volume collected before ECMO, on day 1 and day 3, and 24 hours postdecannulation were included. Antigenic levels and functional activity of FXI and FXII were determined in these samples. Longitudinal profiles of these values were created using a linear mixed model., Results: Sixteen patients were included in this study. Mean FXI and FXII antigenic levels (U/mL) changed from 7.9 and 53.2 before ECMO to 6.0 and 34.5 on day 3 and they recovered to 8.8 and 39.4, respectively, after stopping ECMO. Function (%) of FXI and FXII decreased from 59.1 and 59.0 to 49.0 and 50.7 on day 3 and recovered to 66.0 and 54.4, respectively., Conclusion: This study provides the first insights into changes of the contact pathway in children undergoing ECMO. FXI and FXII antigen and function change during ECMO. Results from this study can be used as starting point for future contact pathway anticoagulant studies in pediatric patients with ECMO., (© 2023 The Authors.)
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- 2023
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49. Characteristics of Long-Stay Patients in a PICU and Healthcare Resource Utilization After Discharge.
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Boerman GH, Haspels HN, de Hoog M, and Joosten KF
- Abstract
Objectives: To examine the characteristics of long-stay patients (LSPs) admitted to a PICU and to investigate discharge characteristics of medical complexity among discharged LSP., Design: We performed a retrospective cohort study where clinical data were collected on all children admitted to our PICU between July 1, 2017, and January 1, 2020., Setting: A single-center study based at Erasmus MC Sophia Children's Hospital, a level III interdisciplinary PICU in The Netherlands, providing all pediatric and surgical subspecialties., Patients: LSP was defined as those admitted for at least 28 consecutive days., Interventions: None., Measurements: Length of PICU stay, diagnosis at admission, length of mechanical ventilation, need for extracorporeal membrane oxygenation, mortality, discharge location after PICU and hospital admission, medical technical support, medication use, and involvement of allied healthcare professionals after hospital discharge., Main Results: LSP represented a small proportion of total PICU patients (108 patients; 3.2%) but consumed 33% of the total admission days, 47% of all days on extracorporeal membrane oxygenation, and 38% of all days on mechanical ventilation. After discharge, most LSP could be classified as children with medical complexity (CMC) (76%); all patients received discharge medications (median 5.5; range 2-19), most patients suffered from a chronic disease (89%), leaving the hospital with one or more technological devices (82%) and required allied healthcare professional involvement after discharge (93%)., Conclusions: LSP consumes a considerable amount of resources in the PICU and its impact extends beyond the point of PICU discharge since the majority are CMC. This indicates complex care needs at home, high family needs, and a high burden on the healthcare system across hospital borders., Competing Interests: The authors have no conflict of interest to disclose relevant to this article., (Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.)
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- 2023
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50. Serum Ivabradine Associates With Heart Rate Reduction But Enteral Exposure Is Unpredictable in Post surgical JET.
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Sylva M, Sassen SD, In 't Veld YL, de Jonge RC, Bartelds B, de Hoog M, Koch BCP, and Kammeraad J
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- Humans, Ivabradine therapeutic use, Ivabradine pharmacology, Heart Rate physiology, Bradycardia, Cardiovascular Agents therapeutic use, Tachycardia, Ectopic Junctional
- Published
- 2023
- Full Text
- View/download PDF
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