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1. CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Author

Affandi, Alsya J., Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J., Brans, Maike A.D., Brandt, Maarten M., Tieland, Ralph G., Lopes, Ana P., Fernández, Beatriz Malvar, Bekker, Cornelis P.J., van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G.K., Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M. Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C.A., van Roon, Joel A.G., Radstake, Timothy R.D.J., and Marut, Wioleta

Published
2022
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2. How open science can support the 3Rs and improve animal research.

Author

Janssens, Monique, Gaillard, Stefan, de Haan, Judith J., de Leeuw, Wim, Brooke, Matthew, Burke, Maura, Flores, Jacques, Kruijen, Iris, Menon, Julia M. L., Smith, Adrian, Tiebosch, Ivo A. C. W., and Weijdema, Felix

Subjects
ANIMAL research, OPEN scholarship, ANIMAL experimentation, ANIMAL welfare, LABORATORY animals
Abstract

Open science in its broadest sense can make better science and provide benefits to researchers. When applied to animal experimentation, it can prevent unnecessary use of animals, because knowledge and experiences about past animal experimentation are shared openly to be consulted and used by other researchers. By extension, open science can accelerate the much anticipated transition towards animal-free innovations or New Approach Methodologies (NAMs). The purpose of this paper is to bring together and further share the preparations and findings of a symposium held at Utrecht University on aspects of open science that researchers doing animal experiments can and should take into account to improve their research and benefit themselves. The paper offers a onefigure guideline for that purpose. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Meaningful public engagement in the context of open science: reflections from early and mid-career academics

Author

Boon, Wouter, de Haan, Judith J., van Sebille, Erik, Gould, Lauren, Janssen, Willem, Jongsma, Karin R, Milota, Megan, Maud, Radstake, Stevens, Saskia, Strick, Madelijn, Swinkels, Marij, Wanders, Niko, Yerkes, Mara, Innovation and Sustainability, Sub Physical Oceanography, Sub Science Education, OGKG - Internationale en Politieke geschiedenis, LS Conflict studies, Economisch publiek recht, OGKG - Antieke Cultuur, LS Late Oudheid, Social-cognitive and interpersonal determinants of behaviour, Leerstoel Bos, Politiek en bestuur, UU LEG Research USG Public Matters, Landscape functioning, Geocomputation and Hydrology, Landdegradatie en aardobservatie, Social Policy and Public Health, and Leerstoel de Wit

Subjects
Rewards & recognition, Co-creation, Reciprocity, rewards and recognitionmmunication, reciprocity, General Medicine, Open science, Citizen science, Stakeholder engagement, Public engagement, Science communication
Abstract

How is public engagement perceived to contribute to open science? This commentary highlights common reflections on this question from interviews with 12 public engagement fellows in Utrecht University’s Open Science Programme in the Netherlands. We identify four reasons why public engagement is an essential enabler of open science. Interaction between academics and society can: (1) better align science with the needs of society; (2) secure a relationship of trust between science and society; (3) increase the quality and impact of science; and (4) support the impact of open access and FAIR data practices (data which meet principles of findability, accessibility, interoperability and reusability). To be successful and sustainable, such public engagement requires support in skills training and a form of institutionalisation in a university-wide system, but, most of all, the fellows express the importance of a formal and informal recognition and rewards system. Our findings suggest that in order to make public engagement an integral part of open science, universities should invest in institutional support, create awareness, and stimulate dialogue among staff members on how to ‘do’ good public engagement.

Published
2022
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5. Meaningful public engagement in the context of open science: reflections of early and mid-career academics

Author

Boon, Wouter, de Haan, Judith J., van Sebille, Erik, Gould, Lauren, Janssen, Willem, Jongsma, Karin R, Milota, Megan, Maud, Radstake, Stevens, Saskia, Strick, Madelijn, Swinkels, Marij, Wanders, Niko, Yerkes, Mara, Boon, Wouter, de Haan, Judith J., van Sebille, Erik, Gould, Lauren, Janssen, Willem, Jongsma, Karin R, Milota, Megan, Maud, Radstake, Stevens, Saskia, Strick, Madelijn, Swinkels, Marij, Wanders, Niko, and Yerkes, Mara

Abstract

How is public engagement perceived to contribute to open science? This commentary highlights common reflections on this question from interviews with 12 public engagement fellows in Utrecht University’s Open Science Programme in the Netherlands. We identify four reasons why public engagement is an essential enabler of open science. Interaction between academics and society can: (1) better align science with the needs of society; (2) secure a relationship of trust between science and society; (3) increase the quality and impact of science; and (4) support the impact of open access and FAIR data practices (data which meet principles of findability, accessibility, interoperability and reusability). To be successful and sustainable, such public engagement requires support in skills training and a form of institutionalisation in a university-wide system, but, most of all, the fellows express the importance of a formal and informal recognition and rewards system. Our findings suggest that in order to make public engagement an integral part of open science, universities should invest in institutional support, create awareness, and stimulate dialogue among staff members on how to ‘do’ good public engagement.

Published
2022

6. Meaningful public engagement in the context of open science: reflections of early and mid-career academics

Author

Innovation and Sustainability, Sub Physical Oceanography, Sub Science Education, OGKG - Internationale en Politieke geschiedenis, LS Conflict studies, Economisch publiek recht, OGKG - Antieke Cultuur, LS Late Oudheid, Social-cognitive and interpersonal determinants of behaviour, Leerstoel Bos, Politiek en bestuur, UU LEG Research USG Public Matters, Landscape functioning, Geocomputation and Hydrology, Landdegradatie en aardobservatie, Social Policy and Public Health, Leerstoel de Wit, Boon, Wouter, de Haan, Judith J., van Sebille, Erik, Gould, Lauren, Janssen, Willem, Jongsma, Karin R, Milota, Megan, Maud, Radstake, Stevens, Saskia, Strick, Madelijn, Swinkels, Marij, Wanders, Niko, Yerkes, Mara, Innovation and Sustainability, Sub Physical Oceanography, Sub Science Education, OGKG - Internationale en Politieke geschiedenis, LS Conflict studies, Economisch publiek recht, OGKG - Antieke Cultuur, LS Late Oudheid, Social-cognitive and interpersonal determinants of behaviour, Leerstoel Bos, Politiek en bestuur, UU LEG Research USG Public Matters, Landscape functioning, Geocomputation and Hydrology, Landdegradatie en aardobservatie, Social Policy and Public Health, Leerstoel de Wit, Boon, Wouter, de Haan, Judith J., van Sebille, Erik, Gould, Lauren, Janssen, Willem, Jongsma, Karin R, Milota, Megan, Maud, Radstake, Stevens, Saskia, Strick, Madelijn, Swinkels, Marij, Wanders, Niko, and Yerkes, Mara

Published
2022

7. CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, CTI Meyaard, Other research (not in main researchprogram), Experimentele Afd. Cardiologie 1, Cardiologie, Translationele immunologie, DBG Metabole en Endocriene Ziekten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 2, Affandi, Alsya J, Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J, Brans, Maike A D, Brandt, Maarten M, Tieland, Ralph G, Lopes, Ana P, Fernández, Beatriz Malvar, Bekker, Cornelis P J, van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G K, Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C A, van Roon, Joel A G, Radstake, Timothy R D J, Marut, Wioleta, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, CTI Meyaard, Other research (not in main researchprogram), Experimentele Afd. Cardiologie 1, Cardiologie, Translationele immunologie, DBG Metabole en Endocriene Ziekten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 2, Affandi, Alsya J, Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J, Brans, Maike A D, Brandt, Maarten M, Tieland, Ralph G, Lopes, Ana P, Fernández, Beatriz Malvar, Bekker, Cornelis P J, van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G K, Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C A, van Roon, Joel A G, Radstake, Timothy R D J, and Marut, Wioleta

Published
2022

9. Open Science Monitor 2020 Utrecht University: Commissioned by the Utrecht University Open Science Programme

Author

Brinkman, L., de Haan, Judith J., van Hemert, Daniël, de Laat, Joost, Rijshouwer, Dominique, Thomaes, Sander, van Veelen, Ruth, Brinkman, L., de Haan, Judith J., van Hemert, Daniël, de Laat, Joost, Rijshouwer, Dominique, Thomaes, Sander, and van Veelen, Ruth

Abstract

This is the first version of the Open Science monitor on awareness, attitudes and behaviours in relation to 10 open science practices. The monitor was conducted among academics at Utrecht University and UMC Utrecht (the Netherlands) in the summer of 2020 with the aim to gain insight in academics’ attitude and behaviours towards various open science practices, the opportunities these practices may provide for the scientific community and the barriers in implementing open science practices the researchers may experience. With this monitor the university hopes to gain insight into what can be done to facilitate and support open science among academics at Utrecht University.

Published
2021

10. A 3-year evaluation of preclinicaltrials.eu reveals room for improvement in preregistration of animal studies

Author

van der Naald, Mira, Chamuleau, Steven A J, Menon, Julia M L, de Leeuw, Wim, de Haan, Judith J, Duncker, Dirk J, Wever, Kimberley E, van der Naald, Mira, Chamuleau, Steven A J, Menon, Julia M L, de Leeuw, Wim, de Haan, Judith J, Duncker, Dirk J, and Wever, Kimberley E

Abstract

In 2018, the first registry dedicated to preregistration of animal study protocols was launched. Despite international support, the overall number of (pre)registered protocols is still low, illustrating the need for pushing the preregistration agenda among researchers and policymakers.

Published
2021

11. Open Science Monitor 2020 Utrecht University: Commissioned by the Utrecht University Open Science Programme

Author

Leerstoel Derks, Work and Organizational Psychology: Occupational Health Psychology, Global Economic challenges, UU LEG Research UUSE Multidisciplinary Economics, Leerstoel Thomaes, Social and personality development: A transactional approach, Brinkman, L., de Haan, Judith J., van Hemert, Daniël, de Laat, Joost, Rijshouwer, Dominique, Thomaes, Sander, van Veelen, Ruth, Leerstoel Derks, Work and Organizational Psychology: Occupational Health Psychology, Global Economic challenges, UU LEG Research UUSE Multidisciplinary Economics, Leerstoel Thomaes, Social and personality development: A transactional approach, Brinkman, L., de Haan, Judith J., van Hemert, Daniël, de Laat, Joost, Rijshouwer, Dominique, Thomaes, Sander, and van Veelen, Ruth

Published
2021

12. The transverse aortic constriction heart failure animal model:a systematic review and meta-analysis

Author

Bosch, Lena, de Haan, Judith J., Bastemeijer, Marissa, van der Burg, Jennifer, van der Worp, Erik, Wesseling, Marian, Viola, Margarida, Odille, Clémene, el Azzouzi, Hamid, Pasterkamp, Gerard, Sluijter, Joost P.G., Wever, Kimberley E., de Jager, Saskia C.A., Bosch, Lena, de Haan, Judith J., Bastemeijer, Marissa, van der Burg, Jennifer, van der Worp, Erik, Wesseling, Marian, Viola, Margarida, Odille, Clémene, el Azzouzi, Hamid, Pasterkamp, Gerard, Sluijter, Joost P.G., Wever, Kimberley E., and de Jager, Saskia C.A.

Abstract

The transverse aortic constriction (TAC) model is frequently used to study adverse cardiac remodeling upon pressure overload. We set out to define the most important characteristics that define the degree of cardiac remodeling in this model. A systematic review and meta-analyses were performed on studies using the TAC mouse/rat model and reporting echocardiographic outcome parameters. We included all animal studies in which a constriction around the transverse aorta and at least one of the predefined echocardiography or MRI outcome parameters were assessed. A total of 502 articles and > 3000 wild-type, untreated animals undergoing TAC were included in this study and referenced to a control group. The duration of aortic constriction correlated to the degree of adverse remodeling. However, the mouse data is strongly biased by the preferential use of male C57Bl/6 mice (66% of studies). Furthermore, mostly ketamine/xylazine anesthetics, 27G needle constriction, and silk sutures are used. Nonetheless, despite the homogeneity in experimental design, the model contained a substantial degree of heterogeneity in the functional outcome measures. When looking at study quality, only 12% reported randomization, 23% mentioned any sort of blinding, 25% adequately addressed the outcomes, and an amazingly low percentage (2%) showed sample size calculation. Meta-analyses did not detect specific study characteristics that explained the heterogeneity in the reported outcome measures, however this might be related to the strong bias towards the use of specific mouse lines, sex as well as age or to poor reporting of characteristics of study quality.

Published
2021

13. The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis

Author

Experimentele Afd. Cardiologie 1, Neurologen, Brain, Circulatory Health, CDL Onderzoek Pasterkamp, Cardiologie Arts-onderzoekers, dLAB Afdelingen, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 2, Bosch, Lena, de Haan, Judith J., Bastemeijer, Marissa, van der Burg, Jennifer, van der Worp, Erik, Wesseling, Marian, Viola, Margarida, Odille, Clémene, el Azzouzi, Hamid, Pasterkamp, Gerard, Sluijter, Joost P.G., Wever, Kimberley E., de Jager, Saskia C.A., Experimentele Afd. Cardiologie 1, Neurologen, Brain, Circulatory Health, CDL Onderzoek Pasterkamp, Cardiologie Arts-onderzoekers, dLAB Afdelingen, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 2, Bosch, Lena, de Haan, Judith J., Bastemeijer, Marissa, van der Burg, Jennifer, van der Worp, Erik, Wesseling, Marian, Viola, Margarida, Odille, Clémene, el Azzouzi, Hamid, Pasterkamp, Gerard, Sluijter, Joost P.G., Wever, Kimberley E., and de Jager, Saskia C.A.

Published
2021

14. Corrigendum to: Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure (vol 279, pg 141, 2019)

Author

Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, and de Jager, Saskia C.A.

Subjects
Published Erratum, Cardiology and Cardiovascular Medicine
Abstract

The authors regret that after the publication of the above paper, the authors noted that the initials of the authors listed on the paper were not included on the paper. Specifically, Judith de Haan should have been be listed as Judith J. de Haan, Tom Seijkens should have been listed as Tom T.P. Seijkens, Claudia van Tiel should have been listed as Claudia M. van Tiel, Maike Brans should have been listed as Maike A.D. Brans, and Saskia de Jager should be listed as Saskia C.A. de Jager. The authors would like to apologise for any inconvenience caused.

Published
2019

15. The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases

Author

Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, de Jager, Saskia C.A., Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, and de Jager, Saskia C.A.

Published
2020

16. The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases

Author

Experimentele Afd. Cardiologie 1, Cardiologie, LKCH Klinische Chemie & Endocrinologie, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Circulatory Health, Experimentele Afd. Cardiologie 2, Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, de Jager, Saskia C.A., Experimentele Afd. Cardiologie 1, Cardiologie, LKCH Klinische Chemie & Endocrinologie, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Circulatory Health, Experimentele Afd. Cardiologie 2, Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, and de Jager, Saskia C.A.

Published
2020

17. Corrigendum to: Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure (vol 279, pg 141, 2019)

Author

Experimentele Afd. Cardiologie 1, Cardiologie, CDL KAM KC, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Circulatory Health, Experimentele Afd. Cardiologie 2, Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, de Jager, Saskia C.A., Experimentele Afd. Cardiologie 1, Cardiologie, CDL KAM KC, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Circulatory Health, Experimentele Afd. Cardiologie 2, Bosch, Lena, de Haan, Judith J., Seijkens, Tom T.P., van Tiel, Claudia M., Brans, Maike A.D., Pasterkamp, Gerard, Lutgens, Esther, and de Jager, Saskia C.A.

Published
2019

18. Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice

Author

Ellenbroek, Guilielmus H. J. M., primary, de Haan, Judith J., additional, van Klarenbosch, Bas R., additional, Brans, Maike A. D., additional, van de Weg, Sander M., additional, Smeets, Mirjam B., additional, de Jong, Sanne, additional, Arslan, Fatih, additional, Timmers, Leo, additional, Goumans, Marie-José T. H., additional, Hoefer, Imo E., additional, Doevendans, Pieter A., additional, Pasterkamp, Gerard, additional, Meyaard, Linde, additional, and de Jager, Saskia C. A., additional

Published
2017
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21. Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload

Author

Wang, Jiong-Wei, primary, Fontes, Magda S. C., additional, Wang, Xiaoyuan, additional, Chong, Suet Yen, additional, Kessler, Elise L., additional, Zhang, Ya-Nan, additional, de Haan, Judith J., additional, Arslan, Fatih, additional, de Jager, Saskia C. A., additional, Timmers, Leo, additional, van Veen, Toon A. B., additional, Lam, Carolyn S. P., additional, and Kleijn, Dominique P. V. de, additional

Published
2017
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22. Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice

Author

De Haan, Judith J., Bosch, Lena, Borgman, Anouska, Bastemeijer, Marissa, Brans, Maike A.D., Van De Weg, Sander M., De Kleijn, Dominique P.V., Sluijter, Joost P.G., El Azzouzi, Hamid, De Jager, Saskia C.A., De Haan, Judith J., Bosch, Lena, Borgman, Anouska, Bastemeijer, Marissa, Brans, Maike A.D., Van De Weg, Sander M., De Kleijn, Dominique P.V., Sluijter, Joost P.G., El Azzouzi, Hamid, and De Jager, Saskia C.A.

Published
2017

23. Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice

Author

Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Klarenbosch, Bas R., Brans, Maike A.D., Van De Weg, Sander M., Smeets, Mirjam B., De Jong, Sanne, Arslan, Fatih, Timmers, Leo, Goumans, Marie José T.H., Hoefer, Imo E., Doevendans, Pieter A., Pasterkamp, Gerard, Meyaard, Linde, De Jager, Saskia C.A., Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Klarenbosch, Bas R., Brans, Maike A.D., Van De Weg, Sander M., Smeets, Mirjam B., De Jong, Sanne, Arslan, Fatih, Timmers, Leo, Goumans, Marie José T.H., Hoefer, Imo E., Doevendans, Pieter A., Pasterkamp, Gerard, Meyaard, Linde, and De Jager, Saskia C.A.

Published
2017

24. Growth differentiation factor 15 is associated with major amputation and mortality in patients with peripheral artery disease

Author

De Haan, Judith J., Haitjema, Saskia, den Ruijter, Hester M., Pasterkamp, Gerard, de Borst, Gert J., Teraa, Martin, Verhaar, Marianne C., Gremmels, Hendrik, de Jager, Saskia C.A., De Haan, Judith J., Haitjema, Saskia, den Ruijter, Hester M., Pasterkamp, Gerard, de Borst, Gert J., Teraa, Martin, Verhaar, Marianne C., Gremmels, Hendrik, and de Jager, Saskia C.A.

Published
2017

25. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Author

Van Hout, Gerardus P.J., Bosch, Lena, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Solinge, Wouter W., Cooper, Matthew A, Arslan, Fatih, De Jager, Saskia C.A., Robertson, Avril A B, Pasterkamp, Gerard, Hoefer, Imo E., Van Hout, Gerardus P.J., Bosch, Lena, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Solinge, Wouter W., Cooper, Matthew A, Arslan, Fatih, De Jager, Saskia C.A., Robertson, Avril A B, Pasterkamp, Gerard, and Hoefer, Imo E.

Published
2017

26. Leukocytic toll-like receptor 2 deficiency preserves cardiac function and reduces fibrosis in sustained pressure overload

Author

Wang, Jiong-Wei, Fontes, Magda S.C., Wang, Xiaoyuan, Chong, Suet Yen, Kessler, Elise L., Zhang, Ya-Nan, De Haan, Judith J., Arslan, Fatih, De Jager, Saskia C.A., Timmers, Leo, Van Veen, Toon A.B., Lam, Carolyn S P, de Kleijn, Dominique P V, Wang, Jiong-Wei, Fontes, Magda S.C., Wang, Xiaoyuan, Chong, Suet Yen, Kessler, Elise L., Zhang, Ya-Nan, De Haan, Judith J., Arslan, Fatih, De Jager, Saskia C.A., Timmers, Leo, Van Veen, Toon A.B., Lam, Carolyn S P, and de Kleijn, Dominique P V

Published
2017

27. Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, Cardiologie, Verpleegafd Vaatchirurgie D4 Oost, Planningssecretariaat HCK, Infection & Immunity, UMC Utrecht, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 2, De Haan, Judith J., Bosch, Lena, Borgman, Anouska, Bastemeijer, Marissa, Brans, Maike A.D., Van De Weg, Sander M., De Kleijn, Dominique P.V., Sluijter, Joost P.G., El Azzouzi, Hamid, De Jager, Saskia C.A., Experimentele Afd. Cardiologie 1, Circulatory Health, Cardiologie, Verpleegafd Vaatchirurgie D4 Oost, Planningssecretariaat HCK, Infection & Immunity, UMC Utrecht, Onderzoek Cardiovasculair Reg. Med., Regenerative Medicine and Stem Cells, Experimentele Afd. Cardiologie 2, De Haan, Judith J., Bosch, Lena, Borgman, Anouska, Bastemeijer, Marissa, Brans, Maike A.D., Van De Weg, Sander M., De Kleijn, Dominique P.V., Sluijter, Joost P.G., El Azzouzi, Hamid, and De Jager, Saskia C.A.

Published
2017

28. Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice

Author

Circulatory Health, Experimentele Afd. Cardiologie 1, Cardiologie, Experimentele Afd. Cardiologie 2, Medische Fysiologie, BMS Algemeen, Planningssecretariaat HCK, Team Medisch, CDL KAM KC, CDL Arcadia, Regenerative Medicine and Stem Cells, CDL Cluster Onderzoek en Onderwijs, CTI Meyaard, Infection & Immunity, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Klarenbosch, Bas R., Brans, Maike A.D., Van De Weg, Sander M., Smeets, Mirjam B., De Jong, Sanne, Arslan, Fatih, Timmers, Leo, Goumans, Marie José T.H., Hoefer, Imo E., Doevendans, Pieter A., Pasterkamp, Gerard, Meyaard, Linde, De Jager, Saskia C.A., Circulatory Health, Experimentele Afd. Cardiologie 1, Cardiologie, Experimentele Afd. Cardiologie 2, Medische Fysiologie, BMS Algemeen, Planningssecretariaat HCK, Team Medisch, CDL KAM KC, CDL Arcadia, Regenerative Medicine and Stem Cells, CDL Cluster Onderzoek en Onderwijs, CTI Meyaard, Infection & Immunity, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Klarenbosch, Bas R., Brans, Maike A.D., Van De Weg, Sander M., Smeets, Mirjam B., De Jong, Sanne, Arslan, Fatih, Timmers, Leo, Goumans, Marie José T.H., Hoefer, Imo E., Doevendans, Pieter A., Pasterkamp, Gerard, Meyaard, Linde, and De Jager, Saskia C.A.

Published
2017

29. Growth differentiation factor 15 is associated with major amputation and mortality in patients with peripheral artery disease

Author

UMC Utrecht, Experimentele Afd. Cardiologie 1, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, Zorgeenheid Vaatchirurgie Medisch, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, MS Nefrologie, Experimentele Afd. Cardiologie 2, De Haan, Judith J., Haitjema, Saskia, den Ruijter, Hester M., Pasterkamp, Gerard, de Borst, Gert J., Teraa, Martin, Verhaar, Marianne C., Gremmels, Hendrik, de Jager, Saskia C.A., UMC Utrecht, Experimentele Afd. Cardiologie 1, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, Zorgeenheid Vaatchirurgie Medisch, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, MS Nefrologie, Experimentele Afd. Cardiologie 2, De Haan, Judith J., Haitjema, Saskia, den Ruijter, Hester M., Pasterkamp, Gerard, de Borst, Gert J., Teraa, Martin, Verhaar, Marianne C., Gremmels, Hendrik, and de Jager, Saskia C.A.

Published
2017

30. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, Cardiovasculaire Immunologie, Centraal Diagnostisch Laboratorium, Infection & Immunity, Aios en Stafsecr. Cardiologie, Arts Assistenten Cardiologie, Experimentele Afd. Cardiologie 2, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, Van Hout, Gerardus P.J., Bosch, Lena, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Solinge, Wouter W., Cooper, Matthew A, Arslan, Fatih, De Jager, Saskia C.A., Robertson, Avril A B, Pasterkamp, Gerard, Hoefer, Imo E., Experimentele Afd. Cardiologie 1, Circulatory Health, Cardiovasculaire Immunologie, Centraal Diagnostisch Laboratorium, Infection & Immunity, Aios en Stafsecr. Cardiologie, Arts Assistenten Cardiologie, Experimentele Afd. Cardiologie 2, Onderzoek Vrouw Hart & Vaatziekten, CDL Staf Research, Van Hout, Gerardus P.J., Bosch, Lena, Ellenbroek, Guilielmus H.J.M., De Haan, Judith J., Van Solinge, Wouter W., Cooper, Matthew A, Arslan, Fatih, De Jager, Saskia C.A., Robertson, Avril A B, Pasterkamp, Gerard, and Hoefer, Imo E.

Published
2017

31. Leukocytic toll-like receptor 2 deficiency preserves cardiac function and reduces fibrosis in sustained pressure overload

Author

Medische Fysiologie, Circulatory Health, Conductiegroep, Onderzoek Vrouw Hart & Vaatziekten, Experimentele Afd. Cardiologie 2, Team Medisch, Infection & Immunity, Zorgeenheid Vaatchirurgie Medisch, Wang, Jiong-Wei, Fontes, Magda S.C., Wang, Xiaoyuan, Chong, Suet Yen, Kessler, Elise L., Zhang, Ya-Nan, De Haan, Judith J., Arslan, Fatih, De Jager, Saskia C.A., Timmers, Leo, Van Veen, Toon A.B., Lam, Carolyn S P, de Kleijn, Dominique P V, Medische Fysiologie, Circulatory Health, Conductiegroep, Onderzoek Vrouw Hart & Vaatziekten, Experimentele Afd. Cardiologie 2, Team Medisch, Infection & Immunity, Zorgeenheid Vaatchirurgie Medisch, Wang, Jiong-Wei, Fontes, Magda S.C., Wang, Xiaoyuan, Chong, Suet Yen, Kessler, Elise L., Zhang, Ya-Nan, De Haan, Judith J., Arslan, Fatih, De Jager, Saskia C.A., Timmers, Leo, Van Veen, Toon A.B., Lam, Carolyn S P, and de Kleijn, Dominique P V

Published
2017

32. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Author

van Hout, Gerardus P.J., primary, Bosch, Lena, additional, Ellenbroek, Guilielmus H.J.M., additional, de Haan, Judith J., additional, van Solinge, Wouter W., additional, Cooper, Matthew A., additional, Arslan, Fatih, additional, de Jager, Saskia C.A., additional, Robertson, Avril A.B., additional, Pasterkamp, Gerard, additional, and Hoefer, Imo E., additional

Published
2016
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34. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction.

Author

van Hout, Gerardus P. J., Bosch, Lena, Ellenbroek, Guilielmus H. J. M., de Haan, Judith J., van Solinge, Wouter W., Cooper, Matthew A., Arslan, Fatih, de Jager, Saskia C. A., Robertson, Avril A. B., Pasterkamp, Gerard, and Hoefer, Imo E.

Abstract

Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 are key players in this response and are controlled by the NLRP3-inflammasome. In the current study, we therefore hypothesized that selective inhibition of the NLRP3-inflammasome reduces infarct size and preserves cardiac function in a porcine MI model. Methods and results Thirty female landrace pigs were subjected to 75 min transluminal balloon occlusion and treated with the NLRP3-inflammasome inhibitor MCC950 (6 or 3 mg/kg) or placebo for 7 days in a randomized, blinded fashion. After 7 days, 3D-echocardiography was performed to assess cardiac function and Evans blue/TTC double staining was executed to assess the area at risk (AAR) and infarct size (IS). The IS/AAR was lower in the 6 mg/kg group (64.6 ± 8.8%, P = 0.004) and 3 mg/kg group (69.7 ± 7.2%, P = 0.038) compared with the control group (77.5 ± 6.3%). MCC950 treatment markedly preserved left ventricular ejection fraction in treated animals (6 mg/kg 47 ± 8%, P = 0.001; 3 mg/kg 45 ± 7%, P = 0.031; control 37 ± 6%). Myocardial neutrophil influx was attenuated in treated compared with non-treated animals (6 mg/kg 132 ± 72 neutrophils/mm², P = 0.035; 3 mg/kg 207 ± 210 neutrophils/mm², P = 0.5; control 266 ± 158 neutrophils/mm²). Myocardial IL-1β levels were dose-dependently reduced in treated animals. Conclusions NLRP3-inflammasome inhibition reduces infarct size and preserves cardiac function in a randomized, blinded translational large animal MI model. Hence, NLRP3-inflammasome inhibition may have therapeutic potential in acute MI patients. [ABSTRACT FROM AUTHOR]

Published
2017
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