7 results on '"de Abreu, André Luiz"'
Search Results
2. Genomic surveillance of Yellow fever virus epizootic in São Paulo, Brazil, 2016-2018
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Hill, Sarah Catherine, de Souza, Renato, Thézé, Julien, Claro, Ingra Morales, Aguiar, Renato Santana, Abade, Leandro, Santos, Fabiana Cristina Pereira Dos F.C.P., Cunha, Mariana Sequetin, Nogueira, Juliana Silva, Salles, Flavia F.C.S., Rocco, Iray Maria, Maeda, Adriana Yurika, Vasami, Fernanda Gisele Silva, du Plessis, Louis, Silveira, Paola Paz, de Jesus, Jaqueline Goes, Quick, Joshua, Fernandes, Natália N.C.C.A., Guerra, Juliana Mariotti, Réssio, Rodrigo Albergaria, Giovanetti, Marta, Alcantara, Luiz Carlos L.C.J., Cirqueira, Cinthya Dos Santos C.S., Díaz-Delgado, Josué, Macedo, Fernando Luiz Lima, Timenetsky, Maria Do Carmo Sampaio Tavares Timenetsky M.d.C.S.T., de Paula, Regiane, Spinola, Roberta, Telles de Deus, Juliana, Mucci, Luís Filipe, Tubaki, Rosa Maria, de Menezes, Regiane María Tironi, Ramos, Patrícia Locosque, de Abreu, André Luiz, Cruz, Laura Nogueira, Loman, Nick, Dellicour, Simon, Pybus, Oliver George, Sabino, Ester Cerdeira, Faria, Nuno Rodrigues, Hill, Sarah Catherine, de Souza, Renato, Thézé, Julien, Claro, Ingra Morales, Aguiar, Renato Santana, Abade, Leandro, Santos, Fabiana Cristina Pereira Dos F.C.P., Cunha, Mariana Sequetin, Nogueira, Juliana Silva, Salles, Flavia F.C.S., Rocco, Iray Maria, Maeda, Adriana Yurika, Vasami, Fernanda Gisele Silva, du Plessis, Louis, Silveira, Paola Paz, de Jesus, Jaqueline Goes, Quick, Joshua, Fernandes, Natália N.C.C.A., Guerra, Juliana Mariotti, Réssio, Rodrigo Albergaria, Giovanetti, Marta, Alcantara, Luiz Carlos L.C.J., Cirqueira, Cinthya Dos Santos C.S., Díaz-Delgado, Josué, Macedo, Fernando Luiz Lima, Timenetsky, Maria Do Carmo Sampaio Tavares Timenetsky M.d.C.S.T., de Paula, Regiane, Spinola, Roberta, Telles de Deus, Juliana, Mucci, Luís Filipe, Tubaki, Rosa Maria, de Menezes, Regiane María Tironi, Ramos, Patrícia Locosque, de Abreu, André Luiz, Cruz, Laura Nogueira, Loman, Nick, Dellicour, Simon, Pybus, Oliver George, Sabino, Ester Cerdeira, and Faria, Nuno Rodrigues
- Abstract
São Paulo, a densely inhabited state in southeast Brazil that contains the fourth most populated city in the world, recently experienced its largest yellow fever virus (YFV) outbreak in decades. YFV does not normally circulate extensively in São Paulo, so most people were unvaccinated when the outbreak began. Surveillance in non-human primates (NHPs) is important for determining the magnitude and geographic extent of an epizootic, thereby helping to evaluate the risk of YFV spillover to humans. Data from infected NHPs can give more accurate insights into YFV spread than when using data from human cases alone. To contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in São Paulo, we generated and analysed virus genomic data and epizootic case data from NHPs in São Paulo. We report the occurrence of three spatiotemporally distinct phases of the outbreak in São Paulo prior to February 2018. We generated 51 new virus genomes from YFV positive cases identified in 23 different municipalities in São Paulo, mostly sampled from NHPs between October 2016 and January 2018. Although we observe substantial heterogeneity in lineage dispersal velocities between phylogenetic branches, continuous phylogeographic analyses of generated YFV genomes suggest that YFV lineages spread in São Paulo at a mean rate of approximately 1km per day during all phases of the outbreak. Viral lineages from the first epizootic phase in northern São Paulo subsequently dispersed towards the south of the state to cause the second and third epizootic phases there. This alters our understanding of how YFV was introduced into the densely populated south of São Paulo state. Our results shed light on the sylvatic transmission of YFV in highly fragmented forested regions in São Paulo state and highlight the importance of continued surveillance of zoonotic pathogens in sentinel species., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2020
3. Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil
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Goes de Jesus, Jaqueline, primary, Gräf, Tiago, additional, Giovanetti, Marta, additional, Mares-Guia, Maria Angélica, additional, Xavier, Joilson, additional, Lima Maia, Maricelia, additional, Fonseca, Vagner, additional, Fabri, Allison, additional, dos Santos, Roberto Fonseca, additional, Mota Pereira, Felicidade, additional, Ferraz Oliveira Santos, Leandro, additional, Reboredo de Oliveira da Silva, Luciana, additional, Pereira Gusmão Maia, Zuinara, additional, Gomes Cerqueira, Jananci Xavier, additional, Thèze, Julien, additional, Abade, Leandro, additional, Cordeiro, Mirza de Carvalho Santana, additional, Torquato, Sintia Sacramento Cerqueira, additional, Santana, Eloisa Bahia, additional, de Jesus Silva, Neuza Santos, additional, Dourado, Rosemary Sarmento Oitiçica, additional, Alves, Ademilson Brás, additional, do Socorro Guedes, Adeilde, additional, da Silva Filho, Pedro Macedo, additional, Rodrigues Faria, Nuno, additional, de Albuquerque, Carlos F. Campelo, additional, de Abreu, André Luiz, additional, Martins Romano, Alessandro Pecego, additional, Croda, Julio, additional, do Carmo Said, Rodrigo Fabiano, additional, Cunha, Gabriel Muricy, additional, da Fonseca Cerqueira, Jeane Magnavita, additional, Mello, Arabela Leal e Silva de, additional, de Filippis, Ana Maria Bispo, additional, and Alcantara, Luiz Carlos Junior, additional
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- 2020
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4. The ongoing COVID-19 epidemic in Minas Gerais, Brazil: insights from epidemiological data and SARS-CoV-2 whole genome sequencing
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Xavier, Joilson, primary, Giovanetti, Marta, additional, Adelino, Talita, additional, Fonseca, Vagner, additional, Barbosa da Costa, Alana Vitor, additional, Ribeiro, Adriana Aparecida, additional, Felicio, Katlin Nascimento, additional, Duarte, Clara Guerra, additional, Ferreira Silva, Marcos Vinicius, additional, Salgado, Álvaro, additional, Lima, Mauricio Teixeira, additional, de Jesus, Ronaldo, additional, Fabri, Allison, additional, Soares Zoboli, Cristiane Franco, additional, Souza Santos, Thales Gutemberg, additional, Iani, Felipe, additional, Ciccozzi, Massimo, additional, Bispo de Filippis, Ana Maria, additional, Teixeira de Siqueira, Marilda Agudo Mendonça, additional, de Abreu, André Luiz, additional, de Azevedo, Vasco, additional, Ramalho, Dario Brock, additional, Campelo de Albuquerque, Carlos F., additional, de Oliveira, Tulio, additional, Holmes, Edward C., additional, Lourenço, José, additional, Junior Alcantara, Luiz Carlos, additional, and Assunção Oliveira, Marluce Aparecida, additional
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- 2020
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5. Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil.
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Adelino, Talita Émile Ribeiro, Giovanetti, Marta, Fonseca, Vagner, Xavier, Joilson, de Abreu, Álvaro Salgado, do Nascimento, Valdinete Alves, Demarchi, Luiz Henrique Ferraz, Oliveira, Marluce Aparecida Assunção, da Silva, Vinícius Lemes, de Mello, Arabela Leal e. Silva, Cunha, Gabriel Muricy, Santos, Roselene Hans, de Oliveira, Elaine Cristina, Júnior, Jorge Antônio Chamon, de Melo Iani, Felipe Campos, de Filippis, Ana Maria Bispo, de Abreu, André Luiz, de Jesus, Ronaldo, de Albuquerque, Carlos Frederico Campelo, and Rico, Jairo Mendez
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DENGUE viruses ,ZIKA Virus Epidemic, 2015-2016 ,MEDICAL personnel ,PHYLOGENETIC models ,EPIDEMIOLOGICAL models ,GRADUATE students ,ARBOVIRUSES - Abstract
Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015–2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases. Using both phylogenetic and epidemiological models we retrospectively reconstructed the recent transmission history of DENV1-2. Phylogenetic analysis revealed complex patterns of transmission, with both lineage co-circulation and replacement. We identified two lineages within the DENV2 BR-4 clade, for which we estimated the effective reproduction number and pattern of seasonality. Overall, the surveillance outputs and training initiative described here serve as a proof-of-concept for the utility of real-time portable sequencing for research and local capacity building in the genomic surveillance of emerging viruses. Here, the authors present results of the ZiBRA-2 project (https://www.zibra2project.org) which is an arbovirus surveillance project, across the Midwest of Brazil using a mobile genomics laboratory, combined with a genomic surveillance training program that targeted post-graduate students, laboratory technicians, and health practitioners in universities and laboratories. [ABSTRACT FROM AUTHOR]
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- 2021
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6. An initiative of cooperation in Zika virus research: the experience of the ZIKABRA study in Brazil.
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Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Kara, Edna Oliveira, Calvet, Guilherme Amaral, de Filippis, Ana Maria Bispo, Lacerda, Marcus Vinícius Guimarães, Bôtto-Menezes, Camila Helena Aguiar, da Costa Castilho, Marcia, Franca, Rafael Freitas Oliveira, Neto, Armando Menezes, Storme, Casey, Lima, Noemia S., Modjarrad, Kayvon, de Oliveira, Maria Cristina Pimenta, Pereira, Gerson Fernando Mendes, Broutet, Nathalie, on behalf of ZIKABRA Study Team, de Abreu, André Luiz, Brasil, Patrícia, and Brito, Carlos Alexandre Antunes
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ZIKA virus ,PUBLIC health ,INTERNATIONAL cooperation on public health ,VIRUS disease transmission ,EMERGENCY management ,INTERNATIONAL agencies - Abstract
Background: The Zika virus outbreak has triggered a set of local and global actions for a rapid, effective, and timely public health response. A World Health Organization (WHO) initiative, supported by the Department of Chronic Condition Diseases and Sexually Transmitted Infections (DCCI) of the Health Surveillance Secretariat (SVS), Brazil Ministry of Health (MoH) and other public health funders, resulted in the start of the "Study on the persistence of Zika virus in body fluids of patients with ZIKV infection in Brazil - ZIKABRA study". The ZIKABRA study was designed to increase understanding of how long ZIKV persists in bodily fluids and informing best measures to prevent its transmission. Data collection began in July 2017 and the last follow up visit occurred in 06/26/2020.Methods: A framework for the ZIKABRA Cooperation initiative is provided through a description and analysis of the mechanisms, strategies and the ethos that have guided the models of international governance and technical cooperation in health for scientific exchange in the context of a public health emergency. Among the methodological strategies, we included a review of the legal documents that supported the ZIKABRA Cooperation; weekly documents produced in the meetings and working sessions; technical reports; memorandum of understanding and the research protocol.Conclusion: We highlight the importance of working in cooperation between different institutional actors to achieve more significant results than that obtained by each group working in isolation. In addition, we point out the advantages of training activities, ongoing supervision, the construction of local installed research capacity, training academic and non-academic human resources, improvement of laboratory equipment, knowledge transfer and the availability of the ZIKABRA study protocol for development of similar studies, favoring the collective construction of knowledge to provide public health emergency responses. Strategy harmonization; human resources and health services; timing and recruiting particularities and processing institutional clearance in the different sites can be mentioned as challenges in this type of initiative. [ABSTRACT FROM AUTHOR]- Published
- 2021
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7. The Experience of Implementing a National Antimicrobial Resistance Surveillance System in Brazil.
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Pillonetto M, Jordão RTS, Andraus GS, Bergamo R, Rocha FB, Onishi MC, de Almeida BMM, Nogueira KDS, Dal Lin A, Dias VMCH, and de Abreu AL
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- Brazil epidemiology, Drug Resistance, Bacterial, Female, Humans, Male, Pilot Projects, Anti-Bacterial Agents pharmacology, Anti-Infective Agents
- Abstract
Antimicrobial resistance (AMR) is a major public health threat of global proportions, which has the potential to lead to approximately ten million deaths per year by 2050. Pressured by this wicked problem, in 2014, the World Health Organization launched a call for member states to share AMR data through the implementation of the Global Antimicrobial Resistance Surveillance System (GLASS), to appropriately scale and monitor the general situation world-widely. In 2017, Brazil joined GLASS and, in 2018, started its own national antimicrobial surveillance program (BR-GLASS) to understand the impact of resistance in the country. We compiled data obtained from the complete routine of three hospitals' microbiology labs during the year of 2018. This pilot data sums up to 200,874 antimicrobial susceptibility test results from 11,347 isolates. It represents 119 different microorganisms recovered from 44 distinct types of clinical samples. Specimens came from patients originating from 301 Brazilian cities, with 4,950 of these isolates from presumed Healthcare-Associated Infections (HAIs) and the other 6,397 community-acquired cases. The female population offered 58% of the collected samples, while the other 42% were of male origin. The urinary tract was the most common topography (6,372/11,347 isolates), followed by blood samples (2,072/11,347). Gram-negative predominated the bacterial isolates: Escherichia coli was the most prevalent in general, representing 4,030 isolates (89.0% of these from the urinary tract). Coagulase-negative Staphylococci were the most prevalent bacteria in blood samples. Besides these two species, the ESKAPE group have consolidated their prevalence. Regarding drug susceptibility results, 141,648 (70.5%) were susceptible, 9,950 (4.9%) intermediate, and 49,276 (24.5%) resistant. Acinetobacter baumannii was the most worrisome microorganism, with 65.3% of the overall antimicrobial susceptibility tests showing resistance, followed by ESBL-producing Klebsiella pneumoniae , with a global resistance rate of 59%. Although this is a pilot project (still limited to one state), this database shows the importance of a nation-wide surveillance program,[153mm][-12mm] Q14 especially considering it already had patients coming from 301 distinct counties and 18 different states. The BR-GLASS Program is an ongoing project that intends to encompass at least 95 hospitals distributed in all five geographical regions in Brazil within the next 5 years., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Pillonetto, Jordão, Andraus, Bergamo, Rocha, Onishi, Almeida, Nogueira, Dal Lin, Dias and Abreu.)
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- 2021
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