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778 results on '"da Silva, T."'

2. Assessing the ultracentral flow puzzle in hydrodynamic modeling of heavy-ion collisions

Author

Giannini, A. V., Ferreira, M. N., Hippert, M., Chinellato, D. D., Denicol, G. S., Luzum, M., Noronha, J., da Silva, T. Nunes, and Takahashi, J.

Subjects
Nuclear Theory, High Energy Physics - Phenomenology
Abstract

An outstanding problem in heavy-ion collisions is the inability for models to accurately describe ultra-central experimental flow data, despite that being precisely the regime where a hydrodynamic description should be most applicable. We reassess the status of this puzzle by computing the flow in ultra-central collisions obtained from multiple recent Bayesian models that were tuned to various observables in different collision systems at typical centralities. While central data can now be described with better accuracy than in previous calculations, tension with experimental observation remains and worsens as one goes to ultra-central collisions. Tuning the model parameters cannot remove this tension without destroying the fit at other centralities. As such, new elements are likely needed in the standard modeling of heavy-ion collisions., Comment: v2: 8 pages, 4 figures. Added new fig. 1; extended discussions in the "results" and "conclusions" sections. Conclusion unchanged. Matches version accepted by PRC

Published
2022
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3. Thiophene-Furan oligomers: Beyond-DFT Study of Electronic and Optical Properties

Author

Alves-Bastos, V., da Silva, T. J., and Caldas, M. J.

Subjects
Condensed Matter - Materials Science
Abstract

Thiophene oligomers are an important class of organic materials for photovoltaic applications, owing to their unique optoelectronic properties. Recently it was suggested that incorporation of furan units to the thiophene chains, maintaining the chain structure, namely thienylfuran linear oligomers, can bring improvements to the final material. In this work, we present a theoretical study of thiophene, furan and thienylfuran short chains, up to 4 units. Structural and electronic properties were obtained using Hartree-Fock (HF) and Density Functional Theory (DFT) calculations plus beyond mean-field methodologies, specifically Second-order M\"oller-Plesset perturbation theory on HF (HF-MP2) and many-body perturbation theory by the G0W0 approximation on DFT (G0W0@DFT). The optical properties were calculated on top of G0W0@DFT data using the Bethe-Salpeter Equation. We investigate properties from the monomers T and F to tetramers with different sequencing of units TT, TF or FF, always bonded through the usual carbon atoms. As well known for the uniform oligothiophene chains, also here for any TT sequencing we find a torsion angle of $150^{\circ}$, while all other sequencing of units result planar, which can be relevant for film producing. Also we find that the first optical transitions for the oligomers reach a promising threshold of $\sim 3$ eV at the tetramer length, combined with ionization potentials around $\sim 7$ eV, which confirms the relevance of these organic compounds for photovoltaic applications., Comment: 11 pages, 3 figures

Published
2021

4. High-dimensional decoy-state quantum key distribution over 0.3 km of multicore telecommunication optical fibers

Author

Cañas, G., Vera, N., Cariñe, J., González, P., Cardenas, J., Connolly, P. W. R., Przysiezna, A., Gómez, E. S., Figueroa, M., Vallone, G., Villoresi, P., da Silva, T. Ferreira, Xavier, G. B., and Lima, G.

Subjects
Quantum Physics
Abstract

Multiplexing is a strategy to augment the transmission capacity of a communication system. It consists of combining multiple signals over the same data channel and it has been very successful in classical communications. However, the use of enhanced channels has only reached limited practicality in quantum communications (QC) as it requires the complex manipulation of quantum systems of higher dimensions. Considerable effort is being made towards QC using high-dimensional quantum systems encoded into the transverse momentum of single photons but, so far, no approach has been proven to be fully compatible with the existing telecommunication infrastructure. Here, we overcome such a technological challenge and demonstrate a stable and secure high-dimensional decoy-state quantum key distribution session over a 0.3 km long multicore optical fiber. The high-dimensional quantum states are defined in terms of the multiple core modes available for the photon transmission over the fiber, and the decoy-state analysis demonstrates that our technique enables a positive secret key generation rate up to 25 km of fiber propagation. Finally, we show how our results build up towards a high-dimensional quantum network composed of free-space and fiber based links, Comment: Please see the complementary work arXiv:1610.01812 (2016)

Published
2016
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5. Quantum random number generation enhanced by weak-coherent states interference

Author

da Silva, T. Ferreira, Xavier, G. B., Amaral, G. C., Temporão, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

We propose and demonstrate a technique for quantum random number generation based on the random population of the output spatial modes of a beam splitter when both inputs are simultaneously fed with indistinguishable weak coherent states. We simulate and experimentally validate the probability of generation of random bits as a function of the average photon number per input, and compare it to the traditional approach of a single weak coherent state transmitted through a beam-splitter, showing an improvement of up to 32\%. The ensuing interference phenomenon reduces the probability of coincident counts between the detectors associated with bits 0 and 1, thus increasing the probability of occurrence of a valid output. A long bit string is assessed by a standard randomness test suite with good confidence. Our proposal can be easily implemented and opens attractive performance gains without a significant trade-off., Comment: 6 pages, 3 figures

Published
2016
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6. Sub-Poisson States Heralded at a Hong-Ou-Mandel Interference Peak

Author

Amaral, G. C., Calliari, F., da Silva, T. Ferreira, Temporão, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

A peak in coincidence events has been observed in a modified Hong-Ou-Mandel interferometer fed with weak coherent states inside the region of overlapping wave-packets. The inversion of the usual interference pattern represented by the HOM dip is equally observed when the wave packets are frequency displaced. The higher rate of coincidences indicates that photons are more likely to take on different output paths of the interferometer. This effect was harnessed so a detection on one of the arms could herald the presence of a photon in the other. The second order autocorrelation function at zero time was experimentally determined by means of the Hanburry-Brown and Twiss experiment and its value below 1 confirmed the sub-Poisson photon statistics of the heralded states., Comment: 9 pages, 5 figures

Published
2016

7. High-dimensional decoy-state quantum key distribution over multicore telecommunication fibers

Author

Cañas, G, Vera, N, Cariñe, J, González, P, Cardenas, J, Connolly, PWR, Przysiezna, A, Gómez, ES, Figueroa, M, Vallone, G, Villoresi, P, da Silva, T Ferreira, Xavier, GB, and Lima, G

Subjects
quant-ph
Abstract

Multiplexing is a strategy to augment the transmission capacity of acommunication system. It consists of combining multiple signals over the samedata channel and it has been very successful in classical communications.However, the use of enhanced channels has only reached limited practicality inquantum communications (QC) as it requires the complex manipulation of quantumsystems of higher dimensions. Considerable effort is being made towards QCusing high-dimensional quantum systems encoded into the transverse momentum ofsingle photons but, so far, no approach has been proven to be fully compatiblewith the existing telecommunication infrastructure. Here, we overcome such atechnological challenge and demonstrate a stable and secure high-dimensionaldecoy-state quantum key distribution session over a 0.3 km long multicoreoptical fiber. The high-dimensional quantum states are defined in terms of themultiple core modes available for the photon transmission over the fiber, andthe decoy-state analysis demonstrates that our technique enables a positivesecret key generation rate up to 25 km of fiber propagation. Finally, we showhow our results build up towards a high-dimensional quantum network composed offree-space and fiber based links

Published
2017

8. Digital twin in high throughput chromatographic process development for monoclonal antibodies

Author

Picanço Castanheira Da Silva, T. (author), Eppink, M.H.M. (author), Ottens, M. (author), Picanço Castanheira Da Silva, T. (author), Eppink, M.H.M. (author), and Ottens, M. (author)

Abstract

The monoclonal antibody (mAb) industry is becoming increasingly digitalized. Digital twins are becoming increasingly important to test or validate processes before manufacturing. High-Throughput Process Development (HTPD) has been progressively used as a tool for process development and innovation. The combination of High-Throughput Screening with fast computational methods allows to study processes in-silico in a fast and efficient manner. This paper presents a hybrid approach for HTPD where equal importance is given to experimental, computational and decision-making stages. Equilibrium adsorption isotherms of 13 protein A and 16 Cation-Exchange resins were determined with pure mAb. The influence of other components in the clarified cell culture supernatant (harvest) has been under-investigated. This work contributes with a methodology for the study of equilibrium adsorption of mAb in harvest to different protein A resins and compares the adsorption behavior with the pure sample experiments. Column chromatography was modelled using a Lumped Kinetic Model, with an overall mass transfer coefficient parameter (kov). The screening results showed that the harvest solution had virtually no influence on the adsorption behavior of mAb to the different protein A resins tested. kov was found to have a linear correlation with the sample feed concentration, which is in line with mass transfer theory. The hybrid approach for HTPD presented highlights the roles of the computational, experimental, and decision-making stages in process development, and how it can be implemented to develop a chromatographic process. The proposed white-box digital twin helps to accelerate chromatographic process development., BT/Bioprocess Engineering, BT/Design and Engineering Education

Published
2024
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9. Continuous Chromatography of Biopharmaceuticals: Next Generation Process Development

Author

Picanço Castanheira Da Silva, T. (author) and Picanço Castanheira Da Silva, T. (author)

Abstract

The biopharmaceutical industry is moving from a batch to a continuous mode of manufacturing. This shift promises to reduce costs and manufacturing footprint while improving productivity and consistency of the product. This thesis implements miniaturized and automated high-throughput screening techniques alongside a mathematical chromatography model for the development of an integrated continuous chromatography process. The model is used for in-silico optimization of a capture and polishing step of a monoclonal antibody (mAb). The optimization focusses on chromatographic processes that would have to deal with higher titer solutions. The transition to Integrated Continuous Biomanufacturing (ICB) is welcomed by industry and regulatory agencies, which are working together to accomplish this shift. Process development plays a crucial role in defining new processes or adapting existing processes to different modes of operation. High-Throughput Process Development (HTPD) has been used in the biopharmaceutical industry to accelerate and reduce costs of process development, by using miniaturized assays and performing computer-aided studies. However, the industry experiences gaps and sees opportunities for improvement in the HTPD tools that can help the transition to ICB. These gaps, together with a state-of-the-art of HTPD for ICB are presented in Chapter 2. Experts in the field identified microfluidics and modeling to be the most promising technologies to fill in the gaps in process development for ICB. Subsequently, an overview on the state-of-the-art of automation and miniaturization for biopharmaceutical process development is given in Chapter 3. The focus is on different degrees of miniaturization and automation of the technologies for process development, for both Upstream and Downstream processing (USP and DSP, respectively). Liquid-Handling Stations (LHS) are the epitome of automation for process development, and have seen great adoption for the past decades., BT/Bioprocess Engineering

Published
2024

10. Chiral symmetry restoration in QCD with many flavours

Author

Lombardo, M. P., Miura, K., da Silva, T. J. Nunes, and Pallante, E.

Subjects
High Energy Physics - Lattice
Abstract

We discuss the phases of QCD in the parameter space spanned by the number of light flavours and the temperature with respect to the realisation of chiral and conformal symmetries. The intriguing interplay of these symmetries is best studied by means of lattice simulations, and some selected results from our recent work are presented here., Comment: 10 pages, proceedings of the 9th International Workshop on Critical Point and Onset of Deconfinement, 17-21 November, 2014, ZiF, Bielefeld, Germany

Published
2015

11. One,Two,Zero: Scales of Strong Interactions

Author

Lombardo, M. P., Miura, K., da Silva, T. J. Nunes, and Pallante, E.

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We discuss our results on QCD with a number of fundamental fermions ranging from zero to sixteen. These theories exhibit a wide array of fascinating phenomena which have been under close scrutiny, especially in recent years, first and foremost is the approach to conformality. To keep this review focused, we have chosen scale generation, or lack thereof as a guiding theme, however the discussion will be set in the general framework of the analysis of the phases and phase transitions of strong interactions at zero and nonzero temperature., Comment: 15 pages, prepared for IJMPA Special Issue 'Recent Nonperturbative Developments in QCD-like Theories'

Published
2014
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12. Quantum key distribution with untrusted detectors

Author

Gonzalez, P., Rebon, L., da Silva, T. Ferreira, Figueroa, M., Saavedra, C., Curty, M., Lima, G., Xavier, G. B., and Nogueira, W. A. T.

Subjects
Quantum Physics
Abstract

Side-channel attacks currently constitute the main challenge for quantum key distribution (QKD) to bridge theory with practice. So far two main approaches have been introduced to address this problem, (full) device-independent QKD and measurement-device-independent QKD. Here we present a third solution that might exceed the performance and practicality of the previous two in circumventing detector side-channel attacks, which arguably is the most hazardous part of QKD implementations. Our proposal has, however, one main requirement: the legitimate users of the system need to ensure that their labs do not leak any unwanted information to the outside. The security in the low-loss regime is guaranteed, while in the high-loss regime we already prove its robustness against some eavesdropping strategies., Comment: 9 pages, 4 figures. Matches published version

Published
2014
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13. On the particle spectrum and the conformal window

Author

Lombardo, M. P., Miura, K., da Silva, T. J. Nunes, and Pallante, E.

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We study the SU(3) gauge theory with twelve flavours of fermions in the fundamental representation as a prototype of non-Abelian gauge theories inside the conformal window. Guided by the pattern of underlying symmetries, chiral and conformal, we analyze the two-point functions theoretically and on the lattice, and determine the finite size scaling and the infinite volume fermion mass dependence of the would-be hadron masses. We show that the spectrum in the Coulomb phase of the system can be described in the context of a universal scaling analysis and we provide the nonperturbative determination of the fermion mass anomalous dimension gamma*=0.235(46) at the infrared fixed point. We comment on the agreement with the four-loop perturbative prediction for this quantity and we provide a unified description of all existing lattice results for the spectrum of this system, them being in the Coulomb phase or the asymptotically free phase. Our results corroborate the view that the fixed point we are studying is not associated to a physical singularity along the bare coupling line and estimates of physical observables can be attempted on either side of the fixed point. Finally, we observe the restoration of the U(1) axial symmetry in the two-point functions., Comment: 40 pages, 22 figures

Published
2014
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14. Phases of many flavors QCD : Lattice results

Author

Deuzeman, A., Lombardo, M. P., Miura, K., da Silva, T. Nunes, and Pallante, E.

Subjects
High Energy Physics - Lattice
Abstract

This note is based on our recent results on QCD with varying number of flavors of fundamental fermions. Topics include unusual, strong dynamics in the preconformal, confining phase, the physics of the conformal window and the role of ab-initio lattice simulations in establishing our current knowledge of the phases of many flavor QCD, Comment: 8 pages. Xth Quark Confinement and the Hadron Spectrum, October 2012, Munchen

Published
2013

15. Polarization-stable long-distance interference of independent photons for quantum communications

Author

da Silva, T. Ferreira, Vitoreti, D., Xavier, G. B., Temporão, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

Interference between fully-independent faint laser sources over two 8.5-km full polarization-controlled fiber links was performed, with stable visibility of 47.8%, an essential step towards practical implementation of quantum communication protocols.

Published
2012
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16. Real-time monitoring of single-photon detectors against eavesdropping in quantum key distribution systems

Author

da Silva, T. Ferreira, Xavier, G. B., Temporão, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

By employing real-time monitoring of single-photon avalanche photodiodes we demonstrate how two types of practical eavesdropping strategies, the after-gate and time-shift attacks, may be detected. Both attacks are identified with the detectors operating without any special modifications, making this proposal well suited for real-world applications. The monitoring system is based on accumulating statistics of the times between consecutive detection events, and extracting the afterpulse and overall efficiency of the detectors in real-time using mathematical models fit to the measured data. We are able to directly observe changes in the afterpulse probabilities generated from the after-gate and faint after-gate attacks, as well as different timing signatures in the time-shift attack. We also discuss the applicability of our scheme to other general blinding attacks.

Published
2012
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17. Real-time characterization of gated-mode single-photon detectors

Author

da Silva, T. Ferreira, Xavier, G. B., and von der Weid, J. P.

Subjects
Quantum Physics, Physics - Instrumentation and Detectors
Abstract

We propose a characterization method for the overall detection efficiency, afterpulse and dark count probabilities of single-photon counting modules in real-time with simple instrumentation. This method can be applied when the module is running in its intended application, and is based on monitoring the statistics of the times between consecutive detections. A mathematical model is derived and fit to the data statistical distribution to simultaneously extract the characterization parameters. The feasibility of our scheme is demonstrated by performing measurements on three commercial devices based on cooled InGaAs APD operating in gated mode. Different statistical ensemble lengths were analyzed and results assess the scheme for real-time application.

Published
2012
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18. Proof-of-principle demonstration of measurement-device-independent quantum key distribution using polarization qubits

Author

da Silva, T. Ferreira, Vitoreti, D., Xavier, G. B., Amaral, G. C. do, Temporão, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

We perform a proof-of-principle demonstration of the measurement-device-independent quantum key distribution (MDI-QKD) protocol using weak coherent states and polarization-encoded qubits over two optical fiber links of 8.5 km each. Each link was independently stabilized against polarization drifts using a full-polarization control system employing two wavelength-multiplexed control channels. A linear-optics-based polarization Bell-state analyzer was built into the intermediate station, Charlie, which is connected to both Alice and Bob via the optical fiber links. Using decoy-states, a lower bound for the secret-key generation rate of 1.04x10^-6 bits/pulse is computed.

Published
2012
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19. Polarisation drift compensation in an 8 km long Mach-Zehnder fibre-optical interferometer for quantum communication

Author

Xavier, G. B., da Silva, T. R., Temporao, G. P., and von der Weid, J. P.

Subjects
Quantum Physics, Physics - Optics
Abstract

We experimentally stabilise the polarisation drift between the arms of an 8 km-long fibre-optical Mach-Zehnder interferometer, while simultaneously compensating the phase fluctuations. The single photons are wavelength-multiplexed with three classical channels, which are used as feedback for the control systems. Two of these channels are used for the active polarisation control systems, while the other is used to phase-lock the interferometer. We demonstrate long-term stabilisation of the single-photon visibility when polarisation control is used., Comment: 3 pages, 3 figures, accepted for publication in Electronics Letters

Published
2011

20. Active polarization control for quantum communication in long-distance optical fibers with shared telecom traffic

Author

Xavier, G. B., de Faria, G. Vilela, da Silva, T. Ferreira, Temporao, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

We experimentally demonstrate the compatibility of wavelength multiplexed active polarization stabilization for quantum communication in an optical fiber carrying telecom traffic. One of the feedback control channels contains a 9.953 Gb/s data stream generated from a BER meter. We verify the ability to transmit single-photons in the two opposite directions of a 23 km optical fiber spool, while maintaining their state of polarization stable and a classical BER in the feedback channel error-free, during 6 hours of continuous operation., Comment: 18 pages, 4 figures

Published
2009

21. Practical random number generation protocol for entanglement-based quantum key distribution

Author

Xavier, G. B., da Silva, T. Ferreira, de Faria, G. Vilela, Temporao, G. P., and von der Weid, J. P.

Subjects
Quantum Physics
Abstract

A simple protocol which takes advantage of the inherent random times of detections in single photon counting modules is presented for random active basis choices when using entanglement-based protocols for Quantum Key Distribution (QKD). It may also be applicable to the BB84 protocol in certain cases. The scheme presented uses the single photon detectors already present on a QKD setup, working on the same rate as the system is capable of detecting, and is, therefore, not limited by the output rates of quantum random number generators. This protocol only requires small hardware modifications making it an attractive solution. We perform a proof-of-principle experiment employing a spontaneous parametric down-conversion process in a $\chi^{(2)}$ non-linear crystal to demonstrate the feasibility of our scheme, and show that the generated sequence passes randomness tests., Comment: 10 pages, 3 figures

Published
2008

22. Levosimendan in outpatients with advanced heart failure: Single-center experience of 200 intermittent perfusions

Author

Ferreira Reis, J, Gonçalves, A, Ilhão Moreira, R, Pereira-da-Silva, T, Timóteo, AT, Pombo, D, Carvalho, T, Correia, C, Santos, C, and Cruz Ferreira, R

Subjects
Male, Heart Failure* / therapy, Cardiotonic Agents / therapeutic use, Hydrazones / therapeutic use, Stroke Volume, HSM CAR, Simendan / therapeutic use, Ventricular Function, Left, Simendan / pharmacology, Outpatients, Humans, Pyridazines* / therapeutic use, Female, Cardiology and Cardiovascular Medicine
Abstract

Introduction: Patients with advanced heart failure (HF) have high morbidity and mortality, with only a small proportion being eligible for advanced therapies. Intermittent outpatient levosimendan infusion has been shown to provide symptomatic relief and reduce the rate of HF events. Our aim was to assess the safety and efficacy of outpatient levosimendan administration in an advanced HF population. Methods: This is a report of a single-center experience of consecutive advanced HF patients referred for intermittent intravenous outpatient administration of levosimendan, between January 2018 and March 2021. Baseline and follow-up evaluation included clinical assessment, laboratory tests, transthoracic echocardiography and cardiopulmonary exercise testing. Baseline and clinical follow-up data were compared using the Wilcoxon signed-rank test. Results: A total of 24 patients (60.8 years, 83% male, mean left ventricular ejection fraction [LVEF] 24%), with a median of 1.5 HF hospitalizations in the previous six months, were referred for outpatient levosimendan pulses, the majority as a bridge to transplantation or due to clinical deterioration. At six-month follow-up there was a significant reduction in HF hospitalizations to 0.4±0.7 (p

Published
2023

23. Growth model with restricted surface relaxation

Author

da Silva, T. J. and Moreira, J. G.

Subjects
Condensed Matter - Statistical Mechanics
Abstract

We simulate a growth model with restricted surface relaxation process in d=1 and d=2, where d is the dimensionality of a flat substrate. In this model, each particle can relax on the surface to a local minimum, as the Edwards-Wilkinson linear model, but only within a distance s. If the local minimum is out from this distance, the particle evaporates through a refuse mechanism similar to the Kim-Kosterlitz nonlinear model. In d=1, the growth exponent beta, measured from the temporal behavior of roughness, indicates that in the coarse-grained limit, the linear term of the Kardar-Parisi-Zhang equation dominates in short times (low-roughness) and, in asymptotic times, the nonlinear term prevails. The crossover between linear and nonlinear behaviors occurs in a characteristic time t_c which only depends on the magnitude of the parameter s, related to the nonlinear term. In d=2, we find indications of a similar crossover, that is, logarithmic temporal behavior of roughness in short times and power law behavior in asymptotic times.

Published
2002
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24. Kinetic roughening model with opposite Kardar-Parisi-Zhang nonlinearities

Author

da Silva, T. J. and Moreira, J. G.

Subjects
Condensed Matter - Statistical Mechanics
Abstract

We introduce a model that simulates a kinetic roughening process with two kinds of particles: one follows the ballistic deposition (BD) kinetic and, the other, the restricted solid-on-solid (KK) kinetic. Both of these kinetics are in the universality class of the nonlinear KPZ equation, but the BD kinetic has a positive nonlinear constant while the KK kinetic has a negative one. In our model, called BD-KK model, we assign the probabilities p and (1-p) to the KK and BD kinetics, respectively. For a specific value of p, the system behaves as a quasi linear model and the up-down symmetry is recuperated. We show that nonlinearities of odd-order are relevant in these low nonlinear limit., Comment: 10 pages; 4 figures

Published
2000
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27. Southern Binary Galaxies. I. a Sample of Isolated Pairs

Author

Soares, D. S. L., de Souza, R. E., de Carvalho, R. R., and da Silva, T. C. Couto

Subjects
Astrophysics
Abstract

A catalogue of binary galaxies with 621 pairs has been determined by applying a surface density enhancement procedure to {\it The Surface Photometry Catalogue of the ESO-Uppsala Galaxies}. The method does not require any redshift information. An additional restriction, based on objective criteria that take into account the completeness of the source catalogue, led to a sample of 189 isolated pairs which are listed. We have obtained the optical luminosity function of binary galaxies in the catalogue, from which we estimate that the luminosity density of galaxies in binaries is $\sim$4% of that found for field galaxies. The general properties of our sample are similar to those from CPG and CMG., Comment: 16pages text+1table+4figures, uuencoded tar file with 6 postscript files, 400 kb, accepted by A&ASS (sept./94), preprint IAG/USP-1994

Published
1994

29. Prehydrodynamic evolution in large and small systems

Author

Nunes Da Silva, T., Chinellato, D.D., Giannini, A.V., Takahashi, J., Ferreira, M.N., Denicol, G.S., Hippert, M., Noronha, J., Luzum, M., Nunes Da Silva, T., Chinellato, D.D., Giannini, A.V., Takahashi, J., Ferreira, M.N., Denicol, G.S., Hippert, M., Noronha, J., and Luzum, M.

Abstract

We extend our previous investigation of the effects of prehydrodynamic evolution on final-state observables in heavy-ion collisions [38] to smaller systems. We use a state-of-the-art hybrid model for the numerical simulations with optimal parameters obtained from a previous Bayesian study. By studying p-Pb collisions, we find that the effects due to the assumption of a conformal evolution in the prehydrodynamical stage are even more important in small systems. We also show that this effect depends on the time duration of the pre-equilibrium stage, which is further enhanced in small systems. Finally, we show that the recent proposal of a free-streaming with subluminal velocity for the pre-equilibrium stage, thus effectively breaking conformal invariance, can alleviate the contamination of final-state observables. Our study further reinforces the need for moving beyond conformal approaches in pre-equilibrium dynamics modeling, especially when extracting transport coefficients from hybrid models in the high-precision era of heavy-ion collisions.

Published
2023

31. Hepatocellular carcinoma progression during bridging before liver transplantation

Author

Renner, P, Da Silva, T, Schnitzbauer, A, Verloh, N, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Sanchez Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, De Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, Renner P., Da Silva T., Schnitzbauer A. A., Verloh N., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Van Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Sanchez Turrion V., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., De Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., Neuhaus P., Renner, P, Da Silva, T, Schnitzbauer, A, Verloh, N, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Sanchez Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, De Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, Renner P., Da Silva T., Schnitzbauer A. A., Verloh N., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Van Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Sanchez Turrion V., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., De Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., and Neuhaus P.

Abstract

Background: Recipient selection for liver transplantation in hepatocellular carcinoma (HCC) is based primarily on criteria affecting the chance of long-term success. Here, the relationship between pretransplant bridging therapy and long-term survival was investigated in a subgroup analysis of the SiLVER Study. Methods: Response to bridging, as defined by comparison of imaging at the time of listing and post-transplant pathology report, was categorized into controlled versus progressive disease (more than 20 per cent tumour growth or development of new lesions). Results: Of 525 patients with HCC who had liver transplantation, 350 recipients underwent pretransplant bridging therapy. Tumour progression despite bridging was an independent risk factor affecting overall survival (hazard ratio 1.80; P=0.005). For patients within the Milan criteria (MC) at listing, mean overall survival was longer for those with controlled versus progressive disease (6.8 versus 5.8 years; P<0.001). Importantly, patients with HCCs outside the MC that were downsized to within the MC before liver transplantation had poor outcomes compared with patients who never exceeded the MC (mean overall survival 6.2 versus 6.6 years respectively; P=0.030). Conclusion: Patients with HCCs within the MC that did not show tumour progression under locoregional therapy had the best outcomes after liver transplantation. Downstaging into the limits of the MC did not improve the probability of survival. Prognostic factors determining the long-term success of liver transplantation in patients with hepatocellular carcinoma are still under discussion. A subgroup analysis of the SiLVER trial showed that disease control under bridging therapy is strongly associated with improved prognosis in terms of overall survival. However, in tumours exceeding the limits of the Milan criteria, downstaging did not restore the probability of survival compared with that of patients within the Milan criteria.

Published
2021

34. Remote Invasive Monitoring of Pulmonary Artery Pressures in Heart Failure Patients: Initial Experience in Portugal in the Context of the Covid-19 Pandemic

Author

Vaz Ferreira, V, Pereira-da-Silva, T, Cacela, D, and Cruz Ferreira, R

Subjects
Heart Failure, Remote Monitoring, Pulmonary Artery, HSM CAR
Abstract

Background: Decompensated heart failure (HF) is associated with poor short- and long-term prognosis. Remote invasive monitoring of pulmonary artery pressures (PAP) enables early detection of HF decompensation before symptoms occur and may improve clinical outcomes. We aimed to describe our initial experience with the use of the CardioMEMS™ remote monitoring system in patients with HF, including its safety and effectiveness. Methods and results: Five patients with HF in New York Heart Association class III and at least one hospitalization due to decompensated HF in last 12 months, who underwent invasive remote monitoring of PAP, were included in this prospective registry. The median age was 66.0 years (interquartile range [IQR] 50.5-77.5 years), 80.0% were men and all had HF with reduced ejection fraction. The pulmonary artery (PA) sensor was placed in a left PA branch in all patients and no major procedural complications occurred. In median follow-up of 40 days (IQR 40-61 days), a total of 271 pressure readings were transmitted, patient compliance was 100% and freedom from sensor failure 98.1%. In three patients, PAP remained within the goal during follow-up. Two patients presented an increase in PAP to values above the targets, despite the absence of symptom worsening. These required dietary and diuretic dose adjustment, without the need for outpatient clinic visits, which reduced PAP. No hospitalizations for HF or deaths occurred during follow-up. Conclusion: Hemodynamic-guided HF monitoring was safe and effective and may be a useful adjunctive tool to the standard-of-care management in selected HF patients, particularly in the context of the COVID-19 pandemic, where a reduction in the number of health care visits may be desirable. Introdução: A insuficiência cardíaca (IC) descompensada está associada a mau prognóstico em curto e longo prazo. A monitoração remota invasiva da pressão na artéria pulmonar (PAP) possibilita a deteção precoce da descompensação da IC, previamente ao início dos sintomas, pode melhorar os resultados clínicos. Descrevemos a experiência inicial com o uso do sistema de monitoração remota CardioMEMSTM em doentes com IC, inclusive a sua segurança e eficácia. Métodos e resultados: Foram incluídos prospetivamente cinco doentes com IC em classe III da New York Heart Association, com pelo menos uma hospitalização por IC descompensada nos últimos 12 meses, submetidos a implantação de sistema de monitoração remota invasiva da PAP. A mediana de idade foi de 66 anos (intervalo interquartil [IIQ] 50,5-77,5 anos), 80% eram do sexo masculino e todos apresentavam IC com fração de ejeção reduzida. O sensor de PAP foi colocado num ramo da artéria pulmonar esquerda em todos os doentes, não ocorreram complicações major. Durante o follow-up mediano de 40 dias (IIQ 40-61 dias), foram transmitidas 271 leituras, verificou-se uma adesão dos doentes de 100% e taxa de transmissão bem-sucedida de 98,1%. A PAP manteve-se dentro do objetivo em três doentes durante o follow-up. Apesar de continuarem assintomáticos, dois doentes apresentaram valores das PAP acima do alvo. Foi feito ajuste dietético e da dose de diurético, sem necessidade de visitas clínicas presenciais, objetivou-se uma redução efetiva das PAP. Durante o seguimento, não se registaram hospitalizações por IC ou óbitos. Conclusão: A monitoração da IC guiada pela hemodinâmica demonstrou ser segura e eficaz, pode assumir-se como uma ferramenta útil no manejo de doentes com IC, particularmente no contexto da pandemia Covid-19, quando é desejável uma redução do número de consultas presenciais hospitalares. info:eu-repo/semantics/publishedVersion

Published
2022

35. Assessing the ultra-central flow puzzle in the Bayesian era

Author

Giannini, A. V., Ferreira, M. N., Hippert, M., Chinellato, D. D., Denicol, G. S., Luzum, M., Noronha, J., da Silva, T. Nunes, Takahashi, J., Giannini, A. V., Ferreira, M. N., Hippert, M., Chinellato, D. D., Denicol, G. S., Luzum, M., Noronha, J., da Silva, T. Nunes, and Takahashi, J.

Abstract

An outstanding problem in the field of relativistic heavy-ion collisions is the inability for any simulation model to accurately describe experimental flow data in extremely central collisions -- in particular, models always predict either an elliptic flow that is too large or triangular flow that is too small (or both). We reassess the status of this puzzle in light of recent progress in Bayesian parameter estimation, in which a large model parameter space can be efficiently explored to determine what parameters are necessary for a good fit to experimental results, and how well state-of-the-art models are able to describe data. We explore predictions for flow in ultra-central collisions from multiple recent Bayesian models that were tuned to various observables in different collision systems at typical centralities. We find that, while ultra-central data can now be described with better accuracy than in previous calculations, tension with experimental observation remains, and progressively gets worse as one goes to more central collisions. Thus, the physics of ultra-central collisions is still not fully understood. A resolution to this puzzle will be an important step in solidifying our understanding of the physics of the strong interactions in these extreme conditions, as well as increasing our confidence in the results of precision analyses., Comment: 7 pages, 3 figures

Published
2022

36. Small, smaller, smallest: Miniaturization of chromatographic process development

Author

Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author), Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), and Ottens, M. (author)

Abstract

Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal antibodies (mAb) are one of the most widely used therapeutic proteins and are important for the treatment of cancer and autoimmune diseases, among others. After cell culture there are still large amounts of other impurities (e.g. host cell proteins) in solution. Chromatography is usually the first purification step, allowing to increase purity and reduce volume. This comes associated with high costs and chromatography accounts for a significant portion of total production costs for therapeutic proteins. Chromatographic process development may be time consuming and use large amounts of resins. Therefore, there is increased interest in finding cheaper techniques for chromatographic process development without compromising accuracy. This paper presents a highly sophisticated microfluidic chip approach for efficient adsorption isotherm determinations compared to current chromatographic process development. Implementation of an image analysis software ensures that chromatographic resin volume is accurately determined. The adsorption isotherm performance of microfluidics was compared to the robotic Liquid-handling Station (LHS) and labor intensive Eppendorf tubes. The microfluidic chip allows a 15-fold volume reduction and resin consumptions as low as 100/200 nl (200/100-fold reduction). The microfluidic chip performed comparably to the other miniaturized techniques, using less liquid and resin volume. For process development of expensive products (e.g. monoclonal antibodies), miniaturization (provided by the microfluidic chip) proved to be the most cost effective alternative whereas for less valuable products (e.g. lysozyme) automation (provided by the LHS) was the most cost effective alternative., BT/Bioprocess Engineering, BT/Design and Engineering Education

Published
2022
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37. Putting people in their place: domestic space and privacy in the Amarna workmen's village

Author

Rocha da Silva, T, Hulin, L, and Frood, E

Subjects
Egyptian Archaeology, Household Archaeology, Egyptology
Abstract

This thesis contributes to the understanding of ancient Egyptian domestic space and the experience of privacy in the Workmen’s Village of Amarna during the New Kingdom (1550-1069 BCE). It provides a new framework with which to investigate domestic space, one not reduced to house units, but which integrates a large dataset from houses (artefacts, architectural features), facilities located outside the enclosure wall (pigpens, the quarry, chapels), and official buildings spatially distributed around the settlement. In addition, the use of anthropologically-orientated frameworks emphasises the relational aspect of domestic life and the way people relate to the surrounding landscape. This research approached dwellings as material culture, as a product and the medium of social relations, and not only as containers for social life. In so doing, it is possible to understand activity areas as arenas for social relations. Phenomenology is critically used and combined with a georeferencing tool (ArcGIS Pro) to understand artefact distribution within the landscape. A holistic approach to the village material offers a more complex picture of domestic space that is extended to the entire settlement. The village is then framed as a large domestic unit which conveys various experiences of privacy not limited to space, but to temporality and to status.

Published
2022

39. Dapagliflozin Impact on the Exercise Capacity of Non-Diabetic Heart Failure with Reduced Ejection Fraction Patients

Author

Reis, J, Teixeira, AR, Valentim Gonçalves, A, Ilhão Moreira, R, Pereira da Silva, T, Timóteo, AT, and Cruz Ferreira, R

Subjects
Heart Failure, Peak Oxygen Uptake, Sodium–Glucose Co-Transporter 2 Inhibitors, Cardiopulmonary Exercise Test, HSM CAR, Heart Failure with Reduced Ejection Fraction
Abstract

Background: Dapagliflozin has been shown to reduce morbidity and mortality in Heart Failure with reduced Ejection Fraction (HFrEF), but its impact on exercise capacity of non-diabetic HF outpatients is unknown. Methods: Adult non-diabetic HF patients with a left ventricular ejection fraction (LVEF)

Published
2022

40. Hepatocellular carcinoma progression during bridging before liver transplantation

Author

Renner P., Da Silva T., Schnitzbauer A. A., Verloh N., Schlitt H. J., Geissler E. K., Zulke C., Lamby P. E., Proneth A., Duvoux C., Burra P., Jauch K. -W., Rentsch M., Ganten T. M., Schmidt J., Settmacher U., Heise M., Rossi G., Cillo U., Kneteman N., Adam R., Van Hoek B., Bachellier P., Wolf P., Rostaing L., Bechstein W. O., Rizell M., Powell J., Hidalgo E., Gugenheim J., Wolters H., Brockmann J., Roy A., Mutzbauer I., Schlitt A., Beckebaum S., Graeb C., Nadalin S., Valente U., Sanchez Turrion V., Jamieson N., Scholz T., Colledan M., Fandrich F., Becker T., Soderdahl G., Chazouilleres O., Makisalo H., Pageaux G. -P., Steininger R., Soliman T., De Jong K. P., Pirenne J., Margreiter R., Pratschke J., Pinna A. D., Hauss J., Schreiber S., Strasser S., Klempnauer J., Troisi R. I., Bhoori S., Lerut J., Bilbao I., Klein C. G., Konigsrainer A., Otto G., Mazzaferro V., Neuhaus P., Renner, P, Da Silva, T, Schnitzbauer, A, Verloh, N, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Van Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Sanchez Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, De Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, Neuhaus, P, and Publica

Subjects
Male, Carcinoma, Hepatocellular, Time Factor, Waiting Lists, AcademicSubjects/MED00910, Prognosi, Risk Factor, Middle Aged, Liver Transplantation, Treatment Outcome, Liver Neoplasm, Disease Progression, Female, Original Article, Survival Analysi, Neoplasm Recurrence, Local, AcademicSubjects/MED00010, Multivariate Analysi, Human
Abstract

Background Recipient selection for liver transplantation in hepatocellular carcinoma (HCC) is based primarily on criteria affecting the chance of long-term success. Here, the relationship between pretransplant bridging therapy and long-term survival was investigated in a subgroup analysis of the SiLVER Study. Methods Response to bridging, as defined by comparison of imaging at the time of listing and post-transplant pathology report, was categorized into controlled versus progressive disease (more than 20 per cent tumour growth or development of new lesions). Results Of 525 patients with HCC who had liver transplantation, 350 recipients underwent pretransplant bridging therapy. Tumour progression despite bridging was an independent risk factor affecting overall survival (hazard ratio 1.80; P = 0.005). For patients within the Milan criteria (MC) at listing, mean overall survival was longer for those with controlled versus progressive disease (6.8 versus 5.8 years; P

Published
2021

46. Consistent improvement with eculizumab across muscle groups in myasthenia gravis

Author

Mantegazza, R., O'Brien, F. L., Yountz, M., Howard, J. F., Gabriel Mazia, C., Wilken, M., Barroso, F., Saba, J., Rugiero, M., Bettini, M., Chaves, M., Vidal, G., Dalila Garcia, A., De Bleecker, J., Van den Abeele, G., de Koning, K., De Mey, K., Mercelis, R., Mahieu, D., Wagemaekers, L., Van Damme, P., Depreitere, A., Schotte, C., Smetcoren, C., Stevens, O., Van Daele, S., Vandenbussche, N., Vanhee, A., Verjans, S., Vynckier, J., D'Hont, A., Tilkin, P., Alves de Siqueira Carvalho, A., Dias Brockhausen, I., Feder, D., Ambrosio, D., Cesar, P., Paula Melo, A., Martins Ribeiro, R., Rocha, R., Bezerra Rosa, B., Veiga, T., Augusto da Silva, L., Santos Engel, M., Goncalves Geraldo, J., da Penha Ananias Morita, M., Nogueira Coelho, E., Paiva, G., Pozo, M., Prando, N., Torres, D. D. M., Fernanda Butinhao, C., Duran, G., Augusto Suriane Fialho, T., Gomes da Silva, T. C., Goncalves, L. O. M., Eduardo Pazetto, L., Renata Cubas Volpe, L., Souza Duca, L., Friedrich, M. A. G., Guerreiro, A., Mohr, H., Pereira Martins, M., da Cruz Pacheco, D., Ferreira, L., Paula Macagnan, A., Pinto, G., de Cassia Santos, A., Souza Bulle Oliveira, A., Amaral de Andrade, A. C., Annes, M., Duarte Silva, L., Cavalcante Lino, V., Pinto, W., Assis, N., Carrara, F., Miranda, C., Souza, I., Fernandes, P., Siddiqi, Z., Phan, C., Narayan, J., Blackmore, D., Mallon, A., Roderus, R., Watt, E., Vohanka, S., Bednarik, J., Chmelikova, M., Cierny, M., Toncrova, S., Junkerova, J., Kurkova, B., Reguliova, K., Zapletalova, O., Pitha, J., Novakova, I., Tyblova, M., Jurajdova, I., Wolfova, M., Andersen, H., Harbo, T., Vinge, L., Krogh, S., Mogensen, A., Vissing, J., Hojgaard, J., Witting, N., Mette Ostergaard Autzen, A., Pedersen, J., Eralinna, J. -P., Laaksonen, M., Oksaranta, O., Harrison, T., Eriksson, J., Rozsa, C., Horvath, M., Lovas, G., Matolcsi, J., Szabo, G., Jakab, G., Szabadosne, B., Vecsei, L., Dezsi, L., Varga, E., Konyane, M., Antonini, G., Di Pasquale, A., Garibaldi, M., Morino, S., Troili, F., Fionda, L., Pasquale, A., Evoli, A., Emilio Alboini, P., D'Amato, V., Iorio, R., Inghilleri, M., Frasca, V., Giacomelli, E., Gori, M., Lopergolo, D., Onesti, E., Gabriele, M., Sacca, F., Filla, A., Costabile, T., Marano, E., Fasanaro, A., Marsili, A., Puorro, G., Antozzi, C., Bonanno, S., Camera, G., Locatelli, A., Maggi, L., Pasanisi, M., Campanella, A., Uzawa, A., Kanai, T., Kawaguchi, N., Mori, M., Kaneko, Y., Kanzaki, A., Kobayashi, E., Murai, H., Masaki, K., Matsuse, D., Matsushita, T., Uehara, T., Shimpo, M., Jingu, M., Kikutake, K., Nakamura, Y., Sano, Y., Utsugisawa, K., Nagane, Y., Kamegamori, I., Tsuda, T., Fujii, Y., Futono, K., Ozawa, Y., Mizugami, A., Saito, Y., Samukawa, M., Suzuki, H., Morikawa, M., Kamakura, S., Miyawaki, E., Okumura, M., Funaka, S., Kawamura, T., Nakamori, M., Takahashi, M., Taichi, N., Hasuike, T., Higuchi, E., Kobayashi, H., Osakada, K., Shiraishi, H., Miyazaki, T., Motomura, M., Mukaino, A., Yoshimura, S., Asada, S., Yoshida, S., Amamoto, S., Kobashikawa, T., Koga, M., Maeda, Y., Takada, K., Takada, M., Tsurumaru, M., Yamashita, Y., Suzuki, Y., Akiyama, T., Narikawa, K., Tano, O., Tsukita, K., Kurihara, R., Meguro, F., Fukuda, Y., Sato, M., Imai, T., Tsuda, E., Shimohama, S., Hayashi, T., Hisahara, S., Kawamata, J., Murahara, T., Saitoh, M., Suzuki, S., Yamamoto, D., Ishiyama, Y., Ishiyama, N., Noshiro, M., Takeyama, R., Uwasa, K., Yasuda, I., van der Kooi, A., de Visser, M., Gibson, T., Kim, B. -J., Nyoung Lee, C., Seo Koo, Y., Youl Seok, H., Nam Kang, H., Ra, H., Joon Kim, B., Bin Cho, E., Choi, M., Lee, H., Min, J. -H., Seok, J., Lee, J., Koh, D. Y., Kwon, J., Park, S., Haw Choi, E., Hong, Y. -H., Ahn, S. -H., Lim Koo, D., Lim, J. -S., Won Shin, C., Ye Hwang, J., Kim, M., Min Kim, S., Jeong, H. -N., Jung, J., Kim, Y. -H., Seok Lee, H., Young Shin, H., Bi Hwang, E., Shin, M., Casasnovas, C., Antonia Alberti Aguilo, M., Homedes-Pedret, C., Julia Palacios, N., Diez Porras, L., Velez Santamaria, V., Lazaro, A., Gamez Carbonell, J., Sune, P., Salvado Figueras, M., Gili, G., Mazuela, G., Illa, I., Cortes Vicente, E., Diaz-Manera, J., Antonio Querol Gutierrez, L., Rojas Garcia, R., Vidal, N., Arribas-Ibar, E., Diez Tejedor, E., Gomez Salcedo, P., Fernandez-Fournier, M., Lopez Ruiz, P., Rodriguez de Rivera, F. J., Sastre, M., Piehl, F., Hietala, A., Bjarbo, L., Sengun, I., Meherremova, A., Ozcelik, P., Balkan, B., Tuga, C., Ugur, M., Erdem-Ozdamar, S., Bekircan-Kurt, C., Pinar Acar, N., Yilmaz, E., Caliskan, Y., Orsel, G., Efendi, H., Aydinlik, S., Cavus, H., Kutlu, A., Becerikli, G., Semiz, C., Tun, O., Terzi, M., Dogan, B., Kazim Onar, M., Sen, S., Kirbas Cavdar, T., Veske, A., Norwood, F., Dimitriou, A., Gollogly, J., Mahdi-Rogers, M., Seddigh, A., Sokratous, G., Maier, G., Sohail, F., Jacob, S., Sadalage, G., Torane, P., Brown, C., Shah, A., Sathasivam, S., Arndt, H., Davies, D., Watling, D., Amato, A., Cochrane, T., Salajegheh, M., Roe, K., Amato, K., Toska, S., Wolfe, G., Silvestri, N., Patrick, K., Zakalik, K., Katz, J., Miller, R., Engel, M., Forshew, D., Bravver, E., Brooks, B., Sanjak, M., Plevka, S., Burdette, M., Cunningham, S., Kramer, M., Nemeth, J., Schommer, C., Scott, T., Juel, V., Guptill, J., Hobson-Webb, L., Massey, J., Beck, K., Carnes, D., Loor, J., Anderson, A., Pascuzzi, R., Bodkin, C., Kincaid, J., Snook, R., Guingrich, S., Micheels, A., Chaudhry, V., Corse, A., Mosmiller, B., Kelley, A., Ho, D., Srinivasan, J., Vytopil, M., Jara, J., Ventura, N., Carter, C., Donahue, C., Herbert, C., Scala, S., Weiner, E., Alam, S., Mckinnon, J., Haar, L., Mckinnon, N., Alcon, K., Mckenna, K., Sattar, N., Daniels, K., Jeffery, D., Freimer, M., Chad Hoyle, J., Kissel, J., Agriesti, J., Chelnick, S., Mezache, L., Pineda, C., Muharrem, F., Karam, C., Khoury, J., Marburger, T., Kaur, H., Dimitrova, D., Gilchrist, J., Agrawal, B., Elsayed, M., Kohlrus, S., Ardoin, A., Darnell, T., Golden, L., Lokaitis, B., Seelbach, J., Muppidi, S., Goyal, N., Sakamuri, S., Y. 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Y., Kwon, J., Park, S., Haw Choi, E., Hong, Y. -H., Ahn, S. -H., Lim Koo, D., Lim, J. -S., Won Shin, C., Ye Hwang, J., Kim, M., Min Kim, S., Jeong, H. -N., Jung, J., Kim, Y. -H., Seok Lee, H., Young Shin, H., Bi Hwang, E., Shin, M., Casasnovas, C., Antonia Alberti Aguilo, M., Homedes-Pedret, C., Julia Palacios, N., Diez Porras, L., Velez Santamaria, V., Lazaro, A., Gamez Carbonell, J., Sune, P., Salvado Figueras, M., Gili, G., Mazuela, G., Illa, I., Cortes Vicente, E., Diaz-Manera, J., Antonio Querol Gutierrez, L., Rojas Garcia, R., Vidal, N., Arribas-Ibar, E., Diez Tejedor, E., Gomez Salcedo, P., Fernandez-Fournier, M., Lopez Ruiz, P., Rodriguez de Rivera, F. J., Sastre, M., Piehl, F., Hietala, A., Bjarbo, L., Sengun, I., Meherremova, A., Ozcelik, P., Balkan, B., Tuga, C., Ugur, M., Erdem-Ozdamar, S., Bekircan-Kurt, C., Pinar Acar, N., Yilmaz, E., Caliskan, Y., Orsel, G., Efendi, H., Aydinlik, S., Cavus, H., Kutlu, A., Becerikli, G., Semiz, C., Tun, O., Terzi, M., Dogan, B., Kazim Onar, M., Sen, S., Kirbas Cavdar, T., Veske, A., Norwood, F., Dimitriou, A., Gollogly, J., Mahdi-Rogers, M., Seddigh, A., Sokratous, G., Maier, G., Sohail, F., Jacob, S., Sadalage, G., Torane, P., Brown, C., Shah, A., Sathasivam, S., Arndt, H., Davies, D., Watling, D., Amato, A., Cochrane, T., Salajegheh, M., Roe, K., Amato, K., Toska, S., Wolfe, G., Silvestri, N., Patrick, K., Zakalik, K., Katz, J., Miller, R., Engel, M., Forshew, D., Bravver, E., Brooks, B., Sanjak, M., Plevka, S., Burdette, M., Cunningham, S., Kramer, M., Nemeth, J., Schommer, C., Scott, T., Juel, V., Guptill, J., Hobson-Webb, L., Massey, J., Beck, K., Carnes, D., Loor, J., Anderson, A., Pascuzzi, R., Bodkin, C., Kincaid, J., Snook, R., Guingrich, S., Micheels, A., Chaudhry, V., Corse, A., Mosmiller, B., Kelley, A., Ho, D., Srinivasan, J., Vytopil, M., Jara, J., Ventura, N., Carter, C., Donahue, C., Herbert, C., Scala, S., Weiner, E., Alam, S., Mckinnon, J., Haar, L., Mckinnon, N., Alcon, K., Mckenna, K., Sattar, N., Daniels, K., Jeffery, D., Freimer, M., Chad Hoyle, J., Kissel, J., Agriesti, J., Chelnick, S., Mezache, L., Pineda, C., Muharrem, F., Karam, C., Khoury, J., Marburger, T., Kaur, H., Dimitrova, D., Gilchrist, J., Agrawal, B., Elsayed, M., Kohlrus, S., Ardoin, A., Darnell, T., Golden, L., Lokaitis, B., Seelbach, J., Muppidi, S., Goyal, N., Sakamuri, S., So, Y. 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Subjects
0301 basic medicine, Malalties neuromusculars, Activities of daily living, Autoimmune diseases, Severity of Illness Index, Complement inhibitor, 0302 clinical medicine, CYCLOPHOSPHAMIDE, Activities of Daily Living, Outcome Assessment, Health Care, Medicine and Health Sciences, Research Articles, Malalties autoimmunitàries, General Neuroscience, Eculizumab, myasthenia, Neuromuscular diseases, Life Sciences & Biomedicine, medicine.drug, RC321-571, Research Article, Adult, medicine.medical_specialty, Cyclophosphamide, Gross motor skill, Clinical Neurology, Neurosciences. Biological psychiatry. Neuropsychiatry, Placebo, Antibodies, Monoclonal, Humanized, ACETYLCHOLINE-RECEPTOR, 03 medical and health sciences, Refractory, Double-Blind Method, Internal medicine, Myasthenia Gravis, medicine, Humans, Muscle Strength, Patient Reported Outcome Measures, RC346-429, Muscle, Skeletal, Science & Technology, business.industry, Neurosciences, medicine.disease, Myasthenia gravis, 030104 developmental biology, Complement Inactivating Agents, ANTIBODY, Monoclonal antibodies, Neurosciences & Neurology, Neurology (clinical), Neurology. Diseases of the nervous system, business, Anticossos monoclonals, 030217 neurology & neurosurgery
Abstract

OBJECTIVE: To assess whether eculizumab, a terminal complement inhibitor, improves patient- and physician-reported outcomes (evaluated using the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale, respectively) in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis across four domains, representing ocular, bulbar, respiratory, and limb/gross motor muscle groups. METHODS: Patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis were randomized 1:1 to receive either placebo or eculizumab during the REGAIN study (NCT01997229). Patients who completed REGAIN were eligible to continue into the open-label extension trial (NCT02301624) for up to 4 years. The four domain scores of each of the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale recorded throughout REGAIN and through 130 weeks of the open-label extension were analyzed. RESULTS: Of the 125 patients who participated in REGAIN, 117 enrolled in the open-label extension; 61 had received placebo and 56 had received eculizumab during REGAIN. Patients experienced rapid improvements in total scores and all four domain scores of both the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale with eculizumab treatment. These improvements were sustained through 130 weeks of the open-label extension. INTERPRETATION: Eculizumab treatment elicits rapid and sustained improvements in muscle strength across ocular, bulbar, respiratory, and limb/gross motor muscle groups and in associated daily activities in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis. ispartof: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY vol:7 issue:8 pages:1327-1339 ispartof: location:United States status: published

Published
2020

47. Chronic Aerobic Training at Different Volumes in the Modulation of Macrophage Function and in vivo Infection of BALB/c Mice by Leishmania major

Author

Guimarães, T. T., primary, Gomes, S. M. R., additional, Albuquerque, R. A. A. C., additional, Lima, A. K. C., additional, Braga, G. F., additional, Souza, J. B., additional, Assis, M., additional, Brito, A. C. S., additional, Santos, R. F., additional, Da Silva, T., additional, Siqueira, L. M., additional, Ventura, B. D., additional, Rodrigues, L. S., additional, Terra, R., additional, Da Silva, S. A. G., additional, and Dutra, P. M. L., additional

Published
2021
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