1. Striatal adenosine A 2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus.
- Author
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Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d'Exaerde AK, Li RX, and Huang ZL
- Subjects
- Adenosine metabolism, Animals, Brain Mapping, Male, Mice, Microscopy, Immunoelectron, Neurons chemistry, Globus Pallidus physiology, Neostriatum physiology, Neurons physiology, Parvalbumins analysis, Receptor, Adenosine A2A analysis, Sleep, Wakefulness
- Abstract
Dysfunction of the striatum is frequently associated with sleep disturbances. However, its role in sleep-wake regulation has been paid little attention even though the striatum densely expresses adenosine A
2A receptors (A2A Rs), which are essential for adenosine-induced sleep. Here we showed that chemogenetic activation of A2A R neurons in specific subregions of the striatum induced a remarkable increase in non-rapid eye movement (NREM) sleep. Anatomical mapping and immunoelectron microscopy revealed that striatal A2A R neurons innervated the external globus pallidus (GPe) in a topographically organized manner and preferentially formed inhibitory synapses with GPe parvalbumin (PV) neurons. Moreover, lesions of GPe PV neurons abolished the sleep-promoting effect of striatal A2A R neurons. In addition, chemogenetic inhibition of striatal A2A R neurons led to a significant decrease of NREM sleep at active period, but not inactive period of mice. These findings reveal a prominent contribution of striatal A2A R neuron/GPe PV neuron circuit in sleep control.- Published
- 2017
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