1. Oxidative stress biomarkers in pregnancy: a systematic review.
- Author
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Ibrahim A, Khoo MI, Ismail EHE, Hussain NHN, Zin AAM, Noordin L, Abdullah S, Mahdy ZA, and Lah NAZN
- Subjects
- Humans, Pregnancy, Female, Diabetes, Gestational metabolism, Diabetes, Gestational diagnosis, Fetal Membranes, Premature Rupture metabolism, Fetal Membranes, Premature Rupture diagnosis, Pre-Eclampsia metabolism, Pre-Eclampsia diagnosis, Oxidative Stress physiology, Biomarkers blood, Pregnancy Complications metabolism, Pregnancy Complications diagnosis
- Abstract
Background: This systematic review explores the level of oxidative stress (OS) markers during pregnancy and their correlation with complications. Unlike previous studies, it refrains from directly investigating the role of OS but instead synthesises data on the levels of these markers and their implications for various pregnancy-related complications such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages., Method: STUDY DESIGN: Utilizing a systematic review approach, we conducted a comprehensive search across databases, including MEDLINE, CINAHL (EBSCOhost), ScienceDirect, Web of Science, and SCOPUS. Our search encompassed all publication years in English., Results: After evaluating 54,173 records, 45 studies with a low risk of bias were selected for inclusion. This systematic review has underscored the importance of these markers in both physiological and pathological pregnancy states such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages., Conclusion: This systematic review provides valuable insights into the role of OS in pregnancy and their connection to complications. These selected studies delved deeply into OS markers during pregnancy and their implications for associated complications. The comprehensive findings highlighted the significance of OS markers in both normal and pathological pregnancy conditions, paving the way for further research in this field., (© 2024. The Author(s).)
- Published
- 2024
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