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Metabolic cardiomyopathy (MC) is characterized by intracellular lipid accumulation and utilizing fatty acids as a foremost energy source, thereby leading to excess oxidative stress and mitochondrial dysfunction. There is no effective therapy available yet. In this study we investigated whether defective mitophagy contributed to MC and whether urolithin A (UA), a naturally occurring microflora-derived metabolite, could protect against MC in experimental obese mice. Mice were fed high fat diet for 20 weeks to establish a diet-induced obese model. We showed that mitochondrial autophagy or mitophagy was significantly downregulated in the heart of experimental obese mice. UA (50 mg·kg

Problem statement: The utilization of inositol was detected for growth performance and erum biochemical parameters of juvenile barramundi (Lates calcarifer). Approach: A 56 day feeding trial was conducted to evaluate the effect of inositol on growth, feed utilization and serum biochemical parameters for juvenile barramundi Lates calcarifer (initial size 5.51±0.07g). Six experimental fish meal-based isonitrogenous (42% crude protein) and isolipidic (10% crude lipid) diets containing levels of inositol (350, 364, 458, 507, 720, 1050 mg kg-1 diet) were formulated. Results: Fish fed diet containing inositol 507 mg kg-1 diet had the significantly highest weight gain (WG, %) among all the groups (p 0.05). However, significantly lower Viscerasomatic Index (VSI) was found in fish fed diet without supplemental inositol (p 0.05). Total protein and triacylglycerol in serum increased with increasing dietary inositol levels up to 507 mg kg-1 diet (p