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Glioma is often recurred after standard treatment due to its complex biological characteristics and the presence of glioma stem cells (GSCs). High -mobility group box 1 (HMGB1) can regulate the malignant progression of glioma through a variety of ways as an oncogene. This article reviews the relationship between HMGB1 gene and the prognosis of glioma patients, tumor pathological grading, GSCs, and the ways including non coding RNA pathway, autophagy pathway, tumor microenvironment, etc., in which HMGB1 gene regulates glioma, so as to provide the reference for the treatment of glioma.

[Objective] Climate change directly affects global wind speed changes and the efficiency of wind energy resource utilization. Analyzing wind speed historical changes is one of the important topics for climate change response, efficient resource utilization, ecological security management, and sustainable social development. [Methods] Using the ERA5-Land grid reanalysis wind speed dataset at the 0.1° resolution from the European Center for Medium Range Weather Forecasts (ECMWF) and methods such as least squares, Theil-Sen slope estimation, and MK trend test to study the annual, seasonal, and monthly average wind speed trends and the evolution of suitable wind power areas over the past 72 years from 1950 to 2021 worldwide. [Results] (1) The global mean land surface wind speed increases slightly at an overall rate of 0.020 m/(s·10a) from 1950 to 2021. (2) The surface wind speed changes on a global scale exhibit significant spatial differences, especially remarkable in Africa and Antarctica in comparison with other continents. (3) As the seasonal changes, the land surface wind speed in winter season shows the significant changes, with a changing rate of 0.033 m/(s·10a). As the months changes, December, January and June exhibit particularly noticeable variations of surface wind speed. The global mean land surface wind speed has a mean rate of change of 0.073 m/(s·10a) and -0.066 m/(s·10a) for significant increases and decreases, respectively, in the regions passing the 95% significance test; and it has the mean rate of change of 0.080 m/(s·10a) and -0.071 m/(s·10a) for extremely significant increases and decreases, respectively, for the region passing the 99% highly significant test. The monthly average wind speed change rate and range in Antarctica are relatively large, affecting significantly the global average wind speed change rate and area assessment. (4) The global wind power energy density has slightly increased, with an average growth rate of 3.017 W/(m2·10a). The increase was most significant in January and December of the year, reaching 7.086 W/(m2·10a) and 6.660 W/(m2·10a), respectively. Antarctica and Africa lead in increasing wind power density for electricity generation, at 14.107 W/(m2·10a) and 4.652 W/(m2·10a) respectively. Asia stands out as the only continent with an overall decrease, while the remaining four continents show minor changes. [Conclusion] There were significant regional, seasonal, and monthly differences in global land surface wind speed changes. In order to accurately support climate change response, resources and ecological protection, and efficient development, dynamic monitoring and detailed analysis of changes in land surface wind speed and wind energy density in each region is still needed.

Objective To analyze clinical characteristics and risk factors of pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii （XDRAB）， evaluate antimicrobial therapy and prognosis of XDRAB patients， aiming to provide references for effective prevention and control of nosocomial infection and clinical diagnosis and treatment. Methods Patients with XDRAB isolated from the lower respiratory tract specimens were collected. The number of repeated cases and colonization strains were excluded. The case data were analyzed and summarized by the method of retrospective case analysis. Results A total of 210 XDRAB strains were detected. The distribution of clinical departments was mainly concentrated in the ICU， with 108 cases （51.4%）. Respiratory diseases （OR = 2.294， 95% CI： 1.018-5.170， P < 0.05）， carbapenems （OR = 12.723， 95% CI： 4.585-35.306， P < 0.05）， quinolones （OR= 10.100， 95% CI： 1.950-52.317， P < 0.05）， β-lactam inhibitors （OR = 4.012， 95% CI： 1.659-9.702， P < 0.05） were the independent risk factors for XDRAB infection. The non-improvement rate in the XDRAB group was higher than that in the non-XDRAB group （χ2 = 94.500， P < 0.05）. Conclusions The proportion of XDRAB isolated from the ICU is the highest. Respiratory diseases and antibacterial drugs （carbapenems， β-lactam inhibitors， quinolones） are the independent risk factors for XDRAB infection. The prognosis of XDRAB infected patients is poor.

The treatment of brain tumors, especially the malignant brain tumors, has entered in the bottleneck period at present. It is difficult for traditional molecular biology, cell and animal experiments to make a major breakthrough in the treatment of brain tumors, so researchers have turned their attention to the anatomy and pathology of human whole brain tissue. However, the human whole brain tissue which is available for research is extremely deficient. It is of great significance to encourage brain tumors patients to donate organs and establish a standard human brain tissue resource bank of brain tumors (shortened to brain bank) for the research of brain science and providing new treatment ideas for brain tumors, while the construction of brain bank in China started late, with a relatively small scale and relatively slow development. This paper intends to provide guidance for the construction and improvement of brain bank and specific brain tumors related brain bank in China by drawing on the relevant experience of the construction of brain bank in other countries.