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9 results on '"Zhao, Yu‐Dong"'

4. Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration.

Author

Zhao, Yu-Dong, Huang, Yong-Can, Lin, Jia-Liang, and Li, Wei-Shi

Subjects
*RNA sequencing, *LUMBAR pain, *PROGENITOR cells, *STROMAL cells, *CELLULAR therapy
Abstract

The tremendous personal and economic burden worldwide caused by low back pain (LBP) has been surging in recent years. While intervertebral disc degeneration (IVDD) is the leading cause of LBP and vast efforts have been made to develop effective therapies, this problem is far from being resolved, as most treatments, such as painkillers and surgeries, mainly focus on relieving the symptoms rather than reversing the cause of IVDD. However, as stem/progenitor cells possess the potential to regenerate IVD, a deeper understanding of the early development and role of these cells could help to improve the effectiveness of stem/progenitor cell therapy in treating LBP. Single-cell RNA sequencing results provide fresh insights into the heterogeneity and development patterns of IVD progenitors; additionally, we compare mesenchymal stromal cells and IVD progenitors to provide a clearer view of the optimal cell source proposed for IVD regeneration. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Gene Expression Network Analysis Identifies Potential Targets for Prevention of Preeclampsia

Author

Xia,Yu, Zhao,Yu-Dong, Sun,Gui-Xiang, Xia,Shuai-Shuai, Yang,Zheng-Wang, Xia,Yu, Zhao,Yu-Dong, Sun,Gui-Xiang, Xia,Shuai-Shuai, and Yang,Zheng-Wang

Abstract

Yu Xia,1– 3 Yu-Dong Zhao,4 Gui-Xiang Sun,1,2 Shuai-Shuai Xia,1 Zheng-Wang Yang3 1Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan Province, 410208, People’s Republic of China; 2Institute of Chinese Medicine Diagnosis, Hunan University of Chinese Medicine, Changsha, Hunan Province, 410208, People’s Republic of China; 3Department of Obstetrics and Gynecology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province, 410007, People’s Republic of China; 4School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, People’s Republic of ChinaCorrespondence: Gui-Xiang SunProvincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, No. 300, Xueshi Road, Yuelu District, Changsha, Hunan Province, 410208, People’s Republic of China, Tel +86-13787272837, Email 84663423@qq.comObjective: Preeclampsia (PE) is a pregnancy-specific multisystem disease as well as an important cause of maternal and perinatal death. This study aimed to analyze the placental transcriptional data and clinical information of PE patients available in the published database and predict the target genes for prevention of PE.Methods: The clinical information and corresponding RNA data of PE patients were downloaded from the GEO database. Cluster analysis was performed to examine the correlation between different genotyping genes and clinical manifestations. Then, bioinformatic approaches including GO, KEGG, WGCNA, and GSEA were employed to functionally characterize candidate target genes involved in pathogenesis of PE.Results: Two PE datasets GSE60438 and GSE75010 were obtained and combined, thereby providing the data of 205 samples in total (100 non-PE and 105 PE samples). After eliminating the batch effect, we grouped and analyzed the integrated data, and further performed GSEA analysis. It was found that the genes in group 1 and group 2 were different from t

Published
2022

8. Propiedades gramaticales y funciones discursivas del vocativo en español y en chino mandarín actuales

Author

Zhao, Yu Dong and Martín Zorraquino, María Antonia

Subjects
vocativo en español y en chino mandarín actuales
Abstract

Resumen: El presente trabajo tiene como objetivo la investigación de algunos aspectos formales y funcionales más destacados del vocativo en español actual y en chino mandarín, tales como su definición, sus propiedades fónicas y distribucionales, las clases de palabras que pueden ejercer la función vocativa, las diversas propuestas sobre la clasificación del vocativo, así como sus usos discursivos. Palabras clave: vocativo, español actual, chino mandarín. Abstract: The objective of this thesis is the investigation into some formal and functional aspects more distinguished of vocative in current spanish and chinese mandarin, such as the definition, the phonic and distributional characteristics, the classes of the words that can practice the vocative function, various proposals for the classification of the vocative and it's speech uses. Key words: vocative, current spanish, chinese mandarin.

Published
2014

9. Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment: Facts and perspectives.

Author

Zhao YD, Huang YC, and Li WS

Abstract

Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies, and pretreatment has proven to enhance cell vitality and function. In a recent publication, Li et al explored a new combination of pretreatment conditions. Here, we present an editorial to comment on their work and provide our view on mesenchymal stem/stromal cell precondition., Competing Interests: Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article., (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)

Published
2024
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