Search

Your search keyword '"Zhang, Yu-Qin"' showing total 167 results
Start Over Author "Zhang, Yu-Qin" Search Limiters Full Text
167 results on '"Zhang, Yu-Qin"'

14. Both epilepsy and anti‐seizure medications affect bone metabolism in children with self‐limited epilepsy with centrotemporal spikes

Author

Shi, Xiu‐Yu, primary, Ju, Jun, additional, Lu, Qian, additional, Hu, Lin‐Yan, additional, Tian, Ya‐Ping, additional, Guo, Guang‐Hong, additional, Liu, Zhi‐Sheng, additional, Wu, Ge‐Fei, additional, Zhu, Hong‐Min, additional, Zhang, Yu‐Qin, additional, Li, Dong, additional, Gao, Li, additional, Yang, Liu, additional, Wang, Chun‐Yu, additional, Liao, Jian‐Xiang, additional, Wang, Ji‐Wen, additional, Zhou, Shui‐Zhen, additional, Wang, Hua, additional, Li, Xiao‐Jing, additional, Gao, Jing‐Yun, additional, Zhang, Li, additional, Shu, Xiao‐Mei, additional, Li, Dan, additional, Li, Yan, additional, Chen, Chun‐Hong, additional, Zhang, Xiu‐Ju, additional, Zhong, Jian‐Min, additional, Zhai, Qiong‐Xiang, additional, Sun, Yan‐Hong, additional, Lin, Xue‐Feng, additional, Ren, Rong‐Na, additional, Yin, Fei, additional, Chen, Yan‐Hui, additional, Jia, Fei‐Yong, additional, Yang, Zhi‐Xian, additional, Wang, Ju‐Li, additional, Xia, Zhe‐Zhi, additional, Wang, Li‐Wen, additional, Luo, Rong, additional, and Zou, Li‐Ping, additional

Published
2023
Full Text
View/download PDF

16. Myofascial acupuncture versus routine acupuncture for mechanical neck pain: a protocol for a multicentre randomised controlled trial

Author

Qiu, Xing-Hua, primary, Yang, Xing-Yue, additional, Wang, Yu-Yu, additional, Tian, Su-Ling, additional, Yan, Yan-Bin, additional, Xu, An-Ping, additional, Fu, Fei, additional, Wen, Feng-Yun, additional, Yang, Yang, additional, Zhang, Yang, additional, Zhang, Yu-Qin, additional, Yang, Zhi-Wen, additional, Xu, Chang, additional, Sun, Qian-Hui, additional, Wu, Xiao-Ling, additional, Dai, Xing-Ye, additional, Li, Na, additional, and Cheng, Kai, additional

Published
2023
Full Text
View/download PDF

28. Key Social Determinants to Narrow the Gap between Health-adjusted Life Expectancy and Life Expectancy in Megacities.

Author

XI, Jun Yan, CHEN, Yuan Yuan, ZHANG, Yu Qin, LUO, Ao, DU, Zhi Cheng, LIANG, Bo Heng, DONG, Hang, LIN, Xiao, QIN, Peng Zhe, and HAO, Yuan Tao

Subjects
LIFE expectancy, PRINCIPAL components analysis, MULTILEVEL models, DEATH certificates, LIFE tables
Abstract

Improvement in the quality of life is reflected in the narrowing of the gap between health-adjusted life expectancy (HALE) and life expectancy (LE). The effect of megacity expansion on narrowing the gap is rarely reported. This study aimed to disclose this potential relationship. Annual life tables were constructed from identified death records and population counts from multiple administrative sources in Guangzhou, China, from 2010 to 2020. Joinpoint regression was used to evaluate the temporal trend. Generalized principal component analysis and multilevel models were applied to examine the county-level association between the gap and social determinants. Although LE and HALE in megacities are increasing steadily, their gap is widening. Socio-economic and health services are guaranteed to narrow this gap. Increasing personal wealth, a growing number of newborns and healthy immigrants, high urbanization, and healthy aging have helped in narrowing this gap. In megacities, parallel LE and HALE growth should be highly considered to narrow their gap. Multiple social determinants need to be integrated as a whole to formulate public health plans. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

41. Analysis on the law of sediments deposition in the three gorges reservoir

Author

Zhou Yin-jun, Yan Xia, Zhang Yu-qin, and Sun Jie

Subjects
Hydrology, 0103 physical sciences, 0208 environmental biotechnology, Environmental science, 02 engineering and technology, Channel width, Sedimentation, Spatial distribution, 01 natural sciences, Deposition (chemistry), 010305 fluids & plasmas, 020801 environmental engineering, Three gorges
Abstract

Since the impoundment of the Three Gorges Reservoir, there were always sustainable deposition, and by December 2015, it was a total of 1 billion 604 million t. Deposition mainly concentrated in the perennial backwater area downstream of Qingxichang station, the deposit amount is 1 billion 486 million t, accounting for 92.7% of the total sedimentation amount; the deposit amount of Qingxichang to Zhutuo section is 118 million t, accounted for 7.3% of the total sedimentation amount. After the impoundment of Three Gorges Reservoir into the 175m trial in 2008, the scope of deposition exhibits extension, the deposit amount of Qingxichang to Zhutuo section increases obviously. The spatial distribution of deposition is related to the channel width and the distance from the dam, deposition in front of the dam and the gully section of Fengjie to Fuling is the largest, while the deposition occurs in 2008 to 2010 in the upstream of Fuling, and it turns to scour after 2010.

Published
2017

48. Clinical application of blood concentration monitoring of active metabolite of oxcarbazepine in childhood focal epilepsy.

Author

ZHANG Pei-yuan, LI Hui-fen, LIU Xiao-jun, YU Xiao-li, and ZHANG Yu-qin

Subjects
ANTICONVULSANTS, CARBAMAZEPINE, COMBINATION drug therapy, DRUG monitoring, DRUG resistance, EPILEPSY, HIGH performance liquid chromatography, SEX distribution, STATISTICS, DATA analysis, CHILDREN, THERAPEUTICS
Abstract

Objective To investigate the value of blood concentration monitoring of 10 - monohydroxy carbamazepine (MHD), the active metabolite of oxcarbazepine (OXC), in the treatment of childhood focal epilepsy. Methods A total of 110 children with focal epilepsy took OXC for 3 months and then the MHD concentrations were determined by high pressure liquid chromatography (HPLC). Results The average dose of OXC in 110 children was (25.52 ± 7.28) mg/(kg ⋅ d) and the valley point concentration of MHD was 7.00 (4.95, 10.50) mg/L, and 89 cases (80.91%) < 12 mg/L. A linear relationship between MHD valley point concentration and OXC dose (r = 0.337, P = 0.000) was shown by Spearman rank correlation analysis. The dosage of OXC for older ( > 7 years) children was significantly lower than that of younger (≼ 7 years) children [(23.13 ± 5.56) mg/(kg ⋅ d) vs. (28.09 ± 8.06) mg/(kg ⋅ d); t = 3.778, P = 0.000], while there was no significant difference between the concentration of children with different sexes (t = 1.067, P = 0.288), between children with and without drug resistant epilepsy (DRE; t = 1.417, P = 0.159) and between monotherapy and combination drug therapy (t = 1.671, P = 0.098). The MHD valley point concentration in DRE group was lower than that of non-DRE group [6.32 (3.05, 8.58) mg/L vs. 8.30 (5.75, 10.85) mg/L; Z = 2.380, P = 0.017], while there was no significant difference between the concentration of children with different sexes (Z = 0.604, P = 0.546), between older and younger children (Z = 0.179, P = 0.858) and between monotherapy and combination drug therapy (Z = 1.583, P = 0.113). Conclusions There is a linear relationship between MHD steady state valley point concentration and the dose of OXC. To achieve the same MHD level, the younger children need to take a larger dose of OXC. When OXC is used to treat drug resistant focal epilepsy in children, the dosage should be adjusted according to the monitoring of blood concentration of MHD. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

49. Clinical phenotype, gene mutation and application of targeted next generation sequencing in patients with early-onset epileptic encephalopathy.

Author

LIU Xiao-jun, ZHANG Pei-yuan, LEI Mei-fang, WEI Xin-ping, YU Xiao-li, LI Dong, SHU Jian-bo, CAI Chun-quan, and ZHANG Yu-qin

Subjects
DIAGNOSIS of epilepsy, GENETICS of epilepsy, METABOLIC disorder diagnosis, AGE factors in disease, ANTICONVULSANTS, BIOTIN, EPILEPSY, GENETIC mutation, VITAMIN B1, VITAMIN B6, PHENOTYPES, SEQUENCE analysis
Abstract

Objective To study the clinical features and gene mutations of early - onset epileptic encephalopathy (EOEE) and to explore the application in pathogenic diagnosis of EOEE by next generation sequencing. Methods The clinical data of 68 cases diagnosed with unexplained EOEE between June 2014 and December 2017 were obtained and analyzed. Specimens were collected from the selected children and their parents. Next generation sequencing was used to detect epilepsy - related genes, and Sanger sequencing was performed to verify the results and confirm the source of parents, further to identify suspected pathogenic mutations of EOEE. Results Among 68 cases with EOEE, 18 cases (26.47%) were detected with epilepsy - related genes. One was diagnosed as pyridoxine dependent epilepsy (PDE), which was caused by ALDH7A1 mutation. One was diagnosed as thiamine metabolism dysfunction syndrome 2 (THMD2), which was caused by SLC19A3 mutation. Among 13 cases of epilepsy syndrome, 6 cases were diagnosed as Dravet's syndrome (DS), 5 caused by SCN1A missense mutation and one by SCN1A nonsense mutation; 4 cases were diagnosed as infantile spasm (IS), one caused by TSC1 nonsense mutation but the pathogenicity cannot be identified while pathogenic mutations were not detected in other 3 cases; 2 cases were diagnosed as Ohtahara's syndrome (OS), one caused by STXBP1 missense mutation and pathogenic mutation was not found in the other; one case of malignant migrating partial seizures in infancy (MMPEI) was not found the pathogenic mutations. Among 53 cases with non - specific EOEE, suspected pathogenic mutations were detected in 9 cases: one case of SCN8A missense mutation, one case of KCNQ2 missense mutation, one case of KCNH5 missense mutation, one case of CACNA1A missense mutation, 2 cases of CDKL5 nonsense mutation, one case of CDKL5 frame - shift mutation, one case of PCDH19 nonsense mutation and one case of GRIN2A missense mutation. All cases were treated by 2 and more antiepileptic drugs (AEDs), one case of PDE was given vitamin B6 20 mg/(kg ⋅ d), and one case of THMD2 was given vitamin B1 25 mg/(kg⋅d) and biotin 2 mg/(kg⋅d). After followed by 6 months to 8 years, 15 cases (22.06%) were seizure free, 21 cases (30.88%) were part of control and 32 cases (47.06%) were out of control. Conclusions The clinical phenotypes of children with unexplained EOEE are varied. One case was diagnosed as PDE and one as THMD2 after gene sequencing. After treated by etiological treatment, patients with remediable genetic disease were seizure free. Some gene sites were denovo mutations which have not been reported such as missense mutation for SCN1A, STXBP1, KCNH5, CACNA1A, frame - shift mutation for CDKL5, and nonsense mutation for PCDH19, which enriched the mutation spectrum of EOEE. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results