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Additional file 1 Figure S1. HPLC-DAD analysis of crude extracts of SYP-A7257 cultured in SYM1 medium. Extracts were analyzed using Agilent 1260 series (Agilent Technologies, USA) with a Diode Array Detector (DAD) (200–600 nm) and a C18 RP-column (Platisil ODS-C18 5 μm, 4.6 × 250 mm), with a gradient from 10% acetonitrile in water to 100% acetonitrile over 60 min., 1.0 ml/min as the flow rate. Figure S2. TIC chromatogram of the extract of strain SYP-A 7257 and MS spectra of peaks F1–F6 obtained by HPLC–HRESIMS in positive mode. Figure S3. HR-ESI-MS in positive-ion mode and UV/vis characteristics of compound F1. Figure S4. HR-ESI-MS in positive-ion mode and UV/vis characteristics of compound F2. Figure S5. HR-ESI-MS in positive-ion mode and UV/vis characteristics of compound F3. Figure S6. HR-ESI-MS in positive-ion mode and UV/vis characteristics of compound F4. Figure S7. HR-ESI-MS in positive-ion mode and UV/vis characteristics of compound F5. Figure S8. HR-ESI-MS in positive-ion mode and UV/vis characteristics of compound F6. Figure S9. ESI-MS in positive and negative-ion mode of compound F1. Figure S10.1H NMR spectrum of compound F1 in CDCl3 recorded at 600 MHz. Figure S11.13C NMR spectrum of compound F1 in CDCl3 recorded at 150 MHz. Figure S12. ESI-MS in positive and negative-ion mode of compound F2. Figure S13.1H NMR spectrum of compound F2 in CD3OD recorded at 600 MHz. Figure S14.13C NMR spectrum of compound F2 in CD3OD recorded at 150 MHz. Figure S15. ESI-MS in negative-ion mode of compound F7. Figure S16.1H NMR spectrum of compound F7 in CD3OD recorded at 600 MHz. Figure S17.13C NMR spectrum of compound F7 in CD3OD recorded at 150 MHz. Figure S18. ESI-MS in positive-ion mode of compound F8. Figure S19.1H NMR spectrum of compound F8 in CD3OD recorded at 600 MHz. Figure S20.13C NMR spectrum of compound F8 in CD3OD recorded at 150 MHz. Table S1. Characteristics of rhizospheric soil samples of P. notoginseng in the Wenshan region of Yunnan Province, China. Table S2. PCR primers used in this study. Table S3.Streptomyces isolated from different soil of P. notoginseng with similarity values of 16S rRNA gene sequences to the closest cultivated species. Table S4. KS domain and NRPS amino acid sequences of the soil-derived Streptomyces isolates from the rhizospheric soil of P. notoginseng. Table S5. NMR Data for compound F1 (600 MHz) in CDCl3 (δ in ppm, J in Hz). Table S6. NMR Data for compound F2 (600 MHz) in CD3OD (δ in ppm, J in Hz). Table S7. NMR Data for compound F7and F8 (600 MHz) in CD3OD (δ in ppm, J in Hz).