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16. e0470 Ultrasound guided thrombin injection for the treatment of iatrogenic postcatheterisation pseudoaneurysms in 76 cases

Author

Zhang Zhenghai, Guo Jincheng, Wang Guozhong, Xu Min, Zhang Linxin, and Ma Changsheng

Subjects
medicine.medical_specialty, Aspirin, Interventional cardiology, medicine.drug_class, business.industry, medicine.medical_treatment, Ultrasound, Low molecular weight heparin, Embolectomy, medicine.disease, Clopidogrel, Thrombosis, Surgery, medicine, Radiology, Thrombus, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Ultrasound-Guided Thrombin Injection For The Treatment Of Iatrogenic Post-Catheterisation Pseudoaneurysms In 76 Cases Objective The purpose of this study was to evaluate the safety and efficacy of ultrasound-guided thrombin injection (UGTI) for the treatment of iatrogenic post-catheterisation pseudoaneurysms (PSAs). Methods A total of 76 patients (36 men, 40 women, 63.4±10.8 years) with iatrogenic PSAs were treated by UGTI. Results The mean diameter of the aneurysms was (3.01±1.27)×(1.65±0.67) cm, 93.4% (71/76) of the patients were under antiplatelet therapy with aspirin or clopidogrel or both, and additional low molecular weight heparin. The mean dose of bovine thrombin was 619±259 (150∼1400) u, single injection was primary successful in 69 patients, of which thrombus formation occurred in 1 patient in the superficial femoral artery after successful closure of the PSA, surgical embolectomy was performed. A second injection was required in 2 of the remaining 7 patients. 5 patients were treated by ultrasound-guided compression because of incomplete thrombosis after UGTI. 1 patient had acute allergy after 2 min of thrombin injection which was resolved by antiallergic therapy. The total success rate was 98.7%(75/76). reperfusion was detected in 4 patients within 72 h follow-up, recurrence rate of UGTI for PSAs was 5.3% (4/75), 3 patients were successfully managed by a second thrombin injection and another was treated with ultrasuound-guidance compression, there is no recurrence at 30days clinical follow up. ultrasound follow-up. At the 2 months were performed in 15 patients. The size of PSAs were significantly reduced from (2.90±1.17), (1.47±0.54) cm to (0.94±0.72)´(0.44±0.35) cm (p Conclusion UGTI is a safe, rapid, well-tolerated and effective noninvasive method for the treatment of iatrogenic PSAs and should be considered as first-line therapy.

Published
2010

18. Effects of respiratory disease on Kele piglets lung microbiome, assessed through 16S rRNA sequencing.

Author

Zhang J, Shi K, Wang J, Zhang X, Zhao C, Du C, and Zhang L

Abstract

Background and Aim: Due to the incomplete development of the immune system in immature piglets, the respiratory tract is susceptible to invasion by numerous pathogens that cause a range of potential respiratory diseases. However, few studies have reported the changes in pig lung microorganisms during respiratory infection. Therefore, we aimed to explore the differences in lung environmental microorganisms between healthy piglets and piglets with respiratory diseases., Materials and Methods: Histopathological changes in lung sections were observed in both diseased and healthy pigs. Changes in the composition and abundance of microbiomes in alveolar lavage fluid from eleven 4-week-old Chinese Kele piglets (three clinically healthy and eight diseased) were studied by IonS5™ XL sequencing of the bacterial16S rRNA genes., Results: Histopathological sections showed that diseased pigs displayed more lung lesions than healthy pigs. Diseased piglets harbored lower bacterial operational taxonomic units, α-diversity, and bacterial community complexity in comparison to healthy piglets. Taxonomic composition analysis showed that in the diseased piglets, the majority of flora was composed of Ureaplasma , Mycoplasma , and Actinobacillus ; while Actinobacillus , Sphingomonas , and Stenotrophomonas were dominant in the control group. The abundance of Ureaplasma was significantly higher in ill piglets (p<0.05), and the phylogenetic tree indicated that Ureaplasma was clustered in Ureaplasma diversum , a conditional pathogen that has the potential to affect the swine respiratory system., Conclusion: The results of this study show that the microbial species and structure of piglets' lungs were changed during respiratory tract infection. The finding of Ureaplasma suggested that besides known pathogens such as Mycoplasma and Actinobacillus , unknown pathogens can exist in the respiratory system of diseased pigs and provide a potential basis for clinical treatment., (Copyright: © Zhang, et al.)

Published
2020
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