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Organosulfur-based polymers have unique properties that make them useful for targeted and managed drug delivery, which can improve therapy while reducing side effects. This work aims to provide a brief review of the synthesis strategies, characterization techniques, and packages of organosulfur-based polymers in drug delivery. More importantly, this work discusses the characterization, biocompatibility, controlled release, nanotechnology, and targeted therapeutic aspects of these important structural units. This review provides not only a good comprehension of organosulfur-based polymers but also an insightful discussion of potential future prospectives in research. The discovery of novel organosulfur polymers and innovations is highly expected to be stimulated in order to synthesize polymer prototypes with increased functional accuracy, efficiency, and low cost for many industrial applications. [ABSTRACT FROM AUTHOR]

Background: Cervical cancer is an important global health problem. In this study we aimed to analyze trends in cervical cancer at the global, regional, and national levels from 1990 to 2019, to inform health service decision-making.Methods: Data on cervical cancer was extracted from the Global Burden of Disease study, 2019. Trends in cervical cancer burden were assessed based on estimated annual percentage change (EAPC) and age-standardized rate (ASR).Results: Globally, decreasing trends were observed in incidence, death, and disability adjusted life years (DALYs) of cervical cancer from 1990 to 2019, with respective EAPCs of - 0.38 (95% confidence interval [CI]: - 0.41 to - 0.34), - 0.93 (95%CI: - 0.98 to - 0.88), and - 0.95 (95 CI%: - 1.00 to - 0.90). Meanwhile, decreasing trends were detected in most sociodemographic index (SDI) areas and geographic regions, particularly death and DALYs in Central Latin America, with respective EAPCs of - 2.61 (95% CI: - 2.76 to - 2.46) and - 2.48 (95% CI: - 2.63 to - 2.32); hhowever, a pronounced increasing trend in incidence occurred in East Asia (EAPC = 1.33; 95% CI: 1.12 to 1.55). At the national level, decreasing trends in cervical cancer were observed in most countries/territories, particularly DALYs in the Maldives (EAPC = - 5.06; 95% CI: - 5.40 to - 4.72), Whereas increasing trends were detected in Lesotho, Zimbabwe, and Bulgaria.Conclusions: Slowly decreasing trends in cervical cancer were detected worldwide from 1990 to 2019. Cervical cancer remains a substantial health problem for women globally, requiring more effective prevention and control strategies. [ABSTRACT FROM AUTHOR]

Samarium (Sm), as one of the lanthanide elements, has a broad application prospect in the synthesis of samarium cobalt permanent magnet materials with high temperature stability, corrosion resistance and oxidation resistance. Due to the unlimited demand of Sm(III), recycling of Sm(III) waste is an effective method to balance economy and supply. In this paper, three novel morpholine carboxylic acid ionic liquids (ILs) were rationally designed and successfully synthesized for the extraction of Sm(III). The effects of alkyl chain length of the ionic liquids, solution acidity, contact time, extractant concentration and temperature were tested in terms of the extraction performances. The results revealed that [(CH 2) 7 COOHmor][NTf 2 ] had the optimal extraction capacity, as well as the extraction efficiency of Sm increased with the increase of pH, reaching >99.9% when the pH was 1.8. In addition, the extraction equilibrium could be achieved within 1 min. Moreover, the slope analysis and FTIR spectral studies proposed a cation exchange extraction mechanism for Sm(III) by [(CH 2) 7 COOHmor][NTf 2 ]. The loaded Sm(III) in organic phase was easy to strip with 0.05 mol/L of HNO 3 , and the [(CH 2) 7 COOHmor][NTf 2 ] remained stable after 5 cycles. The research of transition metal extraction revealed that Sm(III) could be selectively separated from Ni(II) and Co(II) by adjusting the pH value of the solution. Finally, under the optimized extraction conditions, Sm 2 O 3 with 83.9% yield was obtained by the extraction-stripping-precipitation-calcination process, through the large-scale recovery applications of the simulated waste liquid. • The novel carboxyl-functionalized morpholine ionic liquids were designed and fabricated as novel extraction solvents. • The stripping ratios of Sm from ILs reached 99.9% via the back extraction. • The extraction performance of [(CH 2) 7 COOMor][Tf 2 N] maintained stable after 5 cycles. • Via adjusting the initial acidity of the aqueous phase, [(CH 2) 7 COOMor][Tf 2 N] could selectively separate Sm(III) from Co(II). [ABSTRACT FROM AUTHOR]

Sulfoxides and sulfinamides play important roles in the pharmaceutical industry, organic synthesis and fine chemicals. This review will demonstrate that, under catalysis by transition metals, β-sulfinyl esters, as nucleophilic reagents, react with a variety of electrophilic reagents to produce sulfoxides and sulfinamides. The important prospect of the asymmetric catalytic synthesis of chiral sulfur-containing molecules in this field is described. [ABSTRACT FROM AUTHOR]

Sulfoximines, a ubiquitous class of structural motifs, are widely present in bioactive molecules and functional materials that have received considerable attention from modern organic chemistry, pharmaceutical industries, and materials science. Sulfoximines have proved to be an effective directing group for C–H functionalization which was widely investigated for the synthesis of cyclic sulfoximines. Within the last decade, great progress has been achieved in the synthesis of cyclic sulfoximines. Thus, this review highlights the recent advances in the synthesis of cyclic sulfoximines via the C–H activation strategy and is classified based on the substrate types. [ABSTRACT FROM AUTHOR]

Pedunculated hepatocellular carcinoma (P‑HCC) is a rare type of HCC, defined as a carcinoma protruding from the liver with or without a pedicle with a low degree of liver invasion. The present study aimed to evaluate the characteristics of blood supply of P‑HCC prior to and following transcatheter arterial chemoembolization (TACE) treatment. Angiographic findings prior to and following TACE treatment in 39 patients with P‑HCC were analyzed retrospectively. Angiography performed at the first TACE session revealed 70 tumor‑feeding arteries collectively in all patients, including 31/70 (44.0%) extrahepatic parasitic arteries in 23/39 patients (59.0%). The intrahepatic arteries served as the main blood supply to P‑HCC in all patients. Extrahepatic collateral blood supplies to P‑HCCs were significantly associated with larger tumor diameter (χ2=164.000, P<0.001), but not tumor location (χ2=7.358, P=0.061). Following repeated TACE treatment, all angiographies revealed a total of 131 tumor feeding arteries collectively in all patients, including intrahepatic arteries (54/131) and extrahepatic collateral arteries (78/131) in 31 patients (79.5%). Compared with angiographies performed at the initial TACE treatment, these results also demonstrated an increase in the number of extrahepatic collateral arteries, which produced 47 new blood vessels (χ2=4.278, P=0.039). P‑HCC tumor lesions readily acquired a parasitic blood supply from adjacent vessels following repeated TACE. Intrahepatic arteries functioned as the main blood supply for P‑HCC, whereas extrahepatic collateral arteries were complementary to P‑HCC, regardless of whether the patient was pre‑ or post‑TACE. Extrahepatic collateral supplies to P‑HCCs that originated from adjacent vessels were rich, were closely associated with tumor size, and were prone to be newly established following repeated TACE. [ABSTRACT FROM AUTHOR]

Highly efficient adsorbents, which can effectively remove both metal ions and dyes from wastewater with robust stability, are strongly required for the remediation of current polluted aqueous system, but still a challenge to be realized. Herein, a new adsorbent has been designed to solve this problem by anchoring diethylene triamine pentaacetic acid (DTPA) grafted polyethyleneimine (PEI) onto carboxylated GO (GOC-g-PD). Given the amino and carboxyl active groups from PEI and GOC/DTPA, our GOC-g-PD displays good adsorption capacity against not only inorganic metal ions (Cu2+ and Pb2+) but also organic dye (methylene blue: MB). The maximum adsorption capacity of GOC-g-PD for Cu2+, Pb2+ and MB reached 309.60 mg·g−1, 316.17 mg·g−1 and 262.10 mg·g−1, respectively. Furthermore, our GOC-g-PD also exhibits good cycling stability and chemical stability against wide pH values. These outstanding properties revealed our GOC-g-PD held great potential in purifying the sewage discharged from industries. [ABSTRACT FROM AUTHOR]