20 results on '"Zeng, Deng"'
Search Results
2. The research on FBW7 gene enhances antitumor effect of paclitaxel on pancreatic cancer through GSDME-mediated pyroptosis
- Author
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JIA Yuming, YE Zeng, DENG Yanli, LI Shengchao, ZHANG Zhilei, WANG Chao, XU Xiaowu, QIN Yi, PENG Li
- Subjects
pancreatic cancer ,fbw7 ,gsdme ,pyroptosis ,sensitivity ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: Pancreatic cancer is a highly malignant disease. Most patients are in advanced stage upon diagnosis. Systemic chemotherapy is an important treatment method, but the chemotherapy drug resistance to tumors brings many problems to clinical treatment. As a commonly used chemotherapy drug, paclitaxel can induce apoptosis in tumor cells. The FBW7 gene is a tumor suppressor gene, and the loss of its function can lead to tumor occurrence and progression. Research has shown that it has the effect of promoting tumor cell apoptosis and inhibiting tumor proliferation. In addition, this gene has been proven to promote apoptosis and ferroptosis, which increase the effect of chemotherapy drugs. Pyroptosis is a programmed cell death mode mediated by gasdermin (GSDM) protein, and this cell death is often accompanied by inflammatory reactions. This study aimed to investigate whether FBW7 gene can promote the anti-tumor effect of paclitaxel by increasing pyroptosis. Methods: A PANC-1 cell line overexpressing FBW7 was constructed using lentivirus transfection. The correlation between FBW7 and GSDME gene expressions was detected by immunohistochemistry in clinical samples, and the expression levels of mRNA and protein were detected by real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR) and Western blot. We observed the morphological changes of cells treated with paclitaxel under light microscopy. Cell counting kit-8 (CCK-8) was used to detect the effect of paclitaxel on cell viability, and flow cytometry and lactate dehydrogenase (LDH) release assay were performed to detect the effect of paclitaxel on cell death. Western blot was used to detect caspase-3 and GSDME activation after paclitaxel treatment. Results: RTFQ-PCR and Western blot experiments showed that overexpression of FBW7 gene increased the expression of GSDME. Immunohistochemical staining of pathological sections of clinical patients also showed that the expressions of FBW7 and GSDME genes was positively correlated in vivo. Flow cytometry and LDH release experiments showed that the level of cell death in pancreatic cancer cell line PANC-1 overexpressing FBW7 was significantly increased compared with its empty vector (EV) cells after being treated with paclitaxel. Under light microscopy, it was observed that the number of cells with pyroptosis was significantly higher in PANC-1 cell lines overexpressing FBW7 than in EV cells. The CCK-8 experiment results showed that the cell viability was significantly lower in FBW7 overexpressed cell lines than in EV cells after paclitaxel treatment. Western blot experiment results showed that after pancreatic cancer cell line PANC-1 was treated with paclitaxel, the protein expressions of active-caspase-3 and GSDME-NT in FBW7 overexpression cell lines increased, which proved that they had more obvious activation, indicating that the FBW7 gene can increase the sensitivity of PANC-1 cells to paclitaxel through caspase-3/GSDME signaling pathway induced cell pyroptosis. Conclusion: FBW7 can increase the sensitivity of pancreatic cancer cells to paclitaxel by increasing the expression of GSDME, which is realized through caspase-3/GSDME pathway.
- Published
- 2023
- Full Text
- View/download PDF
3. Land subsidence prediction in Beijing based on PS-InSAR technique and improved Grey-Markov model
- Author
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Zeng Deng, Yinghai Ke, Huili Gong, Xiaojuan Li, and Zhenhong Li
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land subsidence ,insar ,grey-markov model ,k-means ,Mathematical geography. Cartography ,GA1-1776 ,Environmental sciences ,GE1-350 - Abstract
Land subsidence induced by excessive groundwater withdrawal has caused serious social, geological, and environmental problems in Beijing. Rapid increases in population and economic development have aggravated the situation. Monitoring and prediction of ground settlement is important to mitigate these hazards. In this study, we combined persistent-scatterer interferometric synthetic aperture radar with Grey system theory to monitor and predict land subsidence in the Beijing plain. Land subsidence during 2003–2014 was determined based on 39 ENVISAT advanced synthetic aperture radar (ASAR) images and 27 RadarSat-2 images. Results were consistent with global positioning system, leveling measurements at the point level and TerraSAR-X subsidence maps at the regional level. The average deformation rate in the line-of-sight was from −124 to 7 mm/year. To predict future subsidence, the time-series deformation was used to build a prediction model based on an improved Grey-Markov model (IGMM), which adapted the conventional GM(1,1) model by utilizing rolling mechanism and integrating a k-means clustering method in Markov-chain state interval partitioning. Evaluation of the IGMM at both point level and regional scale showed good accuracy (root-mean-square error
- Published
- 2017
- Full Text
- View/download PDF
4. Subduction Evolution Controlled Himalayan Orogenesis: Implications from 3-D Subduction Modeling
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Zhu, Weiling, primary, Ding, Lin, additional, Ji, Yingfeng, additional, Qu, Rui, additional, Zhu, Ye, additional, Xie, Chaodi, additional, and Zeng, Deng, additional
- Published
- 2022
- Full Text
- View/download PDF
5. The rise and demise of the Paleogene Central Tibetan Valley
- Author
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Xiong, Zhongyu, Liu, Xiaohui, Ding, Lin, Farnsworth, Alex, Spicer, Robert A, Xu, Qiang, Valdes, Paul, He, Songlin, Zeng, Deng, Wang, Chao, Li, Zhenyu, Guo, Xudong, Su, Tao, Zhao, Chenyuan, Wang, Houqi, and Yue, Yahui
- Subjects
Multidisciplinary - Abstract
Reconstructing the Paleogene topography and climate of central Tibet informs understanding of collisional tectonic mechanisms and their links to climate and biodiversity. Radiometric dates of volcanic/sedimentary rocks and paleotemperatures based on clumped isotopes within ancient soil carbonate nodules from the Lunpola Basin, part of an east-west trending band of basins in central Tibet and now at 4.7 km, suggest that the basin rose from 4.0 km by 29 Ma. The height change is quantified using the rates at which wet-bulb temperatures ( T w ) decline at land surfaces as those surface rise. In this case, T w fell from ~8°C at ~38 Ma to ~1°C at 29 Ma, suggesting at least ~2.0 km of surface uplift in ~10 Ma under warm Eocene to Oligocene conditions. These results confirm that a Paleogene Central Tibetan Valley transformed to a plateau before the Neogene.
- Published
- 2022
6. Temperature distribution and thermal resistance analysis of high-power laser diode arrays
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Wei Dai, Maoqiong Gong, Jun Shen, Zeng Deng, and Wenchi Gong
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Fluid Flow and Transfer Processes ,Materials science ,Laser diode ,business.industry ,Mechanical Engineering ,Thermal resistance ,Numerical analysis ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Chip ,01 natural sciences ,Temperature measurement ,010305 fluids & plasmas ,law.invention ,Power (physics) ,Temperature gradient ,law ,0103 physical sciences ,Thermal ,Optoelectronics ,0210 nano-technology ,business - Abstract
The accurate temperature measurement of high-power laser diode arrays is a considerable challenge due to their large temperature gradient and package structure. In this study, experiments based on the forward voltage method were set up to measure the transient temperature behavior of chips after the removal of heating load. A hybrid experimental/numerical method was developed to calculate multiple unknown interface thermal resistances and improve the prediction of the temperature distribution of high-power laser diode arrays by analyzing the transient temperature behavior of chips. The largest deviation between numerical and experimental results is 1.3 K. Based on the numerical results, thermal resistances for different layers and temperature distribution inside the chip were obtained and evaluated. Some suggestions for improving the thermal design of high-power laser diode arrays were derived.
- Published
- 2019
7. Evaluating reliance level of a virtual metrology system
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Cheng, Fan-Tien, Chen, Yeh-Tung, Su, Yu-Chuan, and Zeng, Deng-Lin
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Semiconductor production equipment -- Properties ,Reliability (Engineering) -- Research ,Semiconductor production equipment ,Business ,Computers ,Electronics ,Electronics and electrical industries - Abstract
This paper proposes a novel method for evaluating the reliability of a virtual metrology system (VMS). The proposed method calculates a reliance index (RI) value between zero and one by analyzing the process data of production equipment to determine the reliability of the virtual metrology results. This method also defines an RI threshold. If an RI value exceeds the threshold, the conjecture result is reliable; otherwise, the conjecture result needs to be further examined. Besides the RI, the method also proposes process data similarity indexes (SIs). The Sis are defined to assess the degree of similarity between the input set of process data and those historical sets of process data used to establish the conjecture model. The proposed method includes two types of SIs: global similarity index (GSI) and individual similarity index (ISI). Both GSI and ISI are applied to assist the RI in gauging the reliance level and locating the key parameter(s) that cause major deviation, thus resolving the VMS manufacturability problem. An illustrative example involving 300-mm semiconductor foundry etching equipment is presented. Experimental results demonstrate that the proposed method is applicable to the VMS of production equipment (such as that for semiconductor and TFT-LCD). Index Terms--Degree of similarity, global similarity index (GSI), individual similarity index (ISI), manufacturability, reliance index (RI), reliance level, virtual metrology system (VMS).
- Published
- 2008
8. A new flow pattern map for flow boiling of R1234ze(E) in a horizontal tube
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Qinglu Song, Zeng Deng, Maoqiong Gong, Jun Shen, Gaofei Chen, Zhiqiang Yang, and Xiaoru Zhuang
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Fluid Flow and Transfer Processes ,Mass flux ,Materials science ,020209 energy ,Mechanical Engineering ,Shear force ,General Physics and Astronomy ,Thermodynamics ,02 engineering and technology ,Mechanics ,01 natural sciences ,Flow measurement ,010305 fluids & plasmas ,law.invention ,Heat flux ,law ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Flow map ,Saturation (chemistry) ,Heat pump ,Dimensionless quantity - Abstract
Considerable attention has recently been given to the new environment-friendly refrigerant of R1234ze(E) for applications such as heat pump and air-conditioning systems. In this study, an experiment was carried out to investigate two-phase flow patterns and flow transitions for R1234ze(E) in a smooth horizontal tube with an inner diameter of 6 mm. The experiments were performed at conditions covering saturation pressures from 0.215 to 0.415 MPa, mass fluxes from 130 to 258 kg/m2 s and heat fluxes from 10.6 to 74.8 kW/m2. The influences of saturation pressure, mass flux and heat flux on flow pattern transition were analyzed. Six well-known flow maps have been compared with the observed flow patterns of R1234ze(E). The results indicated that none of them can predict all the flow pattern transitions well. Thus, three dimensionless numbers K1, K2 and K3 which represent the ratio of the evaporation momentum force to the inertia force, the evaporation momentum force to the surface tension force, and the shear force to the gravity force respectively were introduced. Based on dimensionless numbers K1, K2, K3 and Xtt, a new flow pattern map for R1234ze(E) was proposed which could accurately predict the experimental data.
- Published
- 2018
9. Slab Dehydration in Sumatra: Implications for Fast and Slow Earthquakes and Arc Magmatism
- Author
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Ji, Yingfeng, primary, Yan, Ruyu, additional, Zeng, Deng, additional, Xie, Chaodi, additional, Zhu, Weiling, additional, Qu, Rui, additional, and Yoshioka, Shoichi, additional
- Published
- 2021
- Full Text
- View/download PDF
10. Land subsidence prediction in Beijing based on PS-InSAR technique and improved Grey-Markov model
- Author
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Zhenhong Li, Huili Gong, Yinghai Ke, Xiaojuan Li, and Zeng Deng
- Subjects
education.field_of_study ,010504 meteorology & atmospheric sciences ,business.industry ,Population ,0211 other engineering and technologies ,Subsidence ,02 engineering and technology ,Markov model ,Geodesy ,01 natural sciences ,Geography ,Beijing ,Advanced synthetic aperture radar ,Interferometric synthetic aperture radar ,Global Positioning System ,General Earth and Planetary Sciences ,education ,business ,Groundwater ,021101 geological & geomatics engineering ,0105 earth and related environmental sciences ,Remote sensing - Abstract
Land subsidence induced by excessive groundwater withdrawal has caused serious social, geological, and environmental problems in Beijing. Rapid increases in population and economic development have aggravated the situation. Monitoring and prediction of ground settlement is important to mitigate these hazards. In this study, we combined persistent-scatterer interferometric synthetic aperture radar with Grey system theory to monitor and predict land subsidence in the Beijing plain. Land subsidence during 2003–2014 was determined based on 39 ENVISAT advanced synthetic aperture radar (ASAR) images and 27 RadarSat-2 images. Results were consistent with global positioning system, leveling measurements at the point level and TerraSAR-X subsidence maps at the regional level. The average deformation rate in the line-of-sight was from −124 to 7 mm/year. To predict future subsidence, the time-series deformation was used to build a prediction model based on an improved Grey-Markov model (IGMM), which adapted the conv...
- Published
- 2017
11. Condensation two-phase flow patterns for zeotropic mixtures of tetrafluoromethane/ethane in a horizontal smooth tube
- Author
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Zeng Deng, Qinglu Song, Maoqiong Gong, Yanxing Zhao, and Jun Shen
- Subjects
Fluid Flow and Transfer Processes ,Mass flux ,Materials science ,Mechanical Engineering ,Condensation ,Zeotropic mixture ,Thermodynamics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,010305 fluids & plasmas ,chemistry.chemical_compound ,chemistry ,Heat flux ,0103 physical sciences ,Tetrafluoromethane ,Two-phase flow ,0210 nano-technology ,Saturation (chemistry) ,Adiabatic process - Abstract
Mixed-refrigerant Joule-Thomson refrigeration (MJTR) systems have distinct advantages in the temperature range from 80 to 230 K. Tetrafluoromethane (R14) and ethane (R170) are essential components of mixed-refrigerants. In this paper, the adiabatic flow pattern map for R14/R170 mixtures was firstly developed based on previous flow pattern data. Then an experimental investigation on condensation two-phase flow patterns for R14/R170 mixtures (0.193/0.0.807, 0.437/0.563, 0.632/0.368 and 0.799/0.201 by mole) in a horizontal smooth tube with inner diameter of 4 mm was presented. Experiments were carried out at mass fluxes from 100 to 350 kg m−2s−1, saturation pressures from 1.5 to 2.5 MPa and heat fluxes from 8.4 to 42.2 kW m−2 over the entire range of vapor quality. The effects of mass flux, saturation pressure, heat flux and concentration on flow pattern evolutions were discussed and presented. Analysis results indicated that mass transfer resistance and heat flux account for the nonequilibrium effects of zeotropic mixture condensation, which leads to the different evolutionary trends between condensation and adiabatic two-phase flow. Finally, a new condensation flow pattern map was deduced by containing nonequilibrium effects into adiabatic flow pattern map.
- Published
- 2020
12. Thermal-hydraulic performance enhancement analysis of microtube with superhydrophobic surfaces
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Wenchi Gong, Jun Shen, Zeng Deng, Wei Dai, and Maoqiong Gong
- Subjects
Fluid Flow and Transfer Processes ,Pressure drop ,Materials science ,Mechanical Engineering ,Drop (liquid) ,Laminar flow ,02 engineering and technology ,Mechanics ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,010305 fluids & plasmas ,Volumetric flow rate ,Thermal hydraulics ,0103 physical sciences ,Thermal ,Heat transfer ,Fluid dynamics ,0210 nano-technology - Abstract
Microchannels have an excellent thermal performance but they acquire a large pressure drop. Recent studies show that microchannels with superhydrophobic surfaces may provide an innovative approach to achieve a balance between thermal and hydraulic performances. In this work, the fluid flow and heat transfer in microtube with superhydrophobic surfaces are analyzed at fully developed laminar flow, and the formulas of fRe and Nu are obtained. Comparisons of thermal resistances on superhydrophobic and smooth microtubes are performed at identical flow rate, pressure drop and pumping power, respectively. At indentical flow rate, superhydrophobic surface can’t enhance the thermal-hydraulic performance. At identical pressure drop or pumping power, the critical pressure drop and pumping power exist respertively, which is the boundary point of the thermal-hydraulic performance between superhydrophobic and smooth microtubes. The critical parameters are deduced to help determining whether superhydrophobic surfaces enhance thermal-hydraulic performance.
- Published
- 2019
13. Synergistic myoprotection of L-arginine and adenosine in a canine model of global myocardial ischaemic reperfusion injury
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Shuo-zeng Deng, Lei Du, Wei Wang, Ping-Liang Yang, Ke Dian, Meng-Xing Jia, Hui-Jiao Chen, Jin Liu, and Qi An
- Subjects
Inotrope ,Male ,Adenosine ,Cardiotonic Agents ,Arginine ,Ischemia ,Hemodynamics ,Myocardial Reperfusion Injury ,Pharmacology ,Nitric oxide ,chemistry.chemical_compound ,Adenosine Triphosphate ,Dogs ,Medicine ,Animals ,Peroxidase ,biology ,business.industry ,Myocardium ,Drug Synergism ,General Medicine ,medicine.disease ,Disease Models, Animal ,chemistry ,Myeloperoxidase ,Anesthesia ,biology.protein ,Heart Arrest, Induced ,Female ,business ,Energy Metabolism ,Adenosine triphosphate ,medicine.drug - Abstract
BACKGROUND Endogenous nitric oxide and adenosine increase simultaneously to keep the balance of energy demand and supply when the oxygen supply is insufficient, which suggests that nitric oxide and adenosine might exert a synergistic myoprotection during tissue hypoxia. In this study, we tested this hypothesis utilizing a canine model of prolonged global myocardial ischaemic reperfusion injury. METHODS In this double blind, controlled study, the hearts of 24 anaesthetized mongrel dogs were arrested for 2 hours with aortic cross clamping and blood cardioplegia. The treatment groups were those supplemented with 2 mmol/L L-arginine (ARG), supplemented with 1 mmol/L adenosine (ADO), ARG + ADO supplemented with both, and no supplementation (control) (n = 6 in each group). Haemodynamics, biochemical indices, adenosine triphosphate (ATP) content and myeloperoxidase activities of myocardium were determined to evaluate myocardial injury. Statistical comparison was performed by two way ANOVA. RESULTS Although the requirements for inotropic supports were higher, the cardiac outputs were lower in control group than in ARG, ADO and the combination groups. Plasma cardiac troponin I levels were higher and the areas of hydropic changes were larger in control group than in ARG and ADO groups. Combination of arginine and adenosine provided further myoprotection with respect to better cardiac performance, lower release of cardiac troponin I, and smaller areas of hydropic changes compared with ARG and ADO groups. ATP content was higher, but myeloperoxidase activities of myocardium were significantly lower in the combination group than in control, ARG and ADO groups (P < 0.05). CONCLUSIONS Combination of L-arginine and adenosine provides synergistic myoprotection in a canine model of global myocardial ischaemia. Thus, the combination is recommended when the heart is exposed to a prolonged ischaemia during cardiac surgery.
- Published
- 2007
14. [Perioperative protection of blood]
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Shuo-zeng, Deng and Jin, Liu
- Subjects
Blood Loss, Surgical ,Humans ,Blood Transfusion ,Postoperative Hemorrhage ,Perioperative Care - Published
- 2007
15. Fiber nonlinearity tolerance research of coherent optical orthogonal frequency division multiplexed system based on digital coherent superposition
- Author
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Yang He-Ming, Yi Xingwen, Zeng Deng-Ke, Chen Xue-Mei, Qiu Kun, and Zhang Jing
- Subjects
Physics ,Superposition principle ,Fiber nonlinearity ,Frequency division multiplexed ,Optics ,business.industry ,General Physics and Astronomy ,business ,Computer Science::Information Theory - Abstract
Fiber nonlinearity of optical orthogonal frequency division multiplexed (OFDM) system restricts the capacity improvement of optical fiber transmission. In this paper, we propose a novel digital coherent superposition (DCS) scheme to improve the tolerance to fiber nonlinearity in a coherent optical orthogonal frequency division multiplexed system. In simulation, 71.53 Gbit/s orthogonal frequency division multiplexed signal per channel with Hermitian symmetry is transmitted over 400 km standard single mode fiber in a wave division multiplexed-polarization-division multiplexed-coherent optical orthogonal frequency division multiplexed system with five channels. The 4-quadrature amplitude modulation is used for symbol mapping. For the receiver, after the conventional OFDM signal processing, we conduct DCS for OFDM subcarrier pairs, which requires only conjugation and summation in the x, y polarization direction, respectively. Firstly, the channel spacing is 25 GHz, the maximum signal-to-noise ratio improvement is 9.05 dB or 6.02 dB with or without symmetric dispersion compensation compared with a conventional orthogonal frequency division multiplexed system. The optimum launch power is increased by 2 dB. Secondly, the channel spacing is changed to 50 GHz to investigate the nonlinearity tolerance at different channel spacings in the wave division multiplexed system, the maximum signal-to-noise ratio improvement is 8.75 dB or 4.9 dB with or without symmetric dispersion compensation, respectively. Theoretical and simulation analysis show that the proposed method in this paper can effectively mitigate the first-order nonlinear distortions and hence improve the tolerance of coherent optical orthogonal frequency division multiplexed system with different channel spacings to fiber nonlinear effects.
- Published
- 2015
16. Polyethylene Glycol Electrolyte Lavage Solution versus Colonic Hydrotherapy for Bowel Preparation before Colonoscopy: A Single Center, Randomized, and Controlled Study
- Author
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Cao, Yan, primary, Zhang, Kai-Yuan, additional, Li, Jiao, additional, Lu, Hao, additional, Xie, Wan-Ling, additional, Liao, Sheng-Tao, additional, Chen, Dong-Feng, additional, Zeng, Deng-Feng, additional, and Lan, Chun-Hui, additional
- Published
- 2014
- Full Text
- View/download PDF
17. The rise and demise of the Paleogene Central Tibetan Valley
- Author
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Xiong, Zhongyu, Liu, Xiaohui, Ding, Lin, Farnsworth, Alex, Spicer, Robert A, Xu, Qiang, Valdes, Paul, He, Songlin, Zeng, Deng, Wang, Chao, Li, Zhenyu, Guo, Xudong, Su, Tao, Zhao, Chenyuan, Wang, Houqi, Yue, Yahui, Xiong, Zhongyu, Liu, Xiaohui, Ding, Lin, Farnsworth, Alex, Spicer, Robert A, Xu, Qiang, Valdes, Paul, He, Songlin, Zeng, Deng, Wang, Chao, Li, Zhenyu, Guo, Xudong, Su, Tao, Zhao, Chenyuan, Wang, Houqi, and Yue, Yahui
- Abstract
Reconstructing the Paleogene topography and climate of central Tibet informs understanding of collisional tectonic mechanisms and their links to climate and biodiversity. Radiometric dates of volcanic/sedimentary rocks and paleotemperatures based on clumped isotopes within ancient soil carbonate nodules from the Lunpola Basin, part of an east-west trending band of basins in central Tibet and now at 4.7 km, suggest that the basin rose from <2.0 km at 50 to 38 million years (Ma) to >4.0 km by 29 Ma. The height change is quantified using the rates at which wet-bulb temperatures ( ) decline at land surfaces as those surface rise. In this case, fell from ~8°C at ~38 Ma to ~1°C at 29 Ma, suggesting at least ~2.0 km of surface uplift in ~10 Ma under warm Eocene to Oligocene conditions. These results confirm that a Paleogene Central Tibetan Valley transformed to a plateau before the Neogene.
18. The late Eocene rise of SE Tibet formed an Asian ‘Mediterranean’ climate
- Author
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Zhao, Chenyuan, Xiong, Zhongyu, Farnsworth, Alex, Spicer, Robert A., He, Songlin, Wang, Chao, Zeng, Deng, Cai, Fulong, Wang, Houqi, Tian, Xiaolong, Valdes, Paul J., Lamu, Ciren, Xie, Jing, Yue, Yahui, Ding, Lin, Zhao, Chenyuan, Xiong, Zhongyu, Farnsworth, Alex, Spicer, Robert A., He, Songlin, Wang, Chao, Zeng, Deng, Cai, Fulong, Wang, Houqi, Tian, Xiaolong, Valdes, Paul J., Lamu, Ciren, Xie, Jing, Yue, Yahui, and Ding, Lin
- Abstract
Southeastern (SE) Tibet forms the transition zone between the high interior Tibetan Plateau and the lowlands of southwest China. So understanding the elevation history of SE Tibet, a biodiversity hotspot, enlightens our understanding of the interactions between tectonics, monsoon dynamics and biodiversity. Here we reconstruct the uplift history of the Markam Basin, SE Tibet, during the middle−late Eocene based on U − Pb dating, plant fossil assemblages, and stable and clumped isotope analyses. Our results suggest that the floor of the Markam Basin was at an elevation of 2.6 ± 0.9 km between 42 Ma and 39 Ma, where the mean annual air temperature (MAAT) was 13.2 ± 2.4 °C. The basin then rose rapidly to 3.8 (+0.6/−0.8) km before 36 Ma. Integrated with existing paleoelevation data, we propose that the high plateau boundary (∼3.0 km) of SE Tibet formed during the late Eocene. Numerical climate modeling with realistic paleo-landscapes shows that with the rise of SE Tibet, a Mediterranean-like climate developed in the region characterized by bi-modal precipitation with two wet seasons in boreal spring and autumn. The high topographic relief of SE Tibet, coupled with this distinctive Mediterranean-like climate system, helped develop the high biodiversity of the Hengduan Mountains.
19. A distinctive Eocene Asian monsoon and modern biodiversity resulted from the rise of eastern Tibet
- Author
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He, Songlin, Ding, Lin, Xiong, Zhongyu, Spicer, Robert A., Farnsworth, Alex, Valdes, Paul J., Wang, Chao, Cai, Fulong, Wang, Houqi, Sun, Yong, Zeng, Deng, Xie, Jing, Yue, Yahui, Zhao, Chenyuan, Song, Peiping, Wu, Chen, He, Songlin, Ding, Lin, Xiong, Zhongyu, Spicer, Robert A., Farnsworth, Alex, Valdes, Paul J., Wang, Chao, Cai, Fulong, Wang, Houqi, Sun, Yong, Zeng, Deng, Xie, Jing, Yue, Yahui, Zhao, Chenyuan, Song, Peiping, and Wu, Chen
- Abstract
The uplift of eastern Tibet, Asian monsoon development and the evolution of globally significant Asian biodiversity are all linked, but in obscure ways. Sedimentology, geochronology, clumped isotope thermometry, and fossil leaf-derived numerical climate data from the Relu Basin, eastern Tibet, show at ∼50–45 Ma the basin was a hot (mean annual air temperature, MAAT, ∼27 °C) dry desert at low-elevation of 0.6 ± 0.6 km. Rapid basin rise to 2.0 ± 0.9 km at 45–42 Ma and to 2.9 ± 0.9 km at 42–40 Ma, with MAATs of ∼20 and ∼16 °C, respectively, accompanied seasonally varying increased annual precipitation to >1500 mm. From ∼39 to 34 Ma, the basin attained 3.5 ± 1.0 km, near its present-day elevation (∼3.7 km), and MAAT cooled to ∼6 °C. Numerically-modelled Asian monsoon strength increased significantly when this Eocene uplift of eastern Tibet was incorporated. The simulation/proxy congruence points to a distinctive Eocene Asian monsoon, quite unlike that seen today, in that it featured bimodal precipitation and a winter-wet regime, and this enhanced biodiversity modernisation across eastern Asia. The Paleogene biodiversity of Asia evolved under a continually modifying monsoon influence, with the modern Asian monsoon system being unique to the present and a product of a long gradual development in the context of an ever-changing Earth system.
20. The rise and demise of the Paleogene Central Tibetan Valley
- Author
-
Xiong, Zhongyu, Liu, Xiaohui, Ding, Lin, Farnsworth, Alex, Spicer, Robert A, Xu, Qiang, Valdes, Paul, He, Songlin, Zeng, Deng, Wang, Chao, Li, Zhenyu, Guo, Xudong, Su, Tao, Zhao, Chenyuan, Wang, Houqi, Yue, Yahui, Xiong, Zhongyu, Liu, Xiaohui, Ding, Lin, Farnsworth, Alex, Spicer, Robert A, Xu, Qiang, Valdes, Paul, He, Songlin, Zeng, Deng, Wang, Chao, Li, Zhenyu, Guo, Xudong, Su, Tao, Zhao, Chenyuan, Wang, Houqi, and Yue, Yahui
- Abstract
Reconstructing the Paleogene topography and climate of central Tibet informs understanding of collisional tectonic mechanisms and their links to climate and biodiversity. Radiometric dates of volcanic/sedimentary rocks and paleotemperatures based on clumped isotopes within ancient soil carbonate nodules from the Lunpola Basin, part of an east-west trending band of basins in central Tibet and now at 4.7 km, suggest that the basin rose from <2.0 km at 50 to 38 million years (Ma) to >4.0 km by 29 Ma. The height change is quantified using the rates at which wet-bulb temperatures ( ) decline at land surfaces as those surface rise. In this case, fell from ~8°C at ~38 Ma to ~1°C at 29 Ma, suggesting at least ~2.0 km of surface uplift in ~10 Ma under warm Eocene to Oligocene conditions. These results confirm that a Paleogene Central Tibetan Valley transformed to a plateau before the Neogene.
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