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1. Clinical Features and Management of the Disease Caused by New Coronaviral Infection (COVID-19) in Children. Version 2

Author

Yurii S. Alexandrovich, Ekaterina I. Alekseeva, Maya D. Bakradze, Alexander A. Baranov, Tatiana T. Batysheva, Nato D. Vashakmadze, Marina G. Vershinina, Elena A. Vishneva, Anastasia A. Glazyrina, Olga B. Gordeeva, Elena Yu. Dyakonova, Еlena S. Zholobova, Dmitry V. Zabolotsky, Nadezda N. Zvereva, Irina V. Zelenkova, Dmitry O. Ivanov, Elena V. Kaytukova, George A. Karkashadze, Ivan V. Konovalov, Daria S. Kruchko, Tatiana V. Kulichenko, Seda Kh. Kurbanova, Yliya G. Levina, Yuri V. Lobzin, Ludmila N. Mazankova, Tea V. Margieva, Leyla S. Namazova-Baranova, Yulia Yu. Novikova, Dmitry Yu. Ovsyannikov, Elena E. Petryaykina, Yuriy V. Petrenko, Nataliya V. Petrova, Dmitry V. Prometnoy, Konstantin V. Pshenisov, Gregory V. Revunenkov, Alexey Yu. Rtishchev, Dina S. Rusinova, Mukhammad A. Sayfullin, Ruslan F. Sayfullin, Liliya R. Selimzyanova, Vladimir K. Tatochenko, Rustem F. Tepaev, Aleksandr N. Uskov, Marina V. Fedoseenko, Andrey P. Fisenko, Andrey V. Khar’kin, Kamilla E. Efendieva, and Alexey V. Yakovlev

Subjects
coronaviral infection, covid-19, prevention, diagnostics, treatment, emergency care, indications for hospitalization, rehabilitation, emergency and intensive care, children, Pediatrics, RJ1-570, Therapeutics. Pharmacology, RM1-950
Abstract

The Ministry of Health of the Russian Federation jointly with professional association and experts in the field of pediatrics, infectious diseases and resuscitation has revised guidelines “Clinical Features and Management of the Disease Caused by New Coronaviral Infection (COVID-19) in Children” in order to provide the child population with effective medical care during the pandemic of the new coronaviral infection. The practical experience of specialists from various countries was considered during the development of this document. Special attention should be given to the evidence base of the presented data, as well as to the efficiency and safety issues of medications used in treatment of coronaviral infection and its complications. The authors highlight the problems of prevention, diagnostics and management of pathological conditions caused by COVID-19 in the article according to the presented guidelines. Patient’s management is presented depending on the age and severity of the disease itself. The therapy is considered with regard to etiological, pathogenetic and symptom focus.

Published
2020
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2. Management of Children with Disease Caused by New Coronaviral Infection (SARS-CoV-2)

Author

Yurii S. Alexandrovich, Elena N. Baybarina, Alexander A. Baranov, Elena A. Vishneva, Nadezda N. Zvereva, Dmitry O. Ivanov, Daria S. Kruchko, Ivan V. Konovalov, Tatiana V. Kulichenko, Yuri V. Lobzin, Ludmila N. Mazankova, Leyla S. Namazova-Baranova, Yuriy V. Petrenko, Dmitry V. Prometnoy, Konstantin V. Pshenisov, Alexey Yu. Rtishchev, Mukhammad A. Sayfullin, Liliya R. Selimzyanova, Aleksandr N. Uskov, Marina V. Fedoseenko, Andrey V. Khar’kin, Olga V. Chumakova, Kamilla E. Efendieva, and Alexey V. Yakovlev

Subjects
coronaviral infection, covid-19, prevention, diagnostics, treatment, emergency care, indications for hospitalization, rehabilitation, emergency and intensive care, children, Pediatrics, RJ1-570, Therapeutics. Pharmacology, RM1-950
Abstract

The Ministry of Health of the Russian Federation jointly with professional association and experts in the field of pediatrics, infectious diseases and resuscitation has developed guidelines “Clinical Features and Management of the Disease Caused by New Coronaviral Infection (COVID-19) in Children” in order to provide the child population with effective medical care during the pandemic of the new coronaviral infection. The practical experience of specialists from various countries was considered during the development of this document. Special attention should be given to the evidence base of the presented data, as well as to the efficiency and safety issues of medications used in treatment of coronaviral infection and its complications. The authors highlight the problems of prevention, diagnostics and management of pathological conditions caused by COVID-19 in the article according to the presented guidelines. Patient’s management is presented depending on the age and severity of the disease itself. The therapy is considered with regard to etiological, pathogenetic and symptom focus.

Published
2020
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3. The relationship between labor pain management, cortisol level and risk of postpartum depression development: a prospective nonrandomized observational monocentric trial

Author

Yurii S Alexandrovich, Alexander Ioscovich, and Oksana V. Riazanova

Subjects
Postpartum depression, Rehabilitation, Baby blues, business.industry, Local anesthetic, medicine.drug_class, Ropivacaine, medicine.medical_treatment, Labor pain, Critical Care and Intensive Care Medicine, medicine.disease, Anesthesiology and Pain Medicine, Bolus (medicine), Anesthesia, Blood plasma, Emergency Medicine, Medicine, Original Article, business, reproductive and urinary physiology, medicine.drug
Abstract

Postpartum depression (PPD) is the main psychological status disorder and women suffering from postpartum depression often need long-term psychological and socio-economic rehabilitation. The study is dedicated to the evaluation of the role of labor pain management using epidural analgesia in natural delivery on stress level in labor and frequency of postnatal depression. Materials and methods 210 women were investigated and divided into two groups. In the first group for labor pain management in natural delivery, patient-controlled epidural analgesia was used (bolus - 10.0 - 0.08% ropivacaine hydrochloride, lockout - 30 min, limit - 120 ml/6 h) with a background of continuous-flow infusion of local anesthetic 0.08% ropivacaine hydrocluoride solution. Patients in the second group had no pain relief in delivery. The stress level was evaluated using blood plasma cortisol level in the early stages of labor, 6 hours and 3 days after delivery. The assessment of depression development was carried out step-by-step: Before the delivery, 6 hours after, 3 days and 6 weeks after the delivery. Results The baby blues frequency 6 hours after the delivery in the group where the pain relief was conducted was 29.91%, with cortisol level below and equal to 2310.91 nmol/l. In the group with no pain relief 6 hours after delivery, baby blues was found in 15.53% of puerperas (p < 0.05) and the cortisol level was 2673.82 nmol/l (p < 0.05). Six weeks after the birth, postpartum depression was diagnosed in 4.67% of women who received epidural analgesia during delivery, in comparison to 6.79% with no pain relief during delivery. However, the difference was not statistically significant (p < 0.05). Conclusions The use of epidural analgesia leads to a significant reduction of pain syndrome and stress response during natural delivery, increases the risk of baby blues in the early postnatal period, but slightly influences the frequency of postpartum depression.

Published
2018

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