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This paper is going to focus on the correlation between overbites and anger level based on facial feedback theory，in which it means people can feel emotions based on their facial expressions. Overbites are orthodontics conditions where upper teeth cover the lower teeth completely forcing the upper lip to protrude. Anger is one of the basic emotions, and it’s the condition when people feel hate towards others. This paper will recruit participants who have overbites, people who have overbites tend to have tense muscles around their mouth. and researchers should use self-reports, questionnaires filled by participants’ family members and test the cortisol level of participants before and after participants' teeth correction. The goal of this research is to find out whether correcting overbites can lower people’s anger level, which helps participants reduce more of negative emotions.

Background The addition of immune checkpoint inhibitors (ICIs) to platinum-based chemotherapy has shown promising antitumor activity in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC), who have poor survival outcomes. We therefore compared the efficacy and adverse events of taxanes-cisplatin (TP) chemotherapy and camrelizumab plus TP chemotherapy in patients with RM-NPC.Materials and methods In this retrospective study, we collected the medical records of 194 patients with RM-NPC between June 30, 2019, and December 31, 2021. The patients received camrelizumab plus TP chemotherapy or TP chemotherapy alone as first-line treatment at Wuhan Union Hospital Cancer Center. The survival outcomes, efficacy, and treatment-related adverse reactions were compared between the groups.Results The medical records of 194 patients with RM-NPC were reviewed. Compared with the TP group, patients in the camrelizumab plus TP group had a longer median progression-free survival (PFS) (13.4 vs. 9.5 months; hazard ratio (HR) 0.628 [95% confidence interval (CI) 0.432–0.912]; P = 0.015) and overall survival (OS) (73.91% vs. 57.84%; HR 0.544 [95% CI 0.336–0.878]; P = 0.013). The results of multivariate analysis indicated that Epstein-Barr virus DNA (EBV DNA) load in plasma before treatment was an independent prognostic indicator associated with PFS (HR 0.488 [95% CI 0.336–0.709]; P P = 0.040)Conclusion Our study revealed that adding camrelizumab to taxanes-cisplatin chemotherapy showed a higher PFS and OS in patients with recurrent or metastatic nasopharyngeal carcinoma and had a manageable safety profile.

Transition metal oxides/hydroxides are important pseudocapacitive materials for supercapacitors, however, low electron transfer capability and poor long-term cycle stability limit their applications. Constructing transition metal oxide/hydroxide nanoarrays on conducting collectors is an effective way to solve the above problems. In this thesis, CuO nanowires based on carbon cloths (CuO–CCs) were firstly grown by chemical copper plating and thermal oxidation, and then Ni(OH)2@CuO–CCs and Fe2O3@CuO–CCs were constructed by chemical bath deposition and hydrothermal methods, respectively. The ASC device using Ni(OH)2@CuO–CCs as positive electrodes and Fe2O3@CuO–CCs as negative electrodes were assembled. The results demonstrate that the optimal specific capacities of Ni(OH)2@CuO–CCs and Fe2O3@CuO–CCs are 2.282 F cm−2 (at 1 mA cm−2) and 0.772 F cm−2 (at 2.5 mA cm−2), respectively. The ASC device reaches the energy density of 81.12 Wh kg−1 at a power density of 2.88 kW kg−1, and exhibit the capacitance maintenance of 97.9% after 10,000 cycles.

The pivotal efficacy study assessed efficacy and safety of GSK's AS04-HPV-16/18 vaccine in Chinese women aged 18-25 years up to 6 years. The present extension study, performed 4 years later, offered AS04-HPV-16/18 vaccination to placebo recipients. Vaccine safety and its long-term protective effect were assessed at Year 10.All 6051 women who received AS04-HPV-16/18 or the placebo during the initial study (NCT00779766) were invited to phase III/IV, open-label, partially controlled extension Year 10 study (NCT03629886). Placebo recipients were offered three-dose AS04-HPV-16/18 vaccination and followed up over 12 months to assess the safety. Cervical samples from all women were examined. Vaccine efficacy (VE) against incident infections and cytological lesions associated with HPV-16/18 and other oncogenic types was assessed as exploratory objective.Among 3537 women (out of 6051) enrolled in the extension study, 1791 women (mean age 32.7 years; standard deviation 1.8 years) received AS04-HPV-16/18 and reported no serious adverse events, potential immune-mediated diseases, or adverse pregnancy outcomes related to vaccination. Among 6051 women, VE against incident HPV-16, -18, and -16/18 infections up to Year 10 was 82.8% (95% confidence interval: 72.5-89.7), 79.8% (64.5-89.2), and 80.8% (72.4-87.0), respectively. VE against HPV-16/18 ASC-US+, CIN1+, and CIN2+ was 92.7% (82.2-97.7), 94.8% (67.4-99.9), and 90.5% (34.6-99.8), respectively.AS04-HPV-16/18 vaccine showed an acceptable safety profile in Chinese women vaccinated at age 26 years or above, and a long-term protection similar to other efficacy trials worldwide.

Due to the distributed and decentralized characteristics of air conditioning load, the distributed control strategy has advantages for the air conditioning load to participate in the demand response. However, existing approaches focus on the dynamic control performance with very few considerations on the cost. To fill this gap, this paper proposes a multiagent consensus control method considering the whole-process response cost of air conditioning. Based on the thermodynamic characteristics of air conditioning load in the load reduction process and recovery process, the cost function curve of air conditioning load is established. Then, the multiagent consensus control strategy is adopted to send the power adjustment information to each air conditioner to realize the optimal control of the air conditioning load. The simulation results verify that the proposed method can take into account the whole-process response cost of air conditioning loads and result in smaller control cost than existing methods.

In order to deal with the fluctuation of the renewable energy, this paper proposes rolling scheduling strategy taking into account the capacity of load-side resources. By considering the energy characteristics of shiftable loads, an improved rolling scheduling model is proposed by adopting a full-cycle scheduling and adding periodic power constraints. By this way, the accuracy of the scheduling can be improved. The testing examples verified that the proposed rolling scheduling method can reflect the long-time benefit and therefore result in better performance.

As a triterpene saponin, ilexsaponin A1 is one of the most abundant, representative and active components in plants of Ilex pubescens, used in the treatment of cardiovascular diseases. This study aimed to identify the metabolites of ilexsaponin A1 and evaluate its in vitro inhibitory drug-drug interaction (DDI) potential by using human liver microsomes (HLM) and cytochrome P450 enzymes (CYPs)-specific probes, with all the qualitative and quantitative analysis performed by LC-MS/MS. As a result, two metabolites generated through the metabolic pathways of glucuronic acid conjugation and glucose conjugation were first time detected in the HLM. An inhibitory DDI evaluating system consisting of 7 major CYP enzymes involving 8 CYP-catalyzed reactions was established, validated and then used for the DDI evaluation. Our data suggested ilexsaponin A1 and its metabolite, ilexgenin A, are not direct or mechanism-based inhibitors of CYP1A2, 2B6, 2C8, 2C9, 2D6, 2E1 or 3A4/5 at 0.05–10 μM. A significant decreased remaining activity of CYP2B6 (from 77.89 % to 23.19 %) was observed in a dose-dependent manner when increased the concentration of ilexsaponin A1 from 50 to 500 μM. Collectively, our data demonstrate ilexsaponin A1 is unlikely to cause DDIs by inhibiting co-administered drugs metabolized by these CYP enzymes.

In order to improve the degree of renewable energy integration, the demand response resource, especially on the air conditioning load side, has received attention. Currently, most of the control modes for air conditioners are centralised control, which is difficult to be applied to widely distributed air conditioning. The current studies focus on central air conditioning, but there are few studies on split-type inverter air conditioning, even though inverter air conditioning has become the most common split air system on the market. With this background, this study designs a consensus control strategy on the basis of distributed control mode, which for inverter air conditioners. The strategy is used for renewable energy integration in the studied region. The test results of various cases reveal the following findings: (i) the strategy adapts to the widely distributed air conditioning, (ii) the strategy can guarantee a fair allocation of power imbalance and user comfort, (iii) the control strategy can adapt to the uncertainties of air conditioners and the urban microclimate while efficiently consuming renewable energy. Therefore, the proposed consensus control strategy has practical value.

FTIR and Raman spectroscopy indicate the glass structure during synthesis of tin fluoride phosphate glass was pyrophosphate, mainly built up from Q1 end groups with a low concentration of Q2 polymeric chains. However, sub-optimal melting produced significantly higher concentrations of orthophosphate Q0 structural units. The variationsinNHandP-OHvibrationsinthespectrarevealedthatacriticaltimeandtemperatureofmeltingwere necessary for the conversion of NH4H2PO2 to produce sufficient P2O5 for glass forming. During melting, P2O5 and SnF2 form a low-temperature melt, which facilitates melting of the SnO and promotes the formation of a more stable glass structure. The fluorine breaks the PeOeP bonds and induces depolymerisation. The density of the glass reached a maximum at 450°C for 25min driven by the need for conversion of NH4H2PO4 to P2O5 and miscibility of SnO in the melt. Inadequate melting times and temperatures gave low Tg values because of weak FeSn and FeP linkages. Glass stability improved with melting due to increased P2O5 and SnO miscibility enabling stronger SneOeP linkages. The results show that melting conditions during synthesis strongly influence critical glass properties and future industrial scale-up will require an understanding of optimum processing.

This research investigates tin-fluoride phosphate glasses as liquid-phase fillers in polyamide 11. Optimizing the tin-fluoride content was shown to reduce the glass-transition temperature of the glass down to 106oC and enable both constituents of the composite to be fluid during processing. During extrusion, the phosphate glass was elongated into threads and ultimately broken up into droplets. The interaction parameter between the phosphate and polyamide was found to be - 0.012 due to molecular interactions and enhanced solubility of the ultrafine glass particles. All hybrids showed limited ductility due to the inability of the pinned polymer chains to be drawn into an expanding stable neck. However, there were major increases in both the Young's modulus and flexural modulus owing to the strengthening of molecular bonds by the phosphate-polyamide interactions.

Conventional enamelling requires both the feedstock powder and the substrate component to be heated one or more times in a furnace at 800–900 °C. The process can degrade the substrate and limit the size of the component to the furnace dimensions, which are serious restrictions on the technology. This study concerns the use of combustion- flame spraying as an alternative technique for enamelling. In this process, the heat source (the flame) is separated from the substrate, which enables much lower substrate temperatures and avoids thermal damage. It also removes the need for furnace treatment and opens up the possibility of on-site enamelling and repair. However, experimental trials showed that thick flame-spray coatings delaminated during cooling and had high microporosities due to quenching stresses at the glass-steel interface and inadequate splat flow of small feedstock particles. The research shows that these adverse mechanisms could be overcome by pre-heating the substrate surface to the dilatometric softening temperature and removing fines from the feedstock powder. The control of these two parameters was found to double the adhesion strength, provide coatings of very similar hardness and fracture toughness to conventional enamel aswell as deposit coatings of over 1mmin thickness for heavy-duty corrosion protection. Thermal spraying is well established for ceramic and metal coatings but the fundamentally different structure of glasses requires a different approach. An advantage of combustion flame spraying shown up by this research is that the high energy of the flame accelerates the particles to a high velocity and the resulting impact forces promote the flow of the glass. As a result, lower substrate temperatures may be used with reduced risk of degradation or higher viscosity glasses may be deposited with enhanced properties. The influence of the type of thermal-spray technique on coating quality is also discussed

An obstacle for wider application of 3D printed parts is their inferior mechanical performance compared with those from conventional fabrication. This research aims to overcome this deficiency by developing nanostructured PLA/clay composite filaments that are 3D printable by the FFF technique, investigating the effect of filament composition on mechanical properties, and correlating it with the extent of intercalation of different types of clay. The results showed the addition of 5 wt% organomodified clay to PLA raised the elastic and flexural modulus by 10% and 14% respectively. Einstein’s composite theory did not hold for the PLA/organoclay composites but the Halpin-Tsai model was successful in interpreting the measured moduli of the organoclays. The model also showed that increasing the clay intercalation was much more effective than raising the total clay content.

Thermal spraying is a green solvent-free process with the potential of applying polymer coatings to large components in-house or on-site without the need for prolonged drying. Almost no systematic research has been undertaken on thermally spraying thermoset coatings owing to the complexity and difficulty of managing the curing process. An adequately cured thermoset coating could not be deposited by thermal spraying owing to insufficient cumulative time above the cure temperature. Preheating and post-heating the substrate under a constant heat source were not successful as they led to non-uniform curing, residual stress and the risk of overheating. This study develops and validates a computer model that simulates the deposition of thermoset coatings on metal substrates using thermal spraying and high-energy infrared irradiation. The model uses readily-available commercial software and enables precise control of the coating process to improve energy efficiency and coating quality. Further research showed that evenly cured coatings could be achieved by using variable heat fluxes and controlled utilization of inward conduction from the outer surface layers. Self curing during cooling was significant and maybe employed to increase energy efficiency. The thickness of the metal substrate was shown to be an important variable as it acts as a heat sink and, for heavy sections, can substantially increase energy consumption. The results indicate a need for sufficiently accurate process control and provide a suitable methodology for the deposition of thermoset coatings.