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Sedimentary records of event deposits are crucial for regional natural disaster risk assessments and hazard history reconstructions. After Super Typhoon Haiyan passed through the South China Sea in 2013, five gravity cores were collected along the typhoon path in the southern South China Sea basin (>3800 mbsl). The results showed that Super Typhoon Haiyan deposits with clear graded bedding are preserved at the top of all cores. The thickness of the typhoon layers ranges from 20 to 240 cm and is related to changes in typhoon intensity. The lack of river-connected submarine canyon systems limited the transportation of terrestrial sediments from land to sea. Super Typhoon Haiyan-induced large surface waves played an important role in carrying suspended sediment from the Philippines. The Mn-rich layers at the bottom of the typhoon layers may be related to the soil and rock composition of the Palawan region, which experienced tsunami-like storm surges caused by Super Typhoon Haiyan. These Mn-rich layers may serve as a proxy for sediment export from large-scale extreme terrigenous events. This study provides the first sedimentary record of extreme typhoon events in the deep ocean, which may shed light on reconstructing regional hazard history.

Overpressure and buoyant effect of underlying sediments are generally used to account for the upward motion or formation of submarine mud volcanoes and mud diapirs. In this study, we process and interpret the gravity anomalies associated with the active mud diapirs off SW Taiwan. Geologically, the mud diapirs are just formed and are still very active, thus we can better understand the initial process of the mud diapirs formation through the gravity analysis. Our results show that the density contrasts of the submarine mud diapirs with respect to the surroundings are generally positive. Because the study area is in a tectonically compressive regime and the gas plume venting from the submarine mud volcanoes is very active, we thus infer that mechanically the mud diapirs off SW Taiwan have been formed mainly due to the tectonic compression on the underlying sediments of high pore-fluid pressure, instead of the buoyancy of the buried sediments. The overpressured sediments and fluid are compressed and pushed upwards to pierce the overlying sediments and form the more compacted mud diapirs. The relatively denser material of the mud diapirs probably constrains the flowing courses of the submarine canyons off SW Taiwan, especially for the upper reaches of the Kaoping and Fangliao submarine canyons. [ABSTRACT FROM AUTHOR]

The development of cerebral cortex requires spatially and temporally orchestrated proliferation, migration, and differentiation of neural progenitor cells (NPCs). The molecular mechanisms underlying cortical development are, however, not fully understood. The neural cell adhesion molecule (NCAM) has been suggested to play a role in corticogenesis. Here we show that NCAM is dynamically expressed in the developing cortex. NCAM expression in NPCs is highest in the neurogenic period and declines during the gliogenic period. In mice bearing an NPC-specific NCAM deletion, proliferation of NPCs is reduced, and production of cortical neurons is delayed, while formation of cortical glia is advanced. Mechanistically, NCAM enhances actin polymerization in NPCs by interacting with actin-associated protein profilin2. NCAM-dependent regulation of NPCs is blocked by mutations in the profilin2 binding site. Thus, NCAM plays an essential role in NPC proliferation and fate decision during cortical development by regulating profilin2-dependent actin polymerization. [ABSTRACT FROM AUTHOR]

Temperature-sensitive mutant 2–20/32 of Mycobacte. rium smegmatis mc2155 was isolated and genetically complemented with a Mycobacterium tuberculosis H37Rv DNA fragment that contained a single open reading frame. This open reading frame is designated Rv3265c in the M. tuberculosis H37Rv genome. Rv3265c shows homology to the Escherichia coli gene wbbL, which encodes a dTDP-Rha:α-D-GlcNAc-pyrophosphate polyprenol, α-3-L-rhamnosyltransferase. In E. coli this enzyme is involved in O-antigen synthesis, but in mycobacteria it is required for the rhamnosyl-containing linker unit responsible for the attachment of the cell wall polymer mycolyl-arabinogalactan to the peptidoglycan. The M. tuberculosis wbbL homologne, encoded by Rv3265c, was shown to be capable of restoring an E. coli K12 strain containing an insertionally inactivated wbbL to O-antigen positive. Likewise, the E. coli wbbL gene allowed 2–20/32 to grow at higher non-permissive temperatures. The rhamnosyltransferase activity of M. tuberculosis WbbL was demonstrated in 2–20/32 as was the loss of this transferase activity in 2–20/32 at elevated temperatures. The wbbL of the temperature-sensitive mutant contained a single-base change that converted what was a proline in mc2155 to a serine residue. Exposure of 2–20/32 to higher non-permissive temperatures resulted in bacteria that could not be recovered at the lower permissive temperatures. [ABSTRACT FROM AUTHOR]