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A theoretical study of NO adsorption on $$\hbox {Cu}_{m}\hbox {Co}_{n}$$ (2 $$\le m+n \le $$ 7) clusters was carried out using a density functional method. Generally, NO is absorbed at the top site via the N atom, except in $$\hbox {Cu}_{3}\hbox {NO}$$ and $$\hbox {Cu}_{5}\hbox {NO}$$ clusters, where NO is located at the bridge site. $$\hbox {Co}_{2}\hbox {NO}$$ , $$\hbox {Co}_{3}\hbox {NO}$$ , $$\hbox {Cu}_{2}\hbox {Co}_{2}\hbox {NO}$$ , $$\hbox {Co}_{5}\hbox {NO}$$ , $$\hbox {Cu}_{2}\hbox {Co}_{4}\hbox {NO}$$ and $$\hbox {Cu}_{6}\hbox {CoNO}$$ clusters have larger adsorption energies, indicating that NO of these clusters are more easily adsorbed. After adsorption, N-O bond is weakened and the activity is enhanced as a result of vibration frequency of N-O bond getting lower than that of a single NO molecule. $$\hbox {Cu}_{2}\hbox {CoNO}$$ , $$\hbox {Cu}_{3}\hbox {CoNO}$$ , $$\hbox {Cu}_{2}\hbox {Co}_{2}\hbox {NO}$$ , $$\hbox {Cu}_{3}\hbox {Co}_{3}\hbox {NO}$$ and $$\hbox {Cu}\hbox {Co}_{5}\hbox {NO}$$ clusters are more stable than their neighbours, while CuCoNO, $$\hbox {Co}_{3}\hbox {NO}$$ , $$\hbox {Cu}_{3}\hbox {CoNO}$$ , $$\hbox {Cu}_{2}\hbox {Co}_{3}\hbox {NO}$$ , $$\hbox {Cu}_{3}\hbox {Co}_{3}\hbox {NO}$$ and $$\hbox {Cu}_{6}$$ CoNO clusters display stronger chemical stability. Magnetic and electronic properties are also discussed. The magnetic moment is affected by charge transfer and the spd hybridization. [ABSTRACT FROM AUTHOR]

A facile one-pot synthetic method has been developed for constructing 6- oxa -spiro[4.5]decane skeletons by merging the ring-opening of benzo[ c ]oxepines and formal 1,2-oxygen migration reactions. More than 30 examples of the 6- oxa -spiro[4.5]decane derivatives have been synthesized under transition-metal-free conditions.

A novel multicomponent cascade cyclization reaction in one pot for the preparation of pyrido[3,2- a ]phenoxazin-5-ones from simple o -aminophenols, paraformaldehyde, and enaminones has been established. It is noteworthy that o -aminophenol plays multiple roles serving as both a bis-nucleophile and an iminoquinone precursor, which can in situ generate aminophenoxazinones to undergo the Povarov reaction for the first time to yield pyrido[3,2- a ]phenoxazin-5-ones with a high efficiency. Moreover, the photoluminescence of pyrido[3,2- a ]phenoxazin-5-ones has polarity sensitivity and features aggregation-induced emission (AIE) characteristics, which is promising for bioimaging and theranostic applications.

2-Hydroxy-4-morpholin-2,5-diarylfuran-3(2 H )-one derivatives were constructed sequentially using iodine and zinc dust from simple and readily available methyl ketone and morpholine as the starting materials. Under mild conditions, C-C, C-N, and C-O bonds formed in a one-pot synthesis. A quaternary carbon center was successfully constructed, and the active drug fragment morpholine was introduced into the molecule.

An efficient I 2 -promoted one-pot one-step three-component reaction for the synthesis of sulfhydryl indolizines from methyl ketones, 2-pyridylacetate derivatives, and sulfonyl hydrazides via an in situ cyclization-rethiolation strategy has been developed. This protocol shows excellent substrate compatibility, including for chain and cyclic aliphatic methyl ketones, natural product pregnenolone acetate, and phosphorus-containing methyl ketones, affording a series of valuable aliphatic-substituted indolizines in good yields.

Objective: To elucidate the mechanisms of up regulated expression of cytoplasmic phospholipase A2 (CPLA2) induced by one lung ventilation (OLV) by investigating the interactions between nuclear factor kappaB (NF-κB) and C-PLA2., Methods: Forty-eight healthy Japanese white rabbits were randomized into control group, solvent treatment group (group S), NF-κB inhibitor (PDTC)/solvent treatment group ( group PS), C-PLA2 inhibitor (AACOCF3)/solvent treatment group (group AS), OLV group (group O), solvent treatment plus OLV group (SO group), NFκB inhibitor (PDTC)/solvent treatment plus OLV group (group PSO) and CPLA2 inhibitor (AACOCF3)/solvent treatment plus OLV group (group ASO). ELISA was used to detect arachidonic acid (AA) content in the lung tissues, and NFκB and CPLA2 expressions were detected by Western blotting and quantitative PCR. Lung injuries were assessed based on the lung histological score, and the polymorphonuclear leukocyte count in the bronchial alveolar lavage fluid, myeloperoxidase (MPO) content in the lung tissues, and lung wet/dry weight (W/D) raito were determined., Results: Treatment of the rabbits with the solvent did not produce any adverse effects. OLV caused obvious lung injury in the rabbits and up regulated the expressions of CPLA2 and NFκB in the lung tissues (P<0.05). In rabbits without OLV, treatment with AACOCF3 or PDTC significantly down regulated both CPLA2 and NFκB expressions without affecting the other parameters. In rabbits with OLV, treatment with AACOCF3 or PDTC obviously lowered CPLA2 and NFκB expressions and lessened the OLV-induced lung injuries., Conclusion: Both C-PLA2 and NF-κB play important roles and show interactions in OLV-induced lung injury in rabbits.