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BackgroundHyperuricemia is increasingly common in Southwestern China and poses significant health risks, including gout and cardiovascular disease. Retinol intake has been hypothesized to affect uric acid levels, but this relationship remains unclear.MethodsData from 4,658 participants in the China Health and Nutrition Survey (CHNS) from 1991 to 2018 were analyzed. Dietary retinol intake was categorized using quantile-based methods, and hyperuricemia was identified as the primary outcome. Logistic regression models were used to estimate odds ratios and 95% confidence intervals, with analyses stratified by gender. Restricted cubic splines were utilized to evaluate the dose–response relationship.ResultsThe average age of participants was 40 ± 17.83 years, and 20.29% met the criteria for hyperuricemia. Logistic regression analysis identified a positive association between dietary retinol intake and hyperuricemia, with a more pronounced effect observed in men. The restricted cubic spline analysis revealed that the odds of hyperuricemia increased significantly when dietary retinol intake exceeded 3,538 IU/day for men and 4,504 IU/day for women.ConclusionHigh dietary retinol intake is associated with an increased risk of hyperuricemia, with a stronger association observed in males. These findings suggest that dietary retinol intake under recommendation levels might be necessary to prevent hyperuricemia-related adverse health outcomes.

Summary: Background: Limited studies have suggested an effect of dietary choline intake on uric acid levels. We aim to investigate the associations between choline intake and hyperuricemia (HUA), as well as the mediating role of kidney function in this relationship, among the Chinese population aged 6–17 years. Methods: Participants were divided into quartiles according to residual energy-adjusted dietary choline intake in our cross-sectional study. Dietary choline intake was assessed using the 24-h dietary recalls method over three consecutive days, including two weekdays and one weekend day. The primary outcome was the HUA prevalence. Based on recommendation in Clinical Paediatric Nephrology (3rd ed), HUA is defined based on fasting serum uric acid levels, with cutoffs varying by age and sex. The associations between choline intake and HUA were analysed using weighted logistic regression models, restricted cubic spline models, and linear regression models. The mediated proportions of estimated glomerular filtration rate (eGFR) in the associations were estimated with mediation effect models. The data for this study were collected from the China National Nutrition and Health Surveillance of Children and Lactating Mothers (2016–2017) conducted between October 2016 and December 2018. Eligible participants were identified through a database search conducted from October to December 2023. Findings: Among the 10749 participants, 3398 (31.6%) individuals were found to have HUA. A negative dose-dependent relationship was found between dietary choline intake and HUA. Compared to participants in the lowest intake quartile of total choline, phosphatidylcholine, and betaine, those in the 4th quartile had lower odds of HUA, with odds ratio (OR) of 0.75 (95% confidence interval [95% CI], 0.63–0.90), 0.75 (95% CI, 0.64–0.89), and 0.75 (95% CI, 0.59–0.94), respectively. The eGFR mediated 10.60%–14.58% of the associations. Participants in the 4th quartile of lipid-soluble dietary choline exhibited 24.00% reduced odds of HUA compared to those in the lowest intake quartile, with an OR of 0.76 (95% CI, 0.64–0.90). Interpretation: Moderate to high intake of dietary choline (181.20–357.92 mg/d), particularly phosphatidylcholine (120.22–207.58 mg/d), and betaine (189.24–282.37 mg/d), may reduce the odds of HUA by improving glomerular filtration function. Further interventional studies are needed to establish causal relationships. Funding: This work was supported by the National Natural Science Foundation of China (82003443, 42375180), the Natural Science Foundation of Guangdong Province of China (2024A1515012088), and the Construction of High-level University of Guangdong (G624330422).