7 results on '"Yi-Chiao Li"'
Search Results
2. Prognostic Factors and Epidemiology of Open Globe Injuries from Western Sydney: A Twelve-Year Review
- Author
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Haochi Ho, Jane Foo, Yi-Chiao Li, Samantha Bobba, Christopher Go, Jaya Chandra, and Adrian Fung
- Subjects
genetic structures ,eye diseases - Abstract
BackgroundTo identify prognostic factors determining final visual outcome following open globe injuries.MethodsRetrospective case series of patients presenting to Westmead Hospital, Sydney, Australia with open globe injuries from 1st January 2005 to 31st December 2017. Data collected included demographic information, ocular injury details, management and initial and final visual acuities.ResultsA total of 104 cases were identified. Predictors of poor final visual outcomes included poor presenting visual acuity (p < 0.001), globe rupture (p < 0.001), retinal detachment (p < 0.001), Zone III wounds (p < 0.001), hyphema (p=0.003), lens expulsion (p = 0.003) and vitreous hemorrhage (p < 0.001). Multivariate analysis demonstrated presenting visual acuity (p < 0.001), globe rupture (p = 0.013) and retinal detachment (p = 0.011) as being statistically significant for predicting poor visual outcomes. The presence of lid laceration (p = 0.197) and uveal prolapse (p = 0.667) were not significantly associated with the final visual acuity. ConclusionsPoor presenting visual acuity, globe rupture and retinal detachment are the most important prognostic factors determining final visual acuity following open globe injury.
- Published
- 2021
3. Changing refractive outcomes with increasing astigmatism at longer-term follow-up for infant cataract surgery
- Author
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Yi Chiao Li, John R. Grigg, N Kanapathipillai, and Chameen Samarawickrama
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Male ,medicine.medical_specialty ,genetic structures ,Pseudophakia ,medicine.medical_treatment ,Glaucoma ,Intraocular lens ,Cataract Extraction ,Astigmatism ,Refraction, Ocular ,01 natural sciences ,Cataract ,Neuro-ophthalmology ,03 medical and health sciences ,0302 clinical medicine ,Lens Implantation, Intraocular ,Ophthalmology ,Medicine ,Humans ,0101 mathematics ,Strabismus ,Retrospective Studies ,business.industry ,010102 general mathematics ,Infant ,Retrospective cohort study ,Cataract surgery ,medicine.disease ,eye diseases ,Confidence interval ,030221 ophthalmology & optometry ,Clinical Study ,Female ,sense organs ,business ,Follow-Up Studies - Abstract
PurposeTo present longer-term refractive and ocular health outcomes for patients who had primary intraocular lens (IOL) insertion following infant cataract surgery.Patients and methodsA retrospective review of all infant cataract cases at a tertiary children's hospital between 2003 and 2006 was conducted. Surgery was performed before 12 months of age. IOL power was calculated using the SRK/T formula targeting hyperopia based on the child's age; children under 3 months were targeted at +9.0 D, between 3 and 6 months at +6.0 D, and between 6 and 12 months at +3.0 D. Locally weighted scatterplot smoothing and mixed models were used.ResultsA total of 12 eyes from 9 children were included (4 bilateral and 5 unilateral). Spherical equivalent refraction decreased dramatically in the first 2 years of life, with milder changes from age 2 to 4 years and minimal changes thereafter. Cylinder increased until age 5 years at ∼0.57 dioptres/year (95% confidence intervals 0.27-0.87 D, P
- Published
- 2016
4. Successful treatment of infantile haemangiomas of the orbit with propranolol
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Yi Chiao Li, Emma McCahon, Frank J. Martin, Neil A. Rowe, Geoffrey A. Wilcsek, and Peter A. Martin
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Propranolol ,Surgery ,body regions ,Lesion ,Ophthalmology ,medicine.anatomical_structure ,Infantile haemangioma ,Corticosteroid therapy ,medicine ,Older child ,medicine.symptom ,business ,β adrenergic antagonist ,Orbit (anatomy) ,medicine.drug - Abstract
Background: Propranolol is a novel therapeutic agent in the treatment of cutaneous infantile haemangiomas. We assessed the effect of propranolol therapy in infantile haemangiomas of the orbit. Methods: A case series of four patients with orbital infantile haemangiomas were referred for management in our tertiary referral hospitals. Two of the patients had inadequate responses to prior corticosteroid therapy. One of the patients was commenced on propranolol at 2.5 years of age when the lesion was not in the proliferative phase. This represented the first case report of propranolol treatment for infantile haemangioma outside infancy. The other three children were in their infancy when propranolol was commenced. The patients were treated with oral propranolol. Results: All patients had significant improvement in their physical appearance, ocular examination findings and size of their lesions on radiological evaluation. No side-effects of propranolol treatment were observed. Conclusions: Propranolol is a promising treatment against infantile haemangiomas in the orbit, not only in infants but also in an older child with a stable lesion.
- Published
- 2010
5. Generation of tumour-specific cytotoxic T-cell clones from histocompatibility leucocyte antigen-identical siblings of patients with melanoma
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Catia Traversari, David Gottlieb, Yi-Chiao Li, Kenneth F. Bradstock, V. Russo, Ilaria Lionello, Marina Marangolo, and Silvia Tanzarella
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CD4-Positive T-Lymphocytes ,Cancer Research ,Lymphocyte ,medicine.medical_treatment ,T cells ,Biology ,Immunotherapy, Adoptive ,Epitopes ,Interferon-gamma ,Antigen ,HLA Antigens ,Cell Line, Tumor ,melanoma ,Tumor Cells, Cultured ,medicine ,Humans ,Cytotoxic T cell ,human ,tumour immunity ,Histocompatibility Testing ,Siblings ,Melanoma ,Immunotherapy ,Cytotoxicity Tests, Immunologic ,Donor Lymphocytes ,medicine.disease ,Clone Cells ,Transplantation ,medicine.anatomical_structure ,Oncology ,Immunology ,Translational Therapeutics ,CD8 ,transplantation ,Stem Cell Transplantation ,T-Lymphocytes, Cytotoxic - Abstract
Lymphodepletion and infusion of autologous expanded tumour-infiltrating lymphocytes is effective therapy for patients with malignant melanoma. Antitumour responses are likely to be mediated by HLA class I- and II-restricted immune responses directed at tumour antigens. We assessed whether the peripheral blood of normal HLA-matched siblings of patients with melanoma could be used to generate lymphocytes with antimelanoma activity for adoptive immunotherapy after allogeneic blood or marrow transplantation. Melanoma cell lines were derived from two donors and were used to stimulate the mononuclear cells of three HLA-identical siblings. CD4(+) clones dominated cultures. Of these, approximately half were directly cytotoxic towards recipient melanoma cells and secreted interferon-gamma in response to tumour stimulation. More than half of the noncytotoxic clones also secreted interferon-gamma after melanoma stimulation. No CD4(+) clones responded to stimulation with recipient haemopoietic cells. The majority of CD8(+) clones directly lysed recipient melanoma, but did not persist in long-term culture in vitro. No crossreactivity with recipient haemopoietic cells was observed. The antigenic target of one CD4(+) clone was determined to be an HLA-DR11-restricted MAGE-3 epitope. Antigenic targets of the remaining clones were not elucidated, but appeared to be restricted through a non-HLA-DR class II molecule. We conclude that the blood of allogeneic HLA-matched sibling donors contains melanoma-reactive lymphocyte precursors directed at tumour-associated antigens. Adoptive immunotherapy with unselected or ex vivo-stimulated donor lymphocytes after allogeneic stem cell transplantation has a rational basis for the treatment of malignant melanoma.
- Published
- 2006
6. Reducing oral contamination during corneal scrapes
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Stephanie L Watson, Mark D. P. Willcox, Debarun Dutta, Yi-Chiao Li, Nicole Carnt, and Chameen Samarawickrama
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0303 health sciences ,medicine.medical_specialty ,business.industry ,Negative control ,Contamination ,corneal scrape ,Streptococcus species ,3. Good health ,Surgery ,Face masks ,Agar plate ,03 medical and health sciences ,Ophthalmology ,Surgical mask ,contamination ,0302 clinical medicine ,030221 ophthalmology & optometry ,medicine ,Original Article ,business ,030304 developmental biology - Abstract
Aims: To identify potential contaminants of the corneal sampling procedure and examine the effect of wearing surgical face masks on the rate of contamination. Methods: Ten surgeons recited out loud a 30 s standardised script for corneal scraping with blood agar plates positioned 30 cm away from them. Three groups were identified: in group 1 a surgical mask was worn; group 2 had no mask worn; and group 3 had no mask but used agar plates pretreated with 5% povidone-iodine as a negative control. Each surgeon repeated the process 10 times for all groups, totalling 30 plates per surgeon and 300 plates for the experiment. All plates were masked and incubated aerobically at 37°C for 24 hours, and the number of colony forming units (CFUs) was determined. Results: At 24 hours, group 1 had a mean of 0.3 CFUs per surgeon; group 2 had 6.4 CFUs per surgeon and group 3 had 0.1 CFUs per surgeon. The difference between group 1 and group 2 was significant (p
- Published
- 2017
7. Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor
- Author
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Chieh-Ju Wu, Mei-Yin Chien, Nan-Hei Lin, Yi-Chiao Lin, Wen-Ying Chen, Chao-Hsiang Chen, and Jason T. C. Tzen
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cistanche tubulosa ,echinacoside ,ghrelin ,growth hormone secretion ,phenylethanoid glycosides ,Organic chemistry ,QD241-441 - Abstract
Cistanche species, the ginseng of the desert, has been recorded to possess many biological activities in traditional Chinese pharmacopoeia and has been used as an anti-aging medicine. Three phenylethanoid glycosides—echinacoside, tubuloside A, and acteoside—were detected in the water extract of Cistanche tubulosa (Schenk) R. Wight and the major constituent, echinacoside, was further purified. Echinacoside of a concentration higher than 10−6 M displayed significant activity to stimulate growth hormone secretion of rat pituitary cells. Similar to growth hormone-releasing hormone-6, a synthetic analog of ghrelin, the stimulation of growth hormone secretion by echinacoside was inhibited by [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P, an inverse agonist of the ghrelin receptor. Molecular modeling showed that all the three phenylethanoid glycosides adequately interacted with the binding pocket of the ghrelin receptor, and echinacoside displayed a slightly better interaction with the receptor than tubuloside A and acteoside. The results suggest that phenylethanoid glycosides, particularly echinacoside, are active constituents putatively responsible for the anti-aging effects of C. tubulosa and may be considered to develop as non-peptidyl analogues of ghrelin.
- Published
- 2019
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