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6. Progress in health among regions of Ethiopia, 1990-2019: a subnational country analysis for the Global Burden of Disease Study 2019

Author

Misganaw, Awoke, Mirkuzie, Alemnesh H, Giref, Ababi Zergaw, Berheto, Tezera Moshago, Waktola, Ebba Abate, Kempen, John H, Eticha, Getachew Tollera, Wolde, Tsigereda Kifle, Deguma, Dereje, Abate, Kalkidan Hassen, Abegaz, Kedir Hussein, Ahmed, Muktar Beshir, Akalu, Yonas, Aklilu, Addis, Alemu, Biresaw Wassihun, Asemahagn, Mulusew A, Awedew, Atalel Fentahun, Balakrishnan, Senthilkumar, Bekuma, Tariku Tesfaye, Beyene, Addisu Shunu, Beyene, Misrak Getnet, Bezabih, Yihienew Mequanint, Birhanu, Biruk Tesfaye, Chichiabellu, Tesfaye Yitna, Dachew, Berihun Assefa, Dagnew, Amare Belachew, Demeke, Feleke Mekonnen, Demissie, Getu Debalkie, Molla, Meseret Derbew, Dereje, Nebiyu, Deribe, Kebede, Desta, Abebaw Alemayehu, Eshetu, Munir Kassa, Ferede, Tomas Y, Gebreyohannes, Eyob Alemayehu, Geremew, Abraham, Gesesew, Hailay Abrha, Getacher, Lemma, Glenn, Scott D, Hafebo, Aregash Samuel, Hashi, Abdiwahab, Hassen, Hamid Yimam, Hay, Simon I, Hordofa, Diriba Fufa, Huluko, Dawit Hoyiso, Kasa, Ayele Semachew, Azene, Getinet Kassahun, Kebede, Ermiyas Mulu, Kebede, Hafte Kahsay, Kelkay, Bayew, Kidane, Samuel Z, Legesse, Samson Mideksa, Manamo, Wondimu Ayele, Melaku, Yohannes Adama A, Mengesha, Endalkachew Worku, Mengesha, Sisay Derso, Merie, Hayimro Edemealem, Mersha, Abera M, Mersha, Amanual Getnet, Mirutse, Mizan Kiros, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Salahuddin, Netsere, Henok Biresaw, Nigatu, Dabere, Obsa, Mohammed Suleiman, Odo, Daniel Bogale, Omer, Muktar, Regassa, Lemma Demissie, Sahiledengle, Biniyam, Shaka, Mohammed Feyisso, Shiferaw, Wondimeneh Shibabaw, Sidemo, Negussie Boti, Sinke, Abiy H, Sintayehu, Yitagesu, Sorrie, Muluken Bekele, Tadesse, Birkneh Tilahun, Tadesse, Eyayou Girma, Tamir, Zemenu, Tamiru, Animut Tagele, Tareke, Amare Abera, Tefera, Yonas Getaye, Tekalegn, Yohannes, Tesema, Ayenew Kassie, Tesema, Tefera Tadele, Tesfay, Fisaha Haile, Tessema, Zemenu Tadesse, Tilahun, Tadesse, Tsegaye, Gebiyaw Wudie, Tusa, Biruk Shalmeno, Weledesemayat, Geremew Tassew, Yazie, Taklo Simeneh, Yeshitila, Yordanos Gizachew, Yirdaw, Birhanu Wubale, Zegeye, Desalegn Tegabu, Murray, Christopher JL, and Gebremedhin, Lia Tadesse

Abstract

BACKGROUND: Previous Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) studies have reported national health estimates for Ethiopia. Substantial regional variations in socioeconomic status, population, demography, and access to health care within Ethiopia require comparable estimates at the subnational level. The GBD 2019 Ethiopia subnational analysis aimed to measure the progress and disparities in health across nine regions and two chartered cities. METHODS: We gathered 1057 distinct data sources for Ethiopia and all regions and cities that included census, demographic surveillance, household surveys, disease registry, health service use, disease notifications, and other data for this analysis. Using all available data sources, we estimated the Socio-demographic Index (SDI), total fertility rate (TFR), life expectancy, years of life lost, years lived with disability, disability-adjusted life-years, and risk-factor-attributable health loss with 95% uncertainty intervals (UIs) for Ethiopia's nine regions and two chartered cities from 1990 to 2019. Spatiotemporal Gaussian process regression, cause of death ensemble model, Bayesian meta-regression tool, DisMod-MR 2.1, and other models were used to generate fertility, mortality, cause of death, and disability rates. The risk factor attribution estimations followed the general framework established for comparative risk assessment. FINDINGS: The SDI steadily improved in all regions and cities from 1990 to 2019, yet the disparity between the highest and lowest SDI increased by 54% during that period. The TFR declined from 6·91 (95% UI 6·59-7·20) in 1990 to 4·43 (4·01-4·92) in 2019, but the magnitude of decline also varied substantially among regions and cities. In 2019, TFR ranged from 6·41 (5·96-6·86) in Somali to 1·50 (1·26-1·80) in Addis Ababa. Life expectancy improved in Ethiopia by 21·93 years (21·79-22·07), from 46·91 years (45·71-48·11) in 1990 to 68·84 years (67·51-70·18) in 2019. Addis Ababa had the highest life expectancy at 70·86 years (68·91-72·65) in 2019; Afar and Benishangul-Gumuz had the lowest at 63·74 years (61·53-66·01) for Afar and 64.28 (61.99-66.63) for Benishangul-Gumuz. The overall increases in life expectancy were driven by declines in under-5 mortality and mortality from common infectious diseases, nutritional deficiency, and war and conflict. In 2019, the age-standardised all-cause death rate was the highest in Afar at 1353·38 per 100 000 population (1195·69-1526·19). The leading causes of premature mortality for all sexes in Ethiopia in 2019 were neonatal disorders, diarrhoeal diseases, lower respiratory infections, tuberculosis, stroke, HIV/AIDS, ischaemic heart disease, cirrhosis, congenital defects, and diabetes. With high SDIs and life expectancy for all sexes, Addis Ababa, Dire Dawa, and Harari had low rates of premature mortality from the five leading causes, whereas regions with low SDIs and life expectancy for all sexes (Afar and Somali) had high rates of premature mortality from the leading causes. In 2019, child and maternal malnutrition; unsafe water, sanitation, and handwashing; air pollution; high systolic blood pressure; alcohol use; and high fasting plasma glucose were the leading risk factors for health loss across regions and cities. INTERPRETATION: There were substantial improvements in health over the past three decades across regions and chartered cities in Ethiopia. However, the progress, measured in SDI, life expectancy, TFR, premature mortality, disability, and risk factors, was not uniform. Federal and regional health policy makers should match strategies, resources, and interventions to disease burden and risk factors across regions and cities to achieve national and regional plans, Sustainable Development Goals, and universal health coverage targets. FUNDING: Bill & Melinda Gates Foundation.

Published
2022

8. Antihypertensive medications adherence and associated uncontrolled blood pressure among hypertensive patients in Ethiopia: systematic review and meta-analysis

Author

Desta, Melaku, primary, Yibeltal, Desalegn, additional, Memiah, Peter, additional, Ayenew, Temesgen, additional, Mulugeta, Henok, additional, Gedefaw, Mihretie, additional, Bewket Kidanie, Bekalu, additional, Birhanu, Molla Yigzaw, additional, Tessema, Zenaw, additional, Mengist, Belayneh, additional, Alene, Muluneh, additional, Simieneh, Muluye Molla, additional, Ewunetie, Atsede Alle, additional, Shiferaw, Wondimeneh Shibabaw, additional, and Yeshitila, Yordanos Gizachew, additional

Published
2022
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9. Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease study 2019

Author

Safiri, Saeid, Kolahi, Ali-Asghar, Naghavi, Mohsen, Nejadghaderi, Seyed Aria, Mansournia, Mohammad Ali, Sullman, Mark, Almasi-Hashiani, Amir, Sepidarkish, Mahdi, Ashrafi-Asgarabad, Ahad, Abdoli, Amir, Abu-Gharbieh, Eman, Advani, Shailesh M., Alahdab, Fares, Alipour, Vahid, Amini, Erfan, Anbesu, Etsay Woldu, Anderson, Jason A., Arabloo, Jalal, Awedew, Atalel Fentahun, Baig, Atif Amin, Bhagavathula, Akshaya Srikanth, Bijani, Ali, Biondi, Antonio, Bjørge, Tone, Braithwaite, Dejana, Caetano dos Santos, Florentino Luciano, Carreras, Giulia, Carvalho, Felix, Chu, Dinh-Toi, Compton, Kelly, Costa, Vera Marisa, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Molla, Meseret Derbew, Desta, Abebaw Alemayehu, Dianatinasab, Mostafa, Ebrahimi, Hedyeh, Eftekharzadeh, Sahar, El Sayed, Iman, Eshrati, Babak, Farzadfar, Farshad, Feleke, Berhanu Elfu, Fernandes, Eduarda, Filip, Irina, Fomenkov, Artem Alekseevich, Gallus, Silvano, Ghafourifard, Mansour, Ghashghaee, Ahmad, Golechha, Mahaveer, Gonfa, Kebebe Bekele, Gorini, Giuseppe, Hafezi-Nejad, Nima, Hamidi, Samer, Harvey, James D., Hassanipour, Soheil, Hay, Simon I., Henrikson, Hannah Jacqueline, Househ, Mowafa, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Joukar, Farahnaz, Kumar, G. Anil, La Vecchia, Carlo, Ladi-Seyedian, Seyedeh-Sanam, Lami, Faris Hasan, Landires, Iván, Li, Bingyu, Lugo, Alessandra, Majeed, Azeem, Malekzadeh, Reza, Mestrovic, Tomislav, Miazgowski, Bartosz, Michalek, Irmina Maria, Moghadaszadeh, Masoud, Mohamad, Osama, Mohammadian-Hafshejani, Abdollah, Reza, Mohammadpourhodki, Mohammed, Shafiu, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Moradzadeh, Rahmatollah, Nabavizadeh, Behnam, Naimzada, Mukhammad David, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nikbakhsh, Rajan, Nowroozi, Mohammad Reza, Nuñez-Samudio, Virginia, Otstavnov, Stanislav S., Pham, Hai Quang, Pirestani, Majid, Pottoo, Faheem Hyder, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rezaei, Nima, Roberts, Nicholas L.S., Roshandel, Gholamreza, Samy, Abdallah M., Sepanlou, Sadaf G., Sha, Feng, Shaikh, Masood Ali, Sheikhbahaei, Sara, Malleshappa, Sudeep K. Siddappa, Singh, Jasvinder A., Spurlock, Emma Elizabeth, Tadesse, Eyayou Girma, Tefera, Yonas Getaye, Tekalegn, Yohannes, Titova, Mariya Vladimirovna, Topor-Madry, Roman, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Travillian, Ravensara S., Vacante, Marco, Xu, Rixing, Yeshitila, Yordanos Gizachew, Zadnik, Vesna, Zamanian, Maryam, and Zhang, Zhi-Jiang

Subjects
Male, Medicine (General), Sociodemographic Factors, ALCOHOL-CONSUMPTION, Population, Infectious and parasitic diseases, RC109-216, Global Burden of Disease Bladder Cancer Collaborators, Global Burden of Disease, R5-920, Risk Factors, Medicine, cancer, Humans, education, METAANALYSIS, VEGETABLES, Bladder cancer, Epidemiology, Global burden, Public, Environmental & Occupational Health, Cause of death, Original Research, education.field_of_study, Science & Technology, TEA, FRUIT, business.industry, MORTALITY, Health Policy, Incidence (epidemiology), Mortality rate, Public Health, Environmental and Occupational Health, Disability-Adjusted Life Years, ASSOCIATION, medicine.disease, Years of potential life lost, Urinary Bladder Neoplasms, Attributable risk, Life expectancy, epidemiology, Female, Quality-Adjusted Life Years, business, Life Sciences & Biomedicine, Demography
Abstract

IntroductionThe current study determined the level and trends associated with the incidence, death and disability rates for bladder cancer and its attributable risk factors in 204 countries and territories, from 1990 to 2019, by age, sex and sociodemographic index (SDI; a composite measure of sociodemographic factors).MethodsVarious data sources from different countries, including vital registration and cancer registries were used to generate estimates. Mortality data and incidence data transformed to mortality estimates using the mortality to incidence ratio (MIR) were used in a cause of death ensemble model to estimate mortality. Mortality estimates were divided by the MIR to produce incidence estimates. Prevalence was calculated using incidence and MIR-based survival estimates. Age-specific mortality and standardised life expectancy were used to estimate years of life lost (YLLs). Prevalence was multiplied by disability weights to estimate years lived with disability (YLDs), while disability-adjusted life years (DALYs) are the sum of the YLLs and YLDs. All estimates were presented as counts and age-standardised rates per 100 000 population.ResultsGlobally, there were 524 000 bladder cancer incident cases (95% uncertainty interval 476 000 to 569 000) and 229 000 bladder cancer deaths (211 000 to 243 000) in 2019. Age-standardised death rate decreased by 15.7% (8.6 to 21.0), during the period 1990–2019. Bladder cancer accounted for 4.39 million (4.09 to 4.70) DALYs in 2019, and the age-standardised DALY rate decreased significantly by 18.6% (11.2 to 24.3) during the period 1990–2019. In 2019, Monaco had the highest age-standardised incidence rate (31.9 cases (23.3 to 56.9) per 100 000), while Lebanon had the highest age-standardised death rate (10.4 (8.1 to 13.7)). Cabo Verde had the highest increase in age-standardised incidence (284.2% (214.1 to 362.8)) and death rates (190.3% (139.3 to 251.1)) between 1990 and 2019. In 2019, the global age-standardised incidence and death rates were higher among males than females, across all age groups and peaked in the 95+ age group. Globally, 36.8% (28.5 to 44.0) of bladder cancer DALYs were attributable to smoking, more so in males than females (43.7% (34.0 to 51.8) vs 15.2% (10.9 to 19.4)). In addition, 9.1% (1.9 to 19.6) of the DALYs were attributable to elevated fasting plasma glucose (FPG) (males 9.3% (1.6 to 20.9); females 8.4% (1.6 to 19.1)).ConclusionsThere was considerable variation in the burden of bladder cancer between countries during the period 1990–2019. Although there was a clear global decrease in the age-standardised death, and DALY rates, some countries experienced an increase in these rates. National policy makers should learn from these differences, and allocate resources for preventative measures, based on their country-specific estimates. In addition, smoking and elevated FPG play an important role in the burden of bladder cancer and need to be addressed with prevention programmes.

Published
2021

15. Global mortality from dementia : Application of a new method and results from the Global Burden of Disease Study 2019

Author

Nichols, Emma, Abd‐Allah, Foad, Abdoli, Amir, Abosetugn, Akine Eshete, Abrha, Woldu Aberhe, Abualhasan, Ahmed, Abu‐Gharbieh, Eman, Akinyemi, Rufus Olusola, Alahdab, Fares, Alanezi, Fahad Mashhour, Alipour, Vahid, Ansari, Iman, Arabloo, Jalal, Ashraf‐Ganjouei, Amir, Avan, Abolfazl, Ayano, Getinet, Babar, Zaheer‐Ud‐Din, Baig, Atif Amin, Banach, Maciej, Barboza, Miguel A., Barker‐Collo, Suzanne Lyn, Baune, Bernhard T., Bhagavathula, Akshaya Srikanth, Bhattacharyya, Krittika, Bijani, Ali, Biondi, Antonio, Birhan, Tsegaye Adane, Biswas, Atanu, Bolla, Srinivasa Rao, Boloor, Archith, Brayne, Carol, Brenner, Hermann, Burkart, Katrin, Burns, Richard A., Nagaraja, Sharath Burugina, Carvalho, Felix, Castro‐de‐Araujo, Luis F. S., Catala-Lopez, Ferran, Cerin, Ester, Cernigliaro, Achille, Cherbuin, Nicolas, Choi, Jee‐Young Jasmine, Chu, Dinh‐Toi, Dagnew, Baye, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Diaz, Daniel, Forooshani, Zahra Sadat Dibaji, Douiri, Abdel, Duncan, Bruce B., Edvardsson, David, El‐Jaafary, Shaimaa I., Eskandari, Khalil, Eskandarieh, Sharareh, Feigin, Valery L., Fereshtehnejad, Seyed‐Mohammad, Fernandes, Eduarda, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Gaidhane, Shilpa, Gebregzabiher, Kidane Zereabruk, Ghashghaee, Ahmad, Gholamian, Asadollah, Gnedovskaya, Elena V., Golechha, Mahaveer, Gupta, Rajeev, Hachinski, Vladimir, Hamidi, Samer, Hankey, Graeme J., Haro, Josep Maria, Hassan, Amr, Hay, Simon I., Heidari, Golnaz, Heidari‐Soureshjani, Reza, Househ, Mowafa, Hussain, Rabia, Hwang, Bing‐Fang, Ilic, Irena M., Ilic, Milena D., Irvani, Seyed Sina Naghibi, Iso, Hiroyasu, Iwagami, Masao, Jha, Ravi Prakash, Kalani, Rizwan, Kandel, Himal, Karch, André, Kasa, Ayele Semachew, Kengne, Andre Pascal, Kim, Young‐Eun, Kim, Yun Jin, Kisa, Sezer, Kisa, Adnan, Kivimäki, Mika, Komaki, Hamidreza, Koyanagi, Ai, Kukull, Walter A, Kumar, G. Anil, Kumar, Manasi, Landires, Iván, Leonardi, Matilde, Lim, Stephen S., Liu, Xuefeng, Logroscino, Giancarlo, Lopez, Alan D., Lorkowski, Stefan, Loy, Clement T., Amin, Hawraz Ibrahim M., Manafi, Navid, Manjunatha, Narayana, Mehndiratta, Man Mohan, Menezes, Ritesh G, Meretoja, Atte, Merkin, Alexander, Metekiya, Workua Mekonnen, Misganaw, Awoke Temesgen, Mohajer, Bahram, Ibrahim, Norlinah Mohamed, Mohammad, Yousef, Mohapatra, Archisman, Mohebi, Farnam, Mokdad, Ali H., Mondello, Stefania, Mossie, Tilahun Belete, Mulugeta, Anwar, Nagel, Gabriele, Naveed, Muhammad, Nayak, Vinod C., Kandel, Sandhya Neupane, Nguyen, Son Hoang, Nguyen, Huong Lan Thi, Nuñez‐Samudio, Virginia, Ogbo, Felix Akpojene, Olagunju, Andrew T., Orru, Hans, Ostojic, Sergej M., Ostroff, Samuel M., Otstavnov, Nikita, Otstavnov, Stanislav S, Owolabi, Mayowa O., Pathak, Mona, Toroudi, Hamidreza Pazoki, Peterson, Carrie B., Pham, Hai Quang, Phillips, Michael R., Piradov, Michael A., Pottoo, Faheem Hyder, Prada, Sergio I., Pribadi, Dimas Ria Angga, Radfar, Amir, Raggi, Alberto, Rahim, Fakher, Ram, Pradhum, Rana, Juwel, Rashedi, Vahid, Rawaf, Salman, Rawaf, David Laith, Reinig, Nickolas, Rezaei, Nima, Robinson, Stephen R, Romoli, Michele, Sachdev, Perminder S., Sahathevan, Ramesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sattin, Davide, Saylan, Mete, Sayyah, Mehdi, Schiavolin, Silvia, Schmidt, Maria Inês, Shahid, Izza, Shaikh, Masood Ali, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Siddiqi, Tariq Jamal, Silva, João Pedro, Singh, Jasvinder A., Soheili, Amin, Spurlock, Emma Elizabeth, Szoeke, Cassandra E I, Tabarés‐Seisdedos, Rafael, Taddele, Biruk Wogayehu, Thakur, Bhaskar, ThekkePurakkal, Akhil Soman, Tovani‐Palone, Marcos Roberto, Tran, Bach Xuan, Travillian, Ravensara S., Tripathi, Manjari, Tsegaye, Gebiyaw Wudie, Usman, Muhammad Shariq, Vacante, Marco, Velazquez, Diana Zuleika, Venketasubramanian, Narayanaswamy, Vidale, Simone, Vlassov, Vasily, Wang, Yuan‐Pang, Wei, Jingkai, Weiss, Jordan, Weldemariam, Abrha Hailay, Wimo, Anders, Wu, Chenkai, Yadollahpour, Ali, Yamagishi, Kazumasa, Yeshitila, Yordanos Gizachew, Yonemoto, Naohiro, Zadey, Siddhesh, Zhang, Zhi‐Jiang, Murray, Christopher J. L., Vos, Theo, GBD 2019 Collaborators, Department of Public Health, Clinicum, HUS Neurocenter, Neurologian yksikkö, Bill & Melinda Gates Foundation, Royal Society (Reino Unido), African Academy of Sciences, National Institutes of Health (Estados Unidos), Fundação para a Ciência e Tecnologia (Portugal), Wellcome Trust, Center of Data and Knowledge Integration for Health, Oswaldo Cruz Foundation, National Institute for Health Research (Reino Unido), King College London, Xiamen University Malaysia (Malasia), Medical Research Council (Reino Unido), NIH - National Institute on Aging (NIA) (Estados Unidos), Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá), Federal Ministry of Education & Research (Alemania), Ministero della Salute (Italia), National Natural Science Foundation of China, National Health and Medical Research Council (Australia), Alzheimers Association, University of Melbourne (Australia), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Nichols, E, Abd-Allah, F, Abdoli, A, Abosetugn, A, Abrha, W, Abualhasan, A, Abu-Gharbieh, E, Akinyemi, R, Alahdab, F, Alanezi, F, Alipour, V, Ansari, I, Arabloo, J, Ashraf-Ganjouei, A, Avan, A, Ayano, G, Babar, Z, Baig, A, Banach, M, Barboza, M, Barker-Collo, S, Baune, B, Srikanth Bhagavathula, A, Bhattacharyya, K, Bijani, A, Biondi, A, Birhan, T, Biswas, A, Bolla, S, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, R, Nagaraja, S, Carvalho, F, Castro-De-araujo, L, Catala-Lopez, F, Cerin, E, Cernigliaro, A, Cherbuin, N, Jasmine Choi, J, Chu, D, Dagnew, B, Dai, X, Dandona, L, Dandona, R, Diaz, D, Dibaji Forooshani, Z, Douiri, A, Duncan, B, Edvardsson, D, El-Jaafary, S, Eskandari, K, Eskandarieh, S, Feigin, V, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Gaidhane, S, Gebregzabiher, K, Ghashghaee, A, Gholamian, A, Gnedovskaya, E, Golechha, M, Gupta, R, Hachinski, V, Hamidi, S, Hankey, G, Haro, J, Hassan, A, Hay, S, Heidari, G, Heidari-Soureshjani, R, Househ, M, Hussain, R, Hwang, B, Ilic, I, Ilic, M, Naghibi Irvani, S, Iso, H, Iwagami, M, Jha, R, Kalani, R, Kandel, H, Karch, A, Kasa, A, Kengne, A, Kim, Y, Kisa, S, Kisa, A, Kivimaki, M, Komaki, H, Aikoyanagi, Kukull, W, Kumar, G, Kumar, M, Landires, I, Leonardi, M, Lim, S, Liu, X, Logroscino, G, Lopez, A, Lorkowski, S, Loy, C, Amin, H, Manafi, N, Manjunatha, N, Mehndiratta, M, Menezes, R, Meretoja, A, Merkin, A, Metekiya, W, Misganaw, A, Mohajer, B, Ibrahim, N, Mohammad, Y, Mohapatra, A, Mohebi, F, Mokdad, A, Mondello, S, Mossie, T, Mulugeta, A, Nagel, G, Naveed, M, Nayak, V, Kandel, S, Nguyen, S, Nguyen, H, Nunez-Samudio, V, Ogbo, F, Olagunju, A, Orru, H, Ostojic, S, Ostroff, S, Otstavnov, N, Otstavnov, S, Owolabi, M, Pathak, M, Toroudi, H, Peterson, C, Pham, H, Phillips, M, Piradov, M, Pottoo, F, Prada, S, Angga Pribadi, D, Radfar, A, Raggi, A, Rahim, F, Ram, P, Rana, J, Rashedi, V, Rawaf, S, Rawaf, D, Reinig, N, Rezaei, N, Robinson, S, Romoli, M, Sachdev, P, Sahathevan, R, Sahebkar, A, Sahraian, M, Sattin, D, Saylan, M, Sayyah, M, Schiavolin, S, Schmidt, M, Shahid, I, Shaikh, M, Shigematsu, M, Shin, J, Shiri, R, Siddiqi, T, Silva, J, Singh, J, Soheili, A, Spurlock, E, Szoeke, C, Tabares-Seisdedos, R, Taddele, B, Thakur, B, Thekke Purakkal, A, Tovani-Palone, M, Tran, B, Travillian, R, Tripathi, M, Tsegaye, G, Usman, M, Vacante, M, Velazquez, D, Venketasubramanian, N, Vidale, S, Vlassov, V, Wang, Y, Wei, J, Weiss, J, Weldemariam, A, Wimo, A, Wu, C, Yadollahpour, A, Yamagishi, K, Yeshitila, Y, Yonemoto, N, Zadey, S, Zhang, Z, Murray, C, Vos, T, Fundação para a Ciência e a Tecnologia (Portugal), Center for Data and Knowledge Integration for Health (CIDACS), Imperial College London (Reino Unido), University Hospitals Bristol NHS Foundation Trust, South African Medical Research Council, NIH - National Institute of Mental Health (NIMH) (Estados Unidos), Alzheimer's Association, Australian Research Council, European Regional Development Fund, Ministry of Science and Technology (Shanghái), Nichols, Emma, Abd-Allah, Foad, Abdoli, Amir, Abosetugn, Akine Eshete, Mulugeta, Anwar, and Vos, Theo

Subjects
MILD COGNITIVE IMPAIRMENT, Clinical Neurology, Global health, global health, burden of disease, ALL-CAUSE, 3124 Neurology and psychiatry, 03 medical and health sciences, 0302 clinical medicine, CLINICALLY DIAGNOSED DEMENTIA, mental disorders, 030212 general & internal medicine, REPORTING DEMENTIA, Mortality, RC346-429, GBD 2019 Collaborators, PREDICTORS, Research Articles, POPULATION, Science & Technology, DEATH CERTIFICATES, RC952-954.6, Neurosciences, Burden of disease, 3112 Neurosciences, NURSING-HOME RESIDENTS, mortality, 3. Good health, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Disease burdens, Geriatrics, SURVIVAL, Dementia, Neurology. Diseases of the nervous system, Neurosciences & Neurology, Neurology (clinical), Life Sciences & Biomedicine, 030217 neurology & neurosurgery, Research Article, dementia
Abstract

Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-to-male ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in all-age mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally. This work was funded by the Bill and Melinda Gates Foundation, Seattle, WA, and by Gates Ventures, Seattle, WA. R. Akinyemi is supported as a FLAIR Research Fellow by the UK Royal Society and the African Academy of Science (Grants FLR/R1/191813 and FCG/R1/201034) U01HG010273 and from the National Institutes of Health (NIH), USA as part of the H3Africa Consortium. F. Carvalho and E. Fernandes acknowledge support from UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES, through national funds. L. F. S. Castro-de-Araujo is funded by The Wellcome Trust (Grant 202912/Z/16Z) via a research associate scholarship at Center of Data and Knowledge Integration for Health (CIDACS), Fundação Oswaldo Cruz (Fiocruz). A. Douiri acknowledges financial support from the National Institute for Health Research (NIHR) Biomedical Research and from the NIHR Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital NHS Foundation Trust. The views expressed are those of the author and not necessarily those of the King’s College London, NHS, the NIHR or the Department of Health. B. B. Duncan was supported in part by IATS/FAPERGS (465518/2014-1). A. P. Kengne is supported by the South African Medical Research Council. Y. J. Kim was funded by a grant from the Research Management Centre, Xiamen University Malaysia (Grant number: XMUMRF/2020-C6/ITCM/0004). M. Kivimäki reports grants from the UK Medical Research Council (MRC S011676), the US National Institutes on Ageing (NIA R01AG056477) and NordForsk. W. Kukull acknowledges support from U01 AG016976. M Kumar acknowledges support from FIC/NIMHK43 TW010716-03. I. Landires is member of the Sistema Nacional de Investigación (SNI), which is supported by the Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Panamá. S. Lorkowski acknowledges institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig (Germany; German Federal Ministry of Education and Research; grant agreement number 01EA1808A). S. Mondello acknowledges support by grant number GR-2013-02354960 from the Italian Ministry of Health. M. R. Phillips is supported in part by Global Alliance for Chronic Diseases-National Natural Science Foundation of China (NSFC. No. 81761128031). P. S. Sachdev acknowledges funding support from NHMRC Australia (grant no 1093086). J. P. Silva acknowledges support from grant number UIDB/04378/2020 from the Applied Molecular Biosciences Unit (UCIBIO), supported through Portuguese national funds via FCT/MCTES. C. E. I. Szoeke is supported by the National Med ical Health and Research Council, the Alzheimer’s Association, and The University of Melbourne. R. Tabarés-Seisdedos was supported in part by grant PI17/00719 from ISCIII-FEDER. C. Wu acknowledges support from the Ministry of Science and Technology (2020YFC2005600) and Suzhou Municipal Science and Technology Bureau (SS2019069). Sí

Published
2021

18. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017

Author

Sepanlou, Sadaf G., Safiri, Saeid, Bisignano, Catherine, Ikuta, Kevin S., Merat, Shahin, Saberifiroozi, Mehdi, Poustchi, Hossein, Tsoi, Derrick, Colombara, Danny V., Abdoli, Amir, Adedoyin, Rufus Adesoji, Afarideh, Mohsen, Agrawal, Sutapa, Ahmad, Sohail, Ahmadian, Elham, Ahmadpour, Ehsan, Akinyemiju, Tomi, Akunna, Chisom Joyqueenet, Alipour, Vahid, Almasi-Hashiani, Amir, Almulhim, Abdulaziz M., Al-Raddadi, Rajaa M., Alvis-Guzman, Nelson, Anber, Nahla Hamed, Angus, Colin, Anoushiravani, Amir, Arabloo, Jalal, Araya, Ephrem Mebrahtu, Asmelash, Daniel, Ataeinia, Bahar, Ataro, Zerihun, Atout, Maha Moh'd Wahbi, Ausloos, Floriane, Awasthi, Ashish, Badawi, Alaa, Banach, Maciej, Bejarano Ramirez, Diana Fernanda, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhattacharyya, Krittika, Biondi, Antonio, Bolla, Srinivasa Rao, Boloor, Archith, Borzì, Antonio M., Butt, Zahid A., Cámera, Luis LA Alberto, Campos-Nonato, Ismael R., Carvalho, Félix, Chu, Dinh-Toi, Chung, Sheng-Chia, Cortesi, Paolo Angelo, Costa, Vera M., Cowie, Benjamin C, Daryani, Ahmad, de Courten, Barbora, Demoz, Gebre Teklemariam, Desai, Rupak, Dharmaratne, Samath Dhamminda, Djalalinia, Shirin, Do, Hoa Thi, Dorostkar, Fariba, Drake, Thomas M., Dubey, Manisha, Duncan, Bruce B., Effiong, Andem, Eftekhari, Aziz, Elsharkawy, Aisha, Etemadi, Arash, Farahmand, Mohammad, Farzadfar, Farshad, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Gebremedhin, Ketema Bizuwork Bizuwork, Geta, Birhanu, Gilani, Syed Amir, Gill, Paramjit, Gutirrez, Reyna Alma, Haile, Michael Tamene, Haj-Mirzaian, Arvin, Hamid, Saeed S., Hasankhani, Milad, Hasanzadeh, Amir, Hashemian, Maryam, Hassen, Hamid Yimam, Hay, Simon I., Hayat, Khezar, Heidari, Behnam, Henok, Andualem, Hoang, Chi Linh, Hostiuc, Mihaela, Hostiuc, Sorin, Hsieh, Vivian Chia-rong, Igumbor, Ehimario U., Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Jafari Balalami, Nader, James, Spencer L., Jeemon, Panniyammakal, Jha, Ravi Prakash, Jonas, Jost B., Jozwiak, Jacek Jerzy, Kabir, Ali, Kasaeian, Amir, Kassaye, Hagazi Gebremedhin, Kefale, Adane Teshome, Khalilov, Rovshan, Khan, Muhammad Ali, Khan, Ejaz Ahmad, Khater, Amir, Kim, Yun Jin, Koyanagi, Ai, La Vecchia, Carlo, Lim, Lee-Ling, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Magdy Abd El Razek, Muhammed, Mai, Hue Thi, Manafi, Navid, Manafi, Amir, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Mazzaglia, Giampiero, Mehta, Dhruv, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Melkamu Merid, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miller, Ted R., Mirrakhimov, Erkin M., Mithra, Prasanna, Moazen, Babak, Moghadaszadeh, Masoud, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Mokdad, Ali H., Montero-Zamora, Pablo A., Moradi, Ghobad, Naimzada, Mukhammad David, Nayak, Vinod, Negoi, Ionut, Nguyen, Trang Huyen, Ofori-Asenso, Richard, Oh, In-Hwan, Olagunju, Tinuke O., Padubidri, Jagadish Rao, Pakshir, Keyvan, Pana, Adrian, Pathak, Mona, Pourshams, Akram, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Ramezanzadeh, Kiana, Rana, Saleem Muhammad M., Rawaf, Salman, Rawaf, David Laith, Reiner, Robert C., Roever, Leonardo, Room, Robin, Roshandel, Gholamreza, Safari, Saeed, Samy, Abdallah M., Sanabria, Juan, Sartorius, Benn, Schmidt, Maria Inês, Senthilkumaran, Subramanian, Shaikh, Masood Ali, Sharif, Mehdi, Sharifi, Amrollah, Shigematsu, Mika, Singh, Jasvinder A., Soheili, Amin, Suleria, Hafiz Ansar Rasul, Teklehaimanot, Berhane Fseha, Tesfay, Berhe Etsay, Vacante, Marco, Vahedian-Azimi, Amir, Valdez, Pascual R., Vasankari, Tommi Juhani, Vu, Giang Thu, Waheed, Yasir, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Westerman, Ronny, Wondafrash, Dawit Zewdu, Wondmieneh, Adam Belay, Yeshitila, Yordanos Gizachew, Yonemoto, Naohiro, Yu, Chuanhua, Zaidi, Zoubida, Zarghi, Afshin, Zelber-Sagi, Shira, Zewdie, Kaleab Alemayehu, Zhang, Zhi-Jiang, Zhao, Xiu-Ju, Naghavi, Mohsen, Malekzadeh, Reza, HASH(0x5651c9b09eb8), Institute for Molecular Medicine Finland, HUS Comprehensive Cancer Center, Clinicum, University of Helsinki, Sepanlou, S, Safiri, S, Bisignano, C, Ikuta, K, Merat, S, Saberifiroozi, M, Poustchi, H, Tsoi, D, Colombara, D, Abdoli, A, Adedoyin, R, Afarideh, M, Agrawal, S, Ahmad, S, Ahmadian, E, Ahmadpour, E, Akinyemiju, T, Akunna, C, Alipour, V, Almasi-Hashiani, A, Almulhim, A, Al-Raddadi, R, Alvis-Guzman, N, Anber, N, Angus, C, Anoushiravani, A, Arabloo, J, Araya, E, Asmelash, D, Ataeinia, B, Ataro, Z, Atout, M, Ausloos, F, Awasthi, A, Badawi, A, Banach, M, Bejarano Ramirez, D, Bhagavathula, A, Bhala, N, Bhattacharyya, K, Biondi, A, Bolla, S, Boloor, A, Borzì, A, Butt, Z, Cámera, L, Campos-Nonato, I, Carvalho, F, Chu, D, Chung, S, Cortesi, P, Costa, V, Cowie, B, Daryani, A, de Courten, B, Demoz, G, Desai, R, Dharmaratne, S, Djalalinia, S, Do, H, Dorostkar, F, Drake, T, Dubey, M, Duncan, B, Effiong, A, Eftekhari, A, Elsharkawy, A, Etemadi, A, Farahmand, M, Farzadfar, F, Fernandes, E, Filip, I, Fischer, F, Gebremedhin, K, Geta, B, Gilani, S, Gill, P, Gutirrez, R, Haile, M, Haj-Mirzaian, A, Hamid, S, Hasankhani, M, Hasanzadeh, A, Hashemian, M, Hassen, H, Hay, S, Hayat, K, Heidari, B, Henok, A, Hoang, C, Hostiuc, M, Hostiuc, S, Hsieh, V, Igumbor, E, Ilesanmi, O, Irvani, S, Jafari Balalami, N, James, S, Jeemon, P, Jha, R, Jonas, J, Jozwiak, J, Kabir, A, Kasaeian, A, Kassaye, H, Kefale, A, Khalilov, R, Khan, M, Khan, E, Khater, A, Kim, Y, Koyanagi, A, La Vecchia, C, Lim, L, Lopez, A, Lorkowski, S, Lotufo, P, Lozano, R, Magdy Abd El Razek, M, Mai, H, Manafi, N, Manafi, A, Mansournia, M, Mantovani, L, Mazzaglia, G, Mehta, D, Mendoza, W, Menezes, R, Mengesha, M, Meretoja, T, Mestrovic, T, Miazgowski, B, Miller, T, Mirrakhimov, E, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohammadian-Hafshejani, A, Mohammed, S, Mokdad, A, Montero-Zamora, P, Moradi, G, Naimzada, M, Nayak, V, Negoi, I, Nguyen, T, Ofori-Asenso, R, Oh, I, Olagunju, T, Padubidri, J, Pakshir, K, Pana, A, Pathak, M, Pourshams, A, Rabiee, N, Radfar, A, Rafiei, A, Ramezanzadeh, K, Rana, S, Rawaf, S, Rawaf, D, Reiner RC, J, Roever, L, Room, R, Roshandel, G, Safari, S, Samy, A, Sanabria, J, Sartorius, B, Schmidt, M, Senthilkumaran, S, Shaikh, M, Sharif, M, Sharifi, A, Shigematsu, M, Singh, J, Soheili, A, Suleria, H, Teklehaimanot, B, Tesfay, B, Vacante, M, Vahedian-Azimi, A, Valdez, P, Vasankari, T, Vu, G, Waheed, Y, Weldegwergs, K, Werdecker, A, Westerman, R, Wondafrash, D, Wondmieneh, A, Yeshitila, Y, Yonemoto, N, Yu, C, Zaidi, Z, Zarghi, A, Zelber-Sagi, S, Zewdie, K, Zhang, Z, Zhao, X, Naghavi, M, and Malekzadeh, R

Subjects
Liver Cirrhosis, Male, Cirrhosis, Cost-Benefit Analysis, HEPATITIS-B, Global Burden of Disease, Liver disease, Disability Evaluation, 0302 clinical medicine, Burden, Global, Mortality, Cirrhosis, Non-alcoholic Fatty Liver Disease, Risk Factors, FIBROSIS, Europe, Eastern, POPULATION, Aged, 80 and over, education.field_of_study, Singapore, Mortality rate, 1. No poverty, Gastroenterology, Hepatitis C, Hepatitis B, Middle Aged, 3. Good health, PREVALENCE, 030220 oncology & carcinogenesis, Asia, Central, 030211 gastroenterology & hepatology, Egypt, Female, Quality-Adjusted Life Years, Viral hepatitis, Life Sciences & Biomedicine, Adult, EUROPE, Population, GBD 2017 Cirrhosis Collaborators, Article, 03 medical and health sciences, LIVER-DISEASE, medicine, Humans, education, Liver Diseases, Alcoholic, Africa South of the Sahara, Aged, Science & Technology, Hepatology, Gastroenterology & Hepatology, business.industry, MORTALITY, DISABILITY, DECOMPENSATION, medicine.disease, Years of potential life lost, Early Diagnosis, Socioeconomic Factors, 3121 General medicine, internal medicine and other clinical medicine, INJURIES, Human medicine, business, Demography, RC
Abstract

Background\ud \ud Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories.\ud \ud \ud \ud Methods\ud \ud We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries.\ud \ud \ud \ud Findings\ud \ud In 2017, cirrhosis caused more than 1·32 million (95% UI 1·27–1·45) deaths (440 000 [416 000–518 000; 33·3%] in females and 883 000 [838 000–967 000; 66·7%] in males) globally, compared with less than 899 000 (829 000–948 000) deaths in 1990. Deaths due to cirrhosis constituted 2·4% (2·3–2·6) of total deaths globally in 2017 compared with 1·9% (1·8–2·0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21·0 (19·2–22·3) per 100 000 population in 1990 to 16·5 (15·8–18·1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions for all years of the study period (32·2 [25·8–38·6] deaths per 100 000 population in 2017), and the high-income super-region had the lowest (10·1 [9·8–10·5] deaths per 100 000 population in 2017). The age-standardised death rate decreased or remained constant from 1990 to 2017 in all GBD regions except eastern Europe and central Asia, where the age-standardised death rate increased, primarily due to increases in alcohol-related liver disease prevalence. At the national level, the age-standardised death rate of cirrhosis was lowest in Singapore in 2017 (3·7 [3·3–4·0] per 100 000 in 2017) and highest in Egypt in all years since 1990 (103·3 [64·4–133·4] per 100 000 in 2017). There were 10·6 million (10·3–10·9) prevalent cases of decompensated cirrhosis and 112 million (107–119) prevalent cases of compensated cirrhosis globally in 2017. There was a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017. Cirrhosis caused by NASH had a steady age-standardised death rate throughout the study period, whereas the other four causes showed declines in age-standardised death rate. The age-standardised prevalence of compensated and decompensated cirrhosis due to NASH increased more than for any other cause of cirrhosis (by 33·2% for compensated cirrhosis and 54·8% for decompensated cirrhosis) over the study period. From 1990 to 2017, the number of prevalent cases more than doubled for compensated cirrhosis due to NASH and more than tripled for decompensated cirrhosis due to NASH. In 2017, age-standardised death and DALY rates were lower among countries and territories with higher SDI.\ud \ud \ud \ud Interpretation\ud \ud Cirrhosis imposes a substantial health burden on many countries and this burden has increased at the global level since 1990, partly due to population growth and ageing. Although the age-standardised death and DALY rates of cirrhosis decreased from 1990 to 2017, numbers of deaths and DALYs and the proportion of all global deaths due to cirrhosis increased. Despite the availability of effective interventions for the prevention and treatment of hepatitis B and C, they were still the main causes of cirrhosis burden worldwide, particularly in low-income countries. The impact of hepatitis B and C is expected to be attenuated and overtaken by that of NASH in the near future. Cost-effective interventions are required to continue the prevention and treatment of viral hepatitis, and to achieve early diagnosis and prevention of cirrhosis due to alcohol-related liver disease and NASH.\ud \ud \ud \ud Funding\ud \ud Bill & Melinda Gates Foundation.

Published
2020

19. Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Author

Kinyoki, Damaris K., Ross, Jennifer M., Lazzar-Atwood, Alice, Munro, Sandra B., Schaeffer, Lauren E., Abbasalizad-Farhangi, Mahdieh, Abbasi, Masoumeh, Abbastabar, Hedayat, Abdelalim, Ahmed, Abdoli, Amir, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Nebiyu Dereje, Abebo, Teshome Abuka, Abegaz, Kedir Hussein, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R. M., Abushouk, Abdelrahman I., Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adabi, Maryam, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Aduroja, Posi Emmanuel, Advani, Shailesh M., Afarideh, Mohsen, Aghaali, Mohammad, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Sepideh, Ahmed, Muktar Beshir, Ahmed, Rushdia, Ajumobi, Olufemi, Akal, Chalachew Genet, Akalu, Temesgen Yihunie, Akinyemiju, Tomi, Akombi, Blessing, Al-Aly, Ziyad, Alam, Samiah, Alamene, Genet Melak, Alanzi, Turki M., Rabanal, Jacqueline Elizabeth Alcalde, Alema, Niguse Meles, Ali, Beriwan Abdulqadir, Ali, Muhammad, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Almasi, Afshin, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M., Al-Raddadi, Rajaa M., Altirkawi, Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amare, Azmeraw T., Amegah, Adeladza Kofi, Amini, Saeed, Rarani, Mostafa Amini, Amiri, Fatemeh, Amit, Arianna Maever Loreche, Anber, Nahla Hamed, Andrei, Catalina Liliana, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Anteneh, Zelalem Alamrew, Antonio, Carl Abelardo T., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Araya, Ephrem Mebrahtu, Arefi, Zohreh, Aremu, Olatunde, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Asgari, Samaneh, Asghari, Babak, Ashagre, Alebachew Fasil, Asrat, Anemaw A., Ataeinia, Bahar, Atalay, Hagos Tasew, Atnafu, Desta Debalkie, Atout, Maha Moh’d Wahbi, Ausloos, Marcel, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Aynalem, Yared A. Asmare, Azadmehr, Abbas, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Babaee, Ebrahim, Badawi, Alaa, Badiye, Ashish D., Bahrami, Mohamad Amin, Baig, Atif Amin A., Bakhtiari, Ahad, Bakkannavar, Shankar M., Balakrishnan, Senthilkumar, Bali, Ayele Geleto, Banach, Maciej, Banik, Palash Chandra, Baradaran-Seyed, Zahra, Baraki, Adhanom Gebreegziabher, Barboza, Miguel A., Bärnighausen, Till Winfried, Barua, Lingkan, Basaleem, Huda, Basu, Sanjay, Bayati, Mohsen, Bayih, Mulat Tirfie, Baynes, Habtamu Wondifraw, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Yibeltal Alemu, Bennett, Derrick A., Berbada, Dessalegn Ajema, Berhe, Kidanemaryam, Berhe, Abadi Kidanemariam, Berman, Adam E., Bernstein, Robert S., Bhageerathy, Reshmi, Bhandari, Dinesh, Bharadwaj, Pankaj, Bhattacharjee, Natalia V., Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bililign, Nigus, Sayeed, Muhammad Shahdaat Bin, Birara, Setognal, Birhane, Minuye Biniam Biniam, Birhanu, Minyichil, Biswas, Raaj Kishore, Bitew, Zebenay Workneh, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Bolla, Srinivasa Rao, Boloor, Archith, Borzì, Antonio M., Borzouei, Shiva, Brady, Oliver J., Bragazzi, Nicola Luigi, Braithwaite, Dejana, Briko, Nikolay Ivanovich, Britton, Gabrielle, Budhathoki, Shyam S., Nagaraja, Sharath Burugina, Busse, Reinhard, Butt, Zahid A., Cahuana-Hurtado, Lucero, Cámera, Luis Alberto, Campos-Nonato, Ismael R., Cano, Jorge, Car, Josip, Cárdenas, Rosario, Carrero, Juan J., Carvalho, Félix, Castaldelli-Maia, João Mauricio, Castañeda-Orjuela, Carlos A., Castro, Franz, Cerin, Ester, Chansa, Collins, Charan, Jaykaran, Chatterjee, Pranab, Chattu, Vijay Kumar, Chauhan, Bal Govind, Chavshin, Ali Reza, Chehrazi, Mohammad, Chichiabellu, Tesfaye Yitna, Chin, Ken Lee, Christopher, Devasahayam J., Chu, Dinh-Toi, Cicuttini, Flavia M., Collison, Michael L., Cork, Michael A., Cormier, Natalie, Cortesi, Paolo Angelo, Costa, Vera M., Dadi, Abel Fekadu Fekadu, Dagnew, Baye, Dahlawi, Saad M. A., Damiani, Giovanni, Darwish, Amira Hamed, Daryani, Ahmad, Das, Jai K., Gupta, Rajat Das, Dávila-Cervantes, Claudio, Davis Weaver, Nicole, Leo, Diego De, Neve, Jan-Walter De, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh, Demissie, Dereje Bayissa, Demoz, Gebre Teklemariam, Denova-Gutiérrez, Edgar, Deribe, Kebede, Desai, Rupak, Desalegn, Beruk Berhanu, Desalew, Assefa, Deshpande, Aniruddha, Dey, Sagnik, Dharmaratne, Samath Dhamminda, Dhillon, Preeti, Dhimal, Meghnath, Dhungana, Govinda Prasad, Nasab, Mostafa Dianati, Diaz, Daniel, Forooshani, Zahra Sadat Dibaji, Dinsa, Girmaye Deye, Dipeolu, Isaac Oluwafemi, Djalalinia, Shirin, Do, Hoa Thi, Do, Huyen Phuc, Doku, Paul Narh, Dorostkar, Fariba, Doshmangir, Leila, Dubey, Manisha, Adema, Bereket Duko, Dunachie, Susanna J., Duncan, Bruce B., Cousin, Ewerton, Durães, Andre R., Earl, Lucas, Leylabadlo, Hamed Ebrahimzadeh, Eftekhari, Aziz, El Sayed, Iman, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elbarazi, Iffat, Elemineh, Demelash Abewa, El-Jaafary, Shaimaa I., El-Khatib, Ziad, Elsharkawy, Aisha, El-Sherbiny, Yasser Mohamed, Elyazar, Iqbal R. F., Emamian, Mohammad Hassan, Enany, Shymaa, Endalew, Daniel Adane, Endalifer, Melese Linger, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Faraj, Anwar, Farashi, Sajjad, Fareed, Mohammad, Farioli, Andrea, Faro, Andre, Farzadfar, Farshad, Farzam, Hossein, Fatima, Syeda Sadia, Fattahi, Nazir, Fauk, Nelsensius Klau, Fazaeli, Ali Akbar, Fentahun, Netsanet, Ferede, Tomas Y., Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, João C., Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Förster, Jana, Francis, Joel Msafiri, Fukumoto, Takeshi, Gayesa, Reta Tsegaye, Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Tsegaye Tewelde, Gebremariam, Hadush, Gebremariam, Kidane Tadesse, Gebremedhin, Ketema Bizuwork Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebreslassie, Assefa Ayalew Ayalew, Gebretsadik, Gebretsadkan G. G., Gedefaw, Getnet Azeze, Geramo, Yilma Chisha Dea, Gesesew, Hailay Abrha, Geta, Birhanu, Getenet, Agegnehu Bante, Gezae, Kebede Embaye, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghajar, Alireza, Ghajarzadeh, Mahsa, Ghashghaee, Ahmad, Ghiasvand, Hesam, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Tiffany K., Ginawi, Ibrahim Abdelmageed, Goli, Srinivas, Gomes, Nelson G. M., Gopalani, Sameer Vali, Goudarzi, Houman, Goulart, Alessandra C., Govindakarnavar, Arunkumar, Grada, Ayman, Grivna, Michal, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Hafezi-Nejad, Nima, Haile, Michael Tamene, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Yadollah, Handiso, Demelash Woldeyohannes, Hankey, Graeme J., Haririan, Hamidreza, Hariyani, Ninuk, Hasaballah, Ahmed I., Hasan, Md. Mehedi, Hasankhani, Milad, Hasanpoor, Edris, Hasanzadeh, Amir, Hashemian, Maryam, Hassanipour, Soheil, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hawkes, Corinna, Hayat, Khezar, Hayelom, Desta Haftu, Heidari, Behnam, Heidari-Soureshjani, Reza, Hendrie, Delia, Henok, Andualem, Henry, Nathaniel J., Herrero, Mario, Herteliu, Claudiu, Heydarpour, Fatemeh, de Hidru, Hagos D., Hoang, Chi Linh, Hoek, Hans W., Hole, Michael K., Holla, Ramesh, Hollerich, Gillian, Rad, Enayatollah Homaie, Hong, Sung Hwi, Hoogar, Praveen, Horino, Masako, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hu, Guoqing, Huda, Tanvir M., Humayun, Ayesha, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Milena D., Imani-Nasab, Mohammad Hasan, Inbaraj, Leeberk Raja, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwu, Chidozie C. D., Iwu, Chinwe Juliana, Izadi, Neda, Jaafari, Jalil, Jaca, Anelisa, Jadidi-Niaragh, Farhad, Balalami, Nader Jafari, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalali, Amir, Jalilian, Farzad, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jehan, Fyezah, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Jia, Peng, John, Oommen, John-Akinola, Yetunde O., Johnson, Kimberly B., Jonas, Jost B., Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kahsay, Amaha, Kahssay, Molla, Kalani, Hamed, Kalankesh, Leila L., Kalhor, Rohollah, Kamiab, Zahra, Kanchan, Tanuj, Kapil, Umesh, Kapoor, Neeti, Karami, Manoochehr, Matin, Behzad Karami, Karch, André, Karim, Mohd A., Karki, Surendra, Kasaeian, Amir, Kasahun, Gebremicheal Gebreslassie, Kasaye, Habtamu Kebebe, Kassa, Tesfaye Dessale, Kassaye, Hagazi Gebremedhin, Kassebaum, Nicholas J., Karyani, Ali Kazemi, Kengne, Andre Pascal, Ketema, Daniel Bekele, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khaksarian, Mojtaba, Khalid, Nauman, Khalil, Ibrahim A., Khalilov, Rovshan, Khan, Asad, Khan, Ejaz Ahmad, Khan, Md Nuruzzaman, Khan, Mohammad Saud, Khan, Muhammad Shahzeb, Khatab, Khaled, Khater, Amir, Khater, Mona M., Khatib, Mahalqua Nazli, Khayamzadeh, Maryam, Khazaei-Pool, Maryam, Khazaei, Mohammad, Khazaei, Salman, Khodayari, Mohammad Taghi, Khosravi, Mohammad Hossein, Khundkar, Roba, Kiadaliri, Ali, Kianipour, Neda, Kiirithio, Daniel N., Kim, Yun Jin, Kimokoti, Ruth W., Kisa, Adnan, Kisa, Sezer, Kolola, Tufa, Komaki, Hamidreza, Kondlahalli, Shivakumar K. M., Koolivand, Ali, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U. G., Krishan, Kewal, Krohn, Kris J., Kugbey, Nuworza, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kurmi, Om P., Kuti, Oluwatosin, Vecchia, Carlo La, Lacey, Ben, Lad, Deepesh P., Lal, Aparna, Lal, Dharmesh Kumar, Lami, Faris Hasan, Lamichhane, Prabhat, Lang, Justin J., Lansingh, Van C., Lasrado, Savita, Lebedev, Georgy, Lee, Paul H., Lee, Shaun Wen Huey, Leili, Mostafa, Letourneau, Ian D., Lewycka, Sonia, Li, Shanshan, Lim, Lee-Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Lodha, Rakesh, Longbottom, Joshua, Lopez, Jaifred Christian F., Lorkowski, Stefan, Macarayan, Erlyn Rachelle King, Madadin, Mohammed, El Razek, Hassan Magdy Abd, El Razek, Muhammed Magdy Abd, Maghavani, Dhaval P., Mahasha, Phetole Walter, Mahotra, Narayan Bahadur, Maled, Venkatesh, Maleki, Afshin, Maleki, Shokofeh, Malta, Deborah Carvalho, Manafi, Ali, Manafi, Farzad, Manafi, Navid, Manohar, Narendar Dawanu, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Marczak, Laurie B., Arnedo, Carlos Alberto Marrugo, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Massenburg, Benjamin Ballard, Maulik, Pallab K., Mayala, Benjamin K., Mazidi, Mohsen, Mehndiratta, Man Mohan, Mehri, Freshteh, Mehta, Kala M., Meitei, Wahengbam Bigyananda, Mekonnen, Fantahun Ayenew, Mekonnen, Teferi, Meles, Gebrekiros Gebremichael, Meles, Hagazi Gebre, Melese, Addisu, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Meresa Berwo, Mensah, George A., Meretoja, Tuomo J., Miazgowski, Tomasz, Kostova, Neda Milevska, Miller, Ted R., Mills, Edward J., Mini, G. K., Mir, Seyed Mostafa, Miri, Mohammad, Mirjalali, Hamed, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Mithra, Prasanna, Moazen, Babak, Mohamadi, Efat, Mohamadi-Bolbanabad, Amjad, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammad, Dara K., Darwesh, Aso Mohammad, Mezerji, Naser Mohammad Gholi, Mohammadian-Hafshejani, Abdollah, Mohammadnia-Afrouzi, Mousa, Mohammadoo-Khorasani, Milad, Mohammadpourhodki, Reza, Mohammed, Salahuddin, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mohammed, Ammas Siraj, Mohebi, Farnam, Mokari, Amin, Mokdad, Ali H., Montañez, Julio Cesar, Montero-Zamora, Pablo A., Moodley, Yoshan, Moossavi, Maryam, Moradi, Ghobad, Moradi, Masoud, Moradi, Yousef, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradpour, Farhad, Moradzadeh, Rahmatollah, Moraga, Paula, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mouodi, Simin, Khaneghah, Amin Mousavi, Mozaffarian, Dariush, Mueller, Ulrich Otto, Murray, Christopher J. L., Murthy, G. V. S., Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nadkarni, Girish N., Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nansseu, Jobert Richie, Narayan, K. M. Venkat, Nascimento, Bruno Ramos, Nayak, Vinod, Nazari, Javad, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nigatu, Dabere, Nigatu, Yeshambel T., Nikbakhsh, Rajan, Ningrum, Dina Nur Anggraini, Nnaji, Chukwudi A., Nong, Vuong Minh, Noubiap, Jean Jacques, Nowak, Christoph, Oancea, Bogdan, Ofori-Asenso, Richard, Oghenetega, Onome Bright, Oh, In-Hwan, Oladimeji, Olanrewaju, Oladnabi, Morteza, Olagunju, Andrew T., Olagunju, Tinuke O., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oluwasanu, Mojisola Morenike, Omer, Muktar Omer, Onwujekwe, Obinna E., Asante, Kwaku Oppong, Oren, Eyal, Orisakwe, Orish Ebere, Ortiz, Alberto, Osarenotor, Osayomwanbo, Osgood-Zimmerman, Aaron E., Owolabi, Mayowa Ojo, P. A., Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pana, Adrian, Panda-Jonas, Songhomitra, Parsian, Hadi, Pashaei, Tahereh, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Ashish, Pathak, Mona, Pati, Sanghamitra, Patle, Ajay, Patton, George C., Paulos, Kebreab, Toroudi, Hamidreza Pazoki, Pepito, Veincent Christian Filipino, Perico, Norberto, Petri, William A., Pickering, Brandon V., Pigott, David M., Pirestani, Majid, Piroozi, Bakhtiar, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Kalhori, Reza Pourmirza, Pourshams, Akram, Poustchi, Hossein, Prada, Sergio I., Preotescu, Liliana, Pribadi, Dimas Ria Angga, Syed, Zahiruddin Quazi, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rahman, Sajjad ur, Rai, Rajesh Kumar, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Ramezanzadeh, Kiana, Rana, Saleem Muhammad, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Ray, Sarah E., Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Nima, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Rezapour, Aziz, Riahi, Seyed Mohammad, Ribeiro, Ana Isabel, Rickard, Jennifer, Rodriguez, Alina, Roever, Leonardo, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Rubagotti, Enrico, Saad, Anas M., Saadatagah, Seyedmohammad, Sabde, Yogesh Damodar, Sabour, Siamak, Sadeghi, Ehsan, Sadeghi, Masoumeh, Safari, Saeed, Safari, Yahya, Safarpour, Hamid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salam, Nasir, Salehi, Farkhonde, Zahabi, Saleh Salehi, Salem, Hosni, Salem, Marwa R. 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Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP), Veritati - Repositório Institucional da Universidade Católica Portuguesa, Biosciences, University of Helsinki, Clinicum, HUS Comprehensive Cancer Center, Institute for Molecular Medicine Finland, Department of Earth Observation Science, UT-I-ITC-ACQUAL, Faculty of Geo-Information Science and Earth Observation, Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD), Kinyoki, D, Ross, J, Lazzar-Atwood, A, Munro, S, Schaeffer, L, Abbasalizad-Farhangi, M, Abbasi, M, Abbastabar, H, Abdelalim, A, Abdoli, A, Abdollahi, M, Abdollahpour, I, Abdulkader, R, Abebe, N, Abebo, T, Abegaz, K, Abolhassani, H, Abreu, L, Abrigo, M, Abushouk, A, Accrombessi, M, 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A, Chehrazi, M, Chichiabellu, T, Chin, K, Christopher, D, Chu, D, Cicuttini, F, Collison, M, Cork, M, Cormier, N, Cortesi, P, Costa, V, Dadi, A, Dagnew, B, Dahlawi, S, Damiani, G, Darwish, A, Daryani, A, Das, J, Gupta, R, Davila-Cervantes, C, Davis Weaver, N, Leo, D, Neve, J, Demeke, F, Demis, A, Demissie, D, Demoz, G, Denova-Gutierrez, E, Deribe, K, Desai, R, Desalegn, B, Desalew, A, Deshpande, A, Dey, S, Dharmaratne, S, Dhillon, P, Dhimal, M, Dhungana, G, Nasab, M, Diaz, D, Forooshani, Z, Dinsa, G, Dipeolu, I, Djalalinia, S, Do, H, Doku, P, Dorostkar, F, Doshmangir, L, Dubey, M, Adema, B, Dunachie, S, Duncan, B, Duraes, A, Earl, L, Leylabadlo, H, Eftekhari, A, El Sayed, I, El Sayed Zaki, M, El Tantawi, M, Elbarazi, I, Elemineh, D, El-Jaafary, S, El-Khatib, Z, Elsharkawy, A, El-Sherbiny, Y, Elyazar, I, Emamian, M, Enany, S, Endalew, D, Endalifer, M, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Esteghamati, A, Etemadi, A, Etisso, A, Fanzo, J, Farahmand, M, Faraj, A, Farashi, S, Fareed, M, Farioli, A, Faro, A, Farzadfar, F, Farzam, H, Fatima, S, Fattahi, N, Fauk, N, Fazaeli, A, Fentahun, N, Ferede, T, Fereshtehnejad, S, Fernandes, E, Fernandes, J, Feyissa, G, Filip, I, Fischer, F, Flohr, C, Foigt, N, Folayan, M, Fomenkov, A, Foroutan, M, Forster, J, Francis, J, Fukumoto, T, Gayesa, R, Geberemariyam, B, Gebrehiwot, T, Gebremariam, H, Gebremariam, K, Gebremedhin, K, Gebremeskel, G, Gebreslassie, A, Gebretsadik, G, Gedefaw, G, Geramo, Y, Gesesew, H, Geta, B, Getenet, A, Gezae, K, Ghaffarifar, F, Ghafourifard, M, Ghajar, A, Ghajarzadeh, M, Ghashghaee, A, Ghiasvand, H, Gholamian, A, Gilani, S, Gill, T, Ginawi, I, Goli, S, Gomes, N, Gopalani, S, Goudarzi, H, Goulart, A, Govindakarnavar, A, Grada, A, Grivna, M, Guimaraes, R, Guled, R, Guo, Y, Hafezi-Nejad, N, Haile, M, Haj-Mirzaian, A, Hall, B, Halvaei, I, Hamadeh, R, Hamidi, Y, Handiso, D, Hankey, G, Haririan, H, Hariyani, N, Hasaballah, A, Hasan, M, Hasankhani, M, Hasanpoor, E, Hasanzadeh, A, Hashemian, M, Hassanipour, S, Hassen, H, Havmoeller, R, Hawkes, C, Hayat, K, Hayelom, D, Heidari, B, Heidari-Soureshjani, R, Hendrie, D, Henok, A, Henry, N, Herrero, M, Herteliu, C, Heydarpour, F, de Hidru, H, Hoang, C, Hoek, H, Hole, M, Holla, R, Hollerich, G, Rad, E, Hong, S, Hoogar, P, Horino, M, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Housseh, M, Hsairi, M, Hu, G, Huda, T, Humayun, A, Hwang, B, Ibitoye, S, Ilesanmi, O, Ilic, M, Imani-Nasab, M, Inbaraj, L, Iqbal, U, Irvani, S, Islam, S, Iwu, C, Izadi, N, Jaafari, J, Jaca, A, Jadidi-Niaragh, F, Balalami, N, Jafarinia, M, Jahani, M, Jakovljevic, M, Jalali, A, Jalilian, F, Jayatilleke, A, Jeemon, P, Jehan, F, Jenabi, E, Jha, R, Jha, V, Ji, J, Jia, P, John, O, John-Akinola, Y, Johnson, K, Jonas, J, Joseph, N, Joukar, F, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, A, Kabir, Z, Kahsay, A, Kahssay, M, Kalani, H, Kalankesh, L, Kalhor, R, Kamiab, Z, Kanchan, T, Kapil, U, Kapoor, N, Karami, M, Matin, B, Karch, A, Karim, M, Karki, S, Kasaeian, A, Kasahun, G, Kasaye, H, Kassa, T, Kassaye, H, Kassebaum, N, Karyani, A, Kengne, A, Ketema, D, Khader, Y, Khafaie, M, Khaksarian, M, Khalid, N, Khalil, I, Khalilov, R, Khan, A, Khan, E, Khan, M, Khatab, K, Khater, A, Khater, M, Khatib, M, Khayamzadeh, M, Khazaei-Pool, M, Khazaei, M, Khazaei, S, Khodayari, M, Khosravi, M, Khundkar, R, Kiadaliri, A, Kianipour, N, Kiirithio, D, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kolola, T, Komaki, H, Kondlahalli, S, Koolivand, A, Koul, P, Koyanagi, A, Kraemer, M, Krishan, K, Krohn, K, Kugbey, N, Kumar, M, Kumar, P, Kumar, V, Kurmi, O, Kuti, O, Vecchia, C, Lacey, B, Lad, D, Lal, A, Lal, D, Lami, F, Lamichhane, P, Lang, J, Lansingh, V, Lasrado, S, Lebedev, G, Lee, P, Lee, S, Leili, M, Letourneau, I, Lewycka, S, Li, S, Lim, L, Linn, S, Liu, S, Lodha, R, Longbottom, J, Lopez, J, Lorkowski, S, Macarayan, E, Madadin, M, El Razek, H, El Razek, M, Maghavani, D, Mahasha, P, Mahotra, N, Maled, V, Maleki, A, Maleki, S, Malta, D, Manafi, A, Manafi, F, Manafi, N, Manohar, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, M, Mapoma, C, Marami, D, Marczak, L, Arnedo, C, Martins-Melo, F, Masaka, A, Massenburg, B, Maulik, P, Mayala, B, Mazidi, M, Mehndiratta, M, Mehri, F, Mehta, K, Meitei, W, Mekonnen, F, Mekonnen, T, Meles, G, Meles, H, Melese, A, Mendoza, W, Menezes, R, Mengesha, M, Mensah, G, Meretoja, T, Miazgowski, T, Kostova, N, Miller, T, Mills, E, Mini, G, Mir, S, Miri, M, Mirjalali, H, Mirrakhimov, E, Mirzaei, H, Mirzaei, M, Mirzaei, R, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Mohamadi, E, Mohamadi-Bolbanabad, A, Mohammad, K, Mohammad, Y, Mohammad, D, Darwesh, A, Mezerji, N, Mohammadian-Hafshejani, A, Mohammadnia-Afrouzi, M, Mohammadoo-Khorasani, M, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohammed, A, Mohebi, F, Mokari, A, Mokdad, A, Montanez, J, Montero-Zamora, P, Moodley, Y, Moossavi, M, Moradi, G, Moradi, M, Moradi, Y, Moradi-Joo, M, Moradi-Lakeh, M, Moradpour, F, Moradzadeh, R, Moraga, P, Morrison, S, Mosapour, A, Mosser, J, Mouodi, S, Khaneghah, A, Mozaffarian, D, Mueller, U, Murray, C, Murthy, G, Musa, K, Mustafa, G, Muthupandian, S, Nabavizadeh, B, Naderi, M, Nadkarni, G, Nagarajan, A, Naghavi, M, Naheed, A, Naik, G, Najafi, F, Nansseu, J, Narayan, K, Nascimento, B, Nayak, V, Nazari, J, Ndwandwe, D, Negoi, I, Negoi, R, Ngunjiri, J, Nguyen, C, Nguyen, H, Nigatu, D, Nigatu, Y, Nikbakhsh, R, Ningrum, D, Nnaji, C, Nong, V, Noubiap, J, Nowak, C, Oancea, B, Ofori-Asenso, R, Oghenetega, O, Oh, I, Oladimeji, O, Oladnabi, M, Olagunju, A, Olagunju, T, Olusanya, B, Olusanya, J, Oluwasanu, M, Omer, M, Onwujekwe, O, Asante, K, Oren, E, Orisakwe, O, Ortiz, A, Osarenotor, O, Osgood-Zimmerman, A, Owolabi, M, P. A, M, Padubidri, J, Pakshir, K, Pana, A, Panda-Jonas, S, Parsian, H, Pashaei, T, Pasupula, D, Patel, S, Pathak, A, Pathak, M, Pati, S, Patle, A, Patton, G, Paulos, K, Toroudi, H, Pepito, V, Perico, N, Petri, W, Pickering, B, Pigott, D, Pirestani, M, Piroozi, B, Pirsaheb, M, Pokhrel, K, Postma, M, Pourjafar, H, Pourmalek, F, Kalhori, R, Pourshams, A, Poustchi, H, Prada, S, Preotescu, L, Pribadi, D, Syed, Z, Rabiee, M, Rabiee, N, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rahman, S, Rai, R, Rajabpour-Sanati, A, Rajati, F, Ramezanzadeh, K, Rana, S, Ranabhat, C, Rao, S, Rasella, D, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Ray, S, Remuzzi, G, Renjith, V, Renzaho, A, Resnikoff, S, Rezaei, N, Rezaeian, S, Rezai, M, Rezapour, A, Riahi, S, Ribeiro, A, Rickard, J, Rodriguez, A, Roever, L, Roro, E, Roshandel, G, Rostami, A, Rubagotti, E, Saad, A, Saadatagah, S, Sabde, Y, Sabour, S, Sadeghi, E, Sadeghi, M, Safari, S, Safari, Y, Safarpour, H, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, S, Salahshoor, M, Salam, N, Salehi, F, Zahabi, S, Salem, H, Salem, M, Salimi, Y, Salimzadeh, H, Kafil, H, Sambala, E, Samy, A, Santos, I, Jose, B, Saraswathy, S, Sarker, A, Sartorius, B, Sarveazad, A, Sathian, B, Satpathy, M, Saxena, S, Sayyah, M, Sbarra, A, Schipp, M, Schmidt, M, Schutte, A, Schwebel, D, Senbeta, A, Senthilkumaran, S, Seyedmousavi, S, Shaahmadi, F, Shafaat, O, Shahabi, S, Shaikh, M, Shalash, A, Shams-Beyranvand, M, Shamshirian, A, Shamsizadeh, M, Shannawaz, M, Sharafi, K, Sharif, M, Sharma, R, Shehata, H, Sheikhtaheri, A, Shibuya, K, Shiferaw, W, Shigematsu, M, Shin, J, Shiri, R, Shirkoohi, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, T, Sigfusdottir, I, Silva, D, Simonetti, B, Singh, A, Singh, P, Singh, V, Singh, J, Sinha, D, Sintayehu, Y, Sisay, M, Soheili, A, Soleymani, B, Soltani, F, Soltani, S, Soriano, J, Sorrie, M, Soshnikov, S, Soyiri, I, Spotin, A, Sreeramareddy, C, Srivastava, R, Starodubova, A, Sudaryanto, A, Sufiyan, M, Suleria, H, Sulo, G, Sunguya, B, Sykes, B, Tabares-Seisdedos, R, Tabuchi, T, Tadesse, B, Taherkhani, A, Tamirat, K, Tassew, S, Taveira, N, Teklehaimanot, B, Tekulu, G, Temsah, M, Terkawi, A, Tessema, Z, Thomas, N, Titova, M, Tlaye, K, Tohidinik, H, Tonelli, M, Tovani-Palone, M, Traini, E, Tran, K, Tripathi, M, Uddin, R, Ullah, I, Unnikrishnan, B, Upadhyay, E, Useh, U, Usman, M, Uthman, O, Vacante, M, Vaezghasemi, M, Valdez, P, Vanderheide, J, Varavikova, E, Varughese, S, Vasankari, T, Vasseghian, Y, Veisani, Y, Venkatesh, S, Venketasubramanian, N, Verma, M, Vidale, S, Violante, F, Vlassov, V, Vollmer, S, Vukovic, R, Waheed, Y, Wang, H, Wang, Y, Weldesamuel, G, Werdecker, A, Wiangkham, T, Wiens, K, Wijeratne, T, Wolde, H, Wondafrash, D, Wonde, T, Wondmieneh, A, Wu, A, Xu, G, Yadegar, A, Yadollahpour, A, Jabbari, S, Yamada, T, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yeshaneh, A, Yeshaw, Y, Yeshitila, Y, Yilma, M, Yip, P, Yonemoto, N, Yoon, S, Youm, Y, Younis, M, Yousefi, Z, Yousof, H, Yu, C, Yusefzadeh, H, Moghadam, T, Zaki, L, Zaman, S, Zamani, M, Zamanian, M, Zandian, H, Zarafshan, H, Zepro, N, Zerfu, T, Zewale, T, Zhang, Y, Zhang, Z, Zhao, X, Zodpey, S, Zomorodian, K, Zotor, F, Afshin, A, Hay, S, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), and Microbes in Health and Disease (MHD)

Subjects
Male, Local patterns, Double burden, Börn, Research & Experimental Medicine, Sjúkdómseinkenni, DOUBLE BURDEN, Childhood overweight, Lífefnafræði, Læknisfræði, 0302 clinical medicine, Syndemic, Child, 11 Medical and Health Sciences, under 5 years of age, General Medicine, 3. Good health, Geography, Medicine, Research & Experimental, Child, Preschool, Income, GROWTH, AFRICA, medicine.medical_specialty, Biochemistry & Molecular Biology, RJ, Medicina, Immunology, education, MODELS, wa_395, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Humans, Author Correction, Developing Countries, Poverty, Biology, LBD Double Burden of Malnutrition Collaborators, Demography, Science & Technology, Wasting Syndrome, Public health, MORTALITY, Infant, Næringarskortur, medicine.disease, Obesity, TRENDS, signs and symptoms, Social Class, Risk factors, Sameindalíffræði, ITC-ISI-JOURNAL-ARTICLE, UNDERNUTRITION, Human medicine, Clinical Medicine, 030217 neurology & neurosurgery, Pediatric Obesity, obesity, Offita, Áhættuþættir, Geographic Mapping, Overweight, RA0421, Global health, risk factors, 030212 general & internal medicine, Signs and symptoms, Wasting, Malnutrition, Global Burden of Diseases, Global Nutrition, low- and middle-income countries, 2. Zero hunger, 1. No poverty, Public Health, Global Health, Social Medicine and Epidemiology, A900 Others in Medicine and Dentistry, Childhood wasting, PREVALENCE, Chemistry, Mapping, Female, Lýðheilsa, medicine.symptom, Life Sciences & Biomedicine, GROWTH FAILURE, Nutritional Status, malnutrition, ITC-HYBRID, ws_115, children, Environmental health, medicine, Erfðafræði, wd_200, Malnutrition, Infant, Newborn, Klinisk medicin, Cell Biology, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, NA
Abstract

Artículo con numerosos autores, sólo se mencionan el primero, los de la UAM y grupo colectivo, A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of, This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation awarded to S.I.H.

Published
2020

20. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019

Author

Abbafati, Cristiana, Abbas, Kaja M., Abbasi, Mohammad, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abedi, Aidin, Abedi, Parisa, Abegaz, Kedir Hussein, Abolhassani, Hassan, Abosetugn, Akine Eshete, Aboyans, Victor, Abrams, Elissa M., Abreu, Lucas Guimaraes, Abrigo, Michael R. M., Abu Haimed, Abdulaziz Khalid, Abualhasan, Ahmed, Abu-Gharbieh, Eman, Abu-Raddad, Laith Jamal, Abushouk, Abdelrahman I., Acebedo, Alyssa, Ackerman, Ilana N., Adabi, Maryam, Adair, Tim, Adamu, Abdu A., Adebayo, Oladimeji M., Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adelson, Jaimie D., Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Advani, Shailesh M., Afarideh, Mohsen, Afshari, Mahdi, Afshin, Ashkan, Agardh, Emilie E., Agarwal, Gina, Agasthi, Pradyumna, Agesa, Kareha M., Aghaali, Mohammad, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Alireza, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmadpour, Ehsan, Ahmed, Muktar Beshir, Aji, Budi, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M., Albertson, Samuel B., Alcalde-Rabanal, Jacqueline Elizabeth, Alema, Niguse Meles, Alemu, Biresaw Wassihun, Alemu, Yihun Mulugeta, Alhabib, Khalid F., Alhassan, Robert Kaba, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, Francois, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi, Ali, Almasi-Hashiani, Amir, Almasri, Nihad A., Al-Mekhlafi, Hesham M., Almulhim, Abdulaziz M., Alonso, Jordi, Al-Raddadi, Rajaa M., Altirkawi, Khalid A., Alumran, Arwa Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amare, Azmeraw T., Amare, Bekalu, Amini, Saeed, Amini-Rarani, Mostafa, Aminorroaya, Arya, Amiri, Fatemeh, Amit, Arianna Maever L., Amugsi, Dickson A., Amul, Gianna Gayle Herrera, Anbesu, Etsay Woldu, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A., Andrei, Catalina Liliana, Andrei, Tudorel, Androudi, Sofia, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T., Antony, Catherine M., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y., Arba, Aseb Arba Kinfe, Aremu, Olatunde, Ariani, Filippo, Aripov, Timur, Armoon, Bahram, Arnlov, Johan, Arowosegbe, Oluwaseyi Olalekan, Aryal, Krishna K., Arzani, Afsaneh, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Asgari, Samaneh, Asghari, Babak, Jafarabadi, Mohammad Asghari, Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Athari, Seyyed Shamsadin, Atnafu, Desta Debalkie, Atout, Maha Moh'd Wahbi, Atre, Sachin R., Atteraya, Madhu Sudhan, Ausloos, Floriane, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel Gbenato Arthur, Quintanilla, Beatriz Paulina Ayala, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Getie Lake, Aynalem, Yared Asmare, Ayza, Muluken Altaye, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Azhar, Gulrez, Azzopardi, Peter S., Darshan, B. B., Babaee, Ebrahim, Badawi, Alaa, Badiye, Ashish D., Bagherzadeh, Mojtaba, Bagli, Eleni, Bahrami, Mohammad Amin, Baig, Atif Amin, Bairwa, Mohan, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M., Balachandran, Arun, Balakrishnan, Senthilkumar, Balalla, Shivanthi, Balassyano, Shelly, Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H., Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K., Banik, Palash Chandra, Bannick, Marlena S., Bante, Agegnehu Bante, Bante, Simachew Animen, Baraki, Adhanom Gebreegziabher, Barboza, Miguel A., Barker-Collo, Suzanne Lyn, Barnighausen, Till Winfried, Barrero, Lope H., Barthelemy, Celine M., Barua, Lingkan, Barzegar, Akbar, Basaleem, Huda, Bassat, Quique, Basu, Sanjay, Baune, Bernhard T., Bayati, Mohsen, Baye, Bayisa Abdissa, Bazmandegan, Gholamreza, Becker, Jacob S., Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Bejot, Yannick, Bekuma, Tariku Tesfaye Tesfaye, Bell, Michelle L., Bello, Aminu K., Bender, Rose G., Bennett, Derrick A., Bennitt, Fiona B., Bensenor, Isabela M., Benziger, Catherine P., Berhe, Kidanemaryam, Berman, Adam E., Bernabe, Eduardo, Bernstein, Robert S., Bertolacci, Gregory J., Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhardwaj, Pankaj, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhutta, Zulfiqar A., Bibi, Sadia, Biehl, Molly H., Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisanzio, Donal, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bjorge, Tone, Bockarie, Moses John, Bohlouli, Somayeh, Bohluli, Mehdi, Bojia, Hunduma Amensisa, Bolla, Srinivasa Rao, Boloor, Archith, Boon-Dooley, Alexandra S., Borges, Guilherme, Borzi, Antonio Maria, Borzouei, Shiva, Bose, Dipan, Bosetti, Cristina, Boufous, Soufiane, Bourne, Rupert, Brady, Oliver J., Braithwaite, Dejana, Brauer, Michael, Brayne, Carol, Breitborde, Nicholas J. 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A., Dai, Haijiang, Dai, Hancheng, Damasceno, Albertino Antonio Moura, Damiani, Giovanni, D'Amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Dangel, William James, Danielsson, Anna-Karin, Gela, Jiregna Darega, Dargan, Paul I., Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K., Das Gupta, Rajat, Das Neves, Jose, Dash, Aditya Prasad, Davey, Gail, Davila-Cervantes, Claudio Alberto, Davis, Adrian C., Davitoiu, Dragos Virgil, Davletov, Kairat, De Leo, Diego, De Neve, Jan-Walter, Dean, Frances E., DeCleene, Nicole K., Deen, Amanda, Degenhardt, Louisa, DeLang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-Gutierrez, Edgar, Dereje, Nebiyu Dereje, Deribe, Kebede, Dervenis, Nikolaos, Desai, Rupak, Desalew, Assefa, Dessie, Getenet Ayalew, Deuba, Keshab, Dharmaratne, Samath Dhamminda, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, da Silva, Diana Dias, Diaz, Daniel, Forooshani, Zahra Sadat Dibaji, Dichgans, Martin, Didarloo, Alireza, Dingels, Zachary V., Dippenaar, Ilse N., Dirac, M. 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Q., Kohler, Stefan, Kolola, Tufa, Komaki, Hamidreza, Kopec, Jacek A., Korotkova, Anna V., Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kotlo, Anirudh, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U. G., Kravchenko, Michael A., Krishan, Kewal, Krohn, Kris J., Kromhout, Hans, Shaji, K. S., Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kugbey, Nuworza, Kulkarni, Vaman, Kumar, G. Anil, Kumar, Manasi, Kumar, Nithin, Kumar, Pushpendra, Kumar, Vivek, Kumaresh, Girikumar, Kurmi, Om P., Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lam, Jennifer O., Lami, Faris Hasan, Lan, Qing, Landires, Ivan, Lang, Justin J., Langan, Sinead M., Lansingh, Van Charles, Lansky, Sonia, Larson, Heidi Jane, Larson, Samantha Leigh, Larsson, Anders, Lasrado, Savita, Lassi, Zohra S., Lau, Kathryn Mei-Ming, Lauriola, Paolo, Lavados, Pablo M., Lazarus, Jeffrey V., Leal, Lisiane F., Leasher, Janet L., Ledesma, Jorge R., Lee, Paul H., Lee, Shaun Wen Huey, Leever, Andrew T., LeGrand, Kate E., Leigh, James, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Lewington, Sarah, Li, Bingyu, Li, Shanshan, Lim, Lee-Ling, Lin, Christine, Lin, Ro-Ting, Linehan, Christine, Linn, Shai, Listl, Stefan, Liu, Hung-Chun, Liu, Shiwei, Liu, Simin, Liu, Xuefeng, Liu, Yang, Liu, Zichen, Lo, Justin, Lodha, Rakesh, Logroscino, Giancarlo, Looker, Katharine J., Lopez, Alan D., Lopez, Jaifred Christian F., Lopukhov, Platon D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lu, Alton, Lucas, Tim C. D., Lugo, Alessandra, Lunevicius, Raimundas, Lyons, Ronan A., Ma, Jianing, Machado, Daiane Borges, MacLachlan, Jennifer H., Madadin, Mohammed, Maddison, Emilie R., Maddison, Ralph, Madotto, Fabiana, Abd El Razek, Hassan Magdy, Abd El Razek, Muhammed Magdy, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Mai, Hue Thi, Majeed, Azeem, Malagon-Rojas, Jeadran N., Maled, Venkatesh, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A., Manafi, Amir, Manafi, Navid, Manda, Ana Laura, Manguerra, Helena, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Herrera, Ana M. 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N., Memish, Ziad A., Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Mengesha, Meresa Berwo, Mensah, George A., Mereke, Alibek, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R., Mills, Edward J., Milne, George J., Mini, G. K., Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Mitchell, Philip B., Mithra, Prasanna, Moazen, Babak, Moghadaszadeh, Masoud, Mohajer, Bahram, Mohamad, Osama, Mohamadi, Efat, Mohammad, Dara K., Mohammad, Yousef, Mezerji, Naser Mohammad Gholi, Mohammadbeigi, Abolfazl, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mohebi, Farnam, Bandpei, Mohammad A. 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M., Zlavog, Bianca S., Zodpey, Sanjay, Lim, Stephen S., and Murray, Christopher J. L.

Abstract

In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the post

Published
2020
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21. Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019

Author

Lozano, Rafael, Fullman, Nancy, Mumford, John Everett, Knight, Megan, Barthelemy, Celine M., Abbafati, Cristiana, Abbastabar, Hedayat, Abd-Allah, Foad, Abdollahi, Mohammad, Abedi, Aidin, Abolhassani, Hassan, Abosetugn, Akine Eshete, Abreu, Lucas Guimarães, Abrigo, Michael R.M., Abu Haimed, Abdulaziz Khalid, Abushouk, Abdelrahman I., Adabi, Maryam, Adebayo, Oladimeji M., Adekanmbi, Victor, Adelson, Jaimie, Adetokunboh, Olatunji O., Adham, Davoud, Advani, Shailesh M., Afshin, Ashkan, Agarwal, Gina, Agasthi, Pradyumna, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Akinyemi, Rufus Olusola, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Albertson, Samuel B., Alemu, Yihun Mulugeta, Alhassan, Robert Kaba, Ali, Muhammad, Ali, Saqib, Alipour, Vahid, Aljunid, Syed Mohamed, Alla, François, Almadi, Majid Abdulrahman Hamad, Almasi, Ali, Almasi-Hashiani, Amir, Almasri, Nihad A., Al-Mekhlafi, Hesham M., Almulhim, Abdulaziz M., Alonso, Jordi, Al-Raddadi, Rajaa M., Altirkawi, Khalid A., Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amini, Saeed, Amini-Rarani, Mostafa, Amiri, Fatemeh, Amit, Arianna Maever L., Amugsi, Dickson A., Ancuceanu, Robert, Anderlini, Deanna, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T., Antony, Catherine M., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y., Aremu, Olatunde, Ärnlöv, Johan, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Ashbaugh, Charlie, Athari, Seyyed Shamsadin, Atout, Maha Moh d.Wahbi, Ausloos, Marcel, Avila-Burgos, Leticia, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Aynalem, Getie Lake, Ayza, Muluken Altaye, Azari, Samad, Azzopardi, Peter S., B, Darshan B., Babaee, Ebrahim, Badiye, Ashish D., Bahrami, Mohammad Amin, Baig, Atif Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M., Balachandran, 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Mehedi, Hashi, Abdiwahab, Hassan, Shoaib, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Hendrie, Delia, Herteliu, Claudiu, Hird, Thomas R., Ho, Hung Chak, Hole, Michael K., Holla, Ramesh, Hollingsworth, Bruce, Hoogar, Praveen, Hopf, Kathleen Pillsbury, Horita, Nobuyuki, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsieh, Vivian Chia rong, Hu, Guoqing, Huda, Tanvir M., Humayun, Ayesha, Hwang, Bing Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Inbaraj, Leeberk Raja, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M. Mofizul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Iso, Hiroyasu, Iwu, Chinwe Juliana, Iwu, Chidozie C.D., Jaafari, Jalil, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jahagirdar, Deepa, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, Janjani, Hosna, Javaheri, Tahereh, Jayatilleke, Achala Upendra, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Jia, Peng, John-Akinola, Yetunde O., Jonas, Jost B., Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Kalankesh, Leila R., Kalhor, Rohollah, Kamath, Aruna M., Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karanikolos, Marina, Karimi, Seyed M., Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kayode, Gbenga A., Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khammarnia, Mohammad, Khan, Maseer, Khan, Ejaz Ahmad, Khang, Young Ho, Khatab, Khaled, Khater, Amir M., Khater, Mona M., Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khubchandani, Jagdish, Kianipour, Neda, Kim, Young Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Kneib, Cameron J., Kocarnik, Jonathan M., Kochhar, Sonali, Kohler, Stefan, Kopec, Jacek A., Korotkova, Anna V., Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kotlo, Anirudh, Koul, Parvaiz A., Koyanagi, Ai, Krishan, Kewal, Krohn, Kris J., Kugbey, Nuworza, Kulkarni, Vaman, Kumar, G. Anil, Kumar, Nithin, Kumar, Manasi, Kurmi, Om P., Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Landires, Iván, Lansingh, Van Charles, Larsson, Anders O., Lasrado, Savita, Lau, Kathryn Mei Ming, Lauriola, Paolo, Lazarus, Jeffrey V., Ledesma, Jorge R., Lee, Paul H., Lee, Shaun Wen Huey, Leever, Andrew T., LeGrand, Kate E., Leigh, James, Leonardi, Matilde, Li, Shanshan, Lim, Stephen S., Lim, Lee Ling, Liu, Xuefeng, Logroscino, Giancarlo, Lopez, Alan D., Lopukhov, Platon D., Lotufo, Paulo A., Lu, Alton, Ma, Jianing, Madadin, Mohammed, Mahasha, Phetole Walter, Mahmoudi, Morteza, Majeed, Azeem, Malagón-Rojas, Jeadran N., Maleki, Shokofeh, Malta, Deborah Carvalho, Mansouri, Borhan, Mansournia, Mohammad Ali, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, Massenburg, Benjamin Ballard, Mastrogiacomo, Claudia I., Mathur, Manu Raj, McAlinden, Colm, McKee, Martin, Medina-Solís, Carlo Eduardo, Meharie, Birhanu Geta, Mehndiratta, Man Mohan, Mehrabi Nasab, Entezar, Mehri, Fereshteh, Mehrotra, Ravi, Mekonnen, Teferi, Melese, Addisu, Memiah, Peter T.N., Mendoza, Walter, Menezes, Ritesh G., Mensah, George A., Meretoja, Tuomo J., Meretoja, Atte, Mestrovic, Tomislav, Miazgowski, Bartosz, Michalek, Irmina Maria, Mirrakhimov, Erkin M., Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Mitchell, Philip B., Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Yousef, Mohammad, Dara K., Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mokdad, Ali H., Monasta, Lorenzo, Mondello, Stefania, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mousavi Khaneghah, Amin, Muriithi, Moses K., Mustafa, Ghulam, Nabhan, Ashraf F., Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Nangia, Vinay, Nansseu, Jobert Richie, Nayak, Vinod C., Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Negoi, Ruxandra Irina, Neupane, Subas, Ngari, Kiirithio N., Nguefack-Tsague, Georges, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Diep Ngoc, Nguyen, Huong Lan Thi, Nnaji, Chukwudi A., Nomura, Shuhei, Norheim, Ole F., Noubiap, Jean Jacques, Nowak, Christoph, Nunez-Samudio, Virginia, Otoiu, Adrian, Ogbo, Felix Akpojene, Oghenetega, Onome Bright, Oh, In Hwan, Okunga, Emmanuel Wandera, Oladnabi, Morteza, Olagunju, Andrew T., Olusanya, Jacob Olusegun, Olusanya, Bolajoko Olubukunola, Oluwasanu, Mojisola Morenike, Omar Bali, Ahmed, Omer, Muktar Omer, Ong, Kanyin L., Onwujekwe, Obinna E., Ortega-Altamirano, Doris V.V., Ortiz, Alberto, Ostojic, Sergej M., Otstavnov, Nikita, Otstavnov, Stanislav S., Øverland, Simon, Owolabi, Mayowa O., Padubidri, Jagadish Rao, Pakhale, Smita, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pangaribuan, Helena Ullyartha, Pathak, Mona, Patton, George C., Paudel, Sagun, Pazoki Toroudi, Hamidreza, Pease, Spencer A., Peden, Amy E., Pennini, Alyssa, Peprah, Emmanuel K., Pereira, Jeevan, Pigott, David M., Pilgrim, Thomas, Pilz, Tessa M., Pinheiro, Marina, Piradov, Michael A., Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Pourmirza Kalhori, Reza, Pourshams, Akram, Prada, Sergio I., Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Radfar, Amir, Rafiee, Ata, Rafiei, Alireza, Raggi, Alberto, Rahim, Fakher, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rana, Saleem Muhammad, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rasella, Davide, Rashedi, Vahid, Rath, Goura Kishor, Rathi, Priya, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Rawassizadeh, Reza, Razo, Christian, Renjith, Vishnu, Renzaho, Andre M.N., Reshmi, Bhageerathy, Rezaei, Nima, Riahi, Seyed Mohammad, Ribeiro, Daniel Cury, Rickard, Jennifer, Roberts, Nicholas L.S., Roever, Leonardo, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Rubagotti, Enrico, Rwegerera, Godfrey M., Sabour, Siamak, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Masoumeh, Sadeghi, Ehsan, Safari, Yahya, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salem, Marwa R.Rashad, Salem, Hosni, Salomon, Joshua, Samadi Kafil, Hossein, Samy, Abdallah M., Sanabria, Juan, Santric-Milicevic, Milena M., Saraswathy, Sivan Yegnanarayana Iyer, Sarmiento-Suárez, Rodrigo, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Savic, Miloje, Sawyer, Susan M., Saxena, Deepak, Sbarra, Alyssa N., Schaeffer, Lauren E., Schiavolin, Silvia, Schmidt, Maria Inês, Schutte, Aletta Elisabeth, Schwebel, David C., Schwendicke, Falk, Seedat, Soraya, Sha, Feng, Shahabi, Saeed, Shaheen, Amira A., Shaikh, Masood Ali, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomars, Sharara, Fablina, Sharifi, Hamid, Shaw, David H., Sheikh, Aziz, Sheikhtaheri, Abbas, Shetty, B. Suresh Kumar, Shibuya, Kenji, Shiferaw, Wondimeneh Shibabaw, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Shirkoohi, Reza, Shivakumar, K. M., Shrime, Mark G., Shuval, Kerem, Siabani, Soraya, Sierpinski, Radoslaw, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santos, Silva, João Pedro, Simonetti, Biagio, Simpson, Kyle E., Singh, Jasvinder A., Singh, Pushpendra, Sinha, Dhirendra Narain, Skryabin, Valentin Yurievich, Smith, Emma U.R., Soheili, Amin, Soltani, Shahin, Soofi, Moslem, Sorensen, Reed J.D., Soriano, Joan B., Sorrie, Muluken Bekele, Soyiri, Ireneous N., Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T., Stanaway, Jeffrey D., Steel, Nicholas, Stein, Caroline, Stokes, Mark A., Sufiyan, Mu'awiyyah Babale, Suleria, Hafiz Ansar Rasul, Sultan, Iyad, Szumowski, Łukasz, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadakamadla, Santosh Kumar, Taddele, Biruk Wogayehu, Tadesse, Degena Bahrey, Taherkhani, Amir, Tamiru, Animut Tagele, Tanser, Frank C., Tareque, Md Ismail, Tarigan, Ingan Ukur, Teagle, Whitney L., Tediosi, Fabrizio, Tefera, Yonas Getaye Getaye, Tela, Freweini Gebrearegay, 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A., Yeshitila, Yordanos Gizachew, Yip, Paul, Yonemoto, Naohiro, Younis, Mustafa Z., Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yusefzadeh, Hasan, Zadey, Siddhesh, Zahirian Moghadam, Telma, Zaidi, Syed Saoud, Zaki, Leila, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zastrozhin, Mikhail Sergeevich, Zewdie, Kaleab Alemayehu, Zhang, Yunquan, Zhao, Xiu Ju George, Zhao, Yingxi, Zheng, Peng, Zhu, Cong, Ziapour, Arash, Zlavog, Bianca S., Zodpey, Sanjay, Murray, Christopher J.L., Lozano, Rafael, Fullman, Nancy, Mumford, John Everett, Knight, Megan, Barthelemy, Celine M., Abbafati, Cristiana, Abbastabar, Hedayat, Abd-Allah, Foad, Abdollahi, Mohammad, Abedi, Aidin, Abolhassani, Hassan, Abosetugn, Akine Eshete, Abreu, Lucas Guimarães, Abrigo, Michael R.M., Abu Haimed, Abdulaziz Khalid, Abushouk, Abdelrahman I., Adabi, Maryam, Adebayo, Oladimeji M., Adekanmbi, Victor, Adelson, Jaimie, Adetokunboh, Olatunji O., Adham, Davoud, Advani, Shailesh M., Afshin, Ashkan, Agarwal, 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Young Jasmine, Christensen, Hanne, Chu, Dinh Toi, Chung, Michael T., Ciobanu, Liliana G., Cirillo, Massimo, Comfort, Haley, Compton, Kelly, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Dahlawi, Saad M.A., Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Darega Gela, Jiregna, Darwesh, Aso Mohammad, Daryani, Ahmad, Dash, Aditya Prasad, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, De Neve, Jan Walter, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Desai, Rupak, Dharmaratne, Samath Dhamminda, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N., Do, Hoa Thi, Dorostkar, Fariba, Doshmangir, Leila, Duncan, Bruce B., Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Edvardsson, David, El Sayed, Iman, El Tantawi, Maha, Elgendy, Islam Y., Elyazar, Iqbal RF, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Ezekannagha, Oluchi, Farag, Tamer, Farahmand, Mohammad, Faraon, Emerito Jose A., Farinha, Carla Sofia e.Sá, Farioli, Andrea, Faris, Pawan Sirwan, Faro, Andre, Fazlzadeh, Mehdi, Feigin, Valery L., Fernandes, Eduarda, Ferrara, Pietro, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fisher, James L., Flor, Luisa Sorio, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Francis, Joel Msafiri, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M., Gad, Mohamed M., Gaidhane, Abhay Motiramji, Gakidou, Emmanuela, Galles, Natalie C., Gallus, Silvano, Gardner, William M., Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Abiyu Mekonnen, Gebremeskel, Leake G., Gebremeskel, Gebreamlak Gebremedhn, Gesesew, Hailay Abrha, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghashghaee, Ahmad, Ghith, Nermin, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Paramjit Singh, Gill, Tiffany K., Ginindza, Themba G., Gitimoghaddam, Mojgan, Giussani, Giorgia, Glagn, Mustefa, Gnedovskaya, Elena V., Godinho, Myron Anthony, Goharinezhad, Salime, Gopalani, Sameer Vali, Goudarzian, Amir Hossein, Goulart, Bárbara Niegia Garcia, Gubari, Mohammed Ibrahim Mohialdeen, Guimarães, Rafael Alves, Guled, Rashid Abdi, Gultie, Teklemariam, Guo, Yuming, Gupta, Rajeev, Gupta, Rahul, Hafezi-Nejad, Nima, Hafiz, Abdul, Haile, Teklehaimanot Gereziher, Hamadeh, Randah R., Hameed, Sajid, Hamidi, Samer, Han, Chieh, Han, Hannah, Handiso, Demelash Woldeyohannes, Hanif, Asif, Hankey, Graeme J., Haro, Josep Maria, Hasaballah, Ahmed I., Hasan, Md Mehedi, Hashi, Abdiwahab, Hassan, Shoaib, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Hendrie, Delia, Herteliu, Claudiu, Hird, Thomas R., Ho, Hung Chak, Hole, Michael K., Holla, Ramesh, Hollingsworth, Bruce, Hoogar, Praveen, Hopf, Kathleen Pillsbury, Horita, Nobuyuki, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsieh, Vivian 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Mofizul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Iso, Hiroyasu, Iwu, Chinwe Juliana, Iwu, Chidozie C.D., Jaafari, Jalil, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jahagirdar, Deepa, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, Janjani, Hosna, Javaheri, Tahereh, Jayatilleke, Achala Upendra, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Jia, Peng, John-Akinola, Yetunde O., Jonas, Jost B., Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Kalankesh, Leila R., Kalhor, Rohollah, Kamath, Aruna M., Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karanikolos, Marina, Karimi, Seyed M., Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kayode, Gbenga A., Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khammarnia, Mohammad, Khan, Maseer, Khan, Ejaz Ahmad, Khang, Young Ho, Khatab, Khaled, Khater, Amir M., Khater, Mona M., Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khubchandani, Jagdish, Kianipour, Neda, Kim, Young Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Kneib, Cameron J., Kocarnik, Jonathan M., Kochhar, Sonali, Kohler, Stefan, Kopec, Jacek A., Korotkova, Anna V., Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kotlo, Anirudh, Koul, Parvaiz A., Koyanagi, Ai, Krishan, Kewal, Krohn, Kris J., Kugbey, Nuworza, Kulkarni, Vaman, Kumar, G. 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Abstract

Background: Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods: Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (≥65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0–100 based on the 2·5th and 97·5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UH

Published
2020

22. Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

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Abstract

Background: Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods: Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (≥65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0–100 based on the 2·5th and 97·5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC e

Published
2020

23. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019

Author

Vos, Theo, Lim, Stephen S, Abbafati, Cristiana, Abbas, Kaja M, Abbasi, Mohammad, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abolhassani, Hassan, Aboyans, Victor, Abrams, Elissa M, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abu-Raddad, Laith Jamal, Abushouk, Abdelrahman I, Acebedo, Alyssa, Ackerman, Ilana N, Adabi, Maryam, Adamu, Abdu A, Adebayo, Oladimeji M, Adekanmbi, Victor, Adelson, Jaimie D, Adetokunboh, Olatunji O, Adham, Davoud, Afshari, Mahdi, Afshin, Ashkan, Agardh, Emilie E, Agarwal, Gina, Agesa, Kareha M, Aghaali, Mohammad, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmadpour, Ehsan, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Samiah, Alam, Tahiya, Alanzi, Turki M, Albertson, Samuel B, Alcalde-Rabanal, Jacqueline Elizabeth, Alema, Niguse Meles, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almasi-Hashiani, Amir, Alonso, Jordi, Al-Raddadi, Rajaa M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Amini, Saeed, Amini-Rarani, Mostafa, Aminorroaya, Arya, Amiri, Fatemeh, Amit, Arianna Maever L, Amugsi, Dickson A, Amul, Gianna Gayle Herrera, Anderlini, Deanna, Andrei, Catalina Liliana, Andrei, Tudorel, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Ariani, Filippo, Ärnlöv, Johan, Aryal, Krishna K, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Asghari, Babak, Ashbaugh, Charlie, Atnafu, Desta Debalkie, Atre, Sachin R, Ausloos, Floriane, Ausloos, Marcel, Quintanilla, Beatriz Paulina Ayala, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Babaee, Ebrahim, Badawi, Alaa, Bagherzadeh, Mojtaba, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Balakrishnan, Senthilkumar, Balalla, Shivanthi, Balassyano, Shelly, Banach, Maciej, Banik, Palash Chandra, Bannick, Marlena S, Bante, Agegnehu Bante, Baraki, Adhanom Gebreegziabher, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Barthelemy, Celine M, Barua, Lingkan, Barzegar, Akbar, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Bazmandegan, Gholamreza, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bello, Aminu K, Bender, Rose G, Bennett, Derrick A, Bennitt, Fiona B, Bensenor, Isabela M, Benziger, Catherine P, Berhe, Kidanemaryam, Bernabe, Eduardo, Bertolacci, Gregory J, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bibi, Sadia, Biehl, Molly H, Bikbov, Boris, Sayeed, Muhammad 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Alemayehu, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Jeff T, Zhao, Yingxi, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, Zimsen, Stephanie R M, Naghavi, Mohsen, and Murray, Christopher J L

Abstract

Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th a

Published
2020

26. Burden of hepatitis B surface antigen sero-prevalence and associated factors among pregnant women receiving antenatal care at a public health institution, southern Ethiopia, 2018: implications for public health prevention.

Author

Marama, Tinsae, Shegaze, Mulugeta, Fikadu, Kassahun, Yeshitila, Yordanos Gizachew, Shibru, Tamiru, Memiah, Peter, and Biresaw, Gelila

Subjects
*HEPATITIS associated antigen, *HEALTH facilities, *PREGNANT women, *HEPATITIS B, *PRENATAL care, *WOMEN'S hospitals, *CHRONIC hepatitis B
Abstract

Introduction: Globally, more than 257 million people are living with chronic hepatitis B virus (HBV) infection, which is a major cause of morbidity and mortality in Africa and Asia. The nationwide disease burden of chronic HBV in Ethiopia is estimated to be approximately 8%. Thus, determining the factors associated with HBsAg seroprevalence in different geographical settings and in different population sub-groups is paramount in designing appropriate preventative measures. Aim of the research: To identity the burden of hepatitis B surface antigen sero-prevalence and associated factors among pregnant women. Material and methods: A cross-sectional study was conducted at Jinka Hospital among pregnant mothers. A pre-tested, semi-structured questionnaire was administered by an interviewer and used to collect the data. Serum was obtained from each study subject and used to test for hepatitis B surface antigen (HBsAg) with an enzyme-linked immunosorbent assay test kit. Descriptive, bivariate, and multivariate logistic regression analyses were performed to identify associated factors. Odds ratio and 95% confidence interval were used to determine the degree of association. Results: The HBsAg seroprevalence was nine percent. Scarification (adjusted odds ratio (AOR) = 4.43, 95% CI: 1.77-11.06), having multiple sexual partners (AOR = 4.70, 95% CI: 1.66-13.29), and having a sexually transmitted infection in the past (AOR = 5.57, 95% CI: 2.35-13.17) were significantly associated with HBsAg seroprevalence. Conclusions: The HBsAg seroprevalence among pregnant women was high according to the World Health Organization (WHO) classification criteria. The study identified different factors associated with HBsAg seroprevalence. A properly designed intervention strategy that will lead to reduction of HBsAg seroprevalence, including routine screenings and vaccinations, is warranted. [ABSTRACT FROM AUTHOR]

Published
2020
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27. Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

William M. Gardner, Rawlance Ndejjo, Govinda Prasad Dhungana, Fereshteh Ansari, Kathleen Pillsbury Hopf, João Pedro Silva, M. Mofizul Islam, Cong Zhu, Abdul Hafiz, Irmina Maria Michalek, Syed Mohamed Aljunid, Leonardo Roever, Mustefa Glagn, Davood Anvari, Tessa M. Pilz, Sameer Vali Gopalani, Joel M. Francis, Man Mohan Mehndiratta, Rakhi Dandona, Abbas Sheikhtaheri, Mansour Ghafourifard, Simon Øverland, David Laith Rawaf, Jaykaran Charan, Akram Pourshams, Mostafa Dianatinasab, Morteza Mahmoudi, Alton Lu, Alyssa N. Sbarra, Lorainne Tudor Car, Franz Castro, Hafiz Ansar Rasul Suleria, Luca Ronfani, Marina Pinheiro, Mehran Asadi-Aliabadi, Maziar Moradi-Lakeh, Hoa Thi Do, Whitney L. Teagle, Sofia Androudi, Carl Abelardo T. Antonio, Myron Anthony Godinho, Bhaskaran Unnikrishnan, Oluchi Ezekannagha, Getinet Ayano, Seyyed Shamsadin Athari, Dimas Ria Angga Pribadi, Kyle E. Simpson, Muluken Bekele Sorrie, Vivekanand Jha, Chukwuma David Umeokonkwo, Akshaya Srikanth Bhagavathula, Cuong Tat Nguyen, Amr Hassan, Akine Eshete Abosetugn, Hailay Abrha Gesesew, Anna V. Korotkova, Brijesh Sathian, Marcello Tonelli, Olatunde Aremu, Mohammad Reza Salahshoor, Juan Jesus Carrero, Cameron J. Kneib, Ravi Prakash Jha, David H. Shaw, Hossein Samadi Kafil, Tanuj Kanchan, Khezar Hayat, Hamid Sharifi, Morteza Shamsizadeh, Muktar Omer Omer, Fatemeh Amiri, Hamidreza Pazoki Toroudi, David Edvardsson, Xiu Ju George Zhao, Hannah Han, Leticia Avila-Burgos, Adam E. Berman, Jemal Abdu Mohammed, Thomas Pilgrim, Leila Doshmangir, Mu'awiyyah Babale Sufiyan, David M. Pigott, Hadi Hassankhani, Beatriz Paulina Ayala Quintanilla, Teklemariam Gultie, Arash Ziapour, Seyed Sina Naghibi Irvani, Ilse N. Dippenaar, Jean Jacques Noubiap, Emmanuela Gakidou, Abiyu Mekonnen Gebrehiwot, Maha El Tantawi, Xuefeng Liu, Zulfiqar A. Bhutta, Keyghobad Ghadiri, João Mauricio Castaldelli-Maia, Behzad Karami Matin, Yunquan Zhang, Vera Marisa Costa, Iyad Sultan, Mostafa Hosseini, Abdulaziz Khalid Abu Haimed, Haidong Wang, Kaleab Alemayehu Zewdie, Celine M. Barthelemy, Hosna Janjani, Bartosz Miazgowski, Jobert Richie Nansseu, Arianna Maever L. Amit, John S. Ji, Ata Rafiee, Maria Inês Schmidt, Alireza Rafiei, Somayeh Bohlouli, Joana Morgado-da-Costa, Huong Lan Thi Nguyen, Pradyumna Agasthi, Tiffany K. Gill, Martin McKee, Khaled Khatab, Jae Il Shin, Animut Tagele Tamiru, Giancarlo Logroscino, Hassan Abolhassani, Syed Saoud Zaidi, Sivan Yegnanarayana Iyer Saraswathy, Garumma Tolu Feyissa, Ahmad Daryani, Ziyad Al-Aly, Gebreamlak Gebremedhn Gebremeskel, Michael T. Chung, Amirhossein Sahebkar, Mehedi Hasan, Saeed Shahabi, Diep Ngoc Nguyen, Yohannes Kinfu, Nicholas L S Roberts, Jagadish Rao Padubidri, Mika Shigematsu, Lucero Cahuana-Hurtado, Deepa Jahagirdar, Islam Y. Elgendy, Erkin M. Mirrakhimov, Tanvir M. Huda, Fakher Rahim, Dara K. Mohammad, Yingxi Zhao, Ruxandra Irina Negoi, Vinod C. Nayak, Reinhard Busse, Andrew T. Leever, Muhammad Aziz Rahman, Kathryn Mei Ming Lau, Stefania Mondello, Vivian Chia-Rong Hsieh, Kris J. Krohn, Reza Rawassizadeh, Vishnu Renjith, Jianing Ma, Moses K. Muriithi, Mark G. Shrime, Mayowa O. Owolabi, Nobuyuki Horita, Seyed Hossein Yahyazadeh Jabbari, Daniel Y. Cho, Miloje Savic, Moslem Soofi, Iqbal R. F. Elyazar, Freweini Gebrearegay G. Tela, Jonathan F. Mosser, Palash Chandra Banik, Andre Rodrigues Duraes, Yuan-Pang Wang, Natalie C. Galles, Rashid Abdi Guled, Abdallah M. Samy, Hadi Pourjafar, Roman Topor-Madry, Ayesha Humayun, Leila Zaki, Nuworza Kugbey, Maryam Khayamzadeh, Naznin Hossain, Jiregna Darega Gela, Jordi Alonso, Ruth W Kimokoti, A. A. Fomenkov, Jalal Arabloo, Aletta E. Schutte, Biruk Wogayehu Taddele, Teklehaimanot Gereziher Haile, Diego Augusto Santos Silva, Seyed Mohammad Kazem Aghamir, Maciej Banach, Deanna Anderlini, Moses J. Bockarie, Saleem Muhammad Rana, Randah R. Hamadeh, Farhad Islami, Olalekan A. Uthman, S. Mohammad Sajadi, Francisco Rogerlândio Martins-Melo, Shankar M Bakkannavar, Kairat Davletov, Soraya Seedat, Alan D. Lopez, Masoud Behzadifar, Benjamin B. Massenburg, Santosh Varughese, Ingan Ukur Tarigan, Amin Soheili, Félix Carvalho, Yun Jin Kim, Catalina Liliana Andrei, Caleb Mackay Salpeter Irvine, Mojgan Gitimoghaddam, G Anil Kumar, Rasmus J. Havmoeller, Hiroyasu Iso, Atte Meretoja, Yasir Waheed, João M. Furtado, Christian Razo, Neeti Kapoor, Mowafa Househ, Rajaa Al-Raddadi, Mohammad Khammarnia, Santi Martini, Feng Sha, Marco Vacante, Jacek A. Kopec, Hunduma Amensisa Bojia, Jacob Olusegun Olusanya, Kate E. LeGrand, Nikolay Ivanovich Briko, Robert S. Bernstein, Arun Balachandran, Davoud Adham, Ahad Bakhtiari, Shafiu Mohammed, Leake G. Gebremeskel, Smita Pakhale, Ejaz Ahmad Khan, Daniel Cury Ribeiro, Yousef Mohammad, Bernhard T. Baune, Azeem Majeed, Luis Camera, Mohammad Ali Jahani, Hasan Yusefzadeh, Rahman Shiri, Massimo Cirillo, Nikita Otstavnov, Vahid Yazdi-Feyzabadi, Paolo Lauriola, Irfan Ullah, Aruna M Kamath, Maryam Mirzaei, Zabihollah Yousefi, Iman El Sayed, Mohammad Farahmand, Yetunde O. John-Akinola, Khem Narayan Pokhrel, Felix Akpojene Ogbo, Megan Knight, Nelson J. Alvis-Zakzuk, Teferi Mekonnen, Iván Landires, Robert G. Weintraub, Chukwudi A Nnaji, Lauren E. Schaeffer, Paulo A. Lotufo, Mehdi Naderi, Tomislav Mestrovic, André Faro, Mohsen Bayati, Raffaele Palladino, Shahin Soltani, Vladimir Andreevich Korshunov, Birhanu Geta Meharie, Mihajlo Jakovljevic, Abdiwahab Hashi, Olatunji O. Adetokunboh, Dejana Braithwaite, Sergio I. Prada, Bárbara Niegia Garcia de Goulart, Reza Pourmirza Kalhori, Jee-Young Jasmine Choi, Ernoiz Antriyandarti, Ronny Westerman, Meghdad Pirsaheb, Paul S. F. Yip, Mehdi Mirzaei-Alavijeh, Gebremariam Woldu, Rashmi Gupta, Onome Bright Oghenetega, Shane D. Morrison, Inga Dora Sigfusdottir, Marcel Ausloos, Mehdi Hosseinzadeh, Marcos Roberto Tovani-Palone, K M Shivakumar, Alireza Ansari-Moghaddam, Archith Boloor, Aidin Abedi, Binyam Minuye Birihane, Mohammad Ali Mansournia, Nihad A. Almasri, Simachew Animen Bante, Carlo Eduardo Medina-Solís, Leeberk Raja Inbaraj, Edgar Denova-Gutiérrez, Antonio Biondi, Valentin Yurievich Skryabin, Srinivasa Vittal Katikireddi, Sarika Chaturvedi, Francesco Saverio Violante, Abhay Gaidhane, George A. Mensah, Naohiro Yonemoto, Ahmad Ghashghaee, Ebrahim Babaee, Saman Esmaeilnejad, Sharath Burugina Nagaraja, Avina Vongpradith, Javad Nazari, Amir Khater, Michael K. Hole, Ben Lacey, Razique Anwer, Łukasz Szumowski, Ai Koyanagi, Rajesh Sagar, Ali Rajabpour-Sanati, Seyed M Karimi, Yordanos Gizachew Yeshitila, Mona Pathak, Nithin Kumar, Masoud Foroutan, Mehdi Fazlzadeh, Anusha Ganapati Bhat, Abbas Mosapour, Kebede Deribe, Nermin Ghith, Vaman Kulkarni, Sanjay Zodpey, Asadollah Gholamian, Mohammed Shannawaz, Nancy Fullman, Benn Sartorius, Giulio Castelpietra, Ghulam Mustafa, Silvia Schiavolin, Nelson Alvis-Guzman, Jeffrey D. Stanaway, Rafael Lozano, Christopher J L Murray, Guoqing Hu, Andrew M. Briggs, Ashish Badiye, Yousef Khader, Masoud Moghadaszadeh, Rahmatollah Moradzadeh, Valery L. Feigin, Claudia I. Mastrogiacomo, Emma Smith, Yasser Vasseghian, Saeed Amini, Asif Hanif, Achala Upendra Jayatilleke, Maryam Adabi, Sarah Wulf Hanson, Bhaskar Thakur, Ravi Mehrotra, Virginia Núñez-Samudio, Lalit Dandona, Segun Emmanuel Ibitoye, Simon I. Hay, Kiirithio N. Ngari, Obinna Onwujekwe, Deborah Carvalho Malta, Lorenzo Monasta, Neda Kianipour, Khurshid Alam, Luisa Sorio Flor, Priya Rathi, Ali Bijani, Khalid A Altirkawi, Jaimie Adelson, Hamed Zandian, Frank Tanser, Dharmesh Kumar Lal, John Everett Mumford, Morteza Oladnabi, Telma Zahirian Moghadam, Rodrigo Sarmiento-Suárez, Masoud Moradi, Maseer Khan, Mohammad Ali Sahraian, Amy E. Peden, Dhirendra N Sinha, Shanshan Li, Shailesh Advani, Behshad Naghshtabrizi, Matilde Leonardi, Lope H Barrero, Nicholas Steel, Dinh-Toi Chu, Claudio Alberto Dávila-Cervantes, Pushpendra Singh, Adrian Otoiu, Fabrizio Tediosi, Yonas Getaye Tefera, Pawan Faris, George C. Patton, Christopher Troeger, Mohammed Madadin, Jeffrey V. Lazarus, Paul H. Lee, Mohammad Amin Bahrami, Wondimeneh Shibabaw Shiferaw, Emmanuel Wandera Okunga, Biniyam Sahiledengle Geberemariyam, Samer Hamidi, Young-Ho Khang, Rufus Akinyemi, Farhad Jadidi-Niaragh, Godfrey Mutashambara Rwegerera, Naser Mohammad Gholi Mezerji, Rupak Desai, Eduardo Bernabé, Jamal A. Yearwood, Nima Rezaei, Emerito Jose A. Faraon, Vasily Vlassov, Stanislav S. Otstavnov, Reed J D Sorensen, Elena V. Gnedovskaya, Johan Ärnlöv, Mukhammad David Naimzada, Tahereh Javaheri, Tamer H. Farag, Paolo Cortesi, Gbenga A. Kayode, Lucas Guimarães Abreu, Manu Raj Mathur, Getie Lake Aynalem, Narayanaswamy Venketasubramanian, Doris V.V. Ortega-Altamirano, Giorgia Giussani, Liliana G Ciobanu, Suraj Bhattarai, Basema Saddik, Mustafa Z. Younis, Ensiyeh Jenabi, Ira Martopullo, Mohamed M. Gad, Kanyin L. Ong, Addisu Melese, Fotis Topouzis, Hanne Christensen, In-Hwan Oh, Arash Sarveazad, Shuhei Nomura, Peter Memiah, Sergej M. Ostojic, Santosh Kumar Tadakamadla, Dinesh Bhandari, Ahmed Omar Bali, Farahnaz Joukar, Arielle Wilder Eagan, Emma Elizabeth Spurlock, Ferrán Catalá-López, Caroline Stein, Jonathan M. Kocarnik, Stephen S Lim, Siamak Sabour, Kelly Compton, Shoaib Hassan, Rannveig Sigurvinsdottir, Claudiu Herteliu, Aso Mohammad Darwesh, Muluken Altaye Ayza, Angela Y. Chang, Leila R Kalankesh, Rafael Alves Guimarães, Abdollah Mohammadian-Hafshejani, Lal B. Rawal, Soewarta Kosen, Degena Bahrey Tadesse, Theo Vos, Paula Moraga, Soheil Hassanipour, Abdelrahman Ibrahim Abushouk, Oladimeji Adebayo, Mikk Jürisson, Tuomo J. Meretoja, Ireneous N. Soyiri, Carlo La Vecchia, Khalil Eskandari, Aziz Sheikh, Jagdish Khubchandani, James Leigh, Morteza Arab-Zozani, Sheikh Mohammed Shariful Islam, Stefan Kohler, Olayinka Stephen Ilesanmi, Kazumasa Yamagishi, Michele Romoli, Jasvinder A. Singh, Neeraj Bedi, Ivo Iavicoli, Alyssa Pennini, Subas Neupane, Emmanuel Peprah, Sojib Bin Zaman, Marwa Rashad Salem, Mohammed Ibrahim Mohialdeen Gubari, Ramesh Holla, Bayisa Abdissa Baye, Robert Ancuceanu, Eduarda Fernandes, Chandrashekhar T Sreeramareddy, Ettore Beghi, Quique Bassat, B Reshmi, Masood Ali Shaikh, Ionut Negoi, Peter Azzopardi, Florian Fischer, Kerem Shuval, Sorin Hostiuc, Hmwe H Kyu, Ver Bilano, Siddhesh Zadey, Davide Rasella, Vahid Alipour, Sowmya J. Rao, Radoslaw Sierpinski, Irina Filip, Michelle L. Bell, Malke Asaad, Ravensara S. Travillian, Christopher R. Cederroth, Rafael Tabarés-Seisdedos, Ashkan Afshin, Saqib Ali, Mahalaqua Nazli Khatib, Saad M.A. Dahlawi, Hedayat Abbastabar, Zahid A Butt, Sagun Paudel, Vahid Rashedi, B. Suresh Kumar Shetty, Thomas R. Hird, Shokofeh Maleki, Atif Amin Baig, Reza Heidari-Soureshjani, Shaun Wen Huey Lee, Jorge R. Ledesma, Ai-Min Wu, Fablina Sharara, Zemenu Tadesse Tessema, Ratilal Lalloo, Rohollah Kalhor, Rosario Cárdenas, Amir Radfar, Salime Goharinezhad, Fereshteh Mehri, Katarzyna Kissimova-Skarbek, Spencer A. Pease, Diana Silva, Amir Hossein Goudarzian, Samath D Dharmaratne, Darshan B B, Mariya Vladimirovna Titova, Dickson A. Amugsi, Lee Ling Lim, Agegnehu Bante, Charles D.A. Wolfe, Majid A Almadi, Seyed Mohammad Riahi, Nader Jahanmehr, Yuming Guo, Tauseef Ahmad, Platon D. Lopukhov, Takahiro Tabuchi, Nicholas J Kassebaum, Jacek Jerzy Jozwiak, Ritesh G. Menezes, Giovanni Damiani, Delia Hendrie, Mostafa Amini-Rarani, Sanjay Basu, Mohammad Hossein Bakhshaei, Gholamreza Roshandel, Borhan Mansouri, Enrico Rubagotti, Anurag Agrawal, Alireza Esteghamati, Paramjit Gill, Graeme J. Hankey, Mikhail Sergeevich Zastrozhin, Nima Hafezi-Nejad, Bruce Bartholow Duncan, Silvano Gallus, Jeevan Pereira, Ahamarshan Jayaraman Nagarajan, Giulia Carreras, Fariba Dorostkar, Pietro Ferrara, Andrea Farioli, Christoph Nowak, Ahmed I. Hasaballah, Vijay Kumar Chattu, Bolajoko O. Olusanya, Perminder S. Sachdev, Era Upadhyay, Tommi Vasankari, Susan M Sawyer, Adnan Kisa, Farshad Pourmalek, Kiomars Sharafi, Golnaz Heidari, Mohammad Abdollahi, Georges Nguefack-Tsague, Sajid Hameed, Sanni Yaya, Bach Xuan Tran, Ole Frithjof Norheim, Robert Kaba Alhassan, Morenike Oluwatoyin Folayan, Ismail Tareque, Phetole Walter Mahasha, Kewal Krishan, Soraya Siabani, Aleksandr Y. Aravkin, Helena Ullyartha Pangaribuan, Maryam Zamanian, Joshua A. Salomon, Bianca S. Zlavog, Vinay Nangia, Falk Schwendicke, Takeshi Fukumoto, Hung Chak Ho, Jordan Weiss, Maha Atout, Tariku Tesfaye Bekuma, Efat Mohamadi, Nikolaos Dervenis, Joan B. Soriano, Syed Amir Gilani, Victor Adekanmbi, Marina Karanikolos, Alberto Raggi, Michael R.M. Abrigo, Weijia Fu, Reza Shirkoohi, Aditya Prasad Dash, Peng Jia, Masoumeh Sadeghi, Ashraf Nabhan, Isabela M. Benseñor, Morteza Jafarinia, Joht Singh Chandan, Usman Iqbal, Amira Shaheen, Deepak Saxena, Lauren B. Wilner, Nataliya A. Foigt, Jeadran N. Malagón-Rojas, David C. Schwebel, Gail Davey, Milena Ilic, Josep Maria Haro, Peter Njenga Keiyoro, Stein Emil Vollset, Andrea Werdecker, Zahiruddin Quazi Syed, Yared Asmare Aynalem, Entezar Mehrabi Nasab, Yihun Mulugeta Alemu, Muhammad Ali, Mona M. Khater, Ehsan Sadeghi, Thirunavukkarasu Sathish, Pascual R. Valdez, Jennifer Rickard, Mark A. Stokes, Davide Sattin, Ewerton Cousin, Oliver J. Brady, Krittika Bhattacharyya, Mika Kivimäki, Andrew T Olagunju, Jost B. Jonas, Dian Kusuma, Goura Kishor Rath, Alberto Ortiz, Samad Azari, Nayu Ikeda, James L. Fisher, Peng Zheng, Elisabetta Pupillo, Pankaj Bhardwaj, Suzanne Lyn Barker-Collo, Riaz Uddin, Ester Cerin, Amir Taherkhani, Martin Amogre Ayanore, Richard G. Wamai, Anders Larsson, Josephine W. Ngunjiri, Hosni Salem, Hesham M. Al-Mekhlafi, Sharareh Eskandarieh, Taraneh Yousefinezhadi, Srikanta Banerjee, Yang Xie, Yuichiro Yano, Songhomitra Panda-Jonas, Themba G. Ginindza, Manasi Kumar, Babak Moazen, Bing-Fang Hwang, Cristiana Abbafati, Florentino Luciano Caetano dos Santos, Juan Sanabria, Milena Santric-Milicevic, Carla Sofia e.Sá Farinha, Samuel B. Albertson, Chieh Han, Parvaiz A Koul, Foad Abd-Allah, Mojisola Oluwasanu, Mihaela Hostiuc, Chinwe Juliana Iwu, Colm McAlinden, Mohsen Naghavi, Maarten J. Postma, Chhabi Lal Ranabhat, Jalil Jaafari, Walter Mendoza, Abdulaziz M. Almulhim, Magdalene K. Walters, Ali H. Mokdad, Andre M. N. Renzaho, Catherine M. Antony, Ken Lee Chin, Ali A. Asadi-Pooya, Daniel Diaz, Adrian Pana, Salman Rawaf, Gina Agarwal, Demelash Woldeyohannes Handiso, Savita Lasrado, Amir Almasi-Hashiani, Praveen Hoogar, Srinivasa Rao Bolla, Fares Alahdab, Om P Kurmi, Sonali Kochhar, Van C. Lansingh, François Alla, Ali Almasi, Till Bärnighausen, Michael A. Piradov, Zubair Kabir, Boris Bikbov, Philip B. Mitchell, Amin Mousavi Khaneghah, Yahya Safari, Anirudh Kotlo, Jan-Walter De Neve, Biagio Simonetti, Carlos A Castañeda-Orjuela, Kenji Shibuya, GBD 2019 Universal Health Coverage Collaborator, Violante FS, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Department of Public Health, University of Helsinki, Clinicum, Neurologian yksikkö, HUS Neurocenter, HUS Comprehensive Cancer Center, Helsinki University Hospital Area, GBD 2019 Universal Health Coverage Collaborators, Lozano, Rafael, Fullman, Nancy, Mumford, John Everett, Knight, Megan, Barthelemy, Celine M, Abbafati, Cristiana, Abbastabar, Hedayat, Abd-Allah, Foad, Abdollahi, Mohammad, Abedi, Aidin, Abolhassani, Hassan, Abosetugn, Akine Eshete, Abreu, Lucas Guimarãe, Abrigo, Michael R M, Abu Haimed, Abdulaziz Khalid, Abushouk, Abdelrahman I, Adabi, Maryam, Adebayo, Oladimeji M, Adekanmbi, Victor, Adelson, Jaimie, Adetokunboh, Olatunji O, Adham, Davoud, Advani, Shailesh M, Afshin, Ashkan, Agarwal, Gina, Agasthi, Pradyumna, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Akinyemi, Rufus Olusola, Alahdab, Fare, Al-Aly, Ziyad, Alam, Khurshid, Albertson, Samuel B, Alemu, Yihun Mulugeta, Alhassan, Robert Kaba, Ali, Muhammad, Ali, Saqib, Alipour, Vahid, Aljunid, Syed Mohamed, Alla, Françoi, Almadi, Majid Abdulrahman Hamad, Almasi, Ali, Almasi-Hashiani, Amir, Almasri, Nihad A, Al-Mekhlafi, Hesham M, Almulhim, Abdulaziz M, Alonso, Jordi, Al-Raddadi, Rajaa M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Amini, Saeed, Amini-Rarani, Mostafa, Amiri, Fatemeh, Amit, Arianna Maever L, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Aremu, Olatunde, Ärnlöv, Johan, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Ashbaugh, Charlie, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Ausloos, Marcel, Avila-Burgos, Leticia, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Aynalem, Getie Lake, Ayza, Muluken Altaye, Azari, Samad, Azzopardi, Peter S, B, Darshan B, Babaee, Ebrahim, Badiye, Ashish D, Bahrami, Mohammad Amin, Baig, Atif Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M, Balachandran, Arun, Balassyano, Shelly, Banach, Maciej, Banerjee, Srikanta K, Banik, Palash Chandra, Bante, Agegnehu Bante, Bante, Simachew Animen, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Bassat, Quique, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Baye, Bayisa Abdissa, Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Bekuma, Tariku Tesfaye Tesfaye, Bell, Michelle L, Bensenor, Isabela M, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bhagavathula, Akshaya Srikanth, Bhandari, Dinesh, Bhardwaj, Pankaj, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Bori, Bilano, Ver, Biondi, Antonio, Birihane, Binyam Minuye, Bockarie, Moses John, Bohlouli, Somayeh, Bojia, Hunduma Amensisa, Bolla, Srinivasa Rao Rao, Boloor, Archith, Brady, Oliver J, Braithwaite, Dejana, Briant, Paul Svitil, Briggs, Andrew M, Briko, Nikolay Ivanovich, Burugina Nagaraja, Sharath, Busse, Reinhard, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cahuana-Hurtado, Lucero, Cámera, Luis Alberto, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Castro, Franz, Catalá-López, Ferrán, Causey, Kate, Cederroth, Christopher R, Cercy, Kelly M, Cerin, Ester, Chandan, Joht Singh, Chang, Angela Y, Charan, Jaykaran, Chattu, Vijay Kumar, Chaturvedi, Sarika, Chin, Ken Lee, Cho, Daniel Youngwhan, Choi, Jee-Young Jasmine, Christensen, Hanne, Chu, Dinh-Toi, Chung, Michael T, Ciobanu, Liliana G, Cirillo, Massimo, Comfort, Haley, Compton, Kelly, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Dahlawi, Saad M A, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Darega Gela, Jiregna, Darwesh, Aso Mohammad, Daryani, Ahmad, Dash, Aditya Prasad, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, De Neve, Jan-Walter, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolao, Desai, Rupak, Dharmaratne, Samath Dhamminda, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N, Do, Hoa Thi, Dorostkar, Fariba, Doshmangir, Leila, Duncan, Bruce B, Duraes, Andre Rodrigue, Eagan, Arielle Wilder, Edvardsson, David, El Sayed, Iman, El Tantawi, Maha, Elgendy, Islam Y, Elyazar, Iqbal RF, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Ezekannagha, Oluchi, Farag, Tamer, Farahmand, Mohammad, Faraon, Emerito Jose A, Farinha, Carla Sofia e Sá, Farioli, Andrea, Faris, Pawan Sirwan, Faro, Andre, Fazlzadeh, Mehdi, Feigin, Valery L, Fernandes, Eduarda, Ferrara, Pietro, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fisher, James L, Flor, Luisa Sorio, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Francis, Joel Msafiri, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M, Gad, Mohamed M, Gaidhane, Abhay Motiramji, Gakidou, Emmanuela, Galles, Natalie C, Gallus, Silvano, Gardner, William M, Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Abiyu Mekonnen, Gebremeskel, Leake G, Gebremeskel, Gebreamlak Gebremedhn, Gesesew, Hailay Abrha, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghashghaee, Ahmad, Ghith, Nermin, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Paramjit Singh, Gill, Tiffany K, Ginindza, Themba G, Gitimoghaddam, Mojgan, Giussani, Giorgia, Glagn, Mustefa, Gnedovskaya, Elena V, 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Mestrovic, T, Miazgowski, B, Michalek, I, Mirrakhimov, E, Mirzaei, M, Mirzaei-Alavijeh, M, Mitchell, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, Y, Mohammad, D, Mohammad Gholi Mezerji, N, Mohammadian-Hafshejani, A, Mohammed, S, Mohammed, J, Mokdad, A, Monasta, L, Mondello, S, Moradi, M, Moradi-Lakeh, M, Moradzadeh, R, Moraga, P, Morgado-da-Costa, J, Morrison, S, Mosapour, A, Mosser, J, Mousavi Khaneghah, A, Muriithi, M, Mustafa, G, Nabhan, A, Naderi, M, Nagarajan, A, Naghavi, M, Naghshtabrizi, B, Naimzada, M, Nangia, V, Nansseu, J, Nayak, V, Nazari, J, Ndejjo, R, Negoi, I, Negoi, R, Neupane, S, Ngari, K, Nguefack-Tsague, G, Ngunjiri, J, Nguyen, C, Nguyen, D, Nguyen, H, Nnaji, C, Nomura, S, Norheim, O, Noubiap, J, Nowak, C, Nunez-Samudio, V, Otoiu, A, Ogbo, F, Oghenetega, O, Oh, I, Okunga, E, Oladnabi, M, Olagunju, A, Olusanya, J, Olusanya, B, Oluwasanu, M, Omar Bali, A, Omer, M, Ong, K, Onwujekwe, O, Ortega-Altamirano, D, Ortiz, A, Ostojic, S, Otstavnov, N, Otstavnov, S, Øverland, S, Owolabi, M, Padubidri, J, Pakhale, S, Palladino, R, Pana, A, Panda-Jonas, S, Pangaribuan, H, Pathak, M, Patton, G, Paudel, S, Pazoki Toroudi, H, Pease, S, Peden, A, Pennini, A, Peprah, E, Pereira, J, Pigott, D, Pilgrim, T, Pilz, T, Pinheiro, M, Piradov, M, Pirsaheb, M, Pokhrel, K, Postma, M, Pourjafar, H, Pourmalek, F, Pourmirza Kalhori, R, Pourshams, A, Prada, S, Pribadi, D, Pupillo, E, Quazi Syed, Z, Radfar, A, Rafiee, A, Rafiei, A, Raggi, A, Rahim, F, Rahman, M, Rajabpour-Sanati, A, Rana, S, Ranabhat, C, Rao, S, Rasella, D, Rashedi, V, Rath, G, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Rawassizadeh, R, Razo, C, Renjith, V, Renzaho, A, Reshmi, B, Rezaei, N, Riahi, S, Ribeiro, D, Rickard, J, Roberts, N, Roever, L, Romoli, M, Ronfani, L, Roshandel, G, Rubagotti, E, Rwegerera, G, Sabour, S, Sachdev, P, Saddik, B, Sadeghi, M, Sadeghi, E, Safari, Y, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, S, Salahshoor, M, Salem, M, Salem, H, Salomon, J, Samadi Kafil, H, Samy, A, Sanabria, J, Santric-Milicevic, M, Saraswathy, S, Sarmiento-Suárez, R, Sarveazad, A, Sathian, B, Sathish, T, Sattin, D, Savic, M, Sawyer, S, Saxena, D, Sbarra, A, Schaeffer, L, Schiavolin, S, Schmidt, M, Schutte, A, Schwebel, D, Schwendicke, F, Seedat, S, Sha, F, Shahabi, S, Shaheen, A, Shaikh, M, Shamsizadeh, M, Shannawaz, M, Sharafi, K, Sharara, F, Sharifi, H, Shaw, D, Sheikh, A, Sheikhtaheri, A, Shetty, B, Shibuya, K, Shiferaw, W, Shigematsu, M, Shin, J, Shiri, R, Shirkoohi, R, Shivakumar, K, Shrime, M, Shuval, K, Siabani, S, Sierpinski, R, Sigfusdottir, I, Sigurvinsdottir, R, Silva, D, Silva, J, Simonetti, B, Simpson, K, Singh, J, Singh, P, Sinha, D, Skryabin, V, Smith, E, Soheili, A, Soltani, S, Soofi, M, Sorensen, R, Soriano, J, Sorrie, M, Soyiri, I, Spurlock, E, Sreeramareddy, C, Stanaway, J, Steel, N, Stein, C, Stokes, M, Sufiyan, M, Suleria, H, Sultan, I, Szumowski, Ł, Tabarés-Seisdedos, R, Tabuchi, T, Tadakamadla, S, Taddele, B, Tadesse, D, Taherkhani, A, Tamiru, A, Tanser, F, Tareque, M, Tarigan, I, Teagle, W, Tediosi, F, Tefera, Y, Tela, F, Tessema, Z, Thakur, B, Titova, M, Tonelli, M, Topor-Madry, R, Topouzis, F, Tovani-Palone, M, Tran, B, Travillian, R, Troeger, C, Tudor Car, L, Uddin, R, Ullah, I, Umeokonkwo, C, Unnikrishnan, B, Upadhyay, E, Uthman, O, Vacante, M, Valdez, P, Varughese, S, Vasankari, T, Vasseghian, Y, Venketasubramanian, N, Violante, F, Vlassov, V, Vollset, S, Vongpradith, A, Vos, T, Waheed, Y, Walters, M, Wamai, R, Wang, H, Wang, Y, Weintraub, R, Weiss, J, Werdecker, A, Westerman, R, Wilner, L, Woldu, G, Wolfe, C, Wu, A, Wulf Hanson, S, Xie, Y, Xu, R, Yahyazadeh Jabbari, S, Yamagishi, K, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yearwood, J, Yeshitila, Y, Yip, P, Yonemoto, N, Younis, M, Yousefi, Z, Yousefinezhadi, T, Yusefzadeh, H, Zadey, S, Zahirian Moghadam, T, Zaidi, S, Zaki, L, Zaman, S, Zamani, M, Zamanian, M, Zandian, H, Zastrozhin, M, Zewdie, K, Zhang, Y, Zhao, X, Zhao, Y, Zheng, P, Zhu, C, Ziapour, A, Zlavog, B, Zodpey, S, Murray, C, Tampere University, Health Sciences, 10922180 - Schutte, Aletta Elisabeth, Lozano, R., Fullman, N., Mumford, J. E., Knight, M., Barthelemy, C. M., Abbafati, C., Abbastabar, H., Abd-Allah, F., Abdollahi, M., Abedi, A., Abolhassani, H., Abosetugn, A. E., Abreu, L. G., Abrigo, M. R. M., Abu Haimed, A. K., Abushouk, A. I., Adabi, M., Adebayo, O. M., Adekanmbi, V., Adelson, J., Adetokunboh, O. O., Adham, D., Advani, S. M., Afshin, A., Agarwal, G., Agasthi, P., Aghamir, S. M. K., Agrawal, A., Ahmad, T., Akinyemi, R. O., Alahdab, F., Al-Aly, Z., Alam, K., Albertson, S. B., Alemu, Y. M., Alhassan, R. K., Ali, M., Ali, S., Alipour, V., Aljunid, S. M., Alla, F., Almadi, M. A. H., Almasi, A., Almasi-Hashiani, A., Almasri, N. A., Al-Mekhlafi, H. M., Almulhim, A. M., Alonso, J., Al-Raddadi, R. M., Altirkawi, K. A., Alvis-Guzman, N., Alvis-Zakzuk, N. J., Amini, S., Amini-Rarani, M., Amiri, F., Amit, A. M. L., Amugsi, D. A., Ancuceanu, R., Anderlini, D., Andrei, C. L., Androudi, S., Ansari, F., Ansari-Moghaddam, A., Antonio, C. A. T., Antony, C. M., Antriyandarti, E., Anvari, D., Anwer, R., Arabloo, J., Arab-Zozani, M., Aravkin, A. Y., Aremu, O., Arnlov, J., Asaad, M., Asadi-Aliabadi, M., Asadi-Pooya, A. A., Athari, S. S., Atout, M. M. W., Ausloos, M., Avila-Burgos, L., Ayala Quintanilla, B. P., Ayano, G., Ayanore, M. A., Aynalem, Y. A., Aynalem, G. L., Ayza, M. A., Azari, S., Azzopardi, P. S., B, D. B., Babaee, E., Badiye, A. D., Bahrami, M. A., Baig, A. A., Bakhshaei, M. H., Bakhtiari, A., Bakkannavar, S. M., Balachandran, A., Banach, M., Banerjee, S. K., Banik, P. C., Bante, A. B., Bante, S. A., Barker-Collo, S. L., Barnighausen, T. W., Barrero, L. H., Bassat, Q., Basu, S., Baune, B. T., Bayati, M., Baye, B. A., Bedi, N., Beghi, E., Behzadifar, M., Bekuma, T. T. T., Bell, M. L., Bensenor, I. M., Berman, A. E., Bernabe, E., Bernstein, R. S., Bhagavathula, A. S., Bhandari, D., Bhardwaj, P., Bhat, A. G., Bhattacharyya, K., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bikbov, B., Bilano, V., Biondi, A., Birihane, B. M., Bockarie, M. J., Bohlouli, S., Bojia, H. A., Bolla, S. R. R., Boloor, A., Brady, O. J., Braithwaite, D., Briggs, A. M., Briko, N. I., Burugina Nagaraja, S., Busse, R., Butt, Z. A., Caetano dos Santos, F. L., Cahuana-Hurtado, L., Camera, L. A., Cardenas, R., Carreras, G., Carrero, J. J., Carvalho, F., Castaldelli-Maia, J. M., Castaneda-Orjuela, C. A., Castelpietra, G., Castro, F., Catala-Lopez, F., Cederroth, C. R., Cerin, E., Chandan, J. S., Chang, A. Y., Charan, J., Chattu, V. K., Chaturvedi, S., Chin, K. L., Cho, D. Y., Choi, J. -Y. J., Christensen, H., Chu, D. -T., Chung, M. T., Ciobanu, L. G., Cirillo, M., Compton, K., Cortesi, P. A., Costa, V. M., Cousin, E., Dahlawi, S. M. A., Damiani, G., Dandona, L., Dandona, R., Darega Gela, J., Darwesh, A. M., Daryani, A., Dash, A. P., Davey, G., Davila-Cervantes, C. A., Davletov, K., De Neve, J. -W., Denova-Gutierrez, E., Deribe, K., Dervenis, N., Desai, R., Dharmaratne, S. D., Dhungana, G. P., Dianatinasab, M., Dias da Silva, D., Diaz, D., Dippenaar, I. N., Do, H. T., Dorostkar, F., Doshmangir, L., Duncan, B. B., Duraes, A. R., Eagan, A. W., Edvardsson, D., El Sayed, I., El Tantawi, M., Elgendy, I. Y., Elyazar, I. R., Eskandari, K., Eskandarieh, S., Esmaeilnejad, S., Esteghamati, A., Ezekannagha, O., Farag, T., Farahmand, M., Faraon, E. J. A., Farinha, C. S. E. S., Farioli, A., Faris, P. S., Faro, A., Fazlzadeh, M., Feigin, V. L., Fernandes, E., Ferrara, P., Feyissa, G. T., Filip, I., Fischer, F., Fisher, J. L., Flor, L. S., Foigt, N. A., Folayan, M. O., Fomenkov, A. A., Foroutan, M., Francis, J. M., Fu, W., Fukumoto, T., Furtado, J. M., Gad, M. M., Gaidhane, A. M., Gakidou, E., Galles, N. C., Gallus, S., Gardner, W. M., Geberemariyam, B. S., Gebrehiwot, A. M., Gebremeskel, L. G., Gebremeskel, G. G., Gesesew, H. A., Ghadiri, K., Ghafourifard, M., Ghashghaee, A., Ghith, N., Gholamian, A., Gilani, S. A., Gill, P. S., Gill, T. K., Ginindza, T. G., Gitimoghaddam, M., Giussani, G., Glagn, M., Gnedovskaya, E. V., Godinho, M. A., Goharinezhad, S., Gopalani, S. V., Goudarzian, A. H., Goulart, B. N. G., Gubari, M. I. M., Guimaraes, R. A., Guled, R. A., Gultie, T., Guo, Y., Gupta, R., Hafezi-Nejad, N., Hafiz, A., Haile, T. G., Hamadeh, R. R., Hameed, S., Hamidi, S., Han, C., Han, H., Handiso, D. W., Hanif, A., Hankey, G. J., Haro, J. M., Hasaballah, A. I., Hasan, M. M., Hashi, A., Hassan, S., Hassan, A., Hassanipour, S., Hassankhani, H., Havmoeller, R. J., Hay, S. I., Hayat, K., Heidari, G., Heidari-Soureshjani, R., Hendrie, D., Herteliu, C., Hird, T. R., Ho, H. C., Hole, M. K., Holla, R., Hoogar, P., Hopf, K. P., Horita, N., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsieh, V. C. -R., Hu, G., Huda, T. M., Humayun, A., Hwang, B. -F., Iavicoli, I., Ibitoye, S. E., Ikeda, N., Ilesanmi, O. S., Ilic, M. D., Inbaraj, L. R., Iqbal, U., Irvani, S. S. N., Irvine, C. M. S., Islam, M. M., Islam, S. M. S., Islami, F., Iso, H., Iwu, C. J., Jaafari, J., Jadidi-Niaragh, F., Jafarinia, M., Jahagirdar, D., Jahani, M. A., Jahanmehr, N., Jakovljevic, M., Janjani, H., Javaheri, T., Jayatilleke, A. U., Jenabi, E., Jha, R. P., Jha, V., Ji, J. S., Jia, P., John-Akinola, Y. O., Jonas, J. B., Joukar, F., Jozwiak, J. J., Jurisson, M., Kabir, Z., Kalankesh, L. R., Kalhor, R., Kamath, A. M., Kanchan, T., Kapoor, N., Karami Matin, B., Karanikolos, M., Karimi, S. M., Kassebaum, N. J., Katikireddi, S. V., Kayode, G. A., Keiyoro, P. N., Khader, Y. S., Khammarnia, M., Khan, M., Khan, E. A., Khang, Y. -H., Khatab, K., Khater, A. M., Khater, M. M., Khatib, M. N., Khayamzadeh, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinfu, Y., Kisa, A., Kissimova-Skarbek, K., Kivimaki, M., Kneib, C. J., Kocarnik, J. M., Kochhar, S., Kohler, S., Kopec, J. A., Korotkova, A. V., Korshunov, V. A., Kosen, S., Kotlo, A., Koul, P. A., Koyanagi, A., Krishan, K., Krohn, K. J., Kugbey, N., Kulkarni, V., Kumar, G. A., Kumar, N., Kumar, M., Kurmi, O. P., Kusuma, D., Kyu, H. H., La Vecchia, C., Lacey, B., Lal, D. K., Lalloo, R., Landires, I., Lansingh, V. C., Larsson, A. O., Lasrado, S., Lau, K. M. -M., Lauriola, P., Lazarus, J. V., Ledesma, J. R., Lee, P. H., Lee, S. W. H., Leever, A. T., Legrand, K. E., Leigh, J., Leonardi, M., Li, S., Lim, S. S., Lim, L. -L., Liu, X., Logroscino, G., Lopez, A. D., Lopukhov, P. D., Lotufo, P. A., Lu, A., Ma, J., Madadin, M., Mahasha, P. W., Mahmoudi, M., Majeed, A., Malagon-Rojas, J. N., Maleki, S., Malta, D. C., Mansouri, B., Mansournia, M. A., Martini, S., Martins-Melo, F. R., Martopullo, I., Massenburg, B. B., Mastrogiacomo, C. I., Mathur, M. R., Mcalinden, C., Mckee, M., Medina-Solis, C. E., Meharie, B. G., Mehndiratta, M. M., Mehrabi Nasab, E., Mehri, F., Mehrotra, R., Mekonnen, T., Melese, A., Memiah, P. T. N., Mendoza, W., Menezes, R. G., Mensah, G. A., Meretoja, T. J., Meretoja, A., Mestrovic, T., Miazgowski, B., Michalek, I. M., Mirrakhimov, E. M., Mirzaei, M., Mirzaei-Alavijeh, M., Mitchell, P. B., Moazen, B., Moghadaszadeh, M., Mohamadi, E., Mohammad, Y., Mohammad, D. K., Mohammad Gholi Mezerji, N., Mohammadian-Hafshejani, A., Mohammed, S., Mohammed, J. A., Mokdad, A. H., Monasta, L., Mondello, S., Moradi, M., Moradi-Lakeh, M., Moradzadeh, R., Moraga, P., Morgado-da-Costa, J., Morrison, S. D., Mosapour, A., Mosser, J. F., Mousavi Khaneghah, A., Muriithi, M. K., Mustafa, G., Nabhan, A. F., Naderi, M., Nagarajan, A. J., Naghavi, M., Naghshtabrizi, B., Naimzada, M. D., Nangia, V., Nansseu, J. R., Nayak, V. C., Nazari, J., Ndejjo, R., Negoi, I., Negoi, R. I., Neupane, S., Ngari, K. N., Nguefack-Tsague, G., Ngunjiri, J. W., Nguyen, C. T., Nguyen, D. N., Nguyen, H. L. T., Nnaji, C. A., Nomura, S., Norheim, O. F., Noubiap, J. J., Nowak, C., Nunez-Samudio, V., Otoiu, A., Ogbo, F. A., Oghenetega, O. B., Oh, I. -H., Okunga, E. W., Oladnabi, M., Olagunju, A. T., Olusanya, J. O., Olusanya, B. O., Oluwasanu, M. M., Omar Bali, A., Omer, M. O., Ong, K. L., Onwujekwe, O. E., Ortega-Altamirano, D. V. V., Ortiz, A., Ostojic, S. M., Otstavnov, N., Otstavnov, S. S., Overland, S., Owolabi, M. O., Padubidri, J. R., Pakhale, S., Palladino, R., Pana, A., Panda-Jonas, S., Pangaribuan, H. U., Pathak, M., Patton, G. C., Paudel, S., Pazoki Toroudi, H., Pease, S. A., Peden, A. E., Pennini, A., Peprah, E. K., Pereira, J., Pigott, D. M., Pilgrim, T., Pilz, T. M., Pinheiro, M., Piradov, M. A., Pirsaheb, M., Pokhrel, K. N., Postma, M. J., Pourjafar, H., Pourmalek, F., Pourmirza Kalhori, R., Pourshams, A., Prada, S. I., Pribadi, D. R. A., Pupillo, E., Quazi Syed, Z., Radfar, A., Rafiee, A., Rafiei, A., Raggi, A., Rahim, F., Rahman, M. A., Rajabpour-Sanati, A., Rana, S. M., Ranabhat, C. L., Rao, S. J., Rasella, D., Rashedi, V., Rath, G. K., Rathi, P., Rawaf, S., Rawaf, D. L., Rawal, L., Rawassizadeh, R., Razo, C., Renjith, V., Renzaho, A. M. N., Reshmi, B., Rezaei, N., Riahi, S. M., Ribeiro, D. C., Rickard, J., Roberts, N. L. S., Roever, L., Romoli, M., Ronfani, L., Roshandel, G., Rubagotti, E., Rwegerera, G. M., Sabour, S., Sachdev, P. S., Saddik, B., Sadeghi, M., Sadeghi, E., Safari, Y., Sagar, R., Sahebkar, A., Sahraian, M. A., Sajadi, S. M., Salahshoor, M. R., Salem, M. R. R., Salem, H., Salomon, J., Samadi Kafil, H., Samy, A. M., Sanabria, J., Santric-Milicevic, M. M., Saraswathy, S. Y. I., Sarmiento-Suarez, R., Sartorius, B., Sarveazad, A., Sathian, B., Sathish, T., Sattin, D., Savic, M., Sawyer, S. M., Saxena, D., Sbarra, A. N., Schaeffer, L. E., Schiavolin, S., Schmidt, M. I., Schutte, A. E., Schwebel, D. C., Schwendicke, F., Seedat, S., Sha, F., Shahabi, S., Shaheen, A. A., Shaikh, M. A., Shamsizadeh, M., Shannawaz, M., Sharafi, K., Sharara, F., Sharifi, H., Shaw, D. H., Sheikh, A., Sheikhtaheri, A., Shetty, B. S. K., Shibuya, K., Shiferaw, W. S., Shigematsu, M., Shin, J. I., Shiri, R., Shirkoohi, R., Shivakumar, K. M., Shrime, M. G., Shuval, K., Siabani, S., Sierpinski, R., Sigfusdottir, I. D., Sigurvinsdottir, R., Silva, D. A. S., Silva, J. P., Simonetti, B., Simpson, K. E., Singh, J. A., Singh, P., Sinha, D. N., Skryabin, V. Y., Smith, E. U. R., Soheili, A., Soltani, S., Soofi, M., Sorensen, R. J. D., Soriano, J. B., Sorrie, M. B., Soyiri, I. N., Spurlock, E. E., Sreeramareddy, C. T., Stanaway, J. D., Steel, N., Stein, C., Stokes, M. A., Sufiyan, M. B., Suleria, H. A. R., Sultan, I., Szumowski, L., Tabares-Seisdedos, R., Tabuchi, T., Tadakamadla, S. K., Taddele, B. W., Tadesse, D. B., Taherkhani, A., Tamiru, A. T., Tanser, F. C., Tareque, M. I., Tarigan, I. U., Teagle, W. L., Tediosi, F., Tefera, Y. G. G., Tela, F. G., Tessema, Z. T., Thakur, B., Titova, M. V., Tonelli, M., Topor-Madry, R., Topouzis, F., Tovani-Palone, M. R. R., Tran, B. X., Travillian, R., Troeger, C. 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Subjects
Index (economics), Servicios de Salud, SUSTAINABLE DEVELOPMENT GOALS, 030204 cardiovascular system & hematology, universal health coverage, sustaibale develpment goal, global burden of disease, performance, systematic analysis, Global Burden of Disease, 0302 clinical medicine, Universal Health Insurance, RA0421, 11. Sustainability, Per capita, Medical economics, Disease, 030212 general & internal medicine, 10. No inequality, 11 Medical and Health Sciences, effective coverage of health services, GBD 2019 Universal Health Coverage Collaborators, education.field_of_study, Public health, Medical care, Sjúkdómar, 4. Education, 1. No poverty, Health coverage, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Hälsovetenskaper, 3142 Public health care science, environmental and occupational health, Health services, 3. Good health, Global burden of disease, Health Expenditures, Humans, World Health Organization, Purchasing power parity, Scale (social sciences), Lýðheilsa, universal health coverag, CANCER SURVIVAL, ACCESS, Human, Heilsuhagfræði, medicine.medical_specialty, Health coverage, GBD, GBD, Universal health, GBD 2019, Population, Health expenditures, 3122 Cancers, Population health, 03 medical and health sciences, Health systems, Heilbrigðisvísindi, SDG 3 - Good Health and Well-being, General & Internal Medicine, Development economics, Health Sciences, medicine, Heilbrigðisstefna, Alþjóðaheilbrigðisstofnunin, QUALITY, Global Burden of Disease Study, education, PROGRESS, Disease burden, Health services accessibility, CARE, Heilbrigðisþjónusta, purl.org/pe-repo/ocde/ford#3.02.00 [https], Health Expenditure, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, Morbility, Administración de los Servicios de Salud, Medical policy, Business, Heilbrigðiskerfi
Abstract

Publisher's version (útgefin grein), Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (>= 65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0-100 based on the 2.5th and 97.5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target-1 billion more people benefiting from UHC by 2023-we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. Findings Globally, performance on the UHC effective coverage index improved from 45.8 (95% uncertainty interval 44.2-47.5) in 1990 to 60.3 (58.7-61.9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2.6% [1.9-3.3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010-2019 relative to 1990-2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0.79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach $1398 pooled health spending per capita (US$ adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388.9 million (358.6-421.3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3.1 billion (3.0-3.2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968.1 million [903.5-1040.3]) residing in south Asia. Interpretation The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people-the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close-or how far-all populations are in benefiting from UHC., Lucas Guimaraes Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (Capes) -Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG). Olatunji O Adetokunboh acknowledges South African Department of Science & Innovation, and National Research Foundation. Anurag Agrawal acknowledges support from the Wellcome Trust DBT India Alliance Senior Fellowship IA/CPHS/14/1/501489. Rufus Olusola Akinyemi acknowledges Grant U01HG010273 from the National Institutes of Health (NIH) as part of the H3Africa Consortium. Rufus Olusola Akinyemi is further supported by the FLAIR fellowship funded by the UK Royal Society and the African Academy of Sciences. Syed Mohamed Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. Marcel Ausloos, Claudiu Herteliu, and Adrian Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDSUEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. Till Winfried Barnighausen acknowledges support from the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. Juan J Carrero was supported by the Swedish Research Council (2019-01059). Felix Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. Vera Marisa Costa acknowledges support from grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundacao para a Ciencia e a Tecnologia (FCT), IP, under the Norma TransitA3ria DL57/2016/CP1334/CT0006. Jan-Walter De Neve acknowledges support from the Alexander von Humboldt Foundation. Kebede Deribe acknowledges support by Wellcome Trust grant number 201900/Z/16/Z as part of his International Intermediate Fellowship. Claudiu Herteliu acknowledges partial support by a grant co-funded by European Fund for Regional Development through Operational Program for Competitiveness, Project ID P_40_382. Praveen Hoogar acknowledges the Centre for Bio Cultural Studies (CBiCS), Manipal Academy of Higher Education(MAHE), Manipal and Centre for Holistic Development and Research (CHDR), Kalghatgi. Bing-Fang Hwang acknowledges support from China Medical University (CMU108-MF-95), Taichung, Taiwan. Mihajlo Jakovljevic acknowledges the Serbian part of this GBD contribution was co-funded through the Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. Aruna M Kamath acknowledges funding from the National Institutes of Health T32 grant (T32GM086270). Srinivasa Vittal Katikireddi acknowledges funding from the Medical Research Council (MC_UU_12017/13 & MC_UU_12017/15), Scottish Government Chief Scientist Office (SPHSU13 & SPHSU15) and an NRS Senior Clinical Fellowship (SCAF/15/02). Yun Jin Kim acknowledges support from the Research Management Centre, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/0001). Kewal Krishan acknowledges support from the DST PURSE grant and UGC Center of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. Manasi Kumar acknowledges support from K43 TW010716 Fogarty International Center/NIMH. Ben Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. Ivan Landires is a member of the Sistema Nacional de InvestigaciA3n (SNI), which is supported by the Secretaria Nacional de Ciencia Tecnologia e Innovacion (SENACYT), Panama. Jeffrey V Lazarus acknowledges support by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III/ESF, European Union [CP18/00074]). Peter T N Memiah acknowledges CODESRIA; HISTP. Subas Neupane acknowledges partial support from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital. Shuhei Nomura acknowledges support from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). Alberto Ortiz acknowledges support by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. George C Patton acknowledges support from a National Health & Medical Research Council Fellowship. Marina Pinheiro acknowledges support from FCT for funding through program DL 57/2016 -Norma transitA3ria. Alberto Raggi, David Sattin, and Silvia Schiavolin acknowledge support by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4 -Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). Daniel Cury Ribeiro acknowledges support from the Sir Charles Hercus Health Research Fellowship -Health Research Council of New Zealand (18/111). Perminder S Sachdev acknowledges funding from the NHMRC Australia. Abdallah M Samy acknowledges support from a fellowship from the Egyptian Fulbright Mission Program. Milena M Santric-Milicevic acknowledges support from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No. 175087). Rodrigo Sarmiento-Suarez acknowledges institutional support from University of Applied and Environmental Sciences in Bogota, Colombia, and Carlos III Institute of Health in Madrid, Spain. Maria Ines Schmidt acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. Sheikh Mohammed Shariful Islam acknowledges a fellowship from the National Heart Foundation of Australia and Deakin University. Aziz Sheikh acknowledges support from Health Data Research UK. Kenji Shibuya acknowledges Japan Ministry of Education, Culture, Sports, Science and Technology. Joan B Soriano acknowledges support by Centro de Investigacion en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Rafael Tabares-Seisdedos acknowledges partial support from grant PI17/00719 from ISCIII-FEDER. Santosh Kumar Tadakamadla acknowledges support from the National Health and Medical Research Council Early Career Fellowship, Australia. Marcello Tonelli acknowledges the David Freeze Chair in Health Services Research at the University of Calgary, AB, Canada., "Peer Reviewed"

Published
2020

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