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6 results on '"Yang, Xin-Jie"'

5. Increased Incidence of Severe Adverse Events in Non-Small Cell Lung Cancer Patients with Previous Tuberculosis Episode Treated with PD-1 Inhibitors.

Author

Zhang H, Yuan JF, Xu YY, Yang MJ, Lyu JL, Yang XJ, Sheng SY, Qian Z, Wang QH, Pang Y, and Hu Y

Subjects
Humans, Male, Female, Aged, Middle Aged, Incidence, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Pulmonary epidemiology, Aged, 80 and over, Retrospective Studies, Lung Neoplasms drug therapy, Immune Checkpoint Inhibitors adverse effects, Immune Checkpoint Inhibitors therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy
Abstract

Lung cancer is the top cause of cancer deaths globally. Advances in immune checkpoint inhibitors (ICIs) have transformed cancer treatment, but their use in lung cancer has led to more side effects. This study examined if past pulmonary tuberculosis (TB) affects ICIs' effectiveness and safety in lung cancer treatment. We reviewed lung cancer patients treated with ICIs at Beijing Chest Hospital from January 2019 to August 2022. We compared outcomes and side effects between patients with and without prior TB. Of 116 patients (40 with TB history, 76 without), prior TB didn't reduce treatment effectiveness but did increase severe side effects. Notably, older patients (≥ 65 years) faced a higher risk of severe side effects. Detailed cases of two patients with severe side effects underscored TB as a risk factor in lung cancer patients receiving ICIs, stressing the need for careful monitoring and personalized care., (Copyright © 2024 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)

Published
2024
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6. [Effect of licorice flavonoids on kainic acid-induced seizure in mice].

Author

Liu JX, Liu FR, Yang XJ, Wang YZ, Chen DJ, Xie QM, and Zeng LH

Subjects
Animals, Disease Models, Animal, Kainic Acid adverse effects, Male, Mice, Mice, Inbred ICR, Mossy Fibers, Hippocampal drug effects, Neurogenesis drug effects, Seizures chemically induced, Status Epilepticus drug therapy, Flavonoids pharmacology, Glycyrrhiza chemistry, Seizures drug therapy
Abstract

Objective: To investigate the effect of licorice flavonoid (LF) on kainic acid (KA)-induced seizure in mice and its mechanism., Methods: Male adult ICR mice were injected with 25 mg/kg KA to induce temporal lobe seizure. LF was administrated 7 d before seizure induction (pre-treatment) or 24 h after seizure induction (post-treatment) for 7 d. Acute seizure latency, seizure stage and duration were observed and compared between LF- and vehicle-treated mice. From d2 on, mice with status epilepticus were video-monitored for spontaneous seizures, 10 h/d for 6 w. Immunohistochemical analysis of BrdU and Timm staining was conducted to detect the neurogenesis and mossy fiber sprouting, respectively., Results: No significant difference was observed in acute seizure latency, seizure stage and duration between LF-and vehicle-treated mice. KA-induced acute seizure resulted in spontaneous seizure in mice, and the seizure frequency was increased with time. Pre- and post-treatment with LF decreased seizure frequency from w3 after modeling [(0.58±0.15)/d, (0.38±0.38)/d vs (1.23±0.23)/d, P <0.05]. Furthermore, KA-induced seizure resulted in robust neurogenesis and mossy fiber sprouting, while treatment with LF both pre- and post- KA injection significantly inhibited neurogenesis (15.6±2.6, 17.1±3.1 vs 28.9±3.5, P <0.05) and mossy fiber sprouting (1.33±0.31, 1.56±0.42 vs 3.0±0.37, P <0.05)., Conclusion: LF has no significant anti-seizure effect. However, it can decrease epileptogenesis through inhibition of neurogenesis and mossy fiber sprouting.

Published
2015
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