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5. The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

Author

Zhao, Xiao-Feng, primary, Huffman, Lucas D, primary, Hafner, Hannah, primary, Athaiya, Mitre, additional, Finneran, Matthew C, additional, Kalinski, Ashley L, additional, Kohen, Rafi, additional, Flynn, Corey, additional, Passino, Ryan, additional, Johnson, Craig N, additional, Kohrman, David, additional, Kawaguchi, Riki, additional, Yang, Lynda JS, additional, Twiss, Jeffery L, additional, Geschwind, Daniel H, additional, Corfas, Gabriel, additional, and Giger, Roman J, additional

Published
2022
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6. Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia

Author

Javeed, Saad, primary, Dibble, Christopher F., additional, Greenberg, Jacob K., additional, Zhang, Justin K., additional, Khalifeh, Jawad M., additional, Park, Yikyung, additional, Wilson, Thomas J., additional, Zager, Eric L., additional, Faraji, Amir H., additional, Mahan, Mark A., additional, Yang, Lynda J., additional, Midha, Rajiv, additional, Juknis, Neringa, additional, and Ray, Wilson Z., additional

Published
2022
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9. A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

Author

Bissahoyo, Anika C, primary, Xie, Yuying, additional, Yang, Lynda, additional, Pearsall, R Scott, additional, Lee, Daekee, additional, Elliott, Rosemary W, additional, Demant, Peter, additional, McMillan, Leonard, additional, Pardo-Manuel de Villena, Fernando, additional, Angel, Joe M, additional, and Threadgill, David W, additional

Published
2020
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10. Gangliosides are neuronal ligands for myelin-associated glycoprotein

Author

Yang, Lynda J.-S., Zeller, Cynthia B., Shaper, Nancy L., Kiso, Makoto, Hasegawa, Akira, Shapiro, Robert E., and Schnaar, Ronald L.

Subjects
Gangliosides -- Research, Neurons -- Research, Myelin proteins -- Research, Cell adhesion -- Molecular aspects, Science and technology
Abstract

Some structurally related gangliosides, found in myelinated neurons in vivo, have been determined to be ligands for myelin-associated glycoprotein (MAG). Only GT1b and GD1a allowed cell adhesion of MAG-transfected COS-1 cells, when major brain gangliosides were adsorbed as artificial membranes on plastic microwells. GQ1b-alpha was found more effective than GT1b or GD1a in allowing MAG-induced cell adhesion.

Published
1996

11. Persistence of Neonatal Brachial Plexus Palsy among Nulliparous Versus Parous Women

Author

McLaren, Rodney A., Chang, Kate W.-C., Ankumah, Nana-Ama E., Yang, Lynda J.-S., and Chauhan, Suneet P.

Subjects
Pediatrics, Perinatology and Child Health, nulliparous, persistent, Obstetrics and Gynecology, Original Article, shoulder dystocia, Erratum, neonatal brachial plexus palsy, lcsh:Gynecology and obstetrics, lcsh:RG1-991
Abstract

Objective Our objective was to compare persistence of neonatal brachial plexus palsy (NBPP) at 1 and 2 years in children of nulliparous versus parous women. Study Design We conducted a retrospective cohort study of children diagnosed with NBPP followed at the University of Michigan, Interdisciplinary Brachial Plexus Program (UM-BPP). Self-reported demographics, delivery history, including birth weight (BW) Results Of 337 children with NBPP, 43% (146) were of nulliparas and 57% (191) of multiparas. At 1 year, children with persistent NBPP were similar in both groups (87% vs. 88%, aOR 1.357, 95% CI: 0.297–6.208). Persistent NBPP was not significantly different among nulliparous and multiparous women at 2 years (97% vs. 92% respectively, aOR 0.079, 95% CI: 0.006–1.050). Conclusion In one of the largest cohorts of NBPP, maternal parity did not influence the likelihood of NBPP persistence at 1 and 2 years.

Published
2019
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18. Methodology Rigor in Clinical Research

Author

Yang, Lynda J-S., Chang, Kate W-C., and Chung, Kevin C.

Subjects
Biomedical Research, Evidence-Based Medicine, Decision Making, Humans, Surgery, Plastic, Article
Abstract

Rigorous methodology increases the quality of clinical research by encouraging freedom from the biases inherent in clinical studies. As randomized controlled studies (clinical trial design) are rarely applicable to surgical research, the authors address the commonly used observational study designs and methodologies by presenting guidelines for rigor.The authors performed a review of study designs, including cohort, case-control, and cross-sectional studies and case series/reports, and biases and confounders of study design.Details about biases and confounders at each study stage, study characteristics, rigor checklists, and published literature examples for each study design are summarized and presented in this report.For those surgeons interested in pursuing clinical research, mastery of the principles of methodologic rigor is imperative in the context of evidence-based medicine and widespread publication of clinical studies. Knowledge of the study designs and their appropriate application, and strict adherence to study design methods can provide high-quality evidence to serve as the basis for rational clinical decision-making.

Published
2012

25. Persistence and Extent of Neonatal Brachial Plexus Palsy: Association with Number of Maneuvers and Duration of Shoulder Dystocia.

Author

Doty MS, Chauhan SP, Chang KW, Al-Hafez L, McGovern C, Yang LJ, and Blackwell SC

Abstract

Objective  The main objective of this article is to determine if persistence of neonatal brachial plexus palsy (NBPP) following shoulder dystocia was associated with maneuvers used or duration of impacted shoulder. Study Design  Retrospective review of children with NBPP and documented shoulder dystocia. Student t -tests and chi-squared tests were used to compare outcomes when shoulder dystocia resolved with > 3 versus ≤ 3 maneuvers or duration > versus ≤ 120 seconds. Relative risk (RR) with 95% confidence intervals (CI) was calculated. Results  Among 46 children with NBPP and shoulder dystocia, incidence of persistence was significantly higher at 2 years of age when > 3 versus ≤ 3 maneuvers were used (100 vs. 62%; RR: 1.6, 95% CI: 1.2-2.2). When resolution of impacted shoulder lasted >120 versus ≤ 120 seconds, NBPP at 2 years was significantly more likely (100 vs. 63%; RR: 1.6, 95% CI: 1.1-2.2). Injury to all five nerves of the brachial plexus was more likely if standard deviation lasted > 120 versus ≤ 120 seconds (RR: 2.2; 95% CI: 1.03-4.6). Conclusion  Though the number of maneuvers used and duration of shoulder dystocia are associated with persistence of NBPP, the retrospective nature of the study of a selective cohort precludes recommendations changing the current management of shoulder dystocia., Competing Interests: Conflict of Interest The authors report no conflict of interest. There was no funding received for conducting this project. Presented at the 2018 Central Association of Obstetricians and Gynecologists annual meeting in Minnesota, MN.

Published
2020
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27. Radiation-induced meningeal osteosarcoma of tentorium cerebelli with intradural spinal metastases.

Author

Ziewacz JE, Song JW, Blaivas M, and Yang LJ

Abstract

Background: Primary meningeal osteosarcomas and radiation-induced extraosseous tumors are extremely rare. We encountered a patient with a radiation-induced meningeal osteosarcoma with metastatic spread., Case Description: A 54-year-old man presented with a 2-week history of nausea, vomiting, and ataxia. CT and MRI studies revealed an extra-axial, dural-based mass in the posterior fossa arising from the tentorium cerebelli. The patient underwent complete resection of the tumor with adjuvant chemotherapy. Histopathologic analysis revealed chondroblastic osteosarcoma. Tumor recurrence was observed 9 months after initial diagnosis, and adjuvant radiation therapy was administered. The intracranial disease stabilized; however, multiple cervico-thoracic spinal metastases were discovered 15 months after initial diagnosis. The patient expired 16 months after initial diagnosis., Conclusion: Meningeal osteosarcomas are rare lesions that can metastasize and should be considered in the differential diagnosis for dural-based lesions, especially in the case of previous radiation therapy.

Published
2010
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28. Neonatal brachial plexus palsy.

Author

Yang, Lynda J.-S., MD, PD, FAANS

Subjects
Movement disorders, Fetal growth disorders, Brachial plexus neuropathies
Abstract

Children with neonatal brachial plexus palsy (NBPP) have a weak or paralyzed arm, and their passive range of motion is greater than their active range of motion. NBPP becomes evident early in life and usually results from stretching or compression of the nerves of the brachial plexus during the perinatal period. NBPP occurs with an incidence of 1.5 cases per 1,000 live births, with or without shoulder dystocia at the time of both vaginal and cesarean delivery. Risk factors for NBPP include abnormal positioning of the fetus, labor abnormalities, artificial labor induction, large fetus, and shoulder dystocia. However, except for shoulder dystocia, none of these risk factors are statistically significant clinical predictors for the occurrence of NBPP.

Published
2022

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