6 results on '"Yablon SA"'
Search Results
2. Focal Electroencephalographic Changes Index Post-Traumatic Confusion and Outcome.
- Author
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Shah SA, Mohamadpour M, Askin G, Nakase-Richardson R, Stokic DS, Sherer M, Yablon SA, and Schiff ND
- Subjects
- Adult, Electroencephalography, Female, Humans, Male, Middle Aged, Recovery of Function physiology, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic physiopathology, Confusion etiology, Confusion physiopathology
- Abstract
While the duration and severity of post-traumatic confusional state (PTCS) after traumatic brain injury have well-established implications for long-term outcomes, little is known about the underlying pathophysiology and their role in functional outcomes. Here, we analyzed the delta-to-alpha frequency band power ratios (DAR) from localized scalp areas derived from standard resting electroencephalographic (EEG) data recorded during eyes closed state in 49 patients diagnosed with PTCS. Higher global, occipital, parietal, and temporal DARs were significantly associated with the severity of PTCS, as assessed by the Confusion Assessment Protocol (CAP) observed on the same day, after controlling for injury severity. Also, occipital DARs were positively associated with both the CAP disorientation score 2, and the CAP symptom fluctuation score 4, after controlling for injury severity (n = 35). Posterior DARs were significantly associated with Functional Independence Measure-cognitive subscale average score at 1 (n = 45), 2 (n = 42), and 5 (n = 34) year(s) post-injury. The associations at 1 (temporal left) and 2 (parietal left) years survive after controlling for an injury severity index. Our finding that posterior DAR is a marker of PTCS and functional recovery post-injury, likely reflects functional de-afferentation of the posterior medial complex (PMC) in PTCS. Altered function of the PMC is proposed as a unifying physiological mechanism underlying both acute and chronic confusional states. We discuss the relationship of these findings to electrophysiological markers associated with disorders of consciousness.
- Published
- 2017
- Full Text
- View/download PDF
3. Effect of intrathecal baclofen bolus injection on ankle muscle activation during gait in patients with acquired brain injury.
- Author
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Chow JW, Yablon SA, and Stokic DS
- Subjects
- Adolescent, Adult, Ankle physiopathology, Biomechanical Phenomena, Brain Injuries drug therapy, Electromyography, Female, Gait physiology, Humans, Injections, Spinal, Intracranial Hemorrhages drug therapy, Intracranial Hemorrhages physiopathology, Male, Middle Aged, Muscle Hypertonia physiopathology, Muscle, Skeletal drug effects, Muscle, Skeletal physiopathology, Stroke drug therapy, Treatment Outcome, Young Adult, Baclofen administration & dosage, Brain Injuries physiopathology, Gait drug effects, Muscle Hypertonia drug therapy, Neuromuscular Agents administration & dosage, Stroke physiopathology
- Abstract
Background: Intrathecal baclofen (ITB) bolus injection effectively decreases spinal excitability but the impact on lower limb muscle activation during gait has not been thoroughly investigated., Objective: Examine activation of medial gastrocnemius (MG) and tibialis anterior (TA) muscles during gait before and after ITB bolus injection in patients with resting hypertonia after acquired brain injury., Methods: Lower extremity Ashworth score, temporospatial gait parameters, characteristics of the linear relationship between electromyogram (EMG) and lengthening velocity (LV) in MG during stance, and the duration and magnitude of TA-MG coactivation were assessed before and at 2, 4, and 6 hours after a 50-µg ITB injection via lumbar puncture in 8 hemorrhagic stroke and 11 traumatic brain injury subjects., Results: Temporospatial gait parameters did not significantly differ across the evaluation points (P ≥ .170). However, Ashworth score (P < .001), frequency and gain of significant positive EMG-LV slope (P ≤ .020), and duration of TA-MG coactivation (P ≤ .013) significantly decreased in the more-affected leg after ITB bolus. EMG changes were not significantly different between patients who did (n = 10) and did not (n = 9) increase gait speed after the injection. The timing of the largest decrease in Ashworth score and the largest decrease in EMG parameters coincided in 36% of cases, on average., Conclusions: ITB bolus injection alters the activation of MG and TA during gait. However, the changes in muscle activation are not closely related to the changes in gait speed or resting muscle hypertonia. The analysis of ankle muscle activation during gait better characterizes the response to ITB bolus injection than gait kinematics., (© The Author(s) 2014.)
- Published
- 2015
- Full Text
- View/download PDF
4. Longitudinal outcome of patients with disordered consciousness in the NIDRR TBI Model Systems Programs.
- Author
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Nakase-Richardson R, Whyte J, Giacino JT, Pavawalla S, Barnett SD, Yablon SA, Sherer M, Kalmar K, Hammond FM, Greenwald B, Horn LJ, Seel R, McCarthy M, Tran J, and Walker WC
- Subjects
- Activities of Daily Living, Adult, Brain Injuries complications, Consciousness Disorders etiology, Disability Evaluation, Female, Glasgow Coma Scale, Humans, Longitudinal Studies, Male, Young Adult, Brain Injuries rehabilitation, Consciousness Disorders rehabilitation, Recovery of Function
- Abstract
Few studies address the course of recovery from prolonged disorders of consciousness (DOC) after severe traumatic brain injury (TBI). This study examined acute and long-term outcomes of persons with DOC admitted to acute inpatient rehabilitation within the National Institute on Disability and Rehabilitation Research (NIDRR) TBI Model Systems Programs (TBIMS). Of 9028 persons enrolled from 1988 to 2009, 396 from 20 centers met study criteria. Participants were primarily male (73%), Caucasian (67%), injured in motor vehicle collision (66%), with a median age of 28, and emergency department Glasgow Coma Scale (GCS) score of 3. Participant status was evaluated at acute rehabilitation admission and discharge and at 1, 2, and 5 years post-injury. During inpatient rehabilitation, 268 of 396 (68%) regained consciousness and 91 (23%) emerged from post-traumatic amnesia (PTA). Participants demonstrated significant improvements on GCS (z=16.135, p≤0.001) and Functional Independence Measure (FIM) (z=15.584, p≤0.001) from rehabilitation admission (median GCS=9; FIM=18) to discharge (median GCS=14; FIM=43). Of 337 with at least one follow-up visit, 28 (8%) had died by 2.1 years (mean) after discharge. Among survivors, 66 (21%) improved to become capable of living without in-house supervision, and 63 demonstrated employment potential using the Disability Rating Scale (DRS). Participants with follow-up data at 1, 2, and 5 years post-injury (n=108) demonstrated significant improvement across all follow-up evaluations on the FIM Cognitive and Supervision Rating Scale (p<0.01). Significant improvements were observed on the DRS and FIM Motor at 1 and 2 years post-injury (p<0.01). Persons with DOC at the time of admission to inpatient rehabilitation showed functional improvement throughout early recovery and in years post-injury.
- Published
- 2012
- Full Text
- View/download PDF
5. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review.
- Author
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Stetkarova I, Yablon SA, Kofler M, and Stokic DS
- Subjects
- Adult, Humans, Infusion Pumps, Implantable standards, Injections, Spinal adverse effects, Injections, Spinal instrumentation, Injections, Spinal methods, Muscle Hypertonia physiopathology, Postoperative Complications prevention & control, Baclofen administration & dosage, Baclofen adverse effects, Infusion Pumps, Implantable adverse effects, Muscle Hypertonia drug therapy, Postoperative Complications epidemiology
- Abstract
Background: Intrathecal baclofen (ITB) effectively reduces muscle hypertonia; however, associated complications influence its utility and acceptance., Objective: To systematically review the literature on procedure- and device-related complications associated with ITB infusion therapy for adult muscle hypertonia of spinal or cerebral origin., Methods: The authors searched the PubMed database for full-length articles published in English that reported ITB-associated complications in adults. Of 147 articles retrieved, 32 full-length manuscripts and 10 case reports were reviewed in detail., Results: Overall, 558 complications were reported after 1362 pump implants (0.41 per implant)., Method: s for characterizing complications varied greatly between studies, as did complication rates, ranging from 0 to 2.24 per implant. Of the 558 complications, 148 (27%) were related to surgical procedures, 39 (7%) to pump problems, and 369 (66%) to catheter malfunctions. The overall complication rate was higher for studies that followed patients for more than 18 months on average (mean 0.56/implant) versus studies with shorter follow-up (0.23/implant, P < .05). Although correlation between the number of implants and the number of complications was significant (r = .58), the goodness of linear fit was poor because of clusters with varied complication rates., Conclusions: Catheter problems are relatively common and more frequent than pump or surgical procedure complications after ITB pump implantation. Higher complication rates should be expected in centers that follow patients for a longer period of time. Standardized data collection and complication-reporting procedures along with appropriate training should be implemented in centers offering ITB treatment for management of muscle hypertonia.
- Published
- 2010
- Full Text
- View/download PDF
6. Comment on "Evidence of increased motoneuron excitability in stroke patients without clinical spasticity".
- Author
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Stokic DS, Yablon SA, and Blicher JU
- Subjects
- Humans, Muscle Spasticity diagnosis, Muscle Spasticity etiology, Stroke complications, Motor Neurons physiology, Muscle Spasticity physiopathology, Spinal Cord physiopathology, Stroke physiopathology
- Published
- 2009
- Full Text
- View/download PDF
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