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Information and communication Technologies (ICT) have significantly changed the workplace environment. The rise of remote work and online business processes, especially in the post-pandemic period, has blurred the boundary between work and life balance for many employees, especially academics. The need to respond quickly to messages, e-mails, and work using information and communication technologies has led to an increase in Workplace Telepressure on academics. Increasing demand for information and networks to mitigate the impact of telepressure has led to an increase in workplace FOMO. These two sources of stress have contributed to the burnout experienced by academicians. In this study, the relationship between academicians' WPT, WFOMO, and burnout levels was examined. Data were collected from 286 academicians working in public and private universities using the convenience sampling method. The data were analyzed using SPSS 22 and Smart PLS 4 programs. The study results reveal that the Workplace Telepressure (WPT) levels of academicians have a significant effect on Burnout and Workplace-Fear of Missing Out (WFOMO). Additionally, WFOMO acts as a mediator role in the relationship between WPT and Burnout. These findings expand the existing literature on WPT and WFOMO, two emerging stress factors in the workplace, and provide recommendations for managers and policymakers.

Introduction: As the life expectancy at birth improved, the increase in the elderly population, one of the most vulnerable groups in society, brings about some problems. Frailty is a condition that increases the risk of progressive deterioration in physiological functioning, hypersensitivity to stress and adverse health outcomes. Frailty is quite common in older people. In frail older people, recovery from illnesses is delayed and the likelihood of sequelae is increased. If frailty is recognized early, the likelihood of disease sequelae and mortality can be reduced. Objectives: This study was conducted to determine the relationship between psychological resilience and quality of life on frailty in individuals aged 65 years and older admitted to hospital. Methods: The study group of this cross-sectional study consisted of 504 people who applied to an outpatient clinic at a university hospital. The Tilburg Frailty Scale, the Connor Davidson Psychological Resilience Scale Short Form and the EQ-5D-3L General Quality of Life Scale were used. The Kolmogorov-Simirnov test, the chi-square test, the Spearman correlation analysis and the multivariate logistic regression were used to analyse the data. Results: 292 of the participants in the study group were men. Their ages ranged from 65 to 90 years, and the mean was 70.5±4.9 years. Scores on the Tilburg Frail Scale ranged from 0 to 14, and the mean was 6.3±2.7 points. In the study, 71.1% of participants were classified as frail. It was determined that there was a moderate negative correlation between the results of the Tilburg Frailty Scale and the results of the Connor Davidson Psychological Resilience Scale (r= -0.436) and the EQ-5D-3L VAS Scale (r=-0.608) and a strong positive correlation between the results of the EQ-5D-3L Index Scale (r=0.729)(for each p<0.001). According to multivariate logistic regression, people who did not exercise regularly were 2,33 times more frail than those who did, and people who had a health problem that required bed rest were 2,18 times more frail than those who did not. Conclusions: It was found that the frailty of people aged 65 and over is at a moderate level. An improvement in psychological resilience and general quality of life as well as an improvement in general health reduces frailty. It is recommended that people aged 65 and over to be physically active and to protect from situations that may require prolonged bed rest. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Acute lymphoblastic leukemia (ALL) is a malignant disease of hematopoietic stem cells. B cell ALL (B-ALL) is characterized by highly proliferative and poorly differentiated progenitor B cells in the bone marrow. Chromosomal rearrangements, aberrant cell signaling, and mutations lead to dysregulated cell cycle and clonal proliferation of abnormal B cell progenitors. In this study, we aimed to examine hot spot genetic variations in the RUNX1, IDH2, and IL2RA genes in a group of (n=52) pediatric B-ALL. Sanger sequencing results revealed a rare RUNX1 variant p.Leu148Gln in one B-ALL patient with disease recurrence. Additionally, common intronic variations rs12358961 and rs11256369 of IL2RA were determined in two patients. None of the patients had the IDH2 variant. RUNX1, IDH2, and IL2RA variations were rare events in ALL. This study detected a novel pathogenic RUNX1 variation in a patient with a poor prognosis. Examining prognostically important genetic anomalies of childhood lymphoblastic leukemia patients and the signaling pathway components will pilot more accurate prognosis estimations.

Rare disease patients constitute a significant part of the healthcare system of all countries. However, the information on the experiences during disease processes and daily life of rare disease patients is still limited. So far, there is a small number of studies conducted in Türkiye, and they mainly cover specific issues like education or anxiety. Here we present a comprehensive survey analysis conducted among the patients and their families within the scope of the Istanbul Solution Platform for Undiagnosed and Rare Diseases-ISTisNA project. A total of 498 individuals responded to the survey, and 58% of the participants answered all questions. The majority of the patients were in the age range of 1–10 years (44.7%), and 91% of all the patients had a precise diagnosis. The diagnosis rate in the first 6 months was 69%, and almost 10% of the patients remained undiagnosed. The mothers were the primary caregivers (72%). Nearly 30% of the caregivers had to quit their jobs and 25% of the patients (0–18 years) had to leave school. Accessing physicians with relevant specialization and reaching treatments/medications/supplements were the two main obstacles the participants mentioned, with a frequency of 81% and 73%, respectively. Around 50% of participants noted that they commonly faced difficulties at work/school and in their social lives. The highest expectation or priority was the establishment of rare disease-specific diagnosis and treatment centers, accurate and detailed information on diseases in the Turkish language, and easy access to physicians, treatments, and supportive therapies. To the best of our knowledge, this is the most comprehensive survey conducted on the rare disease community in Türkiye. These results show that regardless of the country, the individuals affected by rare diseases and their families have similar problems and expectations. On the other hand, regional and country-specific issues are still in the line to be solved. These studies can provide a deeper insight into rare diseases and guide the activities of Türkiye's national rare disease action plan.

Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 gene variations and evaluated the clinical findings. Materials and Methods: Fifty diagnostic bone marrow samples of childhood T-ALL cases were investigated for the hotspot regions of the PTEN and AKT1 genes by targeted next-generation sequencing. Results: A total of five PTEN variations were found in three of the 50 T-ALL cases (6%). Three of the PTEN variations were first reported in this study. Furthermore, one patient clearly had two different mutant clones for PTEN. Two intronic single-nucleotide variations were found in AKT1 and none of the patients carried pathogenic AKT1 variations. Conclusion: Targeted deep sequencing allowed us to detect both lowlevel variations and clonal diversity. Low-level PTEN/AKT1 variation frequency makes it harder to investigate the clinical associations of the variants. On the other hand, characterization of the PTEN/ AKT signaling members is important for improving case-specific therapeutic strategies.

Purpose: To model CML progression in vitro and generate a blast crisis (BC-CML) model in vitro in order to identify new targets. Methods: Three different CML-derived iPSC lines were mutagenized with the alkylating agent ENU on a daily basis for 60 days. Cells were analyzed at D12 of hematopoietic differentiation for their phenotype, clonogenicity, and transcriptomic profile. Single-cell RNA-Seq analysis has been performed at three different time points during hematopoietic differentiation in ENU-treated and untreated cells. Results: One of the CML-iPSCs, compared to its non-mutagenized counterpart, generated myeloid blasts after hematopoietic differentiation, exhibiting monoblastic patterns and expression of cMPO, CD45, CD34, CD33, and CD13. Single-cell transcriptomics revealed a delay of differentiation in the mutated condition as compared to the control with increased levels of MSX1 (mesodermal marker) and a decrease in CD45 and CD41. Bulk transcriptomics analyzed along with the GSE4170 GEO dataset reveal a significant overlap between ENU-treated cells and primary BC cells. Among overexpressed genes, CD25 was identified, and its relevance was confirmed in a cohort of CML patients. Conclusions: iPSCs are a valuable tool to model CML progression and to identify new targets. Here, we show the relevance of CD25 identified in the iPSC model as a marker of CML progression.

Agricultural developments mostly depend on rapidly increasing world population. Tomato is a highly nutritious vegetable. Post-harvest technologies are often applied to prolong the consumption periods of tomato. Drying is one of the oldest methods of conservation. In this study, five different drying methods (oven drying, vacuum oven drying, sensitive drying, shaded-open atmosphere drying and sun drying) was used. Drying processes were carried out with dryers at 55°C, 60°C, 65°C and 70°C temperatures. All drying trials were performed in three replications. Drying performance (drying duration, final moisture content), drying kinetics, colour analysis, energy consumption, chemical analyses were performed for all drying methods. Fresh samples reached to desired moisture contents in 20-300 hours. To define time-dependent changes in moisture contents, Page, Logarithmic and Midilli-Küçük equations were used. Page equation yielded the worst estimations. There were not significant differences in “a” redness values of fresh samples, 65-70C of oven dryer and all temperatures of sensitive dryer. Sensitive dryer yielded the closet pH values to fresh samples. Based on current findings, it was concluded that oven drying, and sensitive drying were suitable for drying Selinus tomato variety.

OBJECTIVE: Spontaneous dissection of the abdominal aorta should be considered as a vascular surgical emergency. We report here our experience with this rare pathology. METHODS: At our hospital, we operated on 200 patients for abdominal aortic aneurysm over a 4-year period, and aortic dissection was the underlying pathology in eight of them. Diagnosis was based on history, imaging study findings and visualization at surgery. RESULTS: The mean size of the aorta at the time of diagnosis was 5.5 +/- 0.4 cm. Aortic dissection was complicated by acute ischemia of lower limb and paraplegia in 1 patient and four patients were admitted to hospital with severe abdominal and back pain. Two patients with contained rupture were admitted with hemodynamic collapse and shock. One of the patients who presented with abdominal pain experienced also sudden onset paraplegia. The diagnosis of dissecting abdominal aortic aneurysm was established incidentally in the remaining 2 patients. All patients were treated using open techniques with paramedian transperitoneal incision. We performed aorto-bifemoral bypass operation procedure in all patients; there was no post-operative mortality in our series. One patient had to be reoperated because of bleeding during early postoperative period. One patient required transient dialysis at early postoperative period because of transient rise of serum creatinine level. CONCLUSION: The surgical treatment of spontaneous abdominal aortic dissection is usually associated with low morbidity and mortality rates. However, the clinical form of presentation of acute abdominal aortic dissection is usually nonspecific, and diagnosis requires a high index of suspicion. [ABSTRACT FROM AUTHOR]

Anayasal iktisat kavramı, devletin güç ve yetkilerinin nasıl sınırlandırılabileceğini ve nasıl sınırlandırılması gerektiğini araştıran bir düşünce türüdür. Anayasal iktisadın temel amaçları mali ve parasal disiplini sağlamak, siyasetçilerin seçim ekonomisi ve popülist politikalar uygulamalarını engellemek, devletin sınırlandırılması ile bireylerin iktisadi hak ve özgürlüklerini korumak ve garanti altına almaktır. 2008 Krizi’yle başlayan ve Avro Bölgesi Borç Krizi’yle devam eden süreçte, AB (Avrupa Birliği) ülkelerinin mali disiplini sağlayamadıkları görülmüştür. Bu sebeple çalışmada Avro Bölgesi borç krizinin derinden etkilerini hisseden ülkelerin mali kural olarak nitelendirilen Maastricht Kriterleri’ne uyumunun değerlendirilmesi amaçlanmıştır The concept of constitutional economics is a notion that analyse how the power and authorities of a state can be and must be limited. The basic aims of constitutional economy are to ensure financial and monetary discipline, prevent politicians from implementing an election economics and populist policies and protect and guarantee economic rights and freedoms of individuals. It has been seen that the EU (European Union) countries could not maintain the fiscal discipline during the term starting with 2008 crisis and continuing with the Euro Zone Debt Crisis. For this reason, the aim of the study was to evaluate the compliance of the countries deeply affected by the Euro Sovereign debt crisis to the Maastricht Criteria

In this study, we investigated the relationship between industrial diversification and firm performance using a market-based performance measure and an accounting measure. We used the data of the firms listed on Borsa Istanbul during the period between 2006 and 2012. The results of the panel data indicate that there is a significant positive relationship between diversification and performance. We found that diversified firms outperformed the single firms. As is compatible with a resource-based approach, it was found that diversified firms tended to use their resources more efficiently compared to single firms.

Communication in organizations, within the limits specified and configured in accordance with certain rules arising from the formal channels of communication and interpersonal relationships, and are not included in any configuration takes place through informal channels of communication. Known as the world's oldest media rumor and gossip is the size of the informal communication process. Kalınamayan everyday life, away from the gossip and rumors, sometimes complained, but in a way, sometimes including the Red Crescent owned social media. In fact, rumor and gossip is a way of communication. Despite being one of the most common activities in organizations gossip much studied in the literature of the Turkish government issue. Examine this issue, a descriptive framework in order to contribute to the relevant literature is presented. In this study, informal and non-viral rumor that the perception of a means of communication, the functions of individual and organizational point of view, attitudes were assessed on individual merits.

Along with the technological developments, products that improve the life quality have become commonplace. Cell phones are one of these products. Some of the radioactive waves produced during the communication of cell phones with base stations are absorbed by tissues in human body and negatively affect human health. SAR (Specific Absorption Value) is the rate with which these waves are absorbed by body tissues. The aim of the present study was to determine factors affecting the willingness of consumers in Tokat Province of Turkey to pay more for low SAR value cell phones using ordered probit analysis. Of the variables used in the model, age of the consumer, average monthly income, sickness feeling during long cell phone calls, awareness of SAR value, double SIM-card phone, use of earphone, level of social responsibility had positive coefficient values and were statistically significant.

OBJECTIVE: The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM)-related progenitor cells. METHODS: The study group comprised the total bone marrow cells (CBM) of 10 hematologically normal people, the CD34+ stem cell samples (CD34+CBM) of 9 healthy donors for allogeneic peripheral stem cell transplantation, and the CD34+ stem cell samples (CD34+MM) of 9 MM patients undergoing autologous peripheral stem cell transplantation. We searched for the gene expression of the major RAS components in healthy hematopoietic cells and myeloma cells by quantitative real-time polymerase chain reaction analysis. RESULTS: RENIN, angiotensinogen (ANGTS), and angiotensin converting enzyme-I (ACE I) mRNA expression levels of CBM were significantly higher than those in myeloma patients (p=0.03, p=0.002, and p=0.0008, respectively). Moreover, RENIN and ANGTS mRNA expression levels were significantly higher in CD34+ stem cell samples of healthy allogeneic donors compared to those in myeloma patients (p=0.001 and p=0.01). However, ACE I expression levels were similar in CD34+CBM and CD34+MM hematopoietic cells (p=0.89). CONCLUSION: Although found to be lower than in the CBM and CD34+CBM hematopoietic cells, the local RAS components were also expressed in CD34+MM hematopoietic cells. This point should be kept in mind while focusing on the immunobiology of MM and the processing of autologous cells during the formation of transplantation treatment protocols.

In this study, Chrome mining which has an important place in the Turkish mining industry, analyzed and determined features that can provide a competitive advantage, and also aimed to identifing the existing problems.İn this study qualititive study has done.İn this context, literatüre review was done and descriptive method is used.The first section reviews recent discussions about strategic management approach and its features. The second section includes competetion and competitiveness.İn the context, swot analysis technique, the most preferred method, was utilized for assesing the competetion.And then, swot analysis is done chrome mining lastly, strategic evaluation is done in the context of assesments and analysis for chrome mining and various suppestions have been made about the strategic sense.

OBJECTIVE: T-cell acute lymphoblastic leukemia (T-ALL) is associated with recurrent chromosomal aberrations and abnormal ectopic gene expression during T-cell development. In order to gain insight into the pathogenesis of T-ALL this study aimed to measure the level of expression of 7 T-cell oncogenes (LMO2, LYL1, TAL1, TLX1, TLX3, BMI1, and CALM-AF10) in pediatric T-ALL patients. METHODS: LMO2, LYL1, TLX1, TLX3, BMI1, TAL1, and CALM-AF10 expression was measured using quantitative real-time PCR in 43 pediatric T-ALL patients. RESULTS: A high level of expression of LMO2, LYL1, TAL1, and BMI1 genes was observed in a large group of T-ALL. Several gene expression signatures indicative of leukemic arrest at specific stages of normal thymocyte development (LYL1 and LMO2) were highly expressed during the cortical and mature stages of T-cell development. Furthermore, upregulated TAL1 and BMI1 expression was observed in all phenotypic subgroups. In all, 6 of the patients had TLX1 and TLX3 proto-oncogene expression, which does not occur in normal cells, and none of the patients had CALM-AF10 fusion gene transcription. Expression of LYL1 alone and LMO2-LYL1 co-expression were associated with mediastinal involvement; however, high-level oncogene expression was not predictive of outcome in the present pediatric T-ALL patient group, but there was a trend towards a poor prognostic impact of TAL1 and/or LMO2 and/or LYL1 protooncogene expression. CONCLUSION: Poor prognostic impact of TAL1 and/or LMO2 and/or LYL1 proto-oncogene expression indicate the need for extensive study on oncogenic rearrangement and immunophenotypic markers in T-ALL, and their relationship to treatment outcome.

Objective: Despite the efficacy of the BCR-ABL tyrosine kinase inhibitor imatinib, the development of resistance against imatinib has been observed. The most important mechanisms known to cause resistance are point mutations in the ABL tyrosine kinase and the ATP domain. This study describes the use of denaturing high performance liquid chromatography (dHPLC) as a method to screen for mutations of the ABL gene.Material and Methods: We used the dHPLC based assay for the screening of ABL point mutations. Forty chronic myeloid leukemia (CML) patients who showed resistance to imatinib were screened in parallel by dHPLC and direct sequencing.Results: Nine of the 40 patients (23%) had mutations. Conclusion: dHPLC can be a useful method for pre-screening. Analyzing the mutations and monitoring (high-risk) patients can improve their prognosis and survival rate. dHPLC can potentially become a valuable tool for regular testing of patients in the future.

In our study, the social skills, academic competence and problem behaviors of children with cochlear implants in primary school first, second and third grade were compared with their normal peers and the relationships between social skills, academic competence, problem behaviors and language skills were investigated. For this purpose, 32 cochlear implanted (research group) and 160 healthy classmates (control group) were included. In this study, Social Skills Rating System (SSRS) Inventory Teacher version, standardized to Turkish by Sucuoğlu and Özokçu (2005), applied by teachers of children. Also, receptive and expressive language skills of cochlear implanted children assessed with Turkish Expressive and Receptive Language Test (TİFALDİ). As a result of statistical analysis, significant differences were found in favor of the control group between the SSRS subscales of the study group and the control group. The study group was divided into two groups as early (before 2 years) and late (after 2 years) implants, and when SSRS subscale scores of 3 groups were statistically compared, the difference between the study group and the control group was found as late cochlear implant group. In the analysis of the correlation between TİFALDİ Receptive Language, Expressive Language subtests and SSRS subscales of the study group, a significant positive correlation was found between the scores of the Receptive Language Subtest and the Academic Competence subscale while a significant positive correlations were found between the scores of the Expression Language Subtests and Social Skills and Academic Competence Subscales. It was also found that the scores of SSRS subscales showed significant correlations among themselves. [ABSTRACT FROM AUTHOR]

Adult cochlear implant users' expectations and outcomes are varied among them. The factors impact on cochlear implant outcomes also differentiates than the pediatric group. Such as duration of hearing loss, the configuration of hearing loss, and duration of hearing aid use are essential in pre-implant assessment. However, there are other essential variables that involve cognitive abilities for example verbal learning, visual memory, and auditory memory. In the rehabilitation process, holistic approach is appropriate for comprehensive evaluation. Materials and Methods:In this study, 15 cochlear implant users, who are older than 18 years old, were participated. In the inclusion criteria is using cochlea implant at least 6 months regularly. Before and after cochlear implantation following tests were used: adult sentence recognition test, word identification test, auditory memory test, Auditory- Verbal Learning Test, Glasgow Benefit Inventory, Montreal Cognitive Assessment and Draw a Clock Test. Result: All patients showed significant improvement in all tests. Sentence recognition and word recognition scores were improved as expected. The patients also reported that their life quality increased after cochlear implantation. Patients' adaptation was improved to memory tests after CI. Some of them still need rehabilitation support for memory. The holistic approach is needed to increase cochlear implant users' satisfaction after surgery. This approach helps us to understand patients' needs and expectations. After surgery optimal development can be achieved in all cognitive areas and quality of life in adults. [ABSTRACT FROM AUTHOR]