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740 results on '"Xu Jiake"'

1. Research on Calculation and Simulating Analysis of Cycloidal Pin Wheel Meshing Stiffness

Author

Su Jianxin, Wang Dongfeng, Xu Jiake, Zhang Jing, Li Hongji, and Lü Ruifang

Subjects
Cycloidal and pin wheel, Contact stress, Meshing stiffness, Structural parameters, Mechanical engineering and machinery, TJ1-1570
Abstract

In order to further improve the load-bearing performance of the RV reducer, a force analysis is conducted on the cycloidal pin wheel pair, regarding the contact stress and meshing stiffness of the cycloidal pin wheel as the research objective functions. In order to optimize its load-bearing performance, a mathematical analysis model of contact stress and meshing stiffness is proposed regarding the important structural parameters of cycloidal and pin wheel, as the design variables such as needle tooth distribution circle radius, eccentricity, and needle tooth radius, VB.NET Software is applied to calculate and analyzes the influence of structural parameters of the cycloidal and pin wheel on the meshing stiffness, contact stress, meshing force, and torsional stiffness of the cycloidal and pin wheel pair. The results of calculation and simulation indicate that the meshing stiffness and torsional stiffness of cycloidal and pin wheel increase with the increase of the radius of the distribution circle and eccentricity the decrease of the radius of the teeth. The research provides theoretical foundation for the design and optimization of the structure of cycloidal and pin wheel reducers.

Published
2024

2. ANALYSIS OF INFLUENCE OF CYCLOID GEAR HOLE STRUCTURE ON THE VIBRATION CHARACTERISTIC OF CYCLOIDAL GEAR (MT)

Author

YANG Fan, YANG JianJun, DENG XiaoZhong, LI TianXing, and XU JiaKe

Subjects
Cycloid gear, Comprehensive meshing stiffness, Orthogonal test, Structure optimization, Mechanical engineering and machinery, TJ1-1570, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

The cycloid gear is the key component of the RV reducer, and the hole structure of the cycloid gear has a great influence on the transmission stability of the of the RV reducer. Based on the meshing contact analysis between the cycloid gear and pin of transmission system, the number of actual meshing teeth pairs of the cycloid gear were obtained. The meshing angle of each tooth pair and the comprehensive meshing stiffness were calculated. Taking the comprehensive meshing stiffness as elastic constraint condition in finite element software, the dynamics harmonic resonance analysis of cycloid gear was carried out. The position of maximum vibration and deformation is located at the fan-shaped lightening hole of cycloid gear plate. According to the different shape of fan-shaped holes of cycloid gear, the dynamics simulation was carried out by orthogonal test with three factors and four levels. The results show that the radius of the top and bottom circle of the fan-shaped hole is always the key factor to the vibration of the cycloidal wheel with the increase of rotation speed, while the vibration increases gradually for the radius of the inverted circle, and decreases for the angle between the waist and the waist. The conclusions are helpful for the structure design of cycloid gear wheel.

Published
2023
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11. Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts

Author

Ng, Pei Ying, Ribet, Amy B. P., Guo, Qiang, Mullin, Benjamin H., Tan, Jamie W. Y., Landao-Bassonga, Euphemie, Stephens, Sébastien, Chen, Kai, Yuan, Jinbo, Abudulai, Laila, Bollen, Maike, Nguyen, Edward T. T. T., Kular, Jasreen, Papadimitriou, John M., Søe, Kent, Teasdale, Rohan D., Xu, Jiake, Parton, Robert G., Takayanagi, Hiroshi, and Pavlos, Nathan J.

Published
2023
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28. Macrophages release plasma membrane-derived particles rich in accessible cholesterol

Author

He, Cuiwen, Hu, Xuchen, Weston, Thomas A, Jung, Rachel S, Sandhu, Jaspreet, Huang, Song, Heizer, Patrick, Kim, Jason, Ellison, Rochelle, Xu, Jiake, Kilburn, Matthew, Bensinger, Steven J, Riezman, Howard, Tontonoz, Peter, Fong, Loren G, Jiang, Haibo, and Young, Stephen G

Subjects
Generic health relevance, Animals, Cell-Derived Microparticles, Cholesterol, Lipoproteins, HDL, Macrophages, Mice, Mice, Knockout, Microscopy, Electron, RAW 264.7 Cells, Spectrometry, Mass, Secondary Ion, cholesterol efflux, accessible cholesterol, nanoSIMS
Abstract

Macrophages are generally assumed to unload surplus cholesterol through direct interactions between ABC transporters on the plasma membrane and HDLs, but they have also been reported to release cholesterol-containing particles. How macrophage-derived particles are formed and released has not been clear. To understand the genesis of macrophage-derived particles, we imaged mouse macrophages by EM and nanoscale secondary ion mass spectrometry (nanoSIMS). By scanning EM, we found that large numbers of 20- to 120-nm particles are released from the fingerlike projections (filopodia) of macrophages. These particles attach to the substrate, forming a "lawn" of particles surrounding macrophages. By nanoSIMS imaging we showed that these particles are enriched in the mobile and metabolically active accessible pool of cholesterol (detectable by ALO-D4, a modified version of a cholesterol-binding cytolysin). The cholesterol content of macrophage-derived particles was increased by loading the cells with cholesterol or by adding LXR and RXR agonists to the cell-culture medium. Incubating macrophages with HDL reduced the cholesterol content of macrophage-derived particles. We propose that release of accessible cholesterol-rich particles from the macrophage plasma membrane could assist in disposing of surplus cholesterol and increase the efficiency of cholesterol movement to HDL.

Published
2018

31. Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei.

Author

Chen, Yanni, Mu, Wenbo, Wu, Yongkang, Xu, Jiake, Li, Xiaofang, Hu, Hui, Wang, Siqi, Wang, Dali, Hui, Bin, Wang, Lang, Dong, Yi, and Chen, Wei

Abstract

Spiral ganglia neurons (SGNs) impairment can cause deafness. One important therapeutic approach involves utilizing stem cells to restore impaired auditory circuitry. Nevertheless, the inadequate implementation of research methodologies poses a challenge in accurately assessing the functionality of derived cells within the circuit. Here, we describe a novel method for converting human embryonic stem cells (hESCs) into otic neurons (ONs) and assess their functional connectivity using an optogenetic approach with cells or an organotypic slice of rat cochlear nucleus (CN) in coculture. Embryonic stem cell-derived otic neurons (eONs) exhibited SGN marker expression and generated functional synaptic connection when cocultured with cochlear nucleus neurons (CNNs). Synapsin 1 and VGLUT expression are found in the cochlear nucleus of brain slices, where eONs projected processes during the coculture of eONs and CN brain slices. Action potential spikes and INa+/IK+ of CNNs increased in tandem with light stimulations to eONs. These findings provide further evidence that eONs may be a candidate source to treat SGN-deafness. [ABSTRACT FROM AUTHOR]

Published
2024
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32. The Effects of Different Dietary Patterns on Bone Health.

Author

Liu, Xiaohua, Wu, Yangming, Bennett, Samuel, Zou, Jun, Xu, Jiake, and Zhang, Lingli

Abstract

Bone metabolism is a process in which osteoclasts continuously clear old bone and osteoblasts form osteoid and mineralization within basic multicellular units, which are in a dynamic balance. The process of bone metabolism is affected by many factors, including diet. Reasonable dietary patterns play a vital role in the prevention and treatment of bone-related diseases. In recent years, dietary patterns have changed dramatically. With the continuous improvement in the quality of life, high amounts of sugar, fat and protein have become a part of people's daily diets. However, people have gradually realized the importance of a healthy diet, intermittent fasting, calorie restriction, a vegetarian diet, and moderate exercise. Although these dietary patterns have traditionally been considered healthy, their true impact on bone health are still unclear. Studies have found that caloric restriction and a vegetarian diet can reduce bone mass, the negative impact of a high-sugar and high-fat dietary (HSFD) pattern on bone health is far greater than the positive impact of the mechanical load, and the relationship between a high-protein diet (HPD) and bone health remains controversial. Calcium, vitamin D, and dairy products play an important role in preventing bone loss. In this article, we further explore the relationship between different dietary patterns and bone health, and provide a reference for how to choose the appropriate dietary pattern in the future and for how to prevent bone loss caused by long-term poor dietary patterns in children, adolescents, and the elderly. In addition, this review provides dietary references for the clinical treatment of bone-related diseases and suggests that health policy makers should consider dietary measures to prevent and treat bone loss. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Author Correction: Donkey genomes provide new insights into domestication and selection for coat color

Author

Wang, Changfa, Li, Haijing, Guo, Yu, Huang, Jinming, Sun, Yan, Min, Jiumeng, Wang, Jinpeng, Fang, Xiaodong, Zhao, Zicheng, Wang, Shuai, Zhang, Yanlin, Liu, Qingfeng, Jiang, Qiang, Wang, Xiuge, Guo, Yijun, Yang, Chunhong, Wang, Yinchao, Tian, Fang, Zhuang, Guilong, Fan, Yanna, Gao, Qican, Li, Yuhua, Ju, Zhihua, Li, Jianbin, Li, Rongling, Hou, Minghai, Yang, Guiwen, Liu, Guiqin, Liu, Wenqiang, Guo, Jiao, Pan, Shanshan, Fan, Guangyi, Zhang, Wei, Zhang, Ruitao, Yu, Jie, Zhang, Xinhao, Yin, Qi, Ji, Chuanliang, Jin, Yuanchun, Yue, Guidong, Liu, Mei, Xu, Jiake, Liu, Shimin, Jordana, Jordi, Noce, Antonia, Amills, Marcel, Wu, Dong Dong, Li, Shuaicheng, Zhou, Xiangshan, and Zhong, Jifeng

Published
2021
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40. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells

Author

Bao, Weilian, primary, You, Yan, additional, Ni, Jiahui, additional, Hou, Hui, additional, Lyu, Jiaren, additional, Feng, Guize, additional, Wang, Yirui, additional, You, Keyuan, additional, Zhang, Sulin, additional, Zhang, Lijie, additional, Cao, Xinyue, additional, Wang, Xu, additional, Li, Haidong, additional, Li, Hong, additional, Xu, Jiake, additional, Liu, Chenying, additional, Luo, Xiaomin, additional, Du, Peng, additional, Chen, Daofeng, additional, and Shen, Xiaoyan, additional

Published
2023
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45. Donkey genomes provide new insights into domestication and selection for coat color

Author

Wang, Changfa, Li, Haijing, Guo, Yu, Huang, Jinming, Sun, Yan, Min, Jiumeng, Wang, Jinpeng, Fang, Xiaodong, Zhao, Zicheng, Wang, Shuai, Zhang, Yanlin, Liu, Qingfeng, Jiang, Qiang, Wang, Xiuge, Guo, Yijun, Yang, Chunhong, Wang, Yinchao, Tian, Fang, Zhuang, Guilong, Fan, Yanna, Gao, Qican, Li, Yuhua, Ju, Zhihua, Li, Jianbin, Li, Rongling, Hou, Minghai, Yang, Guiwen, Liu, Guiqin, Liu, Wenqiang, Guo, Jiao, Pan, Shanshan, Fan, Guangyi, Zhang, Wei, Zhang, Ruitao, Yu, Jie, Zhang, Xinhao, Yin, Qi, Ji, Chuanliang, Jin, Yuanchun, Yue, Guidong, Liu, Mei, Xu, Jiake, Liu, Shimin, Jordana, Jordi, Noce, Antonia, Amills, Marcel, Wu, Dong Dong, Li, Shuaicheng, Zhou, Xiangshan, and Zhong, Jifeng

Published
2020
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47. Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis

Author

Mullin, Benjamin H, primary, Zhu, Kun, additional, Brown, Suzanne J, additional, Mullin, Shelby, additional, Dudbridge, Frank, additional, Pavlos, Nathan J, additional, Richards, J Brent, additional, Grundberg, Elin, additional, Bell, Jordana T, additional, Zeggini, Eleftheria, additional, Walsh, John P, additional, Xu, Jiake, additional, and Wilson, Scott G, additional

Published
2023
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49. Corrigendum to “Generation of induced pluripotent stem cell line, ZJUCHi002-A, from Charcot-Marie-Tooth disease type 2A (CMT2A) patient with a mutation of c.752C>T in MFN2” [Stem Cell Res. 36C (2019) 101411]

Author

Xu, Jiake, primary, Fu, Yong, additional, Xia, Weichun, additional, He, Jing, additional, Zou, Yan, additional, Ruan, Wencong, additional, Lou, Qi, additional, Li, Ying, additional, Pan, Jianwei, additional, Li, Haifeng, additional, and Chen, Wei, additional

Published
2023
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