14 results on '"Xu, Jin-dong"'
Search Results
2. The Smad3-miR-29b/miR-29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis
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Liang, Jing-nan, Zou, Xiao, Fang, Xian-hong, Xu, Jin-dong, Xiao, Zhen, Zhu, Jie-ning, Li, Hui, Yang, Jing, Zeng, Ni, Yuan, Shu-jing, Pan, Rong, Fu, Yong-heng, Zhang, Ming, Luo, Jian-fang, Wang, Sheng, and Shan, Zhi-xin
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- 2019
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3. Application of early enteral nutrition nursing based on enhanced recovery after surgery theory in patients with digestive surgery
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Shao, Yan-Ru, primary, Ke, Xia, additional, Luo, Li-Hua, additional, Xu, Jin-Dong, additional, and Xu, Li-Qian, additional
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- 2023
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4. Diverging targets mediate the pathological role of miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis
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Zeng, Ni, primary, Huang, Yu-Qing, additional, Yan, Yu-Min, additional, Hu, Zhi-Qin, additional, Zhang, Zhuo, additional, Feng, Jia-Xin, additional, Guo, Ji-Shen, additional, Zhu, Jie-Ning, additional, Fu, Yong-Heng, additional, Wang, Xi-Pei, additional, Zhang, Meng-Zhen, additional, Duan, Jin-Zhu, additional, Zheng, Xi-Long, additional, Xu, Jin-Dong, additional, and Shan, Zhi-Xin, additional
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- 2021
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5. Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury
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Ni, Shi-Hao, primary, Xu, Jin-Dong, additional, Sun, Shu-Ning, additional, Li, Yue, additional, Zhou, Zheng, additional, Li, Huan, additional, Liu, Xin, additional, Deng, Jian-Ping, additional, Huang, Yu-Sheng, additional, Chen, Zi-Xin, additional, Feng, Wen-Jun, additional, Wang, Jia-Jia, additional, Xian, Shao-Xiang, additional, Yang, Zhong-Qi, additional, Wang, Sheng, additional, Wang, Ling-Jun, additional, and Lu, Lu, additional
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- 2021
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6. Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury.
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Ni, Shi-Hao, Xu, Jin-Dong, Sun, Shu-Ning, Li, Yue, Zhou, Zheng, Li, Huan, Liu, Xin, Deng, Jian-Ping, Huang, Yu-Sheng, Chen, Zi-Xin, Feng, Wen-Jun, Wang, Jia-Jia, Xian, Shao-Xiang, Yang, Zhong-Qi, Wang, Sheng, Wang, Ling-Jun, and Lu, Lu
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HEART cells , *MACROPHAGES , *BONE marrow , *TRANSCRIPTOMES , *HEART injuries - Abstract
Aims The goal of our study was to investigate the heterogeneity of cardiac macrophages (CMφs) in mice with transverse aortic constriction (TAC) via single-cell sequencing and identify a subset of macrophages associated with heart injury. Methods and results We selected all CMφs from CD45+ cells using single-cell mRNA sequencing data. Through dimension reduction, clustering, and enrichment analyses, CD72hi CMφs were identified as a subset of pro-inflammatory macrophages. The pseudo-time trajectory and ChIP-Seq analyses identified Rel as the key transcription factor that induces CD72hi CMφ differentiation. Rel KD and Rel−/− bone marrow chimaera mice subjected to TAC showed features of mitigated cardiac injury, including decreased levels of cytokines and ROS, which prohibited cardiomyocyte death. The transfer of adoptive Rel-overexpressing monocytes and CD72hi CMφ injection directly aggravated heart injury in the TAC model. The CD72hi macrophages also exerted pro-inflammatory and cardiac injury effects associated with myocardial infarction. In humans, patients with heart failure exhibit increased CD72hi CMφ levels following dilated cardiomyopathy and ischaemic cardiomyopathy. Conclusion Bone marrow-derived, Rel-mediated CD72hi macrophages play a pro-inflammatory role, induce cardiac injury and, thus, may serve as a therapeutic target for multiple cardiovascular diseases. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4
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Li, Hui, primary, Xu, Jin-Dong, primary, Fang, Xian-Hong, primary, Zhu, Jie-Ning, primary, Yang, Jing, primary, Pan, Rong, primary, Yuan, Shu-Jing, primary, Zeng, Ni, primary, Yang, Zhen-Zhen, primary, Yang, Hui, primary, Wang, Xi-Pei, primary, Duan, Jin-Zhu, primary, Wang, Sheng, primary, Luo, Jian-Fang, primary, Wu, Shu-Lin, primary, and Shan, Zhi-Xin, primary
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- 2019
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8. Association of MTHFR C677T and A1298C polymorphisms with oral cancer susceptibility: evidence from a meta-analysis
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Jiang,Sui, Xu,Jin-Dong, Zhuo,Zhen-Jian, and Hua,Zhu-Ming
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OncoTargets and Therapy - Abstract
Sui Jiang,1,* Jin-Dong Xu,2 Zhen-Jian Zhuo,3 Zhu-Ming Hua2,* 1Department of Oral and Maxillofacial Surgery, 2Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 3School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China *These authors contributed equally to this work Abstract: Methylenetetrahydrofolate reductase (MTHFR) is a central enzyme involved in folate metabolism and plays an important role in DNA synthesis and methylation. Several studies have been conducted to illustrate the associations between MTHFR C677T and A1298C polymorphisms with oral cancer susceptibility; however, the results are inconsistent. Therefore, we conducted an updated meta-analysis to obtain a more reliable estimation of the associations. We retrieved eligible studies from PubMed, EMBASE, and CBM databases through September 2016. Ultimately, pooled analyses involved 10 studies with 1443 cases and 1640 controls for the C677T polymorphism, as well as five studies with 973 cases and 1024 controls for the A1298C polymorphism. Risk estimates were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Pooled results indicated that neither C677T nor A1298C polymorphism was associated with oral cancer susceptibility. However, a borderline significant association was detected between MTHFR C677T polymorphism and a decreased oral cancer risk (homozygous model: OR=0.71, 95% CI=0.50–1.00) in hospital-based studies. Our results suggested thatMTHFRC677T and A1298C polymorphisms might not be associated with oral cancer risk. However, more evidence is needed to further confirm these findings in the future. Keywords:MTHFR, polymorphisms, oral cancer, susceptibility, meta-analysis
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- 2017
9. Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4.
- Author
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Li, Hui, Xu, Jin-Dong, Fang, Xian-Hong, Zhu, Jie-Ning, Yang, Jing, Pan, Rong, Yuan, Shu-Jing, Zeng, Ni, Yang, Zhen-Zhen, Yang, Hui, Wang, Xi-Pei, Duan, Jin-Zhu, Wang, Sheng, Luo, Jian-Fang, Wu, Shu-Lin, and Shan, Zhi-Xin
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CIRCULAR RNA , *CARDIAC hypertrophy , *LUCIFERASES , *TRANSGENIC mice , *GENETIC regulation , *CELL size - Abstract
Aims Circular RNAs (circRNAs) are involved in gene regulation in a variety of physiological and pathological processes. The present study aimed to investigate the effect of circRNA_000203 on cardiac hypertrophy and the potential mechanisms involved. Methods and results CircRNA_000203 was found to be up-regulated in the myocardium of Ang-II-infused mice and in the cytoplasma of Ang-II-treated neonatal mouse ventricular cardiomyocytes (NMVCs). Enforced expression of circRNA_000203 enhances cell size and expression of atrial natriuretic peptide and β-myosin heavy chain in NMVCs. In vivo , heart function was impaired and cardiac hypertrophy was aggravated in Ang-II-infused myocardium-specific circRNA_000203 transgenic mice (Tg-circ203). Mechanistically, we found that circRNA_000203 could specifically sponge miR-26b-5p, -140-3p in NMVCs. Further, dual-luciferase reporter assay showed that miR-26b-5p, -140-3p could interact with 3′-UTRs of Gata4 gene, and circRNA_000203 could block the above interactions. In addition, Gata4 expression is transcriptionally inhibited by miR-26b-5p, -140-3p mimic in NMVCs but enhanced by over-expression of circRNA_000203 in vitro and in vivo. Functionally, miR-26b-5p, -140-3p, and Gata4 siRNA, could reverse the hypertrophic growth in Ang-II-induced NMVCs, as well as eliminate the pro-hypertrophic effect of circRNA_000203 in NMVCs. Furthermore, we demonstrated that NF-κB signalling mediates the up-regulation of circRNA_000203 in NMVCs exposed to Ang-II treatment. Conclusions Our data demonstrated that circRNA_000203 exacerbates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p leading to enhanced Gata4 levels. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis.
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Zeng N, Huang YQ, Yan YM, Hu ZQ, Zhang Z, Feng JX, Guo JS, Zhu JN, Fu YH, Wang XP, Zhang MZ, Duan JZ, Zheng XL, Xu JD, and Shan ZX
- Abstract
MicroRNA-199a-5p (miR-199a-5p) and -3p are enriched in the myocardium, but it is unknown whether miR-199a-5p and -3p are co-expressed in cardiac remodeling and what roles they have in cardiac hypertrophy and fibrosis. We show that miR-199a-5p and -3p are co-upregulated in the mouse and human myocardium with cardiac remodeling and in Ang-II-treated neonatal mouse ventricular cardiomyocytes (NMVCs) and cardiac fibroblasts (CFs). miR-199a-5p and -3p could aggravate cardiac hypertrophy and fibrosis in vivo and in vitro . PPAR gamma coactivator 1 alpha (Ppargc1a) and sirtuin 1 (Sirt1) were identified as target genes to mediate miR-199a-5p in promoting both cardiac hypertrophy and fibrosis. However, miR-199a-3p aggravated cardiac hypertrophy and fibrosis through targeting RB transcriptional corepressor 1 (Rb1) and Smad1, respectively. Serum response factor and nuclear factor κB p65 participated in the upregulation of miR-199a-5p and -3p in Ang-II-treated NMVCs and mouse CFs, and could be conversely elevated by miR-199a-5p and -3p. Together, Ppargc1a and Sirt1, Rb1 and Smad1 mediated the pathological effect of miR-199a-5p and -3p by promoting cardiac hypertrophy and fibrosis, respectively. This study suggests a possible new strategy for cardiac remodeling therapy by inhibiting miR-199a-5p and -3p., Competing Interests: The authors declared no competing interests., (© 2021 The Author(s).)
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- 2021
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11. [Application of sevoflurane and laryngeal mask in cesarean section in women with heart disease].
- Author
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Wang ZP, Ma J, Wang S, Yu LN, Wei JF, and Xu JD
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- Blood Pressure, Female, Heart Rate, Humans, Infant, Newborn, Intubation, Intratracheal, Methyl Ethers, Pregnancy, Anesthesia methods, Cesarean Section, Heart Diseases complications, Laryngeal Masks, Sevoflurane administration & dosage
- Abstract
Objective: To compare the safety of sevoflurane anesthesia with laryngeal mask and tracheal intubation in cesarean section in women with heart disease., Methods: Fifty-two pregnant women with heart diseases undergoing cesarean section were randomized into laryngeal mask (LAM) group and tracheal intubation group. In LAM group, 6% sevoflurane was given at the rate of 6 L/min for induction with a maintenance sevoflurane concentration of 3%. In the intubation group, 1.5 mg/kg propofol and 1 µg/kg remifentanil were injected intravenously, and after achieving D0 with Narcotrend monitoring, 0.9 mg/kg rocuronium was injected and intubation was performed 1 min later. The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded in the two groups before anesthesia induction (T
0 ), at intubation or laryngeal mask placement (T1 ), skin incision (T2 ), and extubation or laryngeal mask removal (T3 ). The surgery to fetal birth time, uterine incision to fetal childbirth time, drug discontinuation to awake time, and newborn Apgar scores were also recorded. Sevoflurane consumption and maternal comfort during hospitalization were compared between the two groups., Results: In LAM group, HR and MBP at T1 and T3 were significantly lower than those in the intubation group (P<0.05). The drug discontinuation to extubation time and to awaken time were significantly shorter in LAM group than in the intubation group (P<0.05), but the operation time and fetal child birth time were comparable between the two groups (P>0.05). The women in LAM group reported better physical and psychological comforts than those in the intubation group (P<0.05). The neonatal Apgar scores and the scores of health education, satisfaction with hospital environment and service were all similar between the two groups (P>0.05)., Conclusion: Sevoflurane anesthesia with laryngeal mask can achieve satisfactory anesthetic effects in cesarean section in women with heart disease.- Published
- 2018
12. [Protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer].
- Author
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Guo YB, Xu JD, Ji XX, Zhang JX, Liang JX, and Zhou GB
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- Anesthesia, Enzyme-Linked Immunosorbent Assay, Humans, Inflammation prevention & control, Interleukin-10 blood, Interleukin-1beta blood, Malondialdehyde blood, Partial Pressure, Peroxidase blood, Tumor Necrosis Factor-alpha blood, Xanthine Oxidase blood, Dexmedetomidine therapeutic use, Inflammation drug therapy, Lung drug effects, Lung Neoplasms surgery
- Abstract
Objective: To study the protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer., Methods: From May, 2014 to May, 2016, 124 patients with lung cancer receiving radical surgeries were randomized into experimental group (n=62) and control group (n=62). The patients in the control group received a single anesthetic agent for anesthesia, and additional dexmedetomidine was given in the experimental group. The levels of serum interleukin-1β (IL-1β), IL-10, and tumor necrosis factor-alpha (TNF-α) were measured before the operation (T
0 ), at 30 min (T1 ) and 60 min (T2 ) during one lung ventilation (OLV) and at the end of operation (T3 ). Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of malondialdehyde (MDA), myeloperoxidase (MPO) and xanthine oxidase (XOD), and the arterial oxygen partial pressure (PaO2 ), oxygenation index (OI), airway plateau pressure (APP) and airway resistance (AR) were also recorded., Results: At the time points of T1 and T2 , IL-1β, IL-10, MDA, MPO, TNF-α, and XOD levels were significantly increased in both of the groups, but the levels of IL-1, IL-10, TNF-α and MDA were significantly lower and MPO and XOD levels significantly higher in the experimental group than in the control group (P<0.05). In both groups, PaO2 and OI decreased and APP and AR increased significantly at T1 and T2 , but APP and AR were significantly lower and PaO2 and OI significantly higher in the experimental group than in the control group (P<0.05)., Conclusion: Anesthesia with dexmedetomidine in lung cancer patients undergoing radical surgery can effectively reduce the inflammatory response of the lungs and protect the lung function of the patients.- Published
- 2017
13. [Anesthetic effect and safety of ultrasound-guided thoracic paravertebral blockade in sympathectomy for palmar hyperhidrosis: a randomized controlled trial].
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Xu JD, Yu LN, Zhao DQ, Xie L, Zhou HY, and Wang S
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- Anesthetics, Humans, Postoperative Period, Treatment Outcome, Ultrasonography, Hyperhidrosis surgery, Nerve Block methods, Sympathectomy, Thoracic Surgery, Video-Assisted
- Abstract
Objective: To explore the anesthetic effect and safety of ultrasound-guided thoracic paravertebral blockade in video-assisted thoracoscopic sympathectomy for treatment of palmar hyperhidrosis., Methods: A total of 120 patients undergoing video-assisted thoracoscopic sympathectomy for moderate or severe hyperhidrosis were randomized to receive ultrasound-guided thoracic paravertebral blockade (group A, n=60) or general anesthesia with tracheal intubation (group B, n=60). In both groups routine monitoring and radial artery catheterization were used. The patients in group A were given oxygen inhalation via a nasal tube after thoracic paravertebral blockade, and those in group B had intratracheal intubation. Blood gas analyses were conducted 5 min before and 5 min after the operation and the clinical outcomes and complications were recorded in each group., Results: All the patients completed the operations safely and none of the patients with thoracic paravertebral blockade required conversion to general anesthesia. Significant differences were recorded between groups A and B in anesthetic preparation time (6.26∓2.09 vs 46.32∓15.76 min), awakening time (6.26∓2.09 vs 46.32∓15.76 min), and mean hospitalization expense (6355.54∓426.00 vs 8932.25∓725.98 RMB Yuan). Compared with those in group B, the patients in group A showed a significantly lower rate of postoperative throat discomfort (0% vs 100%), a shorter monitoring time (2 h vs 12 h), and faster recovery time for food intake (2 h vs 6 h). The parameters of artery blood gas analysis both before and after the operation were similar between the two groups, but the postoperative variations differed significantly between the two groups in pH value and PaCO
2 but not in PaO2 ., Conclusion: Ultrasound-guided thoracic paravertebral blockade is safe and effective in video-assisted thoracoscopic sympathectomy for palmar hyperhidrosis and is associated with less complications and better postoperative recovery.- Published
- 2016
14. [Effect of noxious stimulation on regional distribution of propofol in canine spinal cord].
- Author
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Lin CS, Xu JD, Gu MN, Chen Y, and Zhou FZ
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- Animals, Dogs, Female, Male, Nociceptors drug effects, Physical Stimulation, Propofol administration & dosage, Propofol pharmacology, Random Allocation, Nociceptors physiology, Pain physiopathology, Propofol pharmacokinetics, Spinal Cord metabolism
- Abstract
Objective: To observe the regional distribution of propofol in canine spinal cord under noxious stimulation., Methods: Twelve healthy hybrid dogs (12-18 months old, weighing 10-12 kg) were randomly divided into control group (n=6) and stimulation group (n=6). All the dogs were anesthetized with a single bolus dose of propofol (7 mg/kg) in 15 seconds followed by propofol infusion at a constant rate of 70 mg/kg/h via the great saphenous vein of the right posterior limb. In the stimulation group, the tails of the dogs were clamped for 5 min after 45 min of propofol infusion. Blood samples were taken from the internal carotid artery and internal jugular vein at 50 min after propofol infusion to detect plasma propofol concentrations by high-pressure liquid chromatography (HPLC). The dogs were then immediately sacrificed by decapitation and the frontal horn, posterior horn, intermediate zone, frontal funiculus, posterior funiculus and lateral funiculus of the spinal cord were dissected for determination of propol content by HPLC., Results: The plasma concentrations of propofol in the internal carotid artery and internal jugular vein were 5.07-/+0.23 and 5.03-/+0.10 microg/ml in the stimulation group, respectively showing no significant differences from those in the control group (5.09-/+0.03 and 5.08-/+0.03 microg/ml, P>0.05). In the control group, the propofol concentration was 5.09-/+0.08 microg/g in the frontal horm, 5.10-/+0.08 microg/g in the posterior horn, 5.05-/+0.19 microg/g in the intermediate zone, 5.06-/+0.14 microg/g in the frontal funiculus, 5.06-/+0.15 microg/g in the posterior funiculus and 5.06-/+0.41 microg/g in the lateral funiculus, showing no significant differences (P>0.05). The propofol concentrations in the frontal horn (7.65-/+0.47 microg/g) and posterior funiculus (7.06-/+0.82 microg/g) in the stimulation group were significantly higher than those in the other spinal cord tissues (P<0.05) and those in the control group (P<0.05)., Conclusion: At 50 min after intravenous injection of propofol at a constant rate of 70 mg/kg/h, plasma propofol concentrations in the internal carotid artery and internal jugular vein reaches equilibrium with a balanced distribution in all the spinal cord regions. Propofol concentration can be higher in the frontal horn and posterior funiculus under noxious stimulation.
- Published
- 2010
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