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Flexible pressure sensors with the capability of monitoring human vital signs show broad application prospects in personalized healthcare. In this work, a hair-based flexible pressure sensor (HBPS) consisting of lost hair and polymer films was proposed for the continuous monitoring of the human epidermal arterial pulse waveform. A macroscale mesh structure formed by lost hair provides a simplified spacer that endows the triboelectric-based flexible pressure sensor with sufficient contact–separation space. Based on this mesh structure design, the hair-based flexible pressure sensor can respond to the slight pressure change caused by an object with 5 mg weight and hold a stable output voltage under 1–30 Hz external pressure excitation. Additionally, the hair-based flexible pressure sensor showed great sensitivity (0.9 V/kPa) and decent stability after 4500 cycles of operation. Given these compelling features, the HBPS can successfully measure the human epidermal arterial pulses with obvious details at different arteries. The proposed HBPS can also be used to monitor the pulse signals of different subjects. Furthermore, the three different pulse wave transmission time (PTT) values (PTT-foot, PTT-middle, and PTT-peak) can be obtained by simultaneously monitoring human pulse and electrocardiogram signals, which has enormous application potential for assessing cardiovascular system health. [ABSTRACT FROM AUTHOR]

Introduction: Watermelon is an annual vine of the family Cucurbitaceae . Watermelon plants produce a fruit that people love and have important nutritional and economic value. With global warming and deterioration of the ecological environment, abiotic stresses, including drought, have become important factors that impact the yield and quality of watermelon plants. Previous research on watermelon drought resistance has included analyzing homologous genes based on known drought-responsive genes and pathways in other species., Methods: However, identifying key pathways and genes involved in watermelon drought resistance through high-throughput omics methods is particularly important. In this study, RNA-seq and metabolomic analysis were performed on watermelon plants at five time points (0 h, 1 h, 6 h, 12 h and 24 h) before and after drought stress., Results: Transcriptomic analysis revealed 7829 differentially expressed genes (DEGs) at the five time points. The DEGs were grouped into five clusters using the k-means clustering algorithm. The functional category for each cluster was annotated based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database; different clusters were associated with different time points after stress. A total of 949 metabolites were divided into 10 categories, with lipids and lipid-like molecules accounting for the most metabolites. Differential expression analysis revealed 22 differentially regulated metabolites (DRMs) among the five time points. Through joint analysis of RNA-seq and metabolome data, the 6-h period was identified as the critical period for watermelon drought resistance, and the starch and sucrose metabolism, plant hormone signal transduction and photosynthesis pathways were identified as important regulatory pathways involved in watermelon drought resistance. In addition, 15 candidate genes associated with watermelon drought resistance were identified through joint RNA-seq and metabolome analysis combined with weighted correlation network analysis (WGCNA). Four of these genes encode transcription factors, including bHLH ( Cla97C03G068160 ), MYB ( Cla97C01G002440 ), HSP ( Cla97C02G033390 ) and GRF ( Cla97C02G042620 ), one key gene in the ABA pathway, SnRK2-4 ( Cla97C10G186750 ), and the GP-2 gene ( Cla97C05G105810 ), which is involved in the starch and sucrose metabolism pathway., Discussion: In summary, our study provides a theoretical basis for elucidating the molecular mechanisms underlying drought resistance in watermelon plants and provides new genetic resources for the study of drought resistance in this crop., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Chen, Zhong, Li, Bai, Xue and Wu.)

Background and Objective: Some cases of lung cancer in addition to a primary tumor are associated with multiple pure ground-glass opacities (pGGOs). The objective of this study is to evaluate the clinical significance of multiple pGGOs on CT images of patients with lung cancer. The number, size, distribution, and morphological characteristics of the pGGOs were evaluated. Serial changes in pGGOs that were not surgically resected were analyzed at follow-up CT., Methods: The cases of 25 patients with proven lung cancer and associated multiple pGGOs on CT images were retrospectively reviewed., Results: In total, 207 pGGOs were detected. The size of the opacities ranged from 2 mm to 31 mm in largest diameter. Lung cancer and pGGOs were seen in the same lobe and/or in other lobes. Of the lesions, 183 (88.4%) had a round shape or well-defined border. Histological findings were obtained for 17 lesions representing 87 pGGOs that were surgically resected, namely, 13 atypical adenomatous hyperplasias, 3 bronchioloalveolar carcinomas, and 1 focal fibrosis. Of the 120 pGGOs followed up with CT for a median duration of 61.5 months, 113 (94.2%) retained their size, 1 decreased in size, and 6 disappeared., Conclusions: The size of most pGGOs associated with lung cancer did not change during the follow-up period. Most of the lesions histologically diagnosed were atypical adenomatous hyperplasias or bronchioloalveolar carcinomas. The results justify the therapeutic strategy of resecting the primary tumor without therapeutic intervention in the remaining pGGOs.