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1. X-ray polarization measurement of the gold standard of radio-quiet active galactic nuclei : NGC 1068

Author: Marin, F., Marinucci, A., Laurenti, M., Kim, D. E., Barnouin, T., Di Marco, A., Ursini, F., Bianchi, S., Ravi, S., Marshall, H. L., Matt, G., Chen, C. -T., Gianolli, V. E., Ingram, A., Maksym, W. P., Panagiotou, C., Podgorny, J., Puccetti, S., Ratheesh, A., Tombesi, F., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W., Bellazzini, R., Bongiorno, S., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Ciprini, S., Costa, E., De Rosa, A., Del Monte, E., Di Gesu, L., Di Lalla, N., Donnarumma, I., Doroshenko, V., Dovciak, M., Ehlert, S., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S., Kaaret, P., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J., Krawczynski, H., La Monaca, F., Latronico, L., Liodakis, I., Madejski, G., Maldera, S., Manfreda, A., Marscher, A., Massaro, F., Mitsuishi, I., Mizuno, T., Muleri, F., Negro, M., Ng, S., O'Dell, S., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G., Perri, M., Pesce-Rollins, M., Petrucci, P. -O., Pilia, M., Possenti, A., Poutanen, J., Ramsey, B., Rankin, J., Roberts, O., Romani, R., Sgro, C., Slane, P., Soffitta, P., Spandre, G., Swartz, D., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A., Thomas, N., Trois, A., Tsygankov, S., Turolla, R., Vink, J., Weisskopf, M., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, J.2.3, J.2.9
Abstract: We used the Imaging X-ray Polarimetry Explorer (IXPE) satellite to measure, for the first time, the 2-8 keV polarization of NGC 1068. We pointed IXPE for a net exposure time of 1.15 Ms on the target, in addition to two ~ 10 ks each Chandra snapshots in order to account for the potential impact of several ultraluminous X-ray source (ULXs) within IXPE's field-of-view. We measured a 2 - 8 keV polarization degree of 12.4% +/- 3.6% and an electric vector polarization angle of 101{\deg} +/- 8{\deg} at 68% confidence level. If we exclude the spectral region containing the bright Fe K lines and other soft X-ray lines where depolarization occurs, the polarization fraction rises up to 21.3% +/- 6.7% in the 3.5 - 6.0 keV band, with a similar polarization angle. The observed polarization angle is found to be perpendicular to the parsec scale radio jet. Using a combined Chandra and IXPE analysis plus multi-wavelength constraints, we estimated that the circumnuclear "torus" may sustain a half-opening angle of 50{\deg} - 55{\deg} (from the vertical axis of the system). Thanks to IXPE, we have measured the X-ray polarization of NGC 1068 and found comparable results, both in terms of polarization angle orientation with respect to the radio-jet and torus half-opening angle, to the X-ray polarimetric measurement achieved for the other archetypal Compton-thick AGN : the Circinus galaxy. Probing the geometric arrangement of parsec-scale matter in extragalactic object is now feasible thanks to X-ray polarimetry., Comment: 9 pages, 5 figures, 2 tables, submited to A&A
Published: 2024
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2. Serving Deep Learning Models from Relational Databases

Author: Zhou, L, Lin, Q, Chowdhury, K, Masood, S, Eichenberger, A, Min, H, Sim, A, Wang, J, Wang, Y, Wu, K, Yuan, B, and Zou, J
Abstract: Serving deep learning (DL) models on relational data has become a critical requirement across diverse commercial and scientific domains, sparking growing interest recently. In this visionary paper, we embark on a comprehensive exploration of representative architectures to address the requirement. We highlight three pivotal paradigms: The state-of-the-art DL-centric architecture offloads DL computations to dedicated DL frameworks. The potential UDF-centric architecture encapsulates one or more tensor computations into User Defined Functions (UDFs) within the relational database management system (RDBMS). The potential relation-centric architecture aims to represent a large-scale tensor computation through relational operators. While each of these architectures demonstrates promise in specific use scenarios, we identify urgent requirements for seamless integration of these architectures and the middle ground in-between these architectures. We delve into the gaps that impede the integration and explore innovative strategies to close them. We present a pathway to establish a novel RDBMS for enabling a broad class of data-intensive DL inference applications.
Published: 2024

3. IXPE observation confirms a high spin in the accreting black hole 4U 1957+115

Author: Marra, L., Brigitte, M., Cavero, N. Rodriguez, Chun, S., Steiner, J. F., Dovčiak, M., Nowak, M., Bianchi, S., Capitanio, F., Ingram, A., Matt, G., Muleri, F., Podgorný, J., Poutanen, J., Svoboda, J., Taverna, R., Ursini, F., Veledina, A., De Rosa, A., Garcia, J. A., Lutovinov, A. A., Mereminskiy, I. A., Farinelli, R., Gunji, S., Kaaret, P., Kallman, T., Krawczynski, H., Kan, Y., Hu, K., Marinucci, A., Mastroserio, G., Mikušincová, R., Parra, M., Petrucci, P. O., Ratheesh, A., Soffitta, P., Tombesi, F., Zane, S., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Castellano, S., Cavazzuti, E., Chen, C., Ciprini, S., Costa, E., Del Monte, E., Di Gesu, L., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Hayashida, K., Heyl, J., Iwakiri, W., Jorstad, S. G., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marin, F., Marscher, A. P., Marshall, H. L., Massaro, F., Mitsuishi, I., Mizuno, T., Negro, M., Ng, C. Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Pilia, M., Possenti, A., Puccetti, S., Ramsey, B. D., Rankin, J., Roberts, O. J., Romani, R. W., Sgro, C., Slane, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., and Xie, F.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the results of the first X-ray polarimetric observation of the low-mass X-ray binary 4U 1957+115, performed with the Imaging X-ray Polarimetry Explorer in May 2023. The binary system has been in a high-soft spectral state since its discovery and is thought to host a black hole. The $\sim$571 ks observation reveals a linear polarisation degree of $1.9\% \pm 0.6\%$ and a polarisation angle of $-41^\circ.8 \pm 7^\circ.9$ in the 2-8 keV energy range. Spectral modelling is consistent with the dominant contribution coming from the standard accretion disc, while polarimetric data suggest a significant role of returning radiation: photons that are bent by strong gravity effects and forced to return to the disc surface, where they can be reflected before eventually reaching the observer. In this setting, we find that models with a black hole spin lower than 0.96 and an inclination lower than $50^\circ$ are disfavoured., Comment: 12 pages, 10 figures, 2 tables, accepted for publication in A&A
Published: 2023

4. Investigating the Utility of Red Blood Cell Distribution Width as a Prognostic Indicator for Deterioration of Patients with Chronic Obstructive Pulmonary Disease Within One Year

Author: Liu Q, Wu K, Lin X, Xiang K, and Wang J
Subjects: red blood cell distribution width, copd, prognosis, deterioration, risk stratification, Medicine (General), R5-920
Abstract: Qianfeng Liu,&ast; Kangbi Wu, Xiaofang Lin, Kali Xiang,&ast; Jing Wang&ast; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi City, Hubei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Kali Xiang; Jing Wang, Department of Pulmonary and Critical Care Medicine, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, No. 158 Wuyang Avenue, Enshi City, Hubei, 445000, People’s Republic of China, Email xkl18963926688@163.com; 366413620@qq.comBackGround: Considerable studies have demonstrated a significant association between red blood cell distribution width (RDW) and clinical adverse events in cardiovascular or respiratory diseases, infections, and pulmonary embolism. However, there are limited data on prognostic predictions for patients suffering from chronic obstructive pulmonary disease (COPD).Methods: This study conducted a retrospective cohort analysis using data gathered from patients who diagnosed with COPD in the respiratory department of The Central hospital of Enshi Tujia and Miao Autonomous Prefecture between 2018 and 2021. Specifically, the RDW was recorded on their first admission. Multivariate logistic regression analysis were employed to examine the correlation between RDW and deterioration of COPD within one-year period.Results: The cohort of 1799 patients in the study comprised 74.7% male and had an average age of 68.9 ± 9.9 years. The fully adjusted model revealed that, the RDW-middle group (≤ 13.7,> 12.8; OR 1.5, 95% CI 1.0– 2.3, p=0.055) and the RDW-high group (> 13.7; OR 1.7, 95% CI 1.1– 2.6, p=0.013) had a 50% and 70% increased risk of deterioration within 1 year, respectively, in comparison with the RDW-low group (≤ 12.8). Subgroup analysis indicated that this trend was more significant in patients with hypertension (p for interaction = 0.016), and the probability of deterioration within 1 year in the RDW-high group was 3.3 times higher compared to the RDW-low group (OR 3.3, 95% CI 1.4– 7.9, p=0.008).Conclusion: A significant association was observed between the increase in RDW and the heightened risk of deterioration within a year in patients diagnosed with COPD. Most importantly, our findings suggested the importance of RDW in enhancing the risk stratification and prevention of deterioration of COPD.Keywords: red blood cell distribution width, COPD, prognosis, deterioration, risk stratification
Published: 2024

5. Evaluating Inflammatory Bowel Disease-Related Quality of Life Using an Interpretable Machine Learning Approach: A Multicenter Study in China

Author: Zhen J, Liu C, Zhang J, Liao F, Xie H, Tan C, An P, Liu Z, Jiang C, Shi J, Wu K, and Dong W
Subjects: clinical research, artificial intelligence, model development, clinical decision support system, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Junhai Zhen,1 Chuan Liu,2 Jixiang Zhang,2 Fei Liao,2 Huabing Xie,1 Cheng Tan,2 Ping An,2 Zhongchun Liu,3 Changqing Jiang,4 Jie Shi,5 Kaichun Wu,6 Weiguo Dong2 1Department of General Practice, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of China; 2Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of China; 3Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 4Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, People’s Republic of China; 5Department of Medical Psychology, Chinese People’s Liberation Army Rocket Army Characteristic Medical Center, Beijing, 100032, People’s Republic of China; 6Department of Gastroenterology, Xijing Hospital, Air Force Medical University, Xi’an, 710032, People’s Republic of ChinaCorrespondence: Kaichun Wu, Department of Gastroenterology, Xijing Hospital, Air Force Medical University, Xi’an, 710032, People’s Republic of China, Tel/Fax +8629-84771600, Email kaicwu@fmmu.edu.cn Weiguo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, Hubei Province, 430060, People’s Republic of China, Tel/Fax +8627-88041911, Email dongweiguo@whu.edu.cnPurpose: Impaired quality of life (QOL) is common in patients with inflammatory bowel disease (IBD). A tool to more quickly identify IBD patients at high risk of impaired QOL improves opportunities for earlier intervention and improves long-term prognosis. The purpose of this study was to use a machine learning (ML) approach to develop risk stratification models for evaluating IBD-related QOL impairments.Patients and Methods: An online questionnaire was used to collect clinical data on 2478 IBD patients from 42 hospitals distributed across 22 provinces in China from September 2021 to May 2022. Eight ML models used to predict the risk of IBD-related QOL impairments were developed and validated. Model performance was evaluated using a set of indexes and the best ML model was explained using a Local Interpretable Model-Agnostic Explanations (LIME) algorithm.Results: The support vector machine (SVM) classifier algorithm-based model outperformed other ML models with an area under the receiver operating characteristic curve (AUC) and an accuracy of 0.80 and 0.71, respectively. The feature importance calculated by the SVM classifier algorithm revealed that glucocorticoid use, anxiety, abdominal pain, sleep disorders, and more severe disease contributed to a higher risk of impaired QOL, while longer disease course and the use of biological agents and immunosuppressants were associated with a lower risk.Conclusion: An ML approach for assessing IBD-related QOL impairments is feasible and effective. This mechanism is a promising tool for gastroenterologists to identify IBD patients at high risk of impaired QOL.Keywords: clinical research, artificial intelligence, model development, clinical decision support system
Published: 2024

6. The Causal Association Between Obstructive Sleep Apnea and Child-Onset Asthma Come to Light: A Mendelian Randomization Study

Author: Gan Q, Liu Q, Wu Y, Zhu X, Wang J, Su X, Zhao D, Zhang N, and Wu K
Subjects: asthma, obstructive sleep apnea, mendelian randomization, genetic, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Qiming Gan,1,&ast; Quanzhen Liu,1,2,&ast; Yanjuan Wu,1,&ast; Xiaofeng Zhu,1,2 Jingcun Wang,1 Xiaofen Su,1 Dongxing Zhao,1 Nuofu Zhang,1 Kang Wu1 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Disease, Department of Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People’s Republic of China; 2Nanshan School, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Kang Wu; Nuofu Zhang, Department of Pulmonary and Critical Care Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, No. 28 Qiaozhong Mid Road, Guangzhou, Guangdong, 510160, People’s Republic of China, Email d102_wk@126.com; nfzhanggird@163.comPurpose: Obstructive sleep apnea (OSA) had been associated with asthma in observational studies, but the effect of OSA on the onset of asthma in childhood or adulthood remains unclear, and the causal inferences have not been confirmed. This study aims to investigate the potential causal association between OSA with asthma, including different age-of-onset subtypes, providing reliable basis for the clinical treatment of OSA and asthma.Patients and Methods: Causality between OSA and asthma was assessed using a two-sample bi-directional Mendelian randomization (MR) analysis. OSA data were obtained from the FinnGen consortium R9, while asthma and its subtypes (adult-onset asthma, child-onset asthma, and moderate-to-severe asthma) were sourced from the IEU OpenGWAS project. The inverse-variance weighted (IVW) method was chosen as the primary analysis and was complemented by various sensitivity analyses. The MR-PRESSO outlier test was employed to systematically identify and remove outlier variants, mitigating heterogeneity and potential effects of horizontal pleiotropy.Results: The MR analyses provided evidence of genetically predicted OSA having a promoting effect on child-onset asthma (OR,1.49; 95% CI, 1.05– 2.11; P=0.025) and moderate-to-severe asthma (OR,1.03; 95% CI, 1.00– 1.06; P=0.046). However, no causal association between OSA with asthma and adult-onset asthma was observed.Conclusion: Our study revealed a causal association between OSA and child asthma, but not in adults. Moderate-to-severe asthma may have a potential promoting effect on OSA. These findings underscore the importance of age-specific considerations in managing asthma and suggests the need for personalized approaches in clinical practice.Keywords: asthma, obstructive sleep apnea, Mendelian randomization, genetic
Published: 2024

7. Higher Chern-Simons-Antoniadis-Savvidy forms based on crossed modules

Author: Song, D. H., Wu, K., and Yang, J.
Subjects: Mathematical Physics
Abstract: We present higher Chern-Simons-Antoniadis-Savvidy (ChSAS) forms based on crossed modules. We start from introducing a generalized multilineal symmetric invariant polynomial for the differential crossed modules and constructing a metric independent, higher gauge invariant, and closed form using the higher curvature forms. Then, we establish the higher Chern-Weil theorem and prove that the higher ChSAS forms is a special case of this theorem. Finally, we get the link of two independent higher ChSAS theories.
Published: 2023
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8. X-ray polarimetry and spectroscopy of the neutron star low-mass X-ray binary GX 9+9: an in-depth study with IXPE and NuSTAR

Author: Ursini, F., Farinelli, R., Gnarini, A., Poutanen, J., Bianchi, S., Capitanio, F., Di Marco, A., Fabiani, S., La Monaca, F., Malacaria, C., Matt, G., Mikušincová, R., Cocchi, M., Kaaret, P., Kajava, J. J. E., Pilia, M., Zhang, W., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Castellano, S., Cavazzuti, E., Chen, C. -T., Ciprini, S., Costa, E., De Rosa, A., Del Monte, E., Di Gesu, L., Di Lalla, N., Donnarumma, I., Doroshenko, V., Dovčiak, M., Ehlert, S. R., Enoto, T., Evangelista, Y., Ferrazzoli, R., Garcia, J. A., Gunji, S., Hayashida, K., Heyl, J., Iwakiri, W., Jorstad, S. G., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., Krawczynski, H., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marin, F., Marinucci, A., Marscher, A. P., Marshall, H. L., Massaro, F., Mitsuishi, I., Mizuno, T., Muleri, F., Negro, M., Ng, C. -Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Petrucci, P. -O., Possenti, A., Puccetti, S., Ramsey, B. D., Rankin, J., Ratheesh, A., Roberts, O. J., Romani, R. W., Sgrò, C., Slane, P., Soffitta, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Tombesi, F., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: We report on a comprehensive analysis of simultaneous X-ray polarimetric and spectral data of the bright atoll source GX 9+9 with the Imaging X-ray Polarimetry Explorer (IXPE) and NuSTAR. The source is significantly polarized in the 4--8 keV band, with a degree of $2.2\% \pm 0.5\%$ (uncertainty at the 68% confidence level). The NuSTAR broad-band spectrum clearly shows an iron line, and is well described by a model including thermal disk emission, a Comptonized component, and reflection. From a spectro-polarimetric fit, we obtain an upper limit to the polarization degree of the disk of 4% (at 99% confidence level), while the contribution of Comptonized and reflected radiation cannot be conclusively separated. However, the polarization is consistent with resulting from a combination of Comptonization in a boundary or spreading layer, plus reflection off the disc, which gives a significant contribution in any realistic scenario., Comment: 10 pages, accepted for publication in A&A
Published: 2023
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9. The X-ray polarisation of the Seyfert 1 galaxy IC 4329A

Author: Ingram, A., Ewing, M., Marinucci, A., Tagliacozzo, D., Rosario, D. J., Veledina, A., Kim, D. E., Marin, F., Bianchi, S., Poutanen, J., Matt, G., Marshall, H. L., Ursini, F., De Rosa, A., Petrucci, P-O., Madejski, G., Barnouin, T., Di Gesu, L., Dovvciak, M., Gianolli, V. E., Krawczynski, H., Loktev, V., Middei, R., Podgorny, J., Puccetti, S., Ratheesh, A., Soffitta, P., Tombesi, F., Ehlert, S. R., Massaro, F., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Chen, C. -T., Ciprini, S., Costa, E., Del Monte, E., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J. A., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S. G., Kaaret, P., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marscher, A. P., Mitsuishi, I., Mizuno, T., Muleri, F., Negro, M., Ng, C. -Y., ODell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Pilia, M., Possenti, A., Ramsey, B. D., Rankin, J., Roberts, O. J., Romani, R. W., Sgro, C., Slane, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present an X-ray spectro-polarimetric analysis of the bright Seyfert galaxy IC 4329A. The Imaging X-ray Polarimetry Explorer (IXPE) observed the source for ~500 ks, supported by XMM-Newton (~60 ks) and NuSTAR (~80 ks) exposures. We detect polarisation in the 2-8 keV band with 2.97 sigma confidence. We report a polarisation degree of $3.3\pm1.1$ per cent and a polarisation angle of $78\pm10$ degrees (errors are 1 sigma confidence). The X-ray polarisation is consistent with being aligned with the radio jet, albeit partially due to large uncertainties on the radio position angle. We jointly fit the spectra from the three observatories to constrain the presence of a relativistic reflection component. From this, we obtain constraints on the inclination angle to the inner disc (< 39 degrees at 99 per cent confidence) and the disc inner radius (< 11 gravitational radii at 99 per cent confidence), although we note that modelling systematics in practice add to the quoted statistical error. Our spectro-polarimetric modelling indicates that the 2-8 keV polarisation is consistent with being dominated by emission directly observed from the X-ray corona, but the polarisation of the reflection component is completely unconstrained. Our constraints on viewer inclination and polarisation degree tentatively favour more asymmetric, possibly out-flowing, coronal geometries that produce more highly polarised emission, but the coronal geometry is unconstrained at the 3 sigma level., Comment: Accepted for publication in MNRAS, 13 pages, 9 figures
Published: 2023

10. The geometry of the hot corona in MCG-05-23-16 constrained by X-ray polarimetry

Author: Tagliacozzo, D., Marinucci, A., Ursini, F., Matt, G., Bianchi, S., Baldini, L., Barnouin, T., Rodriguez, N. Cavero, De Rosa, A., Di Gesu, L., Dovciak, M., Harper, D., Ingram, A., Karas, V., Kim, D. E., Krawczynski, H., Madejski, G., Marin, F., Middei, R., Marshall, H. L., Muleri, F., Panagiotou, C., Petrucci, P. O., Podgorny, J., Poutanen, J., Puccetti, S., Soffitta, P., Tombesi, F., Veledina, A., Zhang, W., Agudo, I., Antonelli, L. A., Bachetti, M., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Chen, C. T., Ciprini, S., Costa, E., Del Monte, E., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J. A., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S. G., Kaaret, P., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marscher, A. P., Massaro, F., Mitsuishi, I., Mizuno, T., Negro, M., Ng, C. Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Rollins, M. Pesce, Pilia, M., Possenti, A., Ramsey, B. D., Rankin, J., Ratheesh, A., Roberts, O. J., Romani, R. W., Sgrò, C., Slane, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on the second observation of the radio-quiet active galactic nucleus (AGN) MCG-05-23-16 performed with the Imaging X-ray Polarimetry Explorer (IXPE). The observation started on 2022 November 6 for a net observing time of 640 ks, and was partly simultaneous with NuSTAR (86 ks). After combining these data with those obtained in the first IXPE pointing on May 2022 (simultaneous with XMM-Newton and NuSTAR) we find a 2-8 keV polarization degree $\Pi$ = 1.6 $\pm$ 0.7 (at 68 per cent confidence level), which corresponds to an upper limit $\Pi$ = 3.2 per cent (at 99 per cent confidence level). We then compare the polarization results with Monte Carlo simulations obtained with the MONK code, with which different coronal geometries have been explored (spherical lamppost, conical, slab and wedge). Furthermore, the allowed range of inclination angles is found for each geometry. If the best fit inclination value from a spectroscopic analysis is considered, a cone-shaped corona along the disc axis is disfavoured., Comment: 9 pages, 8 figures, 3 table. Submitted to MNRAS
Published: 2023

11. Analyzing Transatlantic Network Traffic over Scientific Data Caches

Author: Deng, Z., Sim, A., Wu, K., Guok, C., Hazen, D., Monga, I., Andrijauskas, F., Wuerthwein, F., and Weitzel, D.
Subjects: Computer Science - Networking and Internet Architecture, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract: Large scientific collaborations often share huge volumes of data around the world. Consequently a significant amount of network bandwidth is needed for data replication and data access. Users in the same region may possibly share resources as well as data, especially when they are working on related topics with similar datasets. In this work, we study the network traffic patterns and resource utilization for scientific data caches connecting European networks to the US. We explore the efficiency of resource utilization, especially for network traffic which consists mostly of transatlantic data transfers, and the potential for having more caching node deployments. Our study shows that these data caches reduced network traffic volume by 97% during the study period. This demonstrates that such caching nodes are effective in reducing wide-area network traffic.
Published: 2023
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12. X-ray polarimetry of X-ray pulsar X Persei: another orthogonal rotator?

Author: Mushtukov, A. A., Tsygankov, S. S., Poutanen, J., Doroshenko, V., Salganik, A., Costa, E., Di Marco, A., Heyl, J., La Monaca, F., Lutovinov, A. A., Mereminsky, I. A., Papitto, A., Semena, A. N., Shtykovsky, A. E., Suleimanov, V. F., Forsblom, S. V., González-Caniulef, D., Malacaria, C., Sunyaev, R. A., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bianchi, S., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Chen, C. -T., Ciprini, S., De Rosa, A., Del Monte, E., Di Gesu, L., Di Lalla, N., Donnarumma, I., Dovčiak, M., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J. A., Gunji, S., Hayashida, K., Iwakiri, W., Jorstad, S. G., Kaaret, P., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., Krawczynski, H., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marin, F., Marscher, A. P., Marshall, H. L., Massaro, F., Matt, G., Mitsuishi, I., Mizuno, T., Muleri, F., Negro, M., Ng, C. -Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Petrucci, P. -O., Pilia, M., Possenti, A., Puccetti, S., Ramsey, B. D., Rankin, J., Ratheesh, A., Roberts, O. J., Romani, R. W., Sgrò, C., Slane, P., Soffitta, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Tombesi, F., Trois, A., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: X Persei is a persistent low-luminosity X-ray pulsar of period of $\sim$835 s in a Be binary system. The field strength at the neutron star surface is not known precisely, but indirect signs indicate a magnetic field above $10^{13}$ G, which makes the object one of the most magnetized known X-ray pulsars. Here we present the results of observations X Persei performed with the Imaging X-ray Polarimetry Explorer (IXPE). The X-ray polarization signal was found to be strongly dependent on the spin phase of the pulsar. The energy-averaged polarization degree in 3-8 keV band varied from several to $\sim$20 per cent over the pulse with a positive correlation with the pulsed X-ray flux. The polarization angle shows significant variation and makes two complete revolutions during the pulse period resulting in nearly nil pulse-phase averaged polarization. Applying the rotating vector model to the IXPE data we obtain the estimates for the rotation axis inclination and its position angle on the sky as well as for the magnetic obliquity. The derived inclination is close to the orbital inclination reported earlier for X Persei. The polarimetric data imply a large angle between the rotation and magnetic dipole axes, which is similar to the result reported recently for the X-ray pulsar GRO J1008$-$57. After eliminating the effect of polarization angle rotation over the pulsar phase using the best-fitting rotating vector model, the strong dependence of the polarization degree with energy was discovered with its value increasing from 0% at $\sim$2 keV to 30% at 8 keV., Comment: 11 pages, 7 figures, submitted to MNRAS
Published: 2023
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13. Uncovering the geometry of the hot X-ray corona in the Seyfert galaxy NGC4151 with IXPE

Author: Gianolli, V. E., Kim, D. E., Bianchi, S., Agís-González, B., Madejski, G., Marin, F., Marinucci, A., Matt, G., Middei, R., Petrucci, P-O., Soffitta, P., Tagliacozzo, D., Tombesi, F., Ursini, F., Barnouin, T., De Rosa, A., Di Gesu, L., Ingram, A., Loktev, V., Panagiotou, C., Podgorny, J., Poutanen, J., Puccetti, S., Ratheesh, A., Veledina, A., Zhang, W., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Chen, C. -T., Ciprini, S., Costa, E., Del Monte, E., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Dovčiak, M., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., García, J. A., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S. G., Kaaret, P., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J. J., Krawczynski, H., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marscher, A. P., Marshall, H. L., Massaro, F., Mitsuishi, I., Mizuno, T., Muleri, F., Negro, M., Ng, C. -Y., ODell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Pilia, M., Possenti, A., Ramsey, B. D., Rankin, J., Roberts, O. J., Romani, R. W., Sgrò, C., Slane, P., Spandre, G., Swartz, D. A., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present an X-ray spectro-polarimetric analysis of the bright Seyfert galaxy NGC4151. The source has been observed with the Imaging X-ray Polarimetry Explorer (IXPE) for 700 ks, complemented with simultaneous XMM-Newton (50 ks) and NuSTAR (100 ks) pointings. A polarization degree ${\Pi} = 4.9 {\pm} 1.1 \%$ and angle ${\Psi}= 86{\deg} {\pm} 7{\deg}$ east of north ($68\%$ confidence level) are measured in the 2-8 keV energy range. The spectro-polarimetric analysis shows that the polarization could be entirely due to reflection. Given the low reflection flux in the IXPE band, this requires however a reflection with a very large ($> 38 \%$) polarization degree. Assuming more reasonable values, a polarization degree of the hot corona ranging from ${\sim}4$ to ${\sim}8\%$ is found. The observed polarization degree excludes a spherical lamppost geometry for the corona, suggesting instead a slab-like geometry, possibly a wedge, as determined via Monte Carlo simulations. This is further confirmed by the X-ray polarization angle, which coincides with the direction of the extended radio emission in this source, supposed to match the disc axis. NGC4151 is the first AGN with an X-ray polarization measure for the corona, illustrating the capabilities of X-ray polarimetry and IXPE in unveiling its geometry., Comment: 9 pages, 4 figures
Published: 2023
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14. Mesenchymal Stromal Cells: New Generation Treatment of Inflammatory Bowel Disease

Author: Wei S, Li M, Wang Q, Zhao Y, Du F, Chen Y, Deng S, Shen J, Wu K, Yang J, Sun Y, Gu L, Li X, Li W, Chen M, Ling X, Yu L, Xiao Z, Dong L, and Wu X
Subjects: mesenchymal stem cells, immunomodulation, inflammatory bowel disease, ulcerative colitis, crohn’s disease, cell therapy, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Shulin Wei,1,2,&ast; Mingxing Li,1,2,&ast; Qin Wang,1,2,&ast; Yueshui Zhao,1,2 Fukuan Du,1,2 Yu Chen,1,2 Shuai Deng,1,2 Jing Shen,1,2 Ke Wu,1,2 Jiayue Yang,1,2 Yuhong Sun,1 Li Gu,1 Xiaobing Li,1 Wanping Li,1 Meijuan Chen,1 Xiao Ling,3 Lei Yu,3 Zhangang Xiao,1,2 Lishu Dong,3 Xu Wu1,2 1Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646100, People’s Republic of China; 2South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, 646100, People’s Republic of China; 3Department of Obstetrics, Luzhou Maternal & Child Health Hospital (Luzhou Second People’s Hospital), Luzhou, Sichuan, 646100, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lishu Dong, Department of Obstetrics, Luzhou Maternal & Child Health Hospital (Luzhou Second People’s Hospital), Luzhou, Sichuan, 646100, People’s Republic of China, Email 1275607519@qq.com Xu Wu, Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646100, People’s Republic of China, Email wuxulz@126.comAbstract: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which has a high recurrence rate and is incurable due to a lack of effective treatment. Mesenchymal stromal cells (MSCs) are a class of pluripotent stem cells that have recently received a lot of attention due to their strong self-renewal ability and immunomodulatory effects, and a large number of experimental and clinical models have confirmed the positive therapeutic effect of MSCs on IBD. In preclinical studies, MSC treatment for IBD relies on MSCs paracrine effects, cell-to-cell contact, and its mediated mitochondrial transfer for immune regulation. It also plays a therapeutic role in restoring the intestinal mucosal barrier through the homing effect, regulation of the intestinal microbiome, and repair of intestinal epithelial cells. In the latest clinical trials, the safety and efficacy of MSCs in the treatment of IBD have been confirmed by transfusion of autologous or allogeneic bone marrow, umbilical cord, and adipose MSCs, as well as their derived extracellular vesicles. However, regarding the stable and effective clinical use of MSCs, several concerns emerge, including the cell sources, clinical management (dose, route and frequency of administration, and pretreatment of MSCs) and adverse reactions. This article comprehensively summarizes the effects and mechanisms of MSCs in the treatment of IBD and its advantages over conventional drugs, as well as the latest clinical trial progress of MSCs in the treatment of IBD. The current challenges and future directions are also discussed. This review would add knowledge into the understanding of IBD treatment by applying MSCs.Keywords: mesenchymal stem cells, immunomodulation, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, cell therapy
Published: 2024

15. Efficacy of Electroacupuncture Combined with Chinese Herbal Medicine on Pain Intensity for Chronic Sciatica Secondary to Lumbar Disc Herniation: Study Protocol for a Randomised Controlled Trial

Author: Xia JC, Huang YC, Wu K, Pang J, and Shi Y
Subjects: sciatica of lumbar disc herniation, shenxie zhitong capsule, electroacupuncture treatment, celecoxib, single-center randomized controlled trial, protocol, Medicine (General), R5-920
Abstract: Jing-Chun Xia,1,2,&ast; Yu-Cheng Huang,1,2,&ast; Ke Wu,1,2 Jian Pang,1,2 Ying Shi1,2 1Shi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jian Pang; Ying Shi, Email pangjian@shutcm.edu.cn; shiying1974@126.comPurpose: Chinese herbal medicine and electroacupuncture (EA) have been used to control pain for many decades in China. We aim to explore the efficacy of intervening patients whose discogenic sciatica symptoms lasting longer than 3 months with these conservative treatments.Patients and Methods: This is a single-center, parallel-group, patient-unblinded Randomized Controlled Trial (RCT) with blinded outcome assessment and statistician. One hundred and twenty-four patients will be assigned randomly into 2 groups including conservative treatment group (Shenxie Zhitong capsule combined with EA treatment) and Nonsteroidal Anti-inflammatory Drugs (Nonsteroidal Anti-inflammatory Drugs, NSAIDs) control group (Celecoxib) in a 1:1 ratio. The trial involves a 4-week treatment along with follow-up for 6 months. The primary outcome is the leg pain intensity measured by the visual analogue scale (VAS) at 6 months after randomization. Secondary outcomes include leg pain intensity at other time points, back pain intensity, leg pain and back pain frequency, functional status, quality of life, return to work status and satisfaction of patients. Adverse events will also be recorded.Strengths and Limitations of This Study: Through this study, we want to observe the efficacy of electroacupuncture combined with Chinese herbal medicine on pain intensity for chronic sciatica secondary to Lumbar Disc Herniation. If the final results are favorable, it is expected to be a safe, economical, and effective treatment for patients. The study design has the following limitations: the setup of control group was less than perfect; patients and doctors could not be blinded in this trial; we skipped the feasibility study. We have tried our best to minimize adverse impacts.Trial Registration: ChiCTR2300070884 (Chinese Clinical Trial Registry, http://www.chictr.org.cn, registered on 25th April 2023).Keywords: sciatica of lumbar disc herniation, shenxie zhitong capsule, electroacupuncture treatment, celecoxib, single-center randomized controlled trial, protocol
Published: 2024

16. Accretion geometry of the neutron star low mass X-ray binary Cyg X-2 from X-ray polarization measurements

Author: Farinelli, R., Fabiani, S., Poutanen, J., Ursini, F., Ferrigno, C., Bianchi, S., Cocchi, M., Capitanio, F., De Rosa, A., Gnarini, A., Kislat, F., Matt, G., Mikusincova, R., Muleri, F., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Castellano, S., Cavazzuti, E., Ciprini, S., Costa, E., Del Monte, E., Di Gesu, L., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Dovčiak, M., Ehlert, S. R., Enoto, T., Evangelista, Y., Ferrazzoli, R., Garcia, J. A., Gunji, S., Hayashida, K., Heyl, J., Iwakiri, W., Jorstad, S. G., Karas, V., Kitaguchi, T., Kolodziejczak, J. J., Krawczynski, H., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marin, F., Marscher, A. P., Marshall, H. L., Mitsuishi, I., Mizuno, T., Ng, C. -Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Petrucci, P. O., Pilia, M., Possenti, A., Puccetti, S., Ramsey, B. D., Rankin, J., Ratheesh, A., Romani, R. W., Sgrò, C., Slane, P., Soffitta, P., Spandre, G., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Tombesi, F., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report spectro-polarimetric results of an observational campaign of the bright neutron star low-mass X-ray binary Cyg X-2 simultaneously observed by IXPE, NICER and INTEGRAL. Consistently with previous results, the broad-band spectrum is characterized by a lower-energy component, attributed to the accretion disc with $kT_{\rm in} \approx$ 1 keV, plus unsaturated Comptonization in thermal plasma with temperature $kT_{\rm e} = 3$ keV and optical depth $\tau \approx 4$, assuming a slab geometry. We measure the polarization degree in the 2-8 keV band $P=1.8 \pm 0.3$ per cent and polarization angle $\phi = 140^{\circ} \pm 4^{\circ}$, consistent with the previous X-ray polarimetric measurements by OSO-8 as well as with the direction of the radio jet which was earlier observed from the source. While polarization of the disc spectral component is poorly constrained with the IXPE data, the Comptonized emission has a polarization degree $P =4.0 \pm 0.7$ per cent and a polarization angle aligned with the radio jet. Our results strongly favour a spreading layer at the neutron star surface as the main source of the polarization signal. However, we cannot exclude a significant contribution from reflection off the accretion disc, as indicated by the presence of the iron fluorescence line., Comment: 10 pages, 7 figures, accepted for publication in MNRAS
Published: 2022
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17. An emergent quasi-2D metallic state derived from the Mott insulator framework

Author: Chiang, P. -C., Lin, S. C., Chiang, C. -Y., Ku, C. -S., Huang, S. W., Lee, J. M., Chuang, Y. -D., Lin, H. J., Liao, Y. F., Cheng, C. -M., Haw, S. C., Chen, J. M., Chu, Y. -H., Do, T. H., Luo, C. W., Juang, J. -Y., Wu, K. H., Chang, Y. -W., Yang, J. -C., and Lin, J. -Y.
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity
Abstract: Recent quasi-2D systems with judicious exploitation of the atomic monolayer or few-layer architecture exhibit unprecedented physical properties that challenge the conventional wisdom on the condensed matter physics. Here we show that the infinite layer SrCuO2 (SCO), a topical cuprate Mott insulator in the bulk form, can manifest an unexpected metallic state in the quasi-2D limit when SCO is grown on TiO2-terminated SrTiO3 (STO) substrates. Hard x-ray core-level photoemission spectra demonstrate a definitive Fermi level that resembles the hole doped metal. Soft x-ray absorption spectroscopy also reveals features analogous to those of a hole doped Mott insulator. Based on these results, we conclude that the hole doping does not occur at the interfaces between SCO and STO; instead, it comes from the transient layers between the chain type and the planar type structures within the SCO slab. The present work reveals a novel metallic state in the infinite layer SCO and invites further examination to elucidate the spatial extent of this state., Comment: 31 pages, 11 figures. Physical Review B, in press
Published: 2022
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18. Mapping the circumnuclear regions of the Circinus galaxy with the Imaging X-ray Polarimetry Explorer

Author: Ursini, F., Marinucci, A., Matt, G., Bianchi, S., Marin, F., Marshall, H. L., Middei, R., Poutanen, J., Rogantini, D., De Rosa, A., Di Gesu, L., García, J. A., Ingram, A., Kim, D. E., Krawczynski, H., Puccetti, S., Soffitta, P., Svoboda, J., Tombesi, F., Weisskopf, M. C., Barnouin, T., Perri, M., Podgorny, J., Ratheesh, A., Zaino, A., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Ciprini, S., Costa, E., Del Monte, E., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Dovčiak, M., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S. G., Karas, V., Kitaguchi, T., Kolodziejczak, J. J., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marscher, A. P., Mitsuishi, I., Mizuno, T., Muleri, F., Ng, C. Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Pesce-Rollins, M., Petrucci, P. -O., Pilia, M., Possenti, A., Ramsey, B. D., Rankin, J., Romani, R. W., Sgrò, C., Slane, P., Spandre, G., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on the Imaging X-ray Polarimetry Explorer (IXPE) observation of the closest and X-ray brightest Compton-thick active galactic nucleus (AGN), the Circinus galaxy. We find the source to be significantly polarized in the 2--6 keV band. From previous studies, the X-ray spectrum is known to be dominated by reflection components, both neutral (torus) and ionized (ionization cones). Our analysis indicates that the polarization degree is $28 \pm 7$ per cent (at 68 per cent confidence level) for the neutral reflector, with a polarization angle of $18{\deg} \pm 5{\deg}$, roughly perpendicular to the radio jet. The polarization of the ionized reflection is unconstrained. A comparison with Monte Carlo simulations of the polarization expected from the torus shows that the neutral reflector is consistent with being an equatorial torus with a half-opening angle of 45{\deg}-55{\deg}. This is the first X-ray polarization detection in a Seyfert galaxy, demonstrating the power of X-ray polarimetry in probing the geometry of the circumnuclear regions of AGNs, and confirming the basic predictions of standard Unification Models., Comment: 9 pages, accepted for publication in MNRAS, authors list updated
Published: 2022
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19. Polarization constraints on the X-ray corona in Seyfert Galaxies: MCG-05-23-16

Author: Marinucci, A., Muleri, F., Dovčiak, M., Bianchi, S., Marin, F., Matt, G., Ursini, F., Middei, R., Marshall, H. L., Baldini, L., Barnouin, T., Rodriguez, N. Cavero, De Rosa, A., Di Gesu, L., Harper, D., Ingram, A., Karas, V., Krawczynski, H., Madejski, G., Panagiotou, C., Petrucci, P. O., Podgorny, J., Puccetti, S., Tombesi, F., Veledina, A., Zhang, W., Agudo, I., Antonelli, L. A., Bachetti, M., Baumgartner, W. H., Bellazzini, R., Bongiorno, S. D., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Ciprini, S., Costa, E., Del Monte, E., Di Lalla, N., Di Marco, A., Donnarumma, I., Doroshenko, V., Ehlert, S. R., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J. A., Gunji, S., Hayashida, K., Heyl, J., Iwakiri, W., Jorstad, S. G., Kitaguchi, T., Kolodziejczak, J. J., La Monaca, F., Latronico, L., Liodakis, I., Maldera, S., Manfreda, A., Marscher, A. P., Mitsuishi, I., Mizuno, T., Ng, C. -Y., O'Dell, S. L., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G. G., Peirson, A. L., Perri, M., Pesce-Rollins, M., Pilia, M., Possenti, A., Poutanen, J., Ramsey, B. D., Rankin, J., Ratheesh, A., Romani, R. W., Sgrò, C., Slane, P., Soffitta, P., Spandre, G., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A. F., Thomas, N. E., Trois, A., Tsygankov, S. S., Turolla, R., Vink, J., Weisskopf, M. C., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report on the first observation of a radio-quiet Active Galactic Nucleus (AGN) using polarized X-rays: the Seyfert 1.9 galaxy MCG-05-23-16. This source was pointed with the Imaging X-ray Polarimetry Explorer (IXPE) starting on May 14, 2022 for a net observing time of 486 ks, simultaneously with XMM-Newton (58 ks) and NuSTAR (83 ks). A polarization degree smaller than $\Pi<4.7\%$ (at the 99% c.l.) is derived in the 2-8 keV energy range, where emission is dominated by the primary component ascribed to the hot corona. The broad-band spectrum, inferred from a simultaneous fit to the IXPE, NuSTAR, and XMM-Newton data, is well reproduced by a power law with photon index $\Gamma=1.85\pm0.01$ and a high-energy cutoff $E_{\rm C}=120\pm15$ keV. A comparison with Monte Carlo simulations shows that a lamp-post and a conical geometry of the corona are consistent with the observed upper limit, a slab geometry is allowed only if the inclination angle of the system is less than 50$^{\circ}$., Comment: 7 pages, 3 figures, 1 table. Submitted to MNRAS Letters
Published: 2022
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20. Lipid Metabolism as a Potential Target of Liver Cancer

Author: Wu K and Lin F
Subjects: cholesterol, fatty acid, hepatocellular carcinoma, lipid uptake, lipid catabolism, lipid synthesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Kangze Wu, Feizhuan Lin Department of Hepatobiliary Surgery, Shaoxing People’s Hospital, Shaoxing, People’s Republic of ChinaCorrespondence: Feizhuan Lin, Department of Hepatobiliary Surgery, Shaoxing People’s Hospital, Shaoxing, People’s Republic of China, Email linfeizhuan@163.comAbstract: Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.Keywords: cholesterol, fatty acid, hepatocellular carcinoma, lipid uptake, lipid catabolism, lipid synthesis
Published: 2024

21. Comprehensive Analysis of Fatty Acid Metabolism in Diabetic Nephropathy from the Perspective of Immune Landscapes, Diagnosis and Precise Therapy

Author: Zhu E, Zhong M, Liang T, Liu Y, Wu K, Zhang Z, Zhao S, Guan H, Chen J, Zhang LZ, and Zhang Y
Subjects: diabetic nephropathy, fatty acid metabolism, molecular subtypes, immune landscape, pharmacotherapy, diagnostic model, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Enyi Zhu,1,2,&ast; Ming Zhong,3,&ast; Tiantian Liang,4,&ast; Yu Liu,3,&ast; Keping Wu,1,2 Zhijuan Zhang,1,2 Shuping Zhao,1,2 Hui Guan,5 Jiasi Chen,6 Li-Zhen Zhang,7 Yimin Zhang1,2 1The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong, 510000, People’s Republic of China; 2Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong, 510000, People’s Republic of China; 3Department of Nephrology, Center of Kidney and Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 517108, People’s Republic of China; 4Nephrology Division, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, People’s Republic of China; 5Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450000, People’s Republic of China; 6Department of Nephrology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510030, People’s Republic of China; 7Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yimin Zhang, The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, People’s Republic of China, Email zhangyim@mail.sysu.edu.cn Li-Zhen Zhang, Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China, Email zhanglzh3@mail2.sysu.edu.cnObjective: Diabetic nephropathy (DN) represents the principal cause of end-stage renal diseases worldwide, lacking effective therapies. Fatty acid (FA) serves as the primary energy source in the kidney and its dysregulation is frequently observed in DN. Nevertheless, the roles of FA metabolism in the occurrence and progression of DN have not been fully elucidated.Methods: Three DN datasets (GSE96804/GSE30528/GSE104948) were obtained and combined. Differentially expressed FA metabolism-related genes were identified and subjected to DN classification using “ConsensusClusterPlus”. DN subtypes-associated modules were discovered by “WGCNA”, and module genes underwent functional enrichment analysis. The immune landscapes and potential drugs were analyzed using “CIBERSORT” and “CMAP”, respectively. Candidate diagnostic biomarkers of DN were screened using machine learning algorithms. A prediction model was constructed, and the performance was assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). The online tool “Nephroseq v5” was conducted to reveal the clinical significance of the candidate diagnostic biomarkers in patients with DN. A DN mouse model was established to verify the biomarkers’ expression.Results: According to 39 dysregulated FA metabolism-related genes, DN samples were divided into two molecular subtypes. Patients in Cluster B exhibited worse outcomes with a different immune landscape compared with those in Cluster A. Ten potential small-molecular drugs were predicted to treat DN in Cluster B. The diagnostic model based on PRKAR2B/ANXA1 was created with ideal predictive values in early and advanced stages of DN. The correlation analysis revealed significant association between PRKAR2B/ANXA1 and clinical characteristics. The DN mouse model validated the expression patterns of PRKAR2B/ANXA1.Conclusion: Our study provides new insights into the role of FA metabolism in the classification, immunological pathogenesis, early diagnosis, and precise therapy of DN.Keywords: diabetic nephropathy, fatty acid metabolism, molecular subtypes, immune landscape, pharmacotherapy, diagnostic model
Published: 2024

22. Posttraumatic stress, anxiety, and depression in COVID-19 survivors

Author: Wu, K K, Lee, D, Sze, A M, Ng, V N, Cho, V W, Cheng, J P, Wong, M M, Cheung, S F, and Tsang, O T
Published: 2022

23. Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer [Retraction]

Author: Wei W, Mo X, Yan L, Huang M, Yang Y, Jin Q, Zhong H, Cao W, Wu K, Wu L, Li Z, Wang T, Qin Y, and Chen J
Subjects: circrna_104433, mir-497-5p, cdc25a, gastric cancer, cell proliferation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Wei W, Mo X, Yan L, et al. Cancer Manag Res. 2020;12:15–30. We, the Editor and Publisher of the journal Cancer Management and Research have retracted the published article. Following publication, concerns were raised regarding the use of non-verifiable cell lines described in the article. The concerns related specifically to the use of cell lines which were found to be either contaminated, wrongly identified, improperly indexed, unavailable through external cell line repositories, and/or lacking publications describing their establishment. Overall, these concerns raised doubts about the validity of the findings described in the article. The corresponding author did not respond to our queries and was unable to provide information relating to the use of these cell lines or provide original data relating to the study. As verifying the validity of published work is core to the integrity of the scholarly record, the Publisher and Editor requested to retract the article and the corresponding author was notified of this decision. We have been informed in our decision-making by our editorial policies and COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.
Published: 2024

24. Status and initial physics performance studies of the MPD experiment at NICA

Author: MPD Collaboration, Abgaryan, V., Kado, R. Acevedo, Afanasyev, S. V., Agakishiev, G. N., Alpatov, E., Altsybeev, G., Hernández, M. Alvarado, Andreeva, S. V., Andreeva, T. V., Andronov, E. V., Anfimov, N. V., Aparin, A. A., Astakhov, V. I., Atkin, E., Aushev, T., Averichev, G. S., Averyanov, A. V., Ayala, A., Babkin, V. A., Babutsidze, T., Balashov, I. A., Bancer, A., Barabanov, M. Yu., Baranov, D. A., Baranova, N., Barbashina, N., Baskakov, A. E., Batyuk, P. N., Bazhazhin, A. G., Baznat, D., Baznat, M., Bazylev, S. N., Beltran, L. G. E., Belyaev, A. V., Belyaev, S. E., Belyaeva, E. V., Benda, V., Bielewicz, M., Bietenholz, W., Blaschke, D., Blau, D., Bogdanova, G., Bogoslovsky, D. N., Boguslavsky, I. V., Boos, E., Botvina, A., Bravina, L., Bulychjov, S. A., Buryakov, M. G., Butenko, A. V., Butorin, A. V., Buzin, S. G., Bychkov, A., Bychkov, A. V., Cabellero, R. R., Arciniega, D. Chaires, Chalyshev, V. V., Chen, W., Chen, Z., Cheplakova, V. A., Chepurnov, V. F., Chepurnov, V. V., Cheremnova, M., Cheremukhina, G. A., Chlad, L., Chudoba, P., Chumakov, P. V., Cuautle, E., Czarnynoga, M., Dabrowska, B., Dąbrowski, D., Demanov, A., Dementyev, D. V., Deng, Z., Dmitriev, A. V., Dodokhov, V. Kh., Dolbilina, E. V., Dolbilov, A. G., Domínguez, I., Dominik, W., Donets, D. E., Dronik, V., Dubrovin, A. Yu., Dudziński, A., Dulov, P., Dunin, N. V., Dunin, V. B., Dyatlov, V., Dydyshko, V. F., Efremov, A. A., Egorov, D. S., Elsha, V. V., Emelyanov, A. E., Emelyanov, N. E., Ermakova, V. G., Eyyubova, G., Fang, D., Fateev, O. V., Fedin, O., Fedotov, Yu. I., Fedyunin, A. A., Feng, C., Feng, S., Feofilov, G. A., Filippov, I. A., Fischer, T., Formenko, K., Gaganova, M. A., Gandzhelashvili, T. T., Gavrishchuk, O. P., Geraksiev, N., Gerasimov, S. E., Gertsenberger, K. V., Golosov, O., Golovatyuk, V. M., Golubeva, M., Goncharov, I., Gorbunov, N. V., Grabowski, M., Grodzicka-Kobyłka, M., Grodzicki, K., Grzyb, J., Guber, F., Guirado, A., Guskov, A. V., Guzey, V., He, W., Rosas, L. A. Hernández, Huang, M., Huang, Y., Idczak, R., Idrisov, D., Igolkin, S. N., Ilieva, M., Isupov, A. Yu., Ivanishchev, D., Ivanov, A. V., Ivanytskyi, O., Ivashkin, A., Izvestnyy, A., Jaworska, E., Jiao, J., Kadochnikov, I., Kakurin, S. I., Kankiewicz, P., Kapishin, M. N., Karmanov, D., Karpushkin, N., Kartashova, L. A., Kashirin, E., Kasprowicz, G., Kasumov, Yu., Kechechyan, A. O., Kekelidze, G. D., Kekelidze, V. D., Khanzadeev, A., Kharlamov, P., Khilinova, O. A., Khodzhibagiyan, G. G., Khosravi, N., Khvorostukhin, A., Khyzhniak, Y., Kikvadze, V., Kireyeu, V. A., Kiryushin, Yu. T., Kiryutin, I. S., Kisiel, A., Klyuev, A., Klyukhin, V., Kochenda, L., Kodolova, O., Kolesnikov, V. I., Kolozhvari, A., Komarov, V. G., Kondratiev, V. P., Korolev, M., Korotkikh, V., Kotov, D., Kovalenko, S., Kovalenko, V. N., Kowalski, S., Kozlenko, N. A., Krakowiak, M., Kramarenko, V. A., Krasnova, L. M., Kravchov, P., Krechetov, Yu. F., Kruglova, I. V., Krylov, A. V., Krylov, V., Kryshen, E., Kryukov, A., Kubankin, A., Kugler, A., Kuich, M., Kukarnikov, S. I., Kuklin, S. N., Kukulin, V., Kuleshov, S., Kulikov, E. A., Kulikov, V. V., Kurepin, A., Kushpil, S., Kuzmin, V. S., Kvita, J., Lanskoy, D., Lashmanov, N. A., Ławryńczuk, M., Lazareva, T. V., Lednicky, R., Li, S., Li, Z., Litvinenko, A. G, Litvinenko, E. I., Litvinova, G. N., Liu, D., Liu, F., Livanov, A. N., Lobanov, V. I., Lobanov, Yu. Yu., Lobastov, S. P., Lokhtin, I., Lu, P., Lukstinsh, Yu. R., Luong, B. V., Łysakowski, B., Ma, Y., Machavariani, A., Madigozhin, D. T., Maksiak, B., Maksimenkova, V. I., Malakhov, A. I., Malayev, M., Maldonado, I., Maldonado, J. C., Malikov, I. V., Malinina, L., Maltsev, N. A., Maria, N. V., Shopova, M., Martemianov, M. A., Maslan, M., Matsyuk, M. A., Matulewicz, T., Melnikov, D. G., Merkin, M., Merts, S. P., Meshkov, I. N., Mianowski, S., Migulina, I. I., Mikhaylov, K. R., Milewicz-Zalewska, M., Minaev, Yu. I., Molokanova, N. A., Moreno-Barbosa, E., Morozov, S., Moshkin, A. A., Moshkovsky, I. V., Moskovsky, A. E., Movchan, S. A., Mudrokh, A. A., Mukhin, K. A., Murin, Yu. A., Musul'manbekov, Zh. Zh., Myalkovsky, V. V., Myktybekov, D., Paredes, L. L. Narvaez, Nauruzbaev, D. K., Nazarova, E. N., Nechaevsky, A. V., Nesterov, D. G., Nie, M., Nieto-Marín, P. A., Nigmatkulov, G., Nikitin, V. A., Nioradze, M., Niu, X., Nowak, W., Nozka, L., Oleks, I. A., Olshevsky, A. G., Orlov, O. E., Parfenov, P., Parzhitsky, S. S., Patiño, M. E., Pavlyukevich, V. A., Penkin, V. A., Peresedov, V. F., Peresunko, D., Peshekhonov, D. V., Petrov, V. A., Petrushanko, S., Petukhov, O., Piasecki, K., Pichugina, D. V., Piloyan, A., Pilyar, A. V., Piyadin, S. M., Plamowski, S., Platonova, M., Pluta, J., Potanina, A. E., Potrebenikov, Yu. K., Poźniak, K., Prokhorova, D. S., Prokofiev, N. A., Protoklitow, F., Prozorov, A., Pszczel, D., Puchkov, A. M, Pukhaeva, N., Puławski, S., Rakhmatullina, A. R., Herrera, L. F. Rebolledo, Reyna-Ortiz, V. Z., Riabov, V., Riabov, Yu., Ridinger, N. O., Rikhvitsky, V., Rodriguez-Cahuantzi, M., Rogachevsky, O. V., Rogov, V. Yu., Rokita, P., Romanenko, G., Romaniuk, R., Romanova, A., Rosłon, K., Rossler, T., Calderon, E. F. Rozas, Rufanov, I. A., Rumyantsev, M. M., Rustamov, A., Rybakov, A. A., Rybczyński, M., Rybka, D., Rymshina, A. A., Rzadkiewicz, J., Sadygov, Z. Ya. -O., Samsonov, V. A., Sandul, V. S., Sattarov, R., Savenkov, A. A., Schmidt, K., Seballos, S. S., Sedykh, S. A., Selyuzhenkov, I., Semchukova, T. V., Semenov, A. Yu., Semenova, I. A., Sergeev, S. V., Sergeeva, N. A., Serochkin, E. V., Seryakov, A. Yu., Shabunov, A. V., Shanidze, R., Shcheglova, L., Shchinov, B. G., Shen, C., Shen, Y., Sherbakov, A. N., Sheremetyev, A. D., Sheremetyeva, A. I., Shindin, R. A., Shipunov, A. V., Shitenkov, M. O., Shtejer, D. K., Shukla, U., Shunko, A. A., Shutov, A. V., Shutov, V. B., Sidorin, A. O., Skwira-Chalot, I., Slepnev, I. V., Slepnev, V. M., Slepov, I. P., Solnyshkin, Yu. A., Solomin, A., Solovyeva, T., Sorin, A. S., Starecki, T., Stefanek, G., Stepaniak, J., Streletskaya, E. A., Strikhanov, M., Strizh, T. A., Strizhak, A., Sukhov, N. V., Sukhovarov, S. I., Sun, X., Surkov, N. N., Suvarieva, D., Svalov, V. L., Świderski, L., Syntfeld-Każuch, A., Szcześniak, T., Szewiński, J., Tang, Z., Taranenko, A., Tarasov, N. A., Tcholakov, V., Tejeda-Muñoz, G., Tejeda-Yeomans, M. E., Terletskiy, A. V., Teryaev, O. V., Tikhomirov, V. V., Timoshenko, A. A., Tkachev, G. P., Toneev, V. D., Topilin, N. D., Traczyk, T., Tretyakova, T., Trubnikov, A. V., Trubnikov, G. V., Tyapkin, I. A., Udovenko, S. Yu., Poblete, P. A. Ulloa, Urbaniak, M., Urumov, V., Valenzuela-Cazares, L., Valiev, F. F., Vasendina, V. A., Vasiliev, I. N., Vasilyev, A., Vechernin, V. V., Vereshchagin, S. V., Vladimirova, N. N., Vlasov, N. V., Vodopyanov, A. S., Vokhmyanina, K., Volkov, V., Volodina, O. A., Voronin, A. A., Voronyuk, V., Wang, F., Wang, J., Wang, X., Wang, Y., Wieczorek, P., Wielanek, D., Włodarczyk, Z., Wójcik, K., Wu, K., Xiao, Z., Xu, Q., Yang, C., Yang, H., Yang, Q., Yarygin, G. A., Yordanova, L., Yu, T., Yuan, Z., Yurevich, V. I., Zabołotny, W., Zabrodin, E., Zaitseva, M. V., Saa, J. A. Zamora, Zamyatin, N. I., Zaporozhets, S. A., Zarochentsev, A. K., Zepeda-Fernández, C. H., Zha, W., Zhalov, M., Zhang, Y., Zhang, Z., Zhao, C., Zherebchevsky, V. I., Zhezher, V. N., Zhong, C., Zhou, W., Zhu, X., Zinchenko, A. I., and Zinchenko, D. A.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment, Nuclear Theory
Abstract: The Nuclotron-base Ion Collider fAcility (NICA) is under construction at the Joint Institute for Nuclear Research (JINR), with commissioning of the facility expected in late 2022. The Multi-Purpose Detector (MPD) has been designed to operate at NICA and its components are currently in production. The detector is expected to be ready for data taking with the first beams from NICA. This document provides an overview of the landscape of the investigation of the QCD phase diagram in the region of maximum baryonic density, where NICA and MPD will be able to provide significant and unique input. It also provides a detailed description of the MPD set-up, including its various subsystems as well as its support and computing infrastructures. Selected performance studies for particular physics measurements at MPD are presented and discussed in the context of existing data and theoretical expectations., Comment: 53 pages, 68 figures, submitted as a Review article to EPJA
Published: 2022
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25. Unique irradiation damage behavior and deformation mechanisms in crystalline/amorphous Ag/Cu-Zr nanolaminates

Author: Li, Z.A., Zuo, J.D., Wang, Y.Q., Wu, K., Zhang, J.Y., Liu, G., and Sun, J.
Published: 2024
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26. Bedaquiline Resistance and Molecular Characterization of Rifampicin-Resistant Mycobacterium Tuberculosis Isolates in Zhejiang, China

Author: Tong E, Zhou Y, Liu Z, Zhu Y, Zhang M, Wu K, Pan J, and Jiang J
Subjects: mycobacterium tuberculosis, rifampicin-resistant tuberculosis, bedaquiline, whole-genome sequencing, Infectious and parasitic diseases, RC109-216
Abstract: Enyu Tong,1,&ast; Ying Zhou,1,&ast; Zhengwei Liu,2 Yelei Zhu,2 Mingwu Zhang,2 Kunyang Wu,2 Junhang Pan,2 Jianmin Jiang1– 3 1School of Public Health, Hangzhou Normal University, Hangzhou, 311100, People’s Republic of China; 2Tuberculosis Control Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, People’s Republic of China; 3Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Hangzhou, 310051, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Junhang Pan; Jianmin Jiang, Email jhpan@cdc.zj.cn; jmjiang@cdc.zj.cnPurpose: This study aimed to determine the prevalence and molecular characterization of bedaquiline (BDQ) resistance among rifampicin-resistant tuberculosis (RR-TB) isolates collected from Zhejiang, China.Patients and Methods: A total of 245 RR-TB isolates were collected from 19 municipal TB hospitals in Zhejiang province, China between January and December 2021. Microplate assays were used to determine the minimum inhibitory concentrations (MIC) of BDQ. Whole-genome sequencing (WGS) was performed on isolates with MIC values for BDQ ≥ 0.25 μg/mL.Results: Five (2.04%) BDQ-resistant strains were isolated from 245 tuberculosis patients. The resistance rate of BDQ was not correlated to the sex, age, treatment history, or occupation of patients. Four BDQ-resistant isolates and three BDQ-sensitive isolates were found to carry Rv0678 mutations, and one BDQ-resistant strain carried both Rv0678 and pepQ mutations. No mutations within the atpE and Rv1979c genes were observed.Conclusion: BDQ demonstrated strong in vitro antibacterial activity against RR-TB isolates, and the Rv0678 gene was identified as the primary mechanism contributing to BDQ resistance among RR-TB isolates from Zhejiang, China. Furthermore, in addition to the four currently known resistance-associated genes (atpE, Rv0678, Rv1979c, and pepQ), other mechanisms of resistance to BDQ may exist that need further study.Plain language summary: This study looked at a bacterial species called Mycobacterium tuberculosis, which causes the highly problematic disease, tuberculosis. Certain strains of this bacterium have developed resistance to conventional antibiotics used in tuberculosis treatment, necessitating an investigation into the efficacy of the newer antibiotic, bedaquiline. We collected 245 rifampicin-resistant tuberculosis samples from patients in Zhejiang, China, subjecting them to bedaquiline susceptibility testing. Concurrently, we conducted a genetic analysis of the bacteria to pinpoint mutations linked to bedaquiline resistance. Out of the 245 samples, 5 were found to be resistant to bedaquiline. We found that mutations in a gene called Rv0678 were the main reason for this resistance. This gene had mutations in four of the bedaquiline-resistant samples and three of the bedaquiline-susceptible samples. One of the bedaquiline-resistant samples had mutations in both Rv0678 and another gene called pepQ. We also found that bedaquiline was effective at killing drug-resistant tuberculosis bacteria in the lab. However, there may be other genes or mechanisms that make other bacteria resistant to the drug, which will need further study. Overall, this study helps us understand how bedaquiline works against drug-resistant tuberculosis bacteria and identifies a genetic mechanism that can cause resistance to the drug.Keywords: Mycobacterium tuberculosis, rifampicin-resistant tuberculosis, bedaquiline, whole-genome sequencing
Published: 2023

27. Fluidization behavior of stirred gas–solid fluidized beds: A combined X-ray and CFD–DEM–IBM study

Author: van der Sande, P.C., de Munck, M.J.A., Wu, K., Rieder, D.R., van den Eertwegh, D.E.A., Wagner, E.C., Meesters, G.M.H., Peters, E.A.J.F., Kuipers, J.A.M., and van Ommen, J.R.
Published: 2024
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28. Enhancing IoT anomaly detection performance for federated learning

Author: Weinger, Brett, Kim, Jinoh, Sim, Alex, Nakashima, Makiya, Moustafa, Nour, and Wu, K John
Subjects: Data Management and Data Science, Distributed Computing and Systems Software, Information and Computing Sciences, Patient Safety, Data augmentation, Federated learning, Internet of things, Anomaly detection, Machine learning, Distributed Computing, Communications Technologies, Design Practice and Management, Communications engineering, Distributed computing and systems software
Abstract: Federated Learning (FL) with mobile computing and the Internet of Things (IoT) is an effective cooperative learning approach. However, several technical challenges still need to be addressed. For instance, dividing the training process among several devices may impact the performance of Machine Learning (ML) algorithms, often significantly degrading prediction accuracy compared to centralized learning. One of the primary reasons for such performance degradation is that each device can access only a small fraction of data (that it generates), which limits the efficacy of the local ML model constructed on that device. The performance degradation could be exacerbated when the participating devices produce different classes of events, which is known as the class balance problem. Moreover, if the participating devices are of different types, each device may never observe the same types of events, which leads to the device heterogeneity problem. In this study, we investigate how data augmentation can be applied to address these challenges and improving detection performance in an anomaly detection task using IoT datasets. Our extensive experimental results with three publicly accessible IoT datasets show the performance improvement of up to 22.9% with the approach of data augmentation, compared to the baseline (without relying on data augmentation). In particular, stratified random sampling and uniform random sampling show the best improvement in detection performance with only a modest increase in computation time, whereas the data augmentation scheme using Generative Adversarial Networks is the most time-consuming with limited performance benefits.
Published: 2022

29. New Experimental Limits on Exotic Spin- and Velocity-dependent Interactions Using Rotationally Modulated Source-masses and an Atomic-magnetometer Array

Author: Wu, K. Y., Chen, S. Y., Sun, G. A., Peng, S. M., Peng, M., and Yan, H.
Subjects: Nuclear Experiment
Abstract: We conducted laboratory searching for the exotic spin- and velocity-dependent new interactions according to the previously proposed experimental scheme. Two $\sim$6Kg heavy source masses are rotationally modulated at a frequency of 20Hz. Four identical atomic magnetometers are used in an array form to increase the statistics and cancel the common-mode noise. Data processing method based on high precision numerical integration is applied for the four harmonic frequencies of the signal. The rotation direction of the source masses was reversed to flip the signal. Thus the [1,-3,3,-1] weighting method can be applied to remove possible slow drifting further. The experiment method has noise reduction features, and new constraints for Vector-Axial and Axial-Axial were obtained. The new constraints on VA improved by as much as more than four orders, on AA by as much as two orders in the corresponding force range, respectively.
Published: 2021
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30. Searching for Exotic Spin-Dependent Interactions Using Rotationally Modulated Source Masses and an Atomic Magnetometer Array

Author: Wu, K. Y., Chen, S. Y., Gong, J., Peng, M., and Yan, H.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: We describe a proposed experimental search for exotic spin-dependent interactions using rotationally modulated source masses and an atomic magnetometer array. Rather than further improving the magnetometer sensitivity, noise reduction can be another way to reach higher measurement precision. In this work, we propose to use modulating techniques of the source masses to reduce the noise of the experiment. Better precision can be achieved if the fundamental frequency and harmonics of the rotating source masses are used to detect the new interactions. Furthermore, if an array of magnetometers are applied, the statistic precision can be improved, and some common noises can be canceled. Our analysis and simulations indicate that the proposed experiment scheme can improve the detection precisions of three types of spin-dependent interactions by as much as $\sim$5 orders in the force range of $\sim$cm to $\sim$10m.
Published: 2021
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31. High-temperature steam oxidation behavior and failure mechanisms of Al alloyed Cr coatings on Zr-4 alloy

Author: Wang, Y.Q., Zuo, J.D., Xiao, X., Wu, K., Zhang, J.Y., Liu, G., and Sun, J.
Published: 2024
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32. Systemic Immune-Inflammation Index Was Significantly Associated with All-Cause and Cardiovascular-Specific Mortalities in Patients Receiving Peritoneal Dialysis

Author: Li G, Yu J, Jiang S, Wu K, Xu Y, Lu X, Wang Y, Lin J, Yang X, Li Z, and Mao H
Subjects: all-cause mortality, cardiovascular mortality, peritoneal dialysis, systemic immune-inflammation index, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Guanglan Li,1,2 Jing Yu,1,2 Simin Jiang,1,2 Kefei Wu,1,2 Yiping Xu,1,2 Xiaohui Lu,1,2 Yating Wang,1,2 Jianxiong Lin,1,2 Xiao Yang,1,2 Zhibin Li,3 Haiping Mao1,2 1Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; 2NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China; 3Epidemiology Research Unit, Translational Medicine Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361005, ChinaCorrespondence: Haiping Mao, Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China, Email maohp@mail.sysu.edu.cnPurpose: The prognosis of patients receiving peritoneal dialysis (PD) is associated with inflammation. Systemic immune-inflammation index (SII) is one of inflammatory markers, and the role in predicting clinical outcomes in PD patients is unclear. We aimed to investigate the relationship between the SII and all-cause and cardiovascular-specific mortalities in patients undergoing PD.Patients and Methods: A total of 1419 PD patients from the First Affiliated Hospital of Sun Yat-sen University between January 1, 2007 and December 31, 2019 were retrospectively included at baseline, and the patients were followed up until November 31, 2021. SII was calculated as platelet count×neutrophil count/lymphocyte count. Kaplan–Meier curves and Cox proportional hazards regression models were used to determine the relationship between SII levels and all-cause and cardiovascular-specific mortalities.Results: During follow-up (median period was 42 months), 321 patients died (171 died of cardiovascular disease). With adjustment for the potential confounding factors, each 1-SD increase in the SII was associated with 20.2% increase in all-cause mortality (hazard ratio [HR]: 1.202, 95% confidence interval [CI]: 1.088– 1.327, P< 0.001) and 28.0% increase in cardiovascular-specific mortality (HR: 1.280, 95% CI: 1.126– 1.456, P< 0.001). High SII (vs low SII) was significantly associated with increased risks of all-cause mortality (HR: 1.391, 95% CI: 1.066– 1.815, P-value: 0.015) and cardiovascular-specific mortality (HR: 1.637, 95% CI: 1.185– 2.261, P-value: 0.003). Subgroups analyses showed similar results for those younger than 65-year-old only.Conclusion: Elevated SII level was independently associated with increased risks of all-cause and cardiovascular-specific mortalities in PD patients, especially for those younger than 65-year-old.Keywords: all-cause mortality, cardiovascular mortality, peritoneal dialysis, systemic immune-inflammation index
Published: 2023

33. The Relationship Between Fear of COVID-19 and Psychological Distress in Tour Guides: The Mediating Role of Job Insecurity and the Moderating Role of Psychological Resilience

Author: Jiang Y, Huang L, Guo Y, Yang Q, Li H, Zhou H, and Wu K
Subjects: fear of covid-19, job insecurity, psychological distress, psychological resilience, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract: Yajun Jiang,1 Longfang Huang,1 Yu Guo,1 Qin Yang,2 Haixia Li,1 Huiling Zhou,1 Ke Wu3 1College of Tourism & Landscape Architecture, Guilin University of Technology, Guangxi, 541004, People’s Republic of China; 2School of Preschool Education, Changsha Normal University, Changsha, 410100, People’s Republic of China; 3School of Economics & Management, Hunan University of Science and Technology, Yongzhou, 425199, People’s Republic of ChinaCorrespondence: Ke Wu, School of Economics & Management, Hunan University of Science and Technology, Yongzhou, 425199, People’s Republic of China, Tel +15674662800, Email huse_chn@163.comPurpose: The COVID-19 has greatly affected the tourism industry in China, leading to an increase in psychological distress among tour guides. This study explores the mechanisms by which tour guides’ fear of the COVID-19 affects psychological distress, using job insecurity as a mediating variable and psychological resilience as a moderating variable.Patients and Methods: From August 11 to 30, 2022, 447 Chinese tour guides were invited online to fill in a questionnaire, and SPSS and Mplus tools were used for statistical analysis and hypothesis testing to conduct an empirical analysis of the relationship between COVID-19 fear and psychological distress.Results: A total of 417 questionnaires (effective rate was 93.3%) were collected, among which female (n = 243) and male (41.7%) (n =174). The age concentration of participants was 46.5% between 26 and 35 years old, 9.1% under 25 years old, and 9.8% over 46 years old. Guides’ fear of COVID-19 positively and significantly influenced psychological distress (β= 0.3051), and the relationship between fear of COVID-19 and psychological distress was mediated by job insecurity (β=0.196, 95% CI = 0.141, 0.255). In addition, psychological resilience significantly moderated the pathway from fear of COVID-19 to job insecurity and from fear of COVID-19 to guided psychological distress (β= 0.1371; β=0.116).Conclusion: The diversion of fear of COVID-19 and job insecurity can alleviate the psychological distress of tour guides; strengthening their own psychological construction also helps to alleviate the effects of fear of COVID-19 on job insecurity and psychological distress. The findings of the study can provide theoretical support for the prevention and counseling of psychological problems of tourism employees in public health crises.Keywords: fear of COVID-19, job insecurity, psychological distress, psychological resilience
Published: 2023

34. Correlation Analysis Between Disease Activity and Anxiety, Depression, Sleep Disturbance, and Quality of Life in Patients with Inflammatory Bowel Disease

Author: Yu R, Liu C, Zhang J, Li J, Tian S, Ding F, Liu Z, Wang T, Jiang C, Shi J, Wu K, and Dong W
Subjects: inflammatory bowel disease, disease activity, anxiety, depression, sleep quality, quality of life, survey, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Rong Yu,1,&ast; Chuan Liu,1,&ast; Jixiang Zhang,1,&ast; Jiao Li,1,&ast; Shan Tian,2 Fugui Ding,1 Zhengru Liu,3 Ting Wang,4 Zhongchun Liu,5 Changqing Jiang,6 Jie Shi,7 Kaichun Wu,8 Weiguo Dong1 1Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 2Department of Infectious Diseases, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, People’s Republic of China; 3Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 4Department of Gastroenterology, First Affiliated Hospital of Hainan Medical College, Haikou, 570102, People’s Republic of China; 5Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 6Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, People’s Republic of China; 7Department of Medical Psychology, Chinese People’s Liberation Army Rocket Army Characteristic Medical Center, Beijing, 100088, People’s Republic of China; 8Department of Gastroenterology, Xijing Hospital, Air Force Medical University, Xi’an, 710032, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weiguo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhangzhidong Road, Wuhan, Hubei Province, 430060, People’s Republic of China, Tel +86 027-88041911, Email dongweiguo@whu.edu.cn Kaichun Wu, Department of Gastroenterology, Xijing Hospital, Air Force Medical University, No. 127 West Changle Road, Xi’an, Shaanxi Province, 710032, People’s Republic of China, Tel +86 029-84771600, Email kaicwu@fmmu.edu.cnObjective: To explore the correlation between disease activity and anxiety, depression, sleep quality, and quality of life in patients with inflammatory bowel disease (IBD).Methods: The disease activity of IBD patients was evaluated by 66 gastroenterologists from 42 hospitals in 22 provinces in China from September 2021 to May 2022. Anxiety, depression, sleep quality and quality of life of IBD patients were investigated and statistically analyzed by different scales, including Generalized Anxiety Disorder 7-item Scale (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Pittsburgh Sleep Quality Index (PSQI), and Inflammatory Bowel Disease Quality-of-Life Questionnaire (IBD-Q).Results: A total of 2478 IBD patients were included, of which 1532 (61.8%) were in active stage and 946 (38.2%) were in remission. The proportions of active IBD with anxiety, depression, sleep disturbance, and poor quality of life were 29.5%, 29.7%, 71.1%, and 50.1%, respectively, while the proportions of remission IBD with anxiety, depression, sleep disturbance, and poor quality of life were 19.1%, 24.4%, 69.3%, and 17.4%, respectively. IBD patients who also had anxiety, depression, sleep disturbances and poor quality of life had 80 cases (8.46%) in remission and 114 cases (7.44%) in active stage, with 54 cases (9.18%) in mild activity, 51 cases (6.95%) in moderate activity and 9 cases (4.49%) in severe activity. IBD patients with different disease activity levels differed in GAD-7 scores, PHQ-9 scores, PSQI scores, and IBD-Q scores (all P< 0.001). In IBD patients, anxiety, depression, and sleep disturbance, which interact with each other, can further aggravate their disease activity (all P< 0.001).Conclusion: Anxiety, depression, sleep disturbances, and quality of life are strongly correlated with disease activity in IBD patients, and IBD patients with psychological disturbances are most often in the active stage and have a poor quality of life.Keywords: inflammatory bowel disease, disease activity, anxiety, depression, sleep quality, quality of life, survey
Published: 2023

35. Beam test results of IHEP-NDL Low Gain Avalanche Detectors(LGAD)

Author: Xiao, S., Alderweireldt, S., Ali, S., Allaire, C., Agapopoulou, C., Atanov, N., Ayoub, M. K., Barone, G., Benchekroun, D., Buzatu, A., Caforio, D., García, L. Castillo, Chan, Y., Chen, H., Cindro, V., Ciucu, L., da Costa, J. Barreiro Guimarães, Cui, H., Miralles, F. Davó, Davydov, Y., d'Amen, G., de la Taille, C., Kiuchi, R., Fan, Y., Falou, A., Ferreira, A. S. C., Garau, M., Ge, J., Ghosh, A., Giacomini, G., Gkougkousis, E. L., Grieco, C., Guindon, S., Han, D., Han, S., Holmberg, M., Howard, A., Huang, Y., Jing, M., Khoulaki, Y., Kramberger, G., Kuwertz, E., Lefebvre, H., Leite, M., Leopold, A., Li, C., Li, Q., Liang, H., Liang, Z., Liu, B., Liu, J., Luthfi, A., Lyu, F., Malyukov, S., Mandić, I., Masetti, L., Mikuž, M., Nikolic, I., Polidori, L., Polifka, R., Posopkina, O., Qi, B., Ran, K., Reynolds, B. J. G., Rizzi, C., Manzano, M. Robles, Rossi, E., Rummler, A., Sacerdoti, S., Saito, G. T., Seguin-Moreau, N., Serin, L., Shan, L., Shi, L., Sjostrom, N. F., Ferreira, A. Soares Canas, Soengen, J., Stenzel, H., Szadaj, A. J., Tan, Y., Terzo, S., Thomas, J. O., Tolley, E., Tricoli, A., Trincaz-Duvoid, S., Wang, R., Wang, S. M., Wang, W., Wu, K., Shi, X., Yang, T., Yang, Y., Yu, C., Zhang, X., Zhao, L., Zhao, M., Zhao, Z., Zheng, X., and Zhuang, X.
Subjects: Physics - Instrumentation and Detectors
Abstract: To meet the timing resolution requirement of up-coming High Luminosity LHC (HL-LHC), a new detector based on the Low-Gain Avalanche Detector(LGAD), High-Granularity Timing Detector (HGTD), is under intensive research in ATLAS. Two types of IHEP-NDL LGADs(BV60 and BV170) for this update is being developed by Institute of High Energy Physics (IHEP) of Chinese Academic of Sciences (CAS) cooperated with Novel Device Laboratory (NDL) of Beijing Normal University and they are now under detailed study. These detectors are tested with $5GeV$ electron beam at DESY. A SiPM detector is chosen as a reference detector to get the timing resolution of LGADs. The fluctuation of time difference between LGAD and SiPM is extracted by fitting with a Gaussian function. Constant fraction discriminator (CFD) method is used to mitigate the effect of time walk. The timing resolution of $41 \pm 1 ps$ and $63 \pm 1 ps$ are obtained for BV60 and BV170 respectively.
Published: 2020
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36. Radiation Campaign of HPK Prototype LGAD sensors for the High-Granularity Timing Detector (HGTD)

Author: Shi, X., Ayoub, M. K., da Costa, J. Barreiro Guimarães, Cui, H., Kiuchi, R., Fan, Y., Han, S., Huang, Y., Jing, M., Liang, Z., Liu, B., Liu, J., Lyu, F., Qi, B., Ran, K., Shan, L., Shi, L., Tan, Y., Wu, K., Xiao, S., Yang, T., Yang, Y., Yu, C., Zhao, M., Zhuang, X., García, L. Castillo, Gkougkousis, E. L., Grieco, C., Grinstein, S., Leite, M., Saito, G. T., Howard, A., Cindro, V., Kramberger, G., Mandić, I., Mikuž, M., d'Amen, G., Giacomini, G., Rossi, E., Tricoli, A., Chen, H., Ge, J., Li, C., Liang, H., Yang, X., Zhao, L., Zhao, Z., Zheng, X., Atanov, N., Davydov, Y., Grosse-Knetter, J., Lange, J., Quadt, A., Schwickardi, M., Alderweireldt, S., Ferreira, A. S. C., Guindon, S., Kuwertz, E., Rizzi, C., Christie, S., Galloway, Z., Gee, C., Jin, Y., Labitan, C., Lockerby, M., Mazza, S. M., Martinez-Mckinney, F., Padilla, R., Ren, H., Sadrozinski, H. F. -W., Schumm, B., Seiden, A., Wilder, M., Wyatt, W., Zhao, Y., Han, D., and Zhang, X.
Subjects: Physics - Instrumentation and Detectors
Abstract: We report on the results of a radiation campaign with neutrons and protons of Low Gain Avalanche Detectors (LGAD) produced by Hamamatsu (HPK) as prototypes for the High-Granularity Timing Detector (HGTD) in ATLAS. Sensors with an active thickness of 50~$\mu$m were irradiated in steps of roughly 2$\times$ up to a fluence of $3\times10^{15}~\mathrm{n_{eq}cm^{-2}}$. As a function of the fluence, the collected charge and time resolution of the irradiated sensors will be reported for operation at $-30^{\circ}$.
Published: 2020
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37. Layout and Performance of HPK Prototype LGAD Sensors for the High-Granularity Timing Detector

Author: Yang, X., Alderweireldt, S., Atanov, N., Ayoub, M. K., da Costa, J. Barreiro Guimaraes, Garcia, L. Castillo, Chen, H., Christie, S., Cindro, V., Cui, H., D'Amen, G., Davydov, Y., Fan, Y. Y., Galloway, Z., Ge, J. J., Gee, C., Giacomini, G., Gkougkousis, E. L., Grieco, C., Grinstein, S., Grosse-Knetter, J., Guindon, S., Han, S., Howard, A., Huang, Y. P., Jin, Y., Jing, M. Q., Kiuchi, R., Kramberger, G., Kuwertz, E., Labitan, C., Lange, J., Leite, M., Li, C. H., Li, Q. Y., Liu, B., Liu, J. Y., Liu, Y. W., Liang, H., Liang, Z. J., Lockerby, M., Lyu, F., Mandić, I., Martinez-Mckinney, F., Mazza, S. M., Mikuž, M., Padilla, R., Qi, B. H., Quadt, A., Ran, K. L., Ren, H., Rizzi, C., Rossi, E., Sadrozinski, H. F. -W., Saito, G. T., Schumm, B., Schwickardi, M., Seiden, A., Shan, L. Y., Shi, L. S., Shi, X., Ferreira, A. Soares Canas, Sun, Y. J., Tan, Y. H., Tricoli, A., Wan, G. Y., Wilder, M., Wu, K. W., Wyatt, W., Xiao, S. Y., Yang, T., Yang, Y. Z., Yu, C. J., Zhao, L., Zhao, M., Zhao, Y., Zhao, Z. G., Zheng, X. X., and Zhuang, X. A.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The High-Granularity Timing Detector is a detector proposed for the ATLAS Phase II upgrade. The detector, based on the Low-Gain Avalanche Detector (LGAD) technology will cover the pseudo-rapidity region of $2.4<|\eta|<4.0$ with two end caps on each side and a total area of 6.4 $m^2$. The timing performance can be improved by implanting an internal gain layer that can produce signal with a fast rising edge, which improve significantly the signal-to-noise ratio. The required average timing resolution per track for a minimum-ionising particle is 30 ps at the start and 50 ps at the end of the HL-LHC operation. This is achieved with several layers of LGAD. The innermost region of the detector would accumulate a 1 MeV-neutron equivalent fluence up to $2.5 \times 10^{15} cm^{-2}$ before being replaced during the scheduled shutdowns. The addition of this new detector is expected to play an important role in the mitigation of high pile-up at the HL-LHC. The layout and performance of the various versions of LGAD prototypes produced by Hamamatsu (HPK) have been studied by the ATLAS Collaboration. The breakdown voltages, depletion voltages, inter-pad gaps, collected charge as well as the time resolution have been measured and the production yield of large size sensors has been evaluated., Comment: 17 pages, 20 figures
Published: 2020
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38. Prospects for Fundamental Physics with LISA

Author: Barausse, Enrico, Berti, Emanuele, Hertog, Thomas, Hughes, Scott A., Jetzer, Philippe, Pani, Paolo, Sotiriou, Thomas P., Tamanini, Nicola, Witek, Helvi, Yagi, Kent, Yunes, Nicolas, Abdelsalhin, T., Achucarro, A., Aelst, K. V., Afshordi, N., Akcay, S., Annulli, L., Arun, K. G., Ayuso, I., Baibhav, V., Baker, T., Bantilan, H., Barreiro, T., Barrera-Hinojosa, C., Bartolo, N., Baumann, D., Belgacem, E., Bellini, E., Bellomo, N., Ben-Dayan, I., Bena, I., Benkel, R., Bergshoefs, E., Bernard, L., Bernuzzi, S., Bertacca, D., Besancon, M., Beutler, F., Beyer, F., Bhagwat, S., Bicak, J., Biondini, S., Bize, S., Blas, D., Boehmer, C., Boller, K., Bonga, B., Bonvin, C., Bosso, P., Bozzola, G., Brax, P., Breitbach, M., Brito, R., Bruni, M., Brügmann, B., Bulten, H., Buonanno, A., Burke, A. O., Burko, L. M., Burrage, C., Cabral, F., Calcagni, G., Caprini, C., Cárdenas-Avendaño, A., Celoria, M., Chatziioannou, K., Chernoff, D., Clough, K., Coates, A., Comelli, D., Compère, G., Croon, D., Cruces, D., Cusin, G., Dalang, C., Danielsson, U., Das, S., Datta, S., de Boer, J., De Luca, V., De Rham, C., Desjacques, V., Destounis, K., Di Filippo, F., Dima, A., Dimastrogiovanni, E., Dolan, S., Doneva, D., Duque, F., Durrer, R., East, W., Easther, R., Elley, M., Ellis, J. R., Emparan, R., Ezquiaga, J. M., Fairbairn, M., Fairhurst, S., Farmer, H. F., Fasiello, M. R., Ferrari, V., Ferreira, P. G., Ficarra, G., Figueras, P., Fisenko, S., Foffa, S., Franchini, N., Franciolini, G., Fransen, K., Frauendiener, J., Frusciante, N., Fujita, R., Gair, J., Ganz, A., Garcia, P., Garcia-Bellido, J., Garriga, J., Geiger, R., Geng, C., Gergely, L. Á., Germani, C., Gerosa, D., Giddings, S. B., Gourgoulhon, E., Grandclement, P., Graziani, L., Gualtieri, L., Haggard, D., Haino, S., Halburd, R., Han, W. -B., Hawken, A. J., Hees, A., Heng, I. S., Hennig, J., Herdeiro, C., Hervik, S., Holten, J. v., Hoyle, C. J. D., Hu, Y., Hull, M., Ikeda, T., Isi, M., Jenkins, A., Julié, F., Kajfasz, E., Kalaghatgi, C., Kaloper, N., Kamionkowski, M., Karas, V., Kastha, S., Keresztes, Z., Kidder, L., Kimpson, T., Klein, A., Klioner, S., Kokkotas, K., Kolesova, H., Kolkowitz, S., Kopp, J., Koyama, K., Krishnendu, N. V., Kroon, J. A. V., Kunz, M., Lahav, O., Landragin, A., Lang, R. N., Poncin-Lafitte, C. Le, Lemos, J., Li, B., Liberati, S., Liguori, M., Lin, F., Liu, G., Lobo, F. S. N., Loll, R., Lombriser, L., Lovelace, G., Macedo, R. P., Madge, E., Maggio, E., Maggiore, M., Marassi, S., Marcoccia, P., Markakis, C., Martens, W., Martinovic, K., Martins, C. J. A. P., Maselli, A., Mastrogiovanni, S., Matarrese, S., Matas, A., Mavromatos, N. E., Mazumdar, A., Meerburg, P. D., Megias, E., Miller, J., Mimoso, J. P., Mittnacht, L., Montero, M. M., Moore, B., Martin-Moruno, P., Musco, I., Nakano, H., Nampalliwar, S., Nardini, G., Nielsen, A., Novák, J., Nunes, N. J., Okounkova, M., Oliveri, R., Oppizzi, F., Orlando, G., Oshita, N., Pappas, G., Paschalidis, V., Peiris, H., Peloso, M., Perkins, S., Pettorino, V., Pikovski, I., Pilo, L., Podolsky, J., Pontzen, A., Prabhat, S., Pratten, G., Prokopec, T., Prouza, M., Qi, H., Raccanelli, A., Rajantie, A., Randall, L., Raposo, G., Raymond, V., Renaux-Petel, S., Ricciardone, A., Riotto, A., Robson, T., Roest, D., Rollo, R., Rosofsky, S., Ruan, J. J., Rubiera-García, D., Ruiz, M., Rusu, M., Sabatie, F., Sago, N., Sakellariadou, M., Saltas, I. D., Sberna, L., Sathyaprakash, B., Scheel, M., Schmidt, P., Schutz, B., Schwaller, P., Shao, L., Shapiro, S. L., Shoemaker, D., Silva, A. d., Simpson, C., Sopuerta, C. F., Spallicci, A., Stefanek, B. A., Stein, L., Stergioulas, N., Stott, M., Sutton, P., Svarc, R., Tagoshi, H., Tahamtan, T., Takeda, H., Tanaka, T., Tantilian, G., Tasinato, G., Tattersall, O., Teukolsky, S., Tiec, A. L., Theureau, G., Trodden, M., Tolley, A., Toubiana, A., Traykova, D., Tsokaros, A., Unal, C., Unnikrishnan, C. S., Vagenas, E. C., Valageas, P., Vallisneri, M., Brand, J. Van den, Broeck, C. Van den, van de Meent, M., Vanhove, P., Varma, V., Veitch, J., Vercnocke, B., Verde, L., Vernieri, D., Vernizzi, F., Vicente, R., Vidotto, F., Visser, M., Vlah, Z., Vretinaris, S., Völkel, S., Wang, Q., Wang, Yu-Tong, Werner, M. C., Westernacher, J., Weygaert, R. v. d., Wiltshire, D., Wiseman, T., Wolf, P., Wu, K., Yamada, K., Yang, H., Yi, L., Yue, X., Yvon, D., Zilhão, M., Zimmerman, A., and Zumalacarregui, M.
Subjects: General Relativity and Quantum Cosmology
Abstract: In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA, we present here a sample of what we view as particularly promising directions, based in part on the current research interests of the LISA scientific community in the area of fundamental physics. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics., Comment: 22 pages, 1 figure, to appear in General Relativity and Gravitation
Published: 2020
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39. High-Performance Computational Intelligence and Forecasting Technologies

Author: Wu, K and Simon, HD
Subjects: High-performance computing, Streaming analytics, machine learning
Abstract: This report provides an introduction to the Computational Intelligence and Forecasting Technologies (CIFT) project at Lawrence Berkeley National Laboratory (LBNL). The main objective of CIFT is to promote the use of high-performance computing (HPC) tools and techniques for analysis of streaming data. After noticing the data volume being given as the explanation for the five-month delay for SEC and CFTC to issue their report on the 2010 Flash Crash, LBNL started the CIFT project to apply HPC technologies to manage and analyze financial data. Making timely decisions with streaming data is a requirement for many different applications, such as avoiding impending failure in the electric power grid or a liquidity crisis in financial markets. In all these cases, the HPC tools are well suited in handling the complex data dependencies and providing timely solutions. Over the years, CIFT has worked on a number of different forms of streaming data, including those from vehicle traffic, electric power grid, electricity usage, and so on. The following sections explain the key features of HPC systems, introduce a few special tools used on these systems, and provide examples of streaming data analyses using these HPC tools.
Published: 2021

40. GPU-based Classification for Wireless Intrusion Detection

Author: Lazar, A, Sim, A, and Wu, K
Abstract: Automated network intrusion detection systems (NIDS) continuously monitor the network traffic to detect attacks or/and anomalies. These systems need to be able to detect attacks and alert network engineers in real-time. Therefore, modern NIDS are built using complex machine learning algorithms that require large training datasets and are time-consuming to train. The proposed work shows that machine learning algorithms from the RAPIDS cuML library on Graphics Processing Units (GPUs) can speed-up the training process on large scale datasets. This approach is able to reduce the training time while providing high accuracy and performance. We demonstrate the proposed approach on a large subset of data extracted from the Aegean Wi-Fi Intrusion Dataset (AWID). Multiple classification experiments were performed on both CPU and GPU. We achieve up to 65x acceleration of training several machine learning methods by moving most of the pipeline computations to the GPU and leveraging the new cuML library as well as the GPU version of the CatBoost library.
Published: 2021

41. Access Patterns to Disk Cache for Large Scientific Archive

Author: Wang, Y, Wu, K, Sim, A, Yoo, S, and Misawa, S
Abstract: Large scientific projects are increasing relying on analyses of data for their new discoveries; and a number of different data management systems have been developed to serve this scientific projects. In the work-in-progress paper, we describe an effort on understanding the data access patterns of one of these data management systems, dCache. This particular deployment of dCache acts as a disk cache in front of a large tape storage system primarily containing high-energy physics data. Based on the 15-month dCache logs, the cache is only accessing the tape system once for over 50 file requests, which indicates that it is effective as a disk cache. The on-disk files are repeated used, more than three times a day. We have also identified a number of unusual access patterns that are worth further investigation.
Published: 2021

42. Analyzing Scientific Data Sharing Patterns for In-network Data Caching

Author: Copps, E, Zhang, H, Sim, A, Wu, K, Monga, I, Guok, C, Würthwein, F, Davila, D, and Fajardo, E
Subjects: cs.NI, cs.DC
Abstract: The volume of data moving through a network increases with new scientific experiments and simulations. Network bandwidth requirements also increase proportionally to deliver data within a certain time frame. We observe that a significant portion of the popular dataset is transferred multiple times to different users as well as to the same user for various reasons. In-network data caching for the shared data has shown to reduce the redundant data transfers and consequently save network traffic volume. In addition, overall application performance is expected to improve with in-network caching because access to the locally cached data results in lower latency. This paper shows how much data was shared over the study period, how much network traffic volume was consequently saved, and how much the temporary in-network caching increased the scientific application performance. It also analyzes data access patterns in applications and the impacts of caching nodes on the regional data repository. From the results, we observed that the network bandwidth demand was reduced by nearly a factor of 3 over the study period.
Published: 2021

43. Adaptive Stochastic Gradient Descent for Deep Learning on Heterogeneous CPU+GPU Architectures

Author: Ma, Y, Rusu, F, Wu, K, and Sim, A
Abstract: The widely-adopted practice is to train deep learning models with specialized hardware accelerators, e.g., GPUs or TPUs, due to their superior performance on linear algebra operations. However, this strategy does not employ effectively the extensive CPU and memory resources - which are used only for preprocessing, data transfer, and scheduling - available by default on the accelerated servers. In this paper, we study training algorithms for deep learning on heterogeneous CPU+GPU architectures. Our two-fold objective - maximize convergence rate and resource utilization simultaneously - makes the problem challenging. In order to allow for a principled exploration of the design space, we first introduce a generic deep learning framework that exploits the difference in computational power and memory hierarchy between CPU and GPU through asynchronous message passing. Based on insights gained through experimentation with the framework, we design two heterogeneous asynchronous stochastic gradient descent (SGD) algorithms. The first algorithm - CPU+GPU Hogbatch - combines small batches on CPU with large batches on GPU in order to maximize the utilization of both resources. However, this generates an unbalanced model update distribution which hinders the statistical convergence. The second algorithm - Adaptive Hogbatch - assigns batches with continuously evolving size based on the relative speed of CPU and GPU. This balances the model updates ratio at the expense of a customizable decrease in utilization. We show that the implementation of these algorithms in the proposed CPU+GPU framework achieves both faster convergence and higher resource utilization than TensorFlow on several real datasets.
Published: 2021

44. Modeling Ammonia and Its Uptake by Secondary Organic Aerosol Over China

Author: Wu, K, Zhu, S, Liu, Y, Wang, H, Yang, X, Liu, L, Dabdub, D, and Cappa, CD
Subjects: ammonia uptake, CMAQ, heterogeneous chemistry, particle matter, SOA, Atmospheric Sciences, Physical Geography and Environmental Geoscience
Abstract: Atmospheric ammonia (NH3) can affect nitrogen deposition, particle acidity, and gas-particle partitioning. Although the inorganic chemistry of NH3 in fine particulate (PM2.5) formation are well-constrained, the understanding of interactions between NH3 and secondary organic aerosol (SOA) are rather insufficient until recently. Laboratory studies indicate that NH3 molecule can react with SOA then forms nitrogen-containing organic compounds (NOCs), which can further react to form heterocyclic organic compounds. In this study, we use a modified version of the CMAQ model to simulate the potential importance of the SOA-ammonia uptake mechanism on air quality over China in summer and winter 2017, considering a range of assumed NH3 uptake coefficients (10−3–10−5). Our results show that uptake of NH3 by SOA leads to a decrease in gas-phase NH3 mixing ratio, by as much as 27.5% and 19.0% for the highest uptake coefficient scenario (10−3) in summer and winter, respectively. The largest reduction of ammonia occurs over the Sichuan Basin and the North China Plain. The reduction of gas-phase NH3 engenders a decrease of ammonium nitrate, by up to 30%, but has little impact on the ammonium sulfate concentration. Uptake of NH3 does not significantly affect SOA concentrations owing to overall moderate changes in aerosol acidity, and thus small effects on SOA formation from isoprene. Altogether, NH3 uptake led to a reduction in the average PM2.5 concentration up to 8.9% and 8.7% for the highest uptake coefficient (10−3) in summer and winter, respectively. These results highlight the need for better constraints on the NH3-SOA interactions.
Published: 2021

45. An empirical study of I/O separation for burst buffers in HPC systems

Author: Koo, D, Lee, J, Liu, J, Byun, EK, Kwak, JH, Lockwood, GK, Hwang, S, Antypas, K, Wu, K, and Eom, H
Subjects: Burst buffer, Multi-streamed SSD, I/O separation, Stream-aware, Evaluation, Distributed Computing, Computer Software
Abstract: To meet the exascale I/O requirements for the High-Performance Computing (HPC), a new I/O subsystem, Burst Buffer, based on solid state drives (SSD), has been developed. However, the diverse HPC workloads and the bursty I/O pattern cause severe data fragmentation that requires costly garbage collection (GC) and increases the number of bytes written to the SSD. To address this data fragmentation challenge, a new multi-stream feature has been developed for SSDs. In this work, we develop an I/O Separation scheme called BIOS to leverage this multi-stream feature to group the I/O streams based on the user IDs. We propose a stream-aware scheduling policy based on burst buffer pools in the workload manager, and integrate the BIOS with the workload manager to optimize the I/O separation scheme in burst buffer. We evaluate the proposed framework with a burst buffer I/O traces from Cori Supercomputer including a diverse set of applications. Experimental results show that the BIOS could improve the performance by 1.44x on average and reduce the Write Amplification Factor (WAF) by up to 1.20x. These demonstrate the potential benefits of the I/O separation scheme for solid state storage systems.
Published: 2021

46. Establishment and Application Evaluation of an Improved Obstructive Sleep Apnea Screening Questionnaire for Chinese Community: The CNCQ-OSA

Author: Wang D, Ren Y, Chen R, Zeng X, Gan Q, Zhuang Z, Su X, Wu K, Zhang S, Tang Y, Li S, Zhang H, Zhou Y, Zhang N, and Zhao D
Subjects: obstructive sleep apnea, screening, goal, stop-bang, nosas, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Donghao Wang,1,&ast; Yingying Ren,2,&ast; Riken Chen,1,&ast; Xiangxia Zeng,1,&ast; Qiming Gan,1,&ast; Zhiyang Zhuang,1 Xiaofen Su,1 Kang Wu,1 Sun Zhang,1 Yongkang Tang,1 Shiwei Li,1 Haojie Zhang,1,3 Yanyan Zhou,1 Nuofu Zhang,1 Dongxing Zhao1 1State Key Laboratory of Respiratory Disease, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, National Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Medical Records and Statistics Room, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 3The Clinical Medicine Department, Henan University, Zhengzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Dongxing Zhao; Nuofu Zhang, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, National Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China, Tel +86-13650901411 ; +86-13600460056, Email rieast@msn.com; nfzhanggird@163.comObjective: Obstructive sleep apnea (OSA) is a common sleep-disordered breathing disease. We aimed to establish an improved screening questionnaire without physical examinations for OSA named the CNCQ-OSA (Chinese community questionnaire for OSA).Methods: A total of 2585 participants who visited sleep medicine center and underwent overnight polysomnography were grouped into two independent cohorts: derivation (n = 2180) and validation (n = 405). The CNCQ-OSA was designed according to the baseline of patients in derivation cohort. We comprehensively analyzed the data to evaluate the predictive value of the CNCQ-OSA, compared to the GOAL questionnaire, STOP-Bang questionnaire (SBQ) and NoSAS questionnaire.Results: The CNCQ-OSA included seven variables: loud snoring, BMI ≥ 25 kg/m2, male gender, apnea, sleepiness, hypertension and age ≥ 30, with a total score ranging from 7 to 16.7 points (≥ 13.5 points indicating high risk of OSA, ≥ 14.5 points indicating extremely high risk). In the derivation and validation cohorts, the areas under the curve of the CNCQ-OSA were 0.761 and 0.767, respectively. In the validation cohort, the sensitivity and specificity of a CNCQ-OSA score ≥ 13.5 points for the apnea–hypopnea index (AHI) ≥ 5/h were 0.821 and 0.559, respectively (Youden index, 0.380), and the score ≥ 14.5 points were 0.494 and 0.887, respectively (Youden index, 0.375). The CNCQ-OSA had a better predictive value for AHI ≥ 5/h, AHI > 15/h and AHI > 30/h, with the highest Youden index, compared to the other questionnaires.Conclusion: The CNCQ-OSA can effectively identify the risk of OSA, which is appropriate for self-screening at home without physical examinations.Keywords: obstructive sleep apnea, screening, GOAL, STOP-Bang, NoSAS
Published: 2023

47. Antimicrobial Resistance Patterns, Sequence Types, Virulence and Carbapenemase Genes of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates from a Tertiary Care Teaching Hospital in Zunyi, China

Author: Shen M, Chen X, He J, Xiong L, Tian R, Yang G, Zha H, and Wu K
Subjects: klebsiella pneumonia, antimicrobial resistance gene, virulence gene, sequence type., Infectious and parasitic diseases, RC109-216
Abstract: Meijing Shen,&ast; Xianghao Chen,&ast; Jingyue He, Lin Xiong, Rengui Tian, Guangwu Yang, He Zha, Kaifeng Wu Department of Laboratory Medicine, the First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Kaifeng Wu; He Zha, Department of Laboratory Medicine, the First People’s Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, People’s Republic of China, Email kiphoonwu@126.com; zhahe666@126.comPurpose: Carbapenem-resistant Klebsiella pneumoniae (CRKP) has seriously threatened public health worldwide. This study aimed to investigate the antimicrobial resistance patterns, sequence types (STs), virulence and carbapenemase genes of CRKP isolates from patients in Zunyi, China.Methods: CRKP isolates were collected from the First People’s Hospital of Zunyi between January 2018 and December 2020. Antimicrobial susceptibility was determined using a VITEK® 2 analyzer and confirmed using either the broth dilution method, Kirby–Bauer method, or E-test assays. Carbapenemase production was examined using a modified carbapenem inactivation method. STs of the studied isolates were determined by multilocus sequence typing, and the presence of carbapenemase and virulence genes was examined using polymerase chain reaction assays.Results: In total, 94 CRKP isolates were collected. All studied isolates produced carbapenemase, and the most common carbapenemase gene was New Delhi metallo-β-lactamase (NDM; 72.3%), followed by Klebsiella pneumoniae carbapenemase (KPC; 24.5%), and Verona integron-encoded metallo-β-lactamase (VIM; 3.2%). Of the studied isolates, 74.3% exhibited multidrug-resistant (MDR) phenotype, and 25.7% were either pandrug-resistant (PDR) or extensively drug-resistant (XDR) phenotypes. The most prevalent sequence type was ST2407 (37.2%), followed by ST76 (21.3%) and ST11 (11.7%). The NDM gene was present in 97.1% of ST2407 isolates and 90.0% of ST76 isolates, whereas the KPC gene was present in 90.9% of ST11 isolates. The majority of the isolates carried wabG, uge, and fimH virulence genes, with prevalence rates of 94.7%, 92.6%, and 94.7%, respectively.Conclusion: This study describes NDM-producing ST2407 and ST76, as well as KPC-producing ST11, as the major clonal types of CRKP isolates in Zunyi, China. All CRKP isolates were resistant to multiple types of antibiotics, and the majority of isolates carried carbapenemase and virulence genes. Clonal spread of NDM-producing CRKP ST2407 and ST76, and KPC-producing CRKP ST11 should be strictly monitored.Keywords: Klebsiella pneumoniae, antimicrobial resistance patterns, virulence genes, sequence types, carbapenemase genes
Published: 2023

48. Temporal Trends in the Disease Burden of Colorectal Cancer with Its Risk Factors at the Global and National Level from 1990 to 2019, and Projections Until 2044

Author: Liu Y, Zhang C, Wang Q, Wu K, Sun Z, Tang Z, and Zhang B
Subjects: global burden of disease, colorectal cancer, disability-adjusted life year, estimated annual percentage change, age-standardized incidence rate, bapc: bayesian age-period-cohort, Infectious and parasitic diseases, RC109-216
Abstract: Yang Liu,1 Chao Zhang,2 Qianwen Wang,1 Kangze Wu,3 Zhouyi Sun,1 Zhe Tang,1 Bo Zhang3 1The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, 322000, People’s Republic of China; 2Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 3The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, People’s Republic of ChinaCorrespondence: Bo Zhang, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310000, People’s Republic of China, Tel/Fax +86-0571-87783563, Email jjs10@zju.edu.cnBackground: This study aimed to evaluate the global colorectal cancer(CRC) trend and the relevant risk factors from 1990 to 2019 and for better policymaking and resource allocation.Methods: Data on CRC, including incidence, mortality and disability adjusted life year (DALY) rates, were extracted from the 2019 Global Burden of Disease (GBD) study. The estimated annual percentage changes (EAPCs) were calculated to assess the temporal trend of incidence, mortality and DALYs. The Bayesian age-period-cohort model(BAPC) was used to predict the future burden of CRC.Results: In 2019, a total of 2.17 million CRC cases were reported worldwide, a 157% increase from 1990. In high-social demographic index (SDI) regions, the trend of age-standardized incidence rate(ASIR) tended to decrease, while the proportion of people under 50 years of age tended to increase. Although the number of deaths and DALYs increased, the age-standardized death rate (ASDR) and age-standardized DALY rate decreased. The CRC burden was growing fastest in middle-SDI regions, especially in East Asia, followed by low SDI regions. In addition, the milk intake, High-BMI and high fasting plasma glucose play a more important role in on CRC. The predicted cases and deaths in global continued to increase to 2044. And there is an upward trend in ASIR for both men and women.Conclusion: In developed regions, the CRC burden continues to decrease, while the CRC burden become more and more severe in developing regions. Overall, the burden of CRC will rising in the near future. Therefore, reasonable resource allocation and prevention policies should be implemented. Developing countries needs more attention.Keywords: global burden of disease, colorectal cancer, disability-adjusted life year, estimated annual percentage change, age-standardized incidence rate, Bayesian age-period-cohort
Published: 2023

49. Enhancing IoT Anomaly Detection Performance for Federated Learning

Author: Weinger, Brett, Kim, Jinoh, Sim, Alex, Nakashima, Makiya, Moustafa, Nour, and Wu, K John
Subjects: Federated Learning, Internet of Things, Anomaly Detection, Machine Learning
Abstract: While federated learning (FL) has gained great attention for mobile and Internet of Things (IoT) computing with the benefits of scalable cooperative learning and privacy protection capabilities, there still exist a great deal of technical challenges to make it practically deployable. For instance, the distribution of the training process to a myriad of devices limits the classification performance of machine learning (ML) algorithms, often showing a significantly degraded accuracy compared to centralized learning. In this paper, we investigate the problem of performance limitation under FL and present the benefit of data augmentation with an application of anomaly detection using an IoT dataset. Our initial study reveals that one of the critical reasons for the performance degradation is that each device sees only a small fraction of data (that it generates), which limits the efficacy of the local ML model (constructed by the device). This becomes more critical if the data holds the class imbalance problem, observed not infrequently in practice (e.g., a small fraction of anomalies). Moreover, device heterogeneity with respect to data quantity is an open challenge in FL. Based on these observations, we examine the impact of data augmentation on detection performance in FL settings (both homogeneous and heterogeneous). Our experimental results show that even a simple random oversampling can improve detection performance with manageable learning complexity.
Published: 2020

50. Effective Missing Value Imputation Methods for Building Monitoring Data

Author: Cho, B, Dayrit, T, Gao, Y, Wang, Z, Hong, T, Sim, A, and Wu, K
Subjects: Matrix factorization, interpolation, imputation, building monitoring, Bioengineering
Abstract: To understand behaviors of natural and man-made events, such as energy consumption of buildings, which accounts for 40% of energy uses in the US, we deploy automated monitoring devices to record periodic observations. However, such experimental and observation data often contains problems and irregularities that have to be cleaned up before analyses. Due to various conditions affecting sensor operations, the communication channels, recording steps, or the recording media, the recorded data might have missing values, errors, or anomalous values. An effective way to clean up these problems is to replace these missing values, errors and anomalous values with expected values, a process generally known as imputation. In this work, we survey commonly used missing value imputation techniques and compare their performance on a set of building monitoring data. To compare the different types of sensor measurements with widely varying characteristics, we use normalized root mean squared error (NRMSE) as the key metric for the effectiveness of the imputation methods. We additionally consider periodicity and run time when considering comparing methods. Through extensive testing, we find that for small gap sizes, up to 8 consecutive missing values, linear interpolation performs the best; for larger gaps stretching up to 48 consecutive missing values, K-nearest neighbors provides the most accurate imputations; for even larger gaps, more computational intensive methods, such as matrix factorization, achieve the smallest NRMSE. Additionally, we observe that these computationally intensive algorithms not only provide accurate imputations for large gaps, but are also more robust across all types of sensors.
Published: 2020

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