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4. sj-pdf-1-mde-10.1177_23821205231173289 - Supplemental material for Academic and Wellness Outcomes Associated with use of Anki Spaced Repetition Software in Medical School

Author

Wothe, Jillian K, Wanberg, Lindsey J, Hohle, Rae D, Sakher, Aliya A, Bosacker, Laura E, Khan, Faizel, Olson, Andrew PJ, and Satin, David J

Subjects
Education
Abstract

Supplemental material, sj-pdf-1-mde-10.1177_23821205231173289 for Academic and Wellness Outcomes Associated with use of Anki Spaced Repetition Software in Medical School by Jillian K Wothe, Lindsey J Wanberg, Rae D Hohle, Aliya A Sakher, Laura E Bosacker, Faizel Khan, Andrew PJ Olson and David J Satin in Journal of Medical Education and Curricular Development

Published
2023
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8. Increasing Mortality in Venovenous Extracorporeal Membrane Oxygenation for COVID-19–Associated Acute Respiratory Distress Syndrome

Author

Braaten, Jacob A., primary, Bergman, Zachary R., additional, Wothe, Jillian K., additional, Lofrano, Arianna E., additional, Matzek, Luke J., additional, Doucette, Melissa, additional, Saavedra-Romero, Ramiro, additional, Bohman, John K., additional, Prekker, Matthew E., additional, Lusczek, Elizabeth R., additional, and Brunsvold, Melissa E., additional

Published
2022
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11. Pass/fail assessment: Student, resident, and faculty attitudes.

Author

WOTHE, JILLIAN K. and RAMASWAMY, ARCHANA

Subjects
COLLEGE teacher attitudes, TEACHER attitudes, CLINICAL clerkship, MEDICAL students, RESIDENTS, CONVENIENCE sampling (Statistics)
Abstract

The article offers information on the Medical education which is changing rapidly, with preclinical grades, U.S. Medical Licensing Examination Step 1, and clinical clerkships transitioning to pass/fail reporting rather than numerical scores and tiered grading. It discusses that studies have been done examining the views of those affected by these changes, such as medical students, resident physicians, and attending physicians.

Published
2022

13. Uncoupling the mitochondria facilitates alternans formation in the isolated rabbit heart.

Author

Smith RM, Visweswaran R, Talkachova I, Wothe JK, and Tolkacheva EG

Subjects
Animals, Calcium metabolism, Calcium Signaling, Heart drug effects, In Vitro Techniques, Mitochondria, Heart drug effects, Myocardial Ischemia metabolism, Myocardial Ischemia physiopathology, Rabbits, Ventricular Dysfunction metabolism, Ventricular Dysfunction physiopathology, Action Potentials, Heart physiopathology, Mitochondria, Heart metabolism, Myocardium metabolism, Uncoupling Agents pharmacology
Abstract

Alternans of action potential duration (APD) and intracellular calcium ([Ca²⁺]i) transients in the whole heart are thought to be markers of increased propensity to ventricular fibrillation during ischemia-reperfusion injuries. During ischemia, ATP production is affected and the mitochondria become uncoupled, which may affect alternans formation in the heart. The aim of our study was to investigate the role of mitochondria on the formation of APD and [Ca²⁺]i alternans in the isolated rabbit heart. We performed dual voltage and [Ca²⁺]i optical mapping of isolated rabbit hearts under control conditions, global no-flow ischemia (n = 6), and after treatment with 50 nM of the mitochondrial uncoupler FCCP (n = 6). We investigated the formation of alternans of APD, [Ca²⁺]i amplitude (CaA), and [Ca²⁺]i duration (CaD) under different rates of pacing. We found that treatment with FCCP leads to the early occurrence of APD, CaD, and CaA alternans; an increase of intraventricular APD but not CaD heterogeneity; and significant reduction in conduction velocity compared with that of control. Furthermore, we demonstrated that FCCP and global ischemia have similar effects on the prolongation of [Ca²⁺]i transients, whereas ischemia induces a significantly larger reduction of APD compared with that in FCCP treatment. In conclusion, our results demonstrate that uncoupling of mitochondria leads to an earlier occurrence of alternans in the heart. Thus, in conditions of mitochondrial stress, as seen during myocardial ischemia, uncoupled mitochondria may be responsible for the formation of both APD and [Ca²⁺]i alternans in the heart, which in turn creates a substrate for ventricular arrhythmias.

Published
2013
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