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6. A qualitative assessment of community perceptions and practices towards schistosomiasis prior to introduction of a potential novel treatment option for preschool-age children in Kenya

Author

Masaku, Janet, primary, Gachohi, John M., additional, Sinkeet, Alice, additional, Maghanga, Mary, additional, Wakesho, Florence, additional, Omondi, Wyckliff, additional, Reigl, Lisa Sophie, additional, Lange, Isabelle L., additional, Winkler, Andrea S., additional, Njenga, Sammy M., additional, and Amuyunzu-Nyamongo, Mary, additional

Published
2024
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8. Global brain health—the time to act is now

Author

Winkler, Andrea S, primary, Gupta, Saksham, additional, Patel, Vikram, additional, Bhebhe, Arnold, additional, Fleury, Agnès, additional, Aukrust, Camilla G, additional, Dua, Tarun, additional, Welte, Tamara M, additional, Chakraborty, Sarbani, additional, and Park, Kee B, additional

Published
2024
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11. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study

Author

Roth, Gregory A., Mensah, George A., Johnson, Catherine O., Addolorato, Giovanni, Ammirati, Enrico, Baddour, Larry M., Barengo, Noel C., Beaton, Andrea, Benjamin, Emelia J., Benziger, Catherine P., Bonny, Aime, Brauer, Michael, Brodmann, Marianne, Cahill, Thomas J., Carapetis, Jonathan R., Catapano, Alberico L., Chugh, Sumeet, Cooper, Leslie T., Coresh, Josef, Criqui, Michael H., DeCleene, Nicole K., Eagle, Kim A., Emmons-Bell, Sophia, Feigin, Valery L., Fernández-Sola, Joaquim, Fowkes, F. Gerry R., Gakidou, Emmanuela, Grundy, Scott M., He, Feng J., Howard, George, Hu, Frank, Inker, Lesley, Karthikeyan, Ganesan, Kassebaum, Nicholas J., Koroshetz, Walter J., Lavie, Carl, Lloyd-Jones, Donald, Lu, Hong S., Mirijello, Antonio, Misganaw, Awoke T., Mokdad, Ali H., Moran, Andrew E., Muntner, Paul, Narula, Jagat, Neal, Bruce, Ntsekhe, Mpiko, Oliveira, Gláucia M.M., Otto, Catherine M., Owolabi, Mayowa O., Pratt, Michael, Rajagopalan, Sanjay, Reitsma, Marissa B., Ribeiro, Antonio Luiz P., Rigotti, Nancy A., Rodgers, Anthony, Sable, Craig A., Shakil, Saate S., Sliwa, Karen, Stark, Benjamin A., Sundström, Johan, Timpel, Patrick, Tleyjeh, Imad I., Valgimigli, Marco, Vos, Theo, Whelton, Paul K., Yacoub, Magdi, Zuhlke, Liesl J., Abbasi-Kangevari, Mohsen, Abdi, Alireza, Abedi, Aidin, Aboyans, Victor, Abrha, Woldu A., Abu-Gharbieh, Eman, Abushouk, Abdelrahman I., Acharya, Dilaram, Adair, Tim, Adebayo, Oladimeji M., Ademi, Zanfina, Advani, Shailesh M., Afshari, Khashayar, Afshin, Ashkan, Agarwal, Gina, Agasthi, Pradyumna, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Muktar B., Aji, Budi, Akalu, Yonas, Akande-Sholabi, Wuraola, Aklilu, Addis, Akunna, Chisom J., Alahdab, Fares, Al-Eyadhy, Ayman, Alhabib, Khalid F., Alif, Sheikh M., Alipour, Vahid, Aljunid, Syed M., Alla, François, Almasi-Hashiani, Amir, Almustanyir, Sami, Al-Raddadi, Rajaa M., Amegah, Adeladza K., Amini, Saeed, Aminorroaya, Arya, Amu, Hubert, Amugsi, Dickson A., Ancuceanu, Robert, Anderlini, Deanna, Andrei, Tudorel, Andrei, Catalina Liliana, Ansari-Moghaddam, Alireza, Anteneh, Zelalem A., Antonazzo, Ippazio Cosimo, Antony, Benny, Anwer, Razique, Appiah, Lambert T., Arabloo, Jalal, Ärnlöv, Johan, Artanti, Kurnia D., Ataro, Zerihun, Ausloos, Marcel, Avila-Burgos, Leticia, Awan, Asma T., Awoke, Mamaru A., Ayele, Henok T., Ayza, Muluken A., Azari, Samad, B, Darshan B., Baheiraei, Nafiseh, Baig, Atif A., Bakhtiari, Ahad, Banach, Maciej, Banik, Palash C., Baptista, Emerson A., Barboza, Miguel A., Barua, Lingkan, Basu, Sanjay, Bedi, Neeraj, Béjot, Yannick, Bennett, Derrick A., Bensenor, Isabela M., Berman, Adam E., Bezabih, Yihienew M., Bhagavathula, Akshaya S., Bhaskar, Sonu, Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Boris, Birhanu, Mulugeta M., Boloor, Archith, Brant, Luisa C., Brenner, Hermann, Briko, Nikolay I., Butt, Zahid A., Caetano dos Santos, Florentino Luciano, Cahill, Leah E., Cahuana-Hurtado, Lucero, Cámera, Luis A., Campos-Nonato, Ismael R., Cantu-Brito, Carlos, Car, Josip, Carrero, Juan J., Carvalho, Felix, Castañeda-Orjuela, Carlos A., Catalá-López, Ferrán, Cerin, Ester, Charan, Jaykaran, Chattu, Vijay Kumar, Chen, Simiao, Chin, Ken L., Choi, Jee-Young J., Chu, Dinh-Toi, Chung, Sheng-Chia, Cirillo, Massimo, Coffey, Sean, Conti, Sara, Costa, Vera M., Cundiff, David K., Dadras, Omid, Dagnew, Baye, Dai, Xiaochen, Damasceno, Albertino A.M., Dandona, Lalit, Dandona, Rakhi, Davletov, Kairat, De la Cruz-Góngora, Vanessa, De la Hoz, Fernando P., De Neve, Jan-Walter, Denova-Gutiérrez, Edgar, Derbew Molla, Meseret, Derseh, Behailu T., Desai, Rupak, Deuschl, Günther, Dharmaratne, Samath D., Dhimal, Meghnath, Dhungana, Raja Ram, Dianatinasab, Mostafa, Diaz, Daniel, Djalalinia, Shirin, Dokova, Klara, Douiri, Abdel, Duncan, Bruce B., Duraes, Andre R., Eagan, Arielle W., Ebtehaj, Sanam, Eftekhari, Aziz, Eftekharzadeh, Sahar, Ekholuenetale, Michael, El Nahas, Nevine, Elgendy, Islam Y., Elhadi, Muhammed, El-Jaafary, Shaimaa I., Esteghamati, Sadaf, Etisso, Atkilt E., Eyawo, Oghenowede, Fadhil, Ibtihal, Faraon, Emerito Jose A., Faris, Pawan S., Farwati, Medhat, Farzadfar, Farshad, Fernandes, Eduarda, Fernandez Prendes, Carlota, Ferrara, Pietro, Filip, Irina, Fischer, Florian, Flood, David, Fukumoto, Takeshi, Gad, Mohamed M., Gaidhane, Shilpa, Ganji, Morsaleh, Garg, Jalaj, Gebre, Abadi K., Gebregiorgis, Birhan G., Gebregzabiher, Kidane Z., Gebremeskel, Gebreamlak G., Getacher, Lemma, Obsa, Abera Getachew, Ghajar, Alireza, Ghashghaee, Ahmad, Ghith, Nermin, Giampaoli, Simona, Gilani, Syed Amir, Gill, Paramjit S., Gillum, Richard F., Glushkova, Ekaterina V., Gnedovskaya, Elena V., Golechha, Mahaveer, Gonfa, Kebebe B., Goudarzian, Amir Hossein, Goulart, Alessandra C., Guadamuz, Jenny S., Guha, Avirup, Guo, Yuming, Gupta, Rajeev, Hachinski, Vladimir, Hafezi-Nejad, Nima, Haile, Teklehaimanot G., Hamadeh, Randah R., Hamidi, Samer, Hankey, Graeme J., Hargono, Arief, Hartono, Risky K., Hashemian, Maryam, Hashi, Abdiwahab, Hassan, Shoaib, Hassen, Hamid Y., Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Herteliu, Claudiu, Holla, Ramesh, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Huang, Junjie, Humayun, Ayesha, Iavicoli, Ivo, Ibeneme, Charles U., Ibitoye, Segun E., Ilesanmi, Olayinka S., Ilic, Irena M., Ilic, Milena D., Iqbal, Usman, Irvani, Seyed Sina N., Islam, Sheikh Mohammed Shariful, Islam, Rakibul M., Iso, Hiroyasu, Iwagami, Masao, Jain, Vardhmaan, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jayawardena, Ranil, Jeemon, Panniyammakal, Jha, Ravi P., Jonas, Jost B., Jonnagaddala, Jitendra, Joukar, Farahnaz, Jozwiak, Jacek J., Jürisson, Mikk, Kabir, Ali, Kahlon, Tanvir, Kalani, Rizwan, Kalhor, Rohollah, Kamath, Ashwin, Kamel, Ibrahim, Kandel, Himal, Kandel, Amit, Karch, André, Kasa, Ayele Semachew, Katoto, Patrick D.M.C., Kayode, Gbenga A., Khader, Yousef S., Khammarnia, Mohammad, Khan, Muhammad S., Khan, Md Nuruzzaman, Khan, Maseer, Khan, Ejaz A., Khatab, Khaled, Kibria, Gulam M.A., Kim, Yun Jin, Kim, Gyu Ri, Kimokoti, Ruth W., Kisa, Sezer, Kisa, Adnan, Kivimäki, Mika, Kolte, Dhaval, Koolivand, Ali, Korshunov, Vladimir A., Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kulkarni, Vaman, Kumar, G. Anil, Kumar, Nithin, Kurmi, Om P., Kusuma, Dian, Kwan, Gene F., La Vecchia, Carlo, Lacey, Ben, Lallukka, Tea, Lan, Qing, Lasrado, Savita, Lassi, Zohra S., Lauriola, Paolo, Lawrence, Wayne R., Laxmaiah, Avula, LeGrand, Kate E., Li, Ming-Chieh, Li, Bingyu, Li, Shanshan, Lim, Stephen S., Lim, Lee-Ling, Lin, Hualiang, Lin, Ziqiang, Lin, Ro-Ting, Liu, Xuefeng, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lugo, Alessandra, M, Nirmal K., Madotto, Fabiana, Mahmoudi, Morteza, Majeed, Azeem, Malekzadeh, Reza, Malik, Ahmad A., Mamun, Abdullah A., Manafi, Navid, Mansournia, Mohammad Ali, Mantovani, Lorenzo G., Martini, Santi, Mathur, Manu R., Mazzaglia, Giampiero, Mehata, Suresh, Mehndiratta, Man Mohan, Meier, Toni, Menezes, Ritesh G., Meretoja, Atte, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R., Mirrakhimov, Erkin M., Mirzaei, Hamed, Moazen, Babak, Moghadaszadeh, Masoud, Mohammad, Yousef, Mohammad, Dara K., Mohammed, Shafiu, Mohammed, Mohammed A., Mokhayeri, Yaser, Molokhia, Mariam, Montasir, Ahmed A., Moradi, Ghobad, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Moreno Velásquez, Ilais, Morze, Jakub, Mubarik, Sumaira, Muruet, Walter, Musa, Kamarul Imran, Nagarajan, Ahamarshan J., Nalini, Mahdi, Nangia, Vinay, Naqvi, Atta Abbas, Narasimha Swamy, Sreenivas, Nascimento, Bruno R., Nayak, Vinod C., Nazari, Javad, Nazarzadeh, Milad, Negoi, Ruxandra I., Neupane Kandel, Sandhya, Nguyen, Huong L.T., Nixon, Molly R., Norrving, Bo, Noubiap, Jean Jacques, Nouthe, Brice E., Nowak, Christoph, Odukoya, Oluwakemi O., Ogbo, Felix A., Olagunju, Andrew T., Orru, Hans, Ortiz, Alberto, Ostroff, Samuel M., Padubidri, Jagadish Rao, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Parekh, Utsav, Park, Eun-Cheol, Parvizi, Mojtaba, Pashazadeh Kan, Fatemeh, Patel, Urvish K., Pathak, Mona, Paudel, Rajan, Pepito, Veincent Christian F., Perianayagam, Arokiasamy, Perico, Norberto, Pham, Hai Q., Pilgrim, Thomas, Piradov, Michael A., Pishgar, Farhad, Podder, Vivek, Polibin, Roman V., Pourshams, Akram, Pribadi, Dimas R.A., Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Ur Rahman, Mohammad Hifz, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rakovac, Ivo, Ram, Pradhum, Ramalingam, Sudha, Rana, Juwel, Ranasinghe, Priyanga, Rao, Sowmya J., Rathi, Priya, Rawal, Lal, Rawasia, Wasiq F., Rawassizadeh, Reza, Remuzzi, Giuseppe, Renzaho, Andre M.N., Rezapour, Aziz, Riahi, Seyed Mohammad, Roberts-Thomson, Ross L., Roever, Leonardo, Rohloff, Peter, Romoli, Michele, Roshandel, Gholamreza, Rwegerera, Godfrey M., Saadatagah, Seyedmohammad, Saber-Ayad, Maha M., Sabour, Siamak, Sacco, Simona, Sadeghi, Masoumeh, Saeedi Moghaddam, Sahar, Safari, Saeed, Sahebkar, Amirhossein, Salehi, Sana, Salimzadeh, Hamideh, Samaei, Mehrnoosh, Samy, Abdallah M., Santos, Itamar S., Santric-Milicevic, Milena M., Sarrafzadegan, Nizal, Sarveazad, Arash, Sathish, Thirunavukkarasu, Sawhney, Monika, Saylan, Mete, Schmidt, Maria I., Schutte, Aletta E., Senthilkumaran, Subramanian, Sepanlou, Sadaf G., Sha, Feng, Shahabi, Saeed, Shahid, Izza, Shaikh, Masood A., Shamali, Mahdi, Shamsizadeh, Morteza, Shawon, Md Shajedur Rahman, Sheikh, Aziz, Shigematsu, Mika, Shin, Min-Jeong, Shin, Jae Il, Shiri, Rahman, Shiue, Ivy, Shuval, Kerem, Siabani, Soraya, Siddiqi, Tariq J., Silva, Diego A.S., Singh, Jasvinder A., Mtech, Ambrish Singh, Skryabin, Valentin Y., Skryabina, Anna A., Soheili, Amin, Spurlock, Emma E., Stockfelt, Leo, Stortecky, Stefan, Stranges, Saverio, Suliankatchi Abdulkader, Rizwan, Tadbiri, Hooman, Tadesse, Eyayou G., Tadesse, Degena B., Tajdini, Masih, Tariqujjaman, Md, Teklehaimanot, Berhane F., Temsah, Mohamad-Hani, Tesema, Ayenew K., Thakur, Bhaskar, Thankappan, Kavumpurathu R., Thapar, Rekha, Thrift, Amanda G., Timalsina, Binod, Tonelli, Marcello, Touvier, Mathilde, Tovani-Palone, Marcos R., Tripathi, Avnish, Tripathy, Jaya P., Truelsen, Thomas C., Tsegay, Guesh M., Tsegaye, Gebiyaw W., Tsilimparis, Nikolaos, Tusa, Biruk S., Tyrovolas, Stefanos, Umapathi, Krishna Kishore, Unim, Brigid, Unnikrishnan, Bhaskaran, Usman, Muhammad S., Vaduganathan, Muthiah, Valdez, Pascual R., Vasankari, Tommi J., Velazquez, Diana Z., Venketasubramanian, Narayanaswamy, Vu, Giang T., Vujcic, Isidora S., Waheed, Yasir, Wang, Yanzhong, Wang, Fang, Wei, Jingkai, Weintraub, Robert G., Weldemariam, Abrha H., Westerman, Ronny, Winkler, Andrea S., Wiysonge, Charles S., Wolfe, Charles D.A., Wubishet, Befikadu Legesse, Xu, Gelin, Yadollahpour, Ali, Yamagishi, Kazumasa, Yan, Lijing L., Yandrapalli, Srikanth, Yano, Yuichiro, Yatsuya, Hiroshi, Yeheyis, Tomas Y., Yeshaw, Yigizie, Yilgwan, Christopher S., Yonemoto, Naohiro, Yu, Chuanhua, Yusefzadeh, Hasan, Zachariah, Geevar, Zaman, Sojib Bin, Zaman, Muhammed S., Zamanian, Maryam, Zand, Ramin, Zandifar, Alireza, Zarghi, Afshin, Zastrozhin, Mikhail S., Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhang, Yunquan, Zhang, Wangjian, Zhong, Chenwen, Zou, Zhiyong, Zuniga, Yves Miel H., Murray, Christopher J.L., Fuster, Valentin, Barengo, Noël C., Beaton, Andrea Z., Bonny, Aimé, Carapetis, Jonathan, Chugh, Sumeet S., Criqui, Michael, DeCleene, Nicole, Fernández-Solà, Joaquim, Fowkes, Gerry, Kassebaum, Nicholas, Koroshetz, Walter, Temesgen, Awoke Misganaw, Mokdad, Ali, Moraes de Oliveira, Glaucia, Otto, Catherine, Owolabi, Mayowa, Reitsma, Marissa, Rigotti, Nancy, Sable, Craig, Shakil, Saate, Sliwa-Hahnle, Karen, Stark, Benjamin, Tleyjeh, Imad M., Zuhlke, Liesl, and Murray, Christopher

Published
2020
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14. In‐depth analysis of data from the RAS‐ALS study reveals new insights in rasagiline treatment for amyotrophic lateral sclerosis.

Author

Schuster, Joachim, Dreyhaupt, Jens, Mönkemöller, Karla, Dupuis, Luc, Dieterlé, Stéphane, Weishaupt, Jochen H., Kassubek, Jan, Petri, Susanne, Meyer, Thomas, Grosskreutz, Julian, Schrank, Berthold, Boentert, Matthias, Emmer, Alexander, Hermann, Andreas, Zeller, Daniel, Prudlo, Johannes, Winkler, Andrea S., Grehl, Torsten, Heneka, Michael T., and Johannesen, Siw

Subjects
AMYOTROPHIC lateral sclerosis, SINGLE nucleotide polymorphisms, DATA analysis, RANDOMIZED controlled trials, STATISTICAL power analysis
Abstract

Background and purpose: In 2016, we concluded a randomized controlled trial testing 1 mg rasagiline per day add‐on to standard therapy in 252 amyotrophic lateral sclerosis (ALS) patients. This article aims at better characterizing ALS patients who could possibly benefit from rasagiline by reporting new subgroup analysis and genetic data. Methods: We performed further exploratory in‐depth analyses of the study population and investigated the relevance of single nucleotide polymorphisms (SNPs) related to the dopaminergic system. Results: Placebo‐treated patients with very slow disease progression (loss of Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised [ALSFRS‐R] per month before randomization of ≤0.328 points) showed a per se survival probability after 24 months of 0.85 (95% confidence interval = 0.65–0.94). The large group of intermediate to fast progressing ALS patients showed a prolonged survival in the rasagiline group compared to placebo after 6 and 12 months (p = 0.02, p = 0.04), and a reduced decline of ALSFRS‐R after 18 months (p = 0.049). SNP genotypes in the MAOB gene and DRD2 gene did not show clear associations with rasagiline treatment effects. Conclusions: These results underline the need to consider individual disease progression at baseline in future ALS studies. Very slow disease progressors compromise the statistical power of studies with treatment durations of 12–18 months using clinical endpoints. Analysis of MAOB and DRD2 SNPs revealed no clear relationship to any outcome parameter. More insights are expected from future studies elucidating whether patients with DRD2CC genotype (Rs2283265) show a pronounced benefit from treatment with rasagiline, pointing to the opportunities precision medicine could open up for ALS patients in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Epidemiology of intestinal helminthiasis with an emphasis on taeniasis in Chipata district of the Eastern province of Zambia

Author

Zulu, Gideon, primary, Sikasunge, Chummy S., additional, Welte, Tamara M., additional, Simuunza, Martin C., additional, Stelzle, Dominik, additional, Schmidt, Veronika, additional, Hachangu, Alex, additional, Mutale, Wilbroad, additional, Masuku, Maxwell, additional, Chembensofu, Mwelwa, additional, da Costa, Clarissa Prazeres, additional, Mwape, Kabemba E., additional, Winkler, Andrea S., additional, and Phiri, Isaac K., additional

Published
2023
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17. Epilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns

Author

Arndts, Kathrin, primary, Kegele, Josua, additional, Massarani, Alain S., additional, Ritter, Manuel, additional, Wagner, Thomas, additional, Pfarr, Kenneth, additional, Lämmer, Christine, additional, Dörmann, Peter, additional, Peisker, Helga, additional, Menche, Dirk, additional, Al-Bahra, Mazen, additional, Prazeres da Costa, Clarissa, additional, Schmutzhard, Erich, additional, Matuja, William, additional, Hoerauf, Achim, additional, Layland-Heni, Laura E., additional, and Winkler, Andrea S., additional

Published
2023
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19. The epidemiology of human Taenia solium infections: A systematic review of the distribution in Eastern and Southern Africa

Author

Zulu, Gideon, primary, Stelzle, Dominik, additional, Mwape, Kabemba E., additional, Welte, Tamara M., additional, Strømme, Hilde, additional, Mubanga, Chishimba, additional, Mutale, Wilbroad, additional, Abraham, Annette, additional, Hachangu, Alex, additional, Schmidt, Veronika, additional, Sikasunge, Chummy S., additional, Phiri, Isaac K., additional, and Winkler, Andrea S., additional

Published
2023
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20. Knowledge and misconceptions about epilepsy among people with epilepsy and their caregivers attending mental health clinics: A qualitative study in Taenia solium endemic pig‐keeping communities in Tanzania

Author

Makasi, Charles E, primary, Kilale, Andrew M, additional, Ngowi, Bernard J, additional, Lema, Yakobo, additional, Katiti, Victor, additional, Mahande, Michael J, additional, Msoka, Elizabeth F., additional, Stelzle, Dominik, additional, Winkler, Andrea S, additional, and Mmbaga, Blandina T., additional

Published
2023
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21. The use of artificial intelligence-based innovations in the health sector in Tanzania : A scoping review

Author

Sukums, Felix, Mzurikwao, Deogratias, Sabas, Deodatus, Chaula, Rebecca, Mbuke, Juliana, Kabika, Twaha, Kaswija, John, Ngowi, Bernard, Noll, Josef, Winkler, Andrea S., Wamala, Sarah, Sukums, Felix, Mzurikwao, Deogratias, Sabas, Deodatus, Chaula, Rebecca, Mbuke, Juliana, Kabika, Twaha, Kaswija, John, Ngowi, Bernard, Noll, Josef, Winkler, Andrea S., and Wamala, Sarah

Abstract

Background: Artificial Intelligence (AI) has great potential to transform health systems to improve the quality of healthcare services. However, AI is still new in Tanzania, and there is limited knowledge about the application of AI technology in the Tanzanian health sector.Objectives: This study aims to explore the current status, challenges, and opportunities for AI application in the health system in Tanzania. Methods: A scoping review was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis Extensions for Scoping Review (PRISMA-ScR). We searched different electronic databases such as PubMed, Embase, African Journal Online, and Google Scholar.Results: Eighteen (18) studies met the inclusion criteria out of 2,017 studies from different electronic databases and known AI-related project websites. Amongst AI-driven solutions, the studies mostly used machine learning (ML) and deep learning for various purposes, including prediction and diagnosis of diseases and vaccine stock optimisation. The most commonly used algorithms were conventional machine learning, including Random Forest and Neural network, Naive Bayes K-Nearest Neighbour and Logistic regression. Conclusions: This review shows that AI-based innovations may have a role in improving health service delivery, including early outbreak prediction and detection, disease diagnosis and treatment, and efficient management of healthcare resources in Tanzania. Our results indicate the need for developing national AI policies and regulatory frameworks for adopting responsible and ethical AI solutions in the health sector in accordance with the World Health Organisation (WHO) guidance on ethics and governance of AI for health.

Published
2023
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24. Correction to: Epidemiology of taeniosis/cysticercosis in Europe, a systematic review: eastern Europe

Author

Trevisan, Chiara, Sotiraki, Smaragda, Laranjo-González, Minerva, Dermauw, Veronique, Wang, Ziqi, Kärssin, Age, Cvetkovikj, Aleksandar, Winkler, Andrea S., Abraham, Annette, Bobić, Branko, Lassen, Brian, Cretu, Carmen Michaela, Vasile, Cozma, Arvanitis, Dimitris, Deksne, Gunita, Boro, Ilievski, Kucsera, István, Karamon, Jacek, Stefanovska, Jovana, Koudela, Břetislav, Pavlova, Maja Jurhar, Varady, Marian, Pavlak, Marina, Šarkūnas, Mindaugas, Kaminski, Miriam, Djurković-Djaković, Olgica, Jokelainen, Pikka, Jan, Dagny Stojčević, Schmidt, Veronika, Dakić, Zorica, Gabrië, Sarah, Dorny, Pierre, Omeragić, Jasmin, Alagić, Davor, and Devleesschauwer, Brecht

Published
2019
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26. Correction: Characteristics of people with epilepsy and Neurocysticercosis in three eastern African countries–A pooled analysis

Author

Stelzle, Dominik, primary, Schmidt, Veronika, additional, Keller, Luise, additional, Ngowi, Bernard J., additional, Matuja, William, additional, Escheu, Gabrielle, additional, Hauke, Peter, additional, Richter, Vivien, additional, Ovuga, Emilio, additional, Pfausler, Bettina, additional, Schmutzhard, Erich, additional, Amos, Action, additional, Harrison, Wendy, additional, Kaducu, Joyce, additional, and Winkler, Andrea S., additional

Published
2023
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28. Characteristics of people with epilepsy and Neurocysticercosis in three eastern African countries–A pooled analysis

Author

Stelzle, Dominik, primary, Schmidt, Veronika, additional, Keller, Luise, additional, Ngowi, Bernard J., additional, Matuja, William, additional, Escheu, Gabrielle, additional, Hauke, Peter, additional, Richter, Vivien, additional, Ovuga, Emilio, additional, Pfausler, Bettina, additional, Schmutzhard, Erich, additional, Amos, Action, additional, Harrison, Wendy, additional, Kaducu, Joyce, additional, and Winkler, Andrea S., additional

Published
2022
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29. Community-level prevalence of epilepsy and of neurocysticercosis among people with epilepsy in the Balaka district of Malawi: A cross-sectional study

Author

Keller, Luise, primary, Stelzle, Dominik, additional, Schmidt, Veronika, additional, Carabin, Hélène, additional, Reinhold, Ann-Kristin, additional, Keller, Claudius, additional, Welte, Tamara M., additional, Richter, Vivien, additional, Amos, Action, additional, Boeckman, Lindsay, additional, Harrison, Wendy, additional, and Winkler, Andrea S., additional

Published
2022
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30. Epidemiology of taeniosis/cysticercosis in Europe, a systematic review: eastern Europe

Author

Trevisan, Chiara, Sotiraki, Smaragda, Laranjo-González, Minerva, Dermauw, Veronique, Wang, Ziqi, Kärssin, Age, Cvetkovikj, Aleksandar, Winkler, Andrea S., Abraham, Annette, Bobić, Branko, Lassen, Brian, Cretu, Carmen Michaela, Vasile, Cozma, Arvanitis, Dimitris, Deksne, Gunita, Boro, Ilievski, Kucsera, István, Karamon, Jacek, Stefanovska, Jovana, Koudela, Břetislav, Pavlova, Maja Jurhar, Varady, Marian, Pavlak, Marina, Šarkūnas, Mindaugas, Kaminski, Miriam, Djurković-Djaković, Olgica, Jokelainen, Pikka, Jan, Dagny Stojčević, Schmidt, Veronika, Dakić, Zorica, Gabriël, Sarah, Dorny, Pierre, Omeragić, Jasmin, Alagić, Davor, and Devleesschauwer, Brecht

Published
2018
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32. Consensus Clinical Guidance for Diagnosis and Management of Adult COVID-19 Encephalopathy Patients

Author

Michael, Benedict D, Walton, Dean, Westenberg, Erica, García-Azorín, David, Singh, Bhagteshwar, Tamborska, Arina A, Netravathi, M, Chomba, Mashina, Wood, Greta K, Easton, Ava, Siddiqi, Omar K, Jackson, Thomas A, Pollak, Thomas A, Nicholson, Timothy R, Nair, Shalini, Breen, Gerome, Prasad, Kameshwar, Thakur, Kiran T, Chou, Sherry H-Y, Schmutzhard, Erich, Frontera, Jennifer A, Helbok, Raimund, Padovani, Alessandro, Menon, David K, Solomon, Tom, Winkler, Andrea S, and Global COVID-19 Neuro Research Coalition

Subjects
Psychiatry and Mental health, Neurology (clinical)
Abstract

Encephalopathy, a common condition among patients hospitalized with COVID-19, can be a challenge to manage and negatively affect prognosis. While encephalopathy may present clinically as delirium, subsyndromal delirium, or coma and may be a result of systemic causes such as hypoxia, COVID-19 has also been associated with more prolonged encephalopathy due to less common but nevertheless severe complications, such as inflammation of the brain parenchyma (with or without cerebrovascular involvement), demyelination, or seizures, which may be disproportionate to COVID-19 severity and require specific management. Given the large number of patients hospitalized with severe acute respiratory syndrome coronavirus-2 infection, even these relatively unlikely complications are increasingly recognized and are particularly important because they require specific management. Therefore, the aim of this review is to provide pragmatic guidance on the management of COVID-19 encephalopathy through consensus agreement of the Global COVID-19 Neuro Research Coalition. A systematic literature search of MEDLINE, medRxiv, and bioRxiv was conducted between January 1, 2020, and June 21, 2021, with additional review of references cited within the identified bibliographies. A modified Delphi approach was then undertaken to develop recommendations, along with a parallel approach to score the strength of both the recommendations and the supporting evidence. This review presents analysis of contemporaneous evidence for the definition, epidemiology, and pathophysiology of COVID-19 encephalopathy and practical guidance for clinical assessment, investigation, and both acute and long-term management.

Published
2022

33. Approaches to Understanding COVID‐19 and its Neurological Associations

Author

Beghi, Ettore, Michael, Benedict D., Solomon, Tom, Westenberg, Erica, Winkler, Andrea S., Knauss, Samuel, Sejvar, Jim, Siddiqi, Omar, Netravathi, M., Charway‐Felli, Augustina, Abd‐Allah, Foad, Bassetti, Claudio, Ferreira, Maria Lúcia Brito, Chou, Sherry Hsiang‐Yi, Dalmau, Josep, Delgado‐García, Guillermo, Easton, Ava, Emmrich, Julius, Endres, Matthias, Fleury, Agnès, Frontera, Jennifer A., García‐Azorín, David, Guekht, Alla, Helbok, Raimund, Hellwig, Kerstin, Höglinger, Günter, Hoo, Fan Kee, Klein, Christine, Lant, Suzannah, McNett, Molly, Moro, Elena, Padovani, Alessandro, Pfausler, Bettina, Prasad, Kameshwar, Roman, Gustavo C., Sarfo, Fred S., Satishchandra, Parthasarathy, Saylor, Deanna, Spatola, Marianna, Spencer, Peter, Stark, Richard J., Synofzik, Matthis, Taba, Pille, Tagliavini, Fabrizio, Thakur, Kiran T., Umapathi, Thirugnanam, Vijayabala, Jeevagan, Weissenborn, Karin, Wijeratne, Tissa, Wood, Greta K., Carroll, William M., Oreja‐Guevara, Celia, Leonardi, Matilde, and Schmutzhard, Erich

Subjects
0301 basic medicine, medicine.medical_specialty, Study quality, Coronavirus disease 2019 (COVID-19), business.industry, Clinical study design, Comparability, Psychological intervention, MEDLINE, Clinical neurology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Neurology Grand Rounds, Neurology, medicine, Pooled data, Neurology (clinical), Intensive care medicine, business, 030217 neurology & neurosurgery
Abstract

There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID‐19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID‐19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID‐19 neurological complications and harmonized clinical measures for future research. This will facilitate well‐designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low‐income settings. ANN NEUROL 2021;89:1059–1067

Published
2021

35. The burden of T. solium cysticercosis and selected neuropsychiatric disorders in Mocuba district, Zambézia province, Mozambique

Author

Langa, Irene, primary, Padama, Fernando, additional, Nhancupe, Noémia, additional, Pondja, Alberto, additional, Hlashwayo, Delfina, additional, Gouveia, Lidia, additional, Stelzle, Dominik, additional, da Costa, Clarissa Prazeres, additional, Schmidt, Veronika, additional, Winkler, Andrea S., additional, and Noormahomed, Emília Virgínia, additional

Published
2022
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37. Neurological events reported after COVID-19 vaccines: an analysis of vaccine adverse event reporting system

Author

Frontera, Jennifer A., Tamborska, Arina A., Doheim, Mohamed F., Garcia-Azorin, David, Gezegen, Hasim, Guekht, Alla, Yusof Khan, Abdul Hanif Khan, Santacatterina, Michele, Sejvar, James, Thakur, Kiran T., Westenberg, Erica, Winkler, Andrea S., Beghi, Ettore, Frontera, Jennifer A., Tamborska, Arina A., Doheim, Mohamed F., Garcia-Azorin, David, Gezegen, Hasim, Guekht, Alla, Yusof Khan, Abdul Hanif Khan, Santacatterina, Michele, Sejvar, James, Thakur, Kiran T., Westenberg, Erica, Winkler, Andrea S., and Beghi, Ettore

Abstract

Objective: To identify the rates of neurological events following administration of mRNA (Pfizer, Moderna) or adenovirus vector (Janssen) vaccines in the U.S. Methods: We used publicly available data from the U.S. Vaccine Adverse Event Reporting System (VAERS) collected between January 1, 2021 and June 14, 2021. All free text symptoms that were reported within 42 days of vaccine administration were manually reviewed and grouped into 36 individual neurological diagnostic categories. Post-vaccination neurological event rates were compared between vaccine types and to age-matched baseline incidence rates in the U.S. and rates of neurological events following COVID. Results: Of 306,907,697 COVID vaccine doses administered during the study timeframe, 314,610 (0.1%) people reported any adverse event and 105,214 (0.03%) reported neurological adverse events in a median of 1 day (IQR0-3) from inoculation. Guillain-Barre Syndrome (GBS), and cerebral venous thrombosis (CVT) occurred in fewer than 1 per 1,000,000 doses. Significantly more neurological adverse events were reported following Janssen (Ad26.COV2.S) vaccination compared to either Pfizer-BioNtech (BNT162b2) or Moderna (mRNA-1,273; 0.15% vs 0.03% vs 0.03% of doses, respectively, p < 0.0001). The observed-to-expected ratios for GBS, CVT and seizure following Janssen vaccination were ≥1.5-fold higher than background rates. However, the rate of neurological events after acute SARS-CoV-2 infection was up to 617-fold higher than after COVID vaccination. Interpretation: Reports of serious neurological events following COVID vaccination are rare. GBS, CVT and seizure may occur at higher than background rates following Janssen vaccination. Despite this, rates of neurological complications following acute SARS-CoV-2 infection are up to 617-fold higher than after COVID vaccination. ANN NEUROL 2022;91:756–771.

Published
2022

38. Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania - A cross-sectional study

Author

Stelzle, Dominik, Makasi, Charles, Schmidt, Veronika, Trevisan, Chiara, van Damme, Inge, Welte, Tamara M, Ruether, Charlotte, Fleury, Agnes, Dorny, Pierre, Magnussen, Pascal, Zulu, Gideon, Mwape, Kabemba E, Bottieau, Emmanuel, Gabriël, Sarah, Ngowi, Bernard J, Winkler, Andrea S, Stelzle, Dominik, Makasi, Charles, Schmidt, Veronika, Trevisan, Chiara, van Damme, Inge, Welte, Tamara M, Ruether, Charlotte, Fleury, Agnes, Dorny, Pierre, Magnussen, Pascal, Zulu, Gideon, Mwape, Kabemba E, Bottieau, Emmanuel, Gabriël, Sarah, Ngowi, Bernard J, and Winkler, Andrea S

Abstract

BACKGROUND: Neurocysticercosis (NCC) is common among people with epilepsy in low-resource settings. Prevalence of NCC and radiological characteristics of patients with NCC vary considerably even within small areas but differences have been poorly characterized so far.METHODS: We conducted a cross-sectional study between August 2018 and April 2020 in three district hospitals in southern Tanzania (Ifisi, Tukuyu and Vwawa). Patients with and without epileptic seizures were included in this study. All patients were tested with a novel antibody-detecting point-of-care test for the diagnosis of Taenia solium cysticercosis. All test positives and a subset of test negatives had a further clinical work-up including medical examination and computed tomography of the brain. NCC was defined according to the Del Brutto criteria. We assessed epidemiological, clinical and radiological characteristics of patients with NCC by presence of epileptic seizures and by serology status.RESULTS: In all three district hospitals, more than 30% of all people with epileptic seizures (PWE) had NCC lesions in their brain (38% in Vwawa, 32% in Tukuyu and 31% in Ifisi). Most PWE with NCC had multiple lesions and mostly parenchymal lesions (at least 85%). If patients were serologically positive, they had in the median more lesions than serologically negative patients (15 [interquartile range 8-29] versus 5 [1.8-11]), and only serologically positive patients had active stage lesions. Furthermore, serologically positive PWE had more lesions than serologically positive people without epileptic seizures (10.5 [7-23]), and more often had active lesions. PWE diagnosed with NCC (n = 53) were older, and more commonly had focal onset seizures (68% versus 44%, p = 0.03) and headache episodes (34% versus 14%, p = 0.06), which were also stronger than in PWE without NCC (p = 0.04).CONCLUSION: NCC is common among PWE. A combination of clinical and serological factors could help to establis

Published
2022

39. Additional file 1 of Knowledge, attitudes and practices related to Taenia solium cysticercosis and taeniasis in Tanzania

Author

Nyangi, Chacha, Stelzle, Dominik, Mkupasi, Ernatus M., Ngowi, Helena A., Churi, Ayubu J., Schmidt, Veronika, Mahonge, Christopher, and Winkler, Andrea S.

Abstract

Additional file 1: Table S1A. Knowledge about pork tapeworm (T. solium taeniasis). Table S1B. Knowledge about porcine cysticercosis. Table S1C. Knowledge about human cysticercosis. Table S1D. Knowledge about epilepsy. Table S2. Practice score of Taenia solium taeniasis/cysticercosis (TSCT) by specific variables. Questionnaire

Published
2022
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40. Additional file 1 of Characteristics of people with epilepsy in three Eastern African countries – a pooled analysis

Author

Stelzle, Dominik, Kaducu, Joyce, Schmidt, Veronika, Welte, Tamara M., Ngowi, Bernard J., Matuja, William, Escheu, Gabrielle, Hauke, Peter, Richter, Vivien, Ovuga, Emilio, Pfausler, Bettina, Schmutzhard, Erich, Amos, Action, Harrison, Wendy, Keller, Luise, and Winkler, Andrea S.

Abstract

Additional file 1: Appendix Information 1. Methodology of the included studies. Appendix information 2. Ethical clearance obtained. Appendix Table 1. Epilepsy screening questionnaire Malawi. Appendix Table 2. Epilepsy screening questionnaire Uganda. Appendix Table 3. Type and dosage of ASM among patients treated with monotherapy¥.

Published
2022
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43. Diagnosis of Taenia solium infections based on “mail order” RNA-sequencing of single tapeworm egg isolates from stool samples

Author

Sadlowski, Henrik, primary, Schmidt, Veronika, additional, Hiss, Jonathan, additional, Kuehn, Johannes A., additional, Schneider, Christian G., additional, Zulu, Gideon, additional, Hachangu, Alex, additional, Sikasunge, Chummy S., additional, Mwape, Kabemba E., additional, Winkler, Andrea S., additional, and Schuelke, Markus, additional

Published
2021
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44. Evaluation of an Antibody Detecting Point of Care Test for Diagnosis of Taenia solium Cysticercosis in a Zambian Rural Community: A Prospective Diagnostic Accuracy Study

Author

Mubanga, Chishimba, primary, Van Damme, Inge, additional, Trevisan, Chiara, additional, Schmidt, Veronika, additional, Phiri, Isaac K., additional, Zulu, Gideon, additional, Noh, John, additional, Handali, Sukwan, additional, Mambo, Richard, additional, Chembensofu, Mwelwa, additional, Masuku, Maxwell, additional, Reynders, Dries, additional, Jansen, Famke, additional, Bottieau, Emmanuel, additional, Magnussen, Pascal, additional, Winkler, Andrea S., additional, Dorny, Pierre, additional, Mwape, Kabemba E., additional, and Gabriël, Sarah, additional

Published
2021
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45. Challenges Encountered When Evaluating an Antibody-Detecting Point-of-Care Test for Taeniosis in an Endemic Community in Zambia: A Prospective Diagnostic Accuracy Study

Author

Mubanga, Chishimba, primary, Trevisan, Chiara, additional, Van Damme, Inge, additional, Schmidt, Veronika, additional, Phiri, Isaac K., additional, Zulu, Gideon, additional, Noh, John, additional, Handali, Sukwan, additional, Mambo, Richard, additional, Chembensofu, Mwelwa, additional, Masuku, Maxwell, additional, Reynders, Dries, additional, Jansen, Famke, additional, Bottieau, Emmanuel, additional, Magnussen, Pascal, additional, Winkler, Andrea S., additional, Dorny, Pierre, additional, Mwape, Kabemba E., additional, and Gabriel, Sarah, additional

Published
2021
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47. Nodding syndrome

Author

Dowell, Scott F., Sejvar, James J., Riek, Lul, Vandemaele, Katelijn A.H., Lamunu, Margaret, Kuesel, Annette C., Schmutzhard, Erich, Matuja, William, Bunga, Sudhir, Foltz, Jennifer, Nutman, Thomas B., Winkler, Andrea S., and Mbonye, Anthony K.

Subjects
South Sudan -- Health aspects, Uganda -- Health aspects, Children -- Diseases, Seizures (Medicine) -- Causes of -- Distribution, Epidemiology -- Research, Diseases -- Causes and theories of causation, Onchocerciasis -- Health aspects, Company distribution practices, Health
Abstract

Nodding syndrome as a distinctive entity was reported from southern Sudan in the 1990s and investigated by local authorities and the World Health Organization (WHO) during 2001-2002 (1,2). In retrospect, [...]

Published
2013
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48. Neurocysticercosis and HIV/AIDS co‐infection: A scoping review

Author

Jewell, Paul D., primary, Abraham, Annette, additional, Schmidt, Veronika, additional, Buell, Kevin G., additional, Bustos, Javier A., additional, Garcia, Hector H., additional, Dixon, Matthew A., additional, Walker, Martin, additional, Ngowi, Bernard J., additional, Basáñez, Maria‐Gloria, additional, and Winkler, Andrea S., additional

Published
2021
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49. First description of Nodding Syndrome in the Central African Republic

Author

Metanmo, Salvatore, primary, Boumédiène, Farid, additional, Preux, Pierre-Marie, additional, Colebunders, Robert, additional, Siewe Fodjo, Joseph N., additional, de Smet, Eric, additional, Yangatimbi, Emmanuel, additional, Winkler, Andrea S., additional, Mbelesso, Pascal, additional, and Ajzenberg, Daniel, additional

Published
2021
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