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6. Concentraciones de DDT/DDE y riesgo de hipospadias: un estudio piloto de casos y controles

Author

Flores-Luévano Silvia, Farías Paulina, Hernández Mauricio, Romano-Riquer Patricia, Weber Jean Philippe, Dewailly Eric, Cuevas-Alpuche Juan, and Romieu Isabelle

Subjects
hipospadia, plaguicidas organoclorados, DDT, DDE, México, Public aspects of medicine, RA1-1270
Abstract

OBJETIVO: Evaluar la asociación entre los niveles séricos maternos de DDT/DDE y el riesgo de hipospadias. MATERIAL Y MÉTODOS: Estudio de casos y controles, efectuado en la Ciudad de México durante el periodo 1997-1999, con 41 casos de hipospadias y 28 controles. La informacion obtenida por cuestionario y las muestras sanguíneas fueron evaluadas mediante modelos multivariados de regresión logística. RESULTADOS: Las concentraciones materna de DDT y DDE no mostraron asociación con el riesgo de hipospadias (RM 1.13; IC 95% 0.24-5.29 y RM 0.48; IC 95% 0.15-1.60, respectivamente). Los predictores encontrados fueron hijos de madres con mayor edad (RM 8.69; IC 95% 1.69-44.9), y la actividad laboral durante el embarazo (RM, 4.68; IC 95% 1.15-18.9). CONCLUSIONES: Dado que se cuenta con escasa información sobre los efectos endocrinos a diferentes concentraciones de DDT/DDE en humanos, la dosis pudiera ser un factor determinante sobre el tipo de efecto.

Published
2003

13. Serum concentrations of 1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer

Author

McGlynn, Katherine A., Abnet, Christian C., Zhang, Mingdong, Sun, Xiu-Di, Fan, Jin-Hu, O'Brien, Thomas R., Wei, Wen-Qiang, Ortiz-Conde, Betty A., Dawsey, Sanford M., Weber, Jean-Philippe, Taylor, Philip R., Katki, Hormuzd, Mark, Steven D., and Qiao, You-Lin

Subjects
Insecticides -- Influence, Insecticides -- Case studies, Liver tumors -- Causes of, Liver tumors -- Case studies, Health
Abstract

Background: 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) exposure has been demonstrated to cause liver tumors in laboratory rodents. DDT's persistent metabolite and environmental degradation product, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also been associated with liver tumors in laboratory animals. Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear. Methods: We carried out a nested case-control study among the participants of the Nutritional Intervention Trials in Linxian, China. The case group included 168 individuals who developed liver cancer during the trials, and the control group included 385 individuals frequency-matched on age and sex who were alive and well at the end of the study. Serum concentrations of DDT and DDE were measured by gas chromatography--mass spectrometry. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable analysis. Results: In multivariable-adjusted models, the risk of developing liver cancer increased with increased serum DDT concentration (OR for quintile 1 versus quintile 5 = 3.8, 95% CI = 1.7 to 8.6, [P.sub.trend] = .0024). In contrast, there was no statistically significant association between liver cancer and serum DDE concentration. The association between high serum DDT concentration and liver cancer was stronger among individuals with DDE concentrations below the median value (odds ratio for tertile 3 versus tertile 1 = 3.55, 95% CI = 1.45 to 8.74) than those with concentrations above the median (OR = 1.70, 95% CI = 0.97 to 2.98). A calculation of crude liver cancer risk found that there would be 26 liver cancers per 100000 persons per year in the lowest quintile of DDT exposure versus 46 liver cancers per 100000 persons per year in the highest quintile of DDT exposure. Conclusions: DDT may be a risk factor for liver cancer, particularly among persons with lower DDE concentrations. Risk may be particularly increased among persons exposed directly to DDT (resulting in a higher ratio of DDT to DDE) or, alternatively, risk may be associated with individual ability to metabolize DDT to DDE.

Published
2006

18. Algal and Vegetable Oils as Sustainable Fish Oil Substitutes in Rainbow Trout Diets: An Approach to Reduce Contaminant Exposure

Author

Bélanger-Lamonde, Amélie, primary, Sarker, Pallab K., additional, Ayotte, Pierre, additional, Bailey, Janice L., additional, Bureau, Dominique P., additional, Chouinard, P. Yvan, additional, Dewailly, Éric, additional, Leblanc, Alain, additional, Weber, Jean-Philippe, additional, and Vandenberg, Grant W., additional

Published
2018
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20. Smoking During Labour

Author

Latulippe, Louis G., Marcoux, Sylvie, Fabia, Jacqueline, Weber, Jean-Philippe, and Tennina, Sonia

Published
1992

24. Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma

Author

Ng, Carmen H., primary, Janoo-Gilani, Rozmin, additional, Sipahimalani, Payal, additional, Gallagher, Richard P., additional, Gascoyne, Randy D., additional, Connors, Joseph M., additional, Weber, Jean-Philippe, additional, Lai, Agnes S., additional, Leach, Stephen, additional, Le, Nhu D., additional, Brooks-Wilson, Angela R., additional, and Spinelli, John J., additional

Published
2009
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26. Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation

Author

Arnaud, Josiane, primary, Weber, Jean-Philippe, primary, Weykamp, Cas W, primary, Parsons, Patrick J, primary, Angerer, Jurgen, primary, Mairiaux, Eric, primary, Mazarrasa, Olav, primary, Valkonen, Sinikka, primary, Menditto, Antonio, primary, Patriarca, Marina, primary, and Taylor, Andrew, primary

Published
2008
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28. Maternal and umbilical cord blood levels of mercury, lead, cadmium, and essential trace elements in Arctic Canada

Author

Butler Walker, Jody, primary, Houseman, Jan, additional, Seddon, Laura, additional, McMullen, Ed, additional, Tofflemire, Karen, additional, Mills, Carole, additional, Corriveau, André, additional, Weber, Jean-Philippe, additional, LeBlanc, Alain, additional, Walker, Mike, additional, Donaldson, Shawn G., additional, and Van Oostdam, Jay, additional

Published
2006
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32. [DDT/DDE concentrations and risk of hypospadias. Pilot case-control study].

Author

Flores-Luévano S, Farías P, Hernández M, Romano-Riquer P, Weber JP, Dewailly E, Cuevas-Alpuche J, and Romieu I

Subjects
Adolescent, Case-Control Studies, Child, Child, Preschool, Female, Humans, Male, Pilot Projects, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, DDT blood, Dichlorodiphenyl Dichloroethylene blood, Hypospadias chemically induced, Maternal Exposure
Abstract

Objective: To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias., Material and Methods: A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models., Results: Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR = 0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9)., Conclusions: Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect. The English version of this paper is available at:http://www.insp.mx/salud/index.html.

Published
2003

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