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1. Quantitative Study of the Effect of Nanoparticles on the Mechanical Properties of Colon Cancer Cells

Author

Cui Haobo, Xu Hongmei, Li Jingxin, Zhang Ziyu, Liu Xuwei, Yuan Lixin, Wang Ying, and Wang Zuobin

Subjects
Microbiology, QR1-502, Physiology, QP1-981, Zoology, QL1-991
Abstract

Magnetic nanoparticles (MNPs) are often used as drug-carrying particles for targeted therapy of tumors. Studying their effects on cell activity and mechanical properties is of great significance for the targeted treatment of tumors. In this paper, we used a combination of atomic force microscopy (AFM) and fluorescent labeling to study the mechanical properties of cells after the endocytosis of MNPs. Colon cancer cells SW480 were selected to co-culture with MNPs with a particle size of 50 nm, and the cell viability was measured and systematically analyzed under different conditions. The results showed that the safe dose of MNPs to colon cancer cells SW480 was 50 µg/mL, and when the amount exceeded 50 µg/mL, the cell viability decreased significantly. Increase the concentration of MNPs step by step within the safe dose of 0-50 µg/mL. Through the analysis of a large number of data measured by AFM, the results show that the mechanical properties of cells change significantly with the increase of MNPs concentration. In this paper, the experimental results are analyzed by comparing concentration gradients. The concentrations are set to 0, 30, and 50 µg/mL , respectively, to verify the influence of MNPs on the mechanical properties of cells.

Published
2023
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16. Research Progress on Saccharide Molecule Detection Based on Nanopores.

Author

Yin, Bohua, Xie, Wanyi, Fang, Shaoxi, He, Shixuan, Ma, Wenhao, Liang, Liyuan, Yin, Yajie, Zhou, Daming, Wang, Zuobin, and Wang, Deqiang

Subjects
SACCHARIDES, ARTIFICIAL intelligence, BORONIC acids, MONOSACCHARIDES, POLYSACCHARIDES
Abstract

Saccharides, being one of the fundamental molecules of life, play essential roles in the physiological and pathological functions of cells. However, their intricate structures pose challenges for detection. Nanopore technology, with its high sensitivity and capability for single-molecule-level analysis, has revolutionized the identification and structural analysis of saccharide molecules. This review focuses on recent advancements in nanopore technology for carbohydrate detection, presenting an array of methods that leverage the molecular complexity of saccharides. Biological nanopore techniques utilize specific protein binding or pore modifications to trigger typical resistive pulses, enabling the high-sensitivity detection of monosaccharides and oligosaccharides. In solid-state nanopore sensing, boronic acid modification and pH gating mechanisms are employed for the specific recognition and quantitative analysis of polysaccharides. The integration of artificial intelligence algorithms can further enhance the accuracy and reliability of analyses. Serving as a crucial tool in carbohydrate detection, we foresee significant potential in the application of nanopore technology for the detection of carbohydrate molecules in disease diagnosis, drug screening, and biosensing, fostering innovative progress in related research domains. [ABSTRACT FROM AUTHOR]

Published
2024
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19. AI‐Enabled Soft Sensing Array for Simultaneous Detection of Muscle Deformation and Mechanomyography for Metaverse Somatosensory Interaction

Author

Suo, Jiao, primary, Liu, Yifan, additional, Wang, Jianfei, additional, Chen, Meng, additional, Wang, Keer, additional, Yang, Xiaomeng, additional, Yao, Kuanming, additional, Roy, Vellaisamy A. L., additional, Yu, Xinge, additional, Daoud, Walid A., additional, Liu, Na, additional, Wang, Jianping, additional, Wang, Zuobin, additional, and Li, Wen Jung, additional

Published
2024
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35. Nanoscale Morphologies on the Surface of 3D-Printed Titanium Implants for Improved Osseointegration: A Systematic Review of the Literature

Author

Yang,Shiyan, Jiang,Weibo, Ma,Xiao, Wang,Zuobin, Sah,Robert L, Wang,Jincheng, Sun,Yang, Yang,Shiyan, Jiang,Weibo, Ma,Xiao, Wang,Zuobin, Sah,Robert L, Wang,Jincheng, and Sun,Yang

Abstract

Shiyan Yang,1,* Weibo Jiang,1,* Xiao Ma,2,* Zuobin Wang,3 Robert L Sah,4,5 Jincheng Wang,1 Yang Sun1 1Orthopedic Medical Center, the Second Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of China; 2Department of Orthopedics, the China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130000, People’s Republic of China; 3International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun, Jilin, 130000, People’s Republic of China; 4Department of Bioengineering, University of California–San Diego, La Jolla, CA, 92037, USA; 5Center for Musculoskeletal Research, Institute of Engineering in Medicine, University of California–San Diego, La Jolla, CA, 92037, USA*These authors contributed equally to this workCorrespondence: Yang Sun, Orthopedic Medical Center, the Second Hospital of Jilin University, Changchun, 130000, Jilin, People’s Republic of China, Tel/Fax +86 18744000871, Email sunyang@jlu.edu.cnAbstract: Three-dimensional (3D) printing is serving as the most promising approach to fabricate personalized titanium (Ti) implants for the precise treatment of complex bone defects. However, the bio-inert nature of Ti material limits its capability for rapid osseointegration and thus influences the implant lifetime in vivo. Despite the macroscale porosity for promoting osseointegration, 3D-printed Ti implant surface morphologies at the nanoscale have gained considerable attention for their potential to improve specific outcomes. To evaluate the influence of nanoscale surface morphologies on osseointegration outcomes of 3D-printed Ti implants and discuss the available strategies, we systematically searched evidence according to the PRISMA on PubMed, Embase, Web of Science, and Cochrane (until June 2022). The inclusion criteria were in vivo (animal) studies reporting the osseointegration outcomes of nanoscale morphologies on the sur

Published
2023

36. Tailored Design of a Water-Based Nanoreactor Technology for Producing Processable Sub-40 Nm 3D COF Nanoparticles at Atmospheric Conditions

Author

Ministerio de Ciencia e Innovación (España), 0000-0002-7510-9815, Llauradó-Capdevila, Gemma, Veciana, Andrea, Guarducci, Maria Aurora, Mayoral, Alvaro, Pons, Ramon, Hertle, Lukas, Ye, Hao, Mao, Minmin, Sevim, Semih, Rodríguez-San-Miguel, David, Sorrenti, Alessandro, Jang, Bumjin, Wang, Zuobin, Chen, Xiang-Zhong, Nelson, Bradley J., Matheu, Roc, Franco, Carlos, Pané, Salvador, Puigmartí-Luis, Josep, Ministerio de Ciencia e Innovación (España), 0000-0002-7510-9815, Llauradó-Capdevila, Gemma, Veciana, Andrea, Guarducci, Maria Aurora, Mayoral, Alvaro, Pons, Ramon, Hertle, Lukas, Ye, Hao, Mao, Minmin, Sevim, Semih, Rodríguez-San-Miguel, David, Sorrenti, Alessandro, Jang, Bumjin, Wang, Zuobin, Chen, Xiang-Zhong, Nelson, Bradley J., Matheu, Roc, Franco, Carlos, Pané, Salvador, and Puigmartí-Luis, Josep

Abstract

Covalent organic frameworks (COFs) are crystalline materials with intrinsic porosity that offer a wide range of potential applications spanning diverse fields. Yet, the main goal in the COF research area is to achieve the most stable thermodynamic product while simultaneously targeting the desired size and structure crucial for enabling specific functions. While significant progress is made in the synthesis and processing of 2D COFs, the development of processable 3D COF nanocrystals remains challenging. Here, a water-based nanoreactor technology for producing processable sub-40 nm 3D COF nanoparticles at ambient conditions is presented. Significantly, this technology not only improves the processability of the synthesized 3D COF, but also unveils exciting possibilities for their utilization in previously unexplored domains, such as nano/microrobotics and biomedicine, which are limited by larger crystallites.

Published
2023

37. New approaches in optical interferometry

Author

Wang, Zuobin

Subjects
535, TA Engineering (General). Civil engineering (General)
Abstract

This thesis presents two new approaches in optical interferometry: phase difference determination by fringe pattern matching and a spatial phase-shifting interferometry (spatial PSI) algorithm. These two approaches are both theoretically described and experimentally illustrated in this thesis. The method of phase difference determination by fringe pattern matching is capable of detecting the phase difference between two interferograms with subpixel resolution. In this method, the phase curves are obtained from mean-square difference calculations of any two fringe patterns shifted pixel by pixel, and the phase difference between the interferograms can be achieved by linear interpolation or polynomial curve fitting from the phase curves. The signal to noise ratio is significantly improved due to the region-based matching and its effect of averaging noise. The equations derived from the statistical analysis of matching process clearly explain the reason that the larger image patches have a better accuracy in the measurement of phase difference. The three applications of fringe pattern matching, measurement of electrostatic force displacement, displacement measurement based on Youngs experiment, and phase-shifting interferometry with arbitrary phase steps, are also investigated in this thesis. Computer simulation and experimental results have proved that fringe pattern matching is a powerful technique for measuring some basic parameters in optical interferometry such as phase difference, fringe spacing and displacement. In the algorithm of spatial PSI, one fringe pattern is captured by a CCD camera, and the other two shifted fringe patterns with the phase steps of 90oC and 180oc are generated by computer, according to the features of the light intensity distributions and the method of interpolation. The phase is then calculated by a standard three-step algorithm of phase-shifting interferometry. Experimental results have shown that it is a useful approach to spatial PSI.

Published
1997

41. Self‐repair behaviour of the neuronal cell membrane by conductive atomic force indentation

Author

Chuanzhi Liu, Zhengxun Song, Yang Huanzhou, Xueying Yang, Liguo Tian, Ge Zenghui, Ying Wang, Cuihua Hu, Wang Zuobin, Xueyan Han, Caijun Liu, Zhankun Weng, and Xinyue Wang

Subjects
Materials science, 02 engineering and technology, Microscopy, Atomic Force, 010402 general chemistry, 01 natural sciences, Cell membrane, Mice, Indentation, Microscopy, medicine, Animals, Electrical and Electronic Engineering, Electrical conductor, Cells, Cultured, Neurons, Membrane potential, Atomic force microscopy, Cell Membrane, Self repair, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, medicine.anatomical_structure, Membrane, nervous system, Biophysics, 0210 nano-technology, Research Article, Biotechnology
Abstract

Conductive atomic force indentation (CAFI) was proposed to study the self‐repair behaviour of the neuronal cell membrane here. CAFI was used to detect the changes of membrane potentials by performing the mechanical indentation on neurons with a conductive atomic force microscope. In the experiment, a special insulation treatment was made on the conductive probe, which turned out to be a conductive nanoelectrode, to implement the CAFI function. The mechanical properties of the neuronal cell membrane surface were tested and the membrane potential changes of neurons cultured in vitro were detected. The self‐repair behaviour of the neuronal cell membrane after being punctured was investigated. The experiment results show that CAFI provides a new way for the study of self‐repair behaviours of neuronal cell membranes and mechanical and electrical properties of living cells.

Published
2019
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42. Design an Asymmetrical Three-Beam Laser Interference Lithography for Fabricating Micro- and Nano-Structures

Author

Mengnan Liu, Ziang Zhang, Dong Litong, Dayou Li, and Wang Zuobin

Subjects
Materials science, business.industry, Fast Fourier transform, Polarization (waves), Industrial and Manufacturing Engineering, Laser interference lithography, Interference lithography, Azimuth, Optics, Nano, Beam laser, Electrical and Electronic Engineering, business, Instrumentation
Published
2020
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