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Background and purpose: Tumor necrosis factor-α (TNF-α) not only acts as proinflammatory cytokine conducing to wide spectrum of human diseases including inflammatory diseases, but also can induce tumor development. In the current study, we investigated the relationship between TNF-α gene polymorphisms and the occurrence and development of non-small cell lung cancer (NSCLC) in Han population of Yunnan Province. Methods: A total of 425 lung cancer patients with NSCLC and 438 healthy individuals were included from Han population of Yunnan Province. The genotypes of 5 polymorphism loci, rs1799964 (-1031T>C), rs1800630 (-863C>A), rs1799724 (-857C>T), rs1800629 (-308G>A) and rs361525 (-238G>A) of TNF-α gene were detected by TaqMan assay. The frequency distributions of allele, genotype and haplotype in NSCLC patients and healthy controls were analyzed. Results: There was no significant difference in the allele and genotype frequency among 5 single nucleotide polymorphism (SNP) sites in TNF-α gene promoter (P>0.05). And in stratification analysis, the frequency of rs1799724-T was significantly higher in the adenocarcinoma patients than in the controls (P=0.010, OR=1.56, 95% CI: 1.11-2.19), and the rs1799724-TT+TC carrier showed significantly higher susceptibility to adenocarcinoma in dominant model (P=0.007, OR=1.66, 95% CI: 1.146-2.417). The frequency of rs1800630-A was significantly higher in adenocarcinoma, squamous cell carcinoma and other histological types of carcinoma patients (P=0.013, OR=2.15, 95% CI: 1.16-3.96). The haplotype analysis indicated that the frequency of haplotype rs1799724T-rs1800629G was higher in the adenocarcinoma group than in the control group (P=0.048, OR=1.42, 95% CI: 1.00-2.01). Conclusion: The T allele and TT genotype of rs1799724 (C>T) in TNF-α gene promoter might be associated with the susceptibility to lung adenocarcinoma in Han population of Yunnan Province. And rs1800630 (C>T) -A might be a risk factor of other histological lung cancer in Han population of Yunnan Province.

Organic afterglow is a fascinating phenomenon with exceptional applications. However, it encounters challenges such as low intensity and efficiency, and typically requires UV-light excitation and facile intersystem crossing (ISC) due to its spin-forbidden nature. Here, we develop a novel strategy that bypasses the conventional ISC pathway by promoting singlet-triplet transition through the synergistic effects of the intra/intermolecular heavy-atom effect in aromatic crystals, enabling the direct population of triplet excited states from the ground state. The resulting materials exhibit a bright organic afterglow with a remarkably enhanced quantum efficiency of up to 5.81%, and a significantly increased organic afterglow lifetime of up to 157 microseconds under visible light. Moreover, given the high-efficiency visible-light excitable organic afterglow emission, the potential application is demonstrated in lifetime-resolved, color-encoded, and excitation wavelength-dependent pattern encryption. This work demonstrates the importance of the direct population method in enhancing the organic afterglow performance and red-shifting the excitation wavelength, and provides crucial insights for advancing organic optoelectronic technologies that involve triplet states. [ABSTRACT FROM AUTHOR]

A dynamic pressure measuring system has been developed in this study. This system can be used for static pressure measuring, real-time dynamic pressure measuring and pressure fatigue analysis. A 3D geometric model on fabric deformation as well as mechanical behavior has been developed, which can be used for simulating the fabric elongation during dynamic pressing, and to deduce relationship between the press depth and fabric elongation. The process parameters of measuring system have been systematically estimated and analyzed. The range of press depth fixed for dynamic pressure measurement is found to be 58-115 mm, which responds to the fabric elongation from 10% to 40%. The press velocity at 100 mm/min is considered as the optional one for dynamic pressure measurement. Five repeated test cycles can be satisfied to assess the dynamic pressure fatigue performance quickly. [ABSTRACT FROM AUTHOR]