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4. Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors

Author

Savage, Paul, Pacis, Alain, Kuasne, Hellen, Liu, Leah, Lai, Daniel, Wan, Adrian, Dankner, Matthew, Martinez, Constanza, Muñoz-Ramos, Valentina, Pilon, Virginie, Monast, Anie, Zhao, Hong, Souleimanova, Margarita, Annis, Matthew G., Aguilar-Mahecha, Adriana, Lafleur, Josiane, Bertos, Nicholas R., Asselah, Jamil, Bouganim, Nathaniel, Petrecca, Kevin, Siegel, Peter M., Omeroglu, Atilla, Shah, Sohrab P., Aparicio, Samuel, Basik, Mark, Meterissian, Sarkis, and Park, Morag

Published
2020
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5. Protocol for a mixed-methods randomised controlled trial evaluating the effectiveness of a dyadic expressive arts-based intervention in improving the psychosocial well-being of children with intellectual disability in special schools and their mothers

Author

Lo, Temmy Lee Ting, primary, Wan, Adrian Ho Yin, additional, Fong, Ted Chun Tat, additional, Wong, Phyllis King Shui, additional, Lo, Herman Hay Ming, additional, Chan, Caitlin Kar Pui, additional, and Ho, Rainbow Tin Hung, additional

Published
2023
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6. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Author

Eirew, Peter, Steif, Adi, Khattra, Jaswinder, Ha, Gavin, Yap, Damian, Farahani, Hossein, Gelmon, Karen, Chia, Stephen, Mar, Colin, Wan, Adrian, Laks, Emma, Biele, Justina, Shumansky, Karey, Rosner, Jamie, McPherson, Andrew, Nielsen, Cydney, Roth, Andrew J. L., Lefebvre, Calvin, Bashashati, Ali, de Souza, Camila, Siu, Celia, Aniba, Radhouane, Brimhall, Jazmine, Oloumi, Arusha, Osako, Tomo, Bruna, Alejandra, Sandoval, Jose L., Algara, Teresa, Greenwood, Wendy, Leung, Kaston, Cheng, Hongwei, Xue, Hui, Wang, Yuzhuo, Lin, Dong, Mungall, Andrew J., Moore, Richard, Zhao, Yongjun, Lorette, Julie, Nguyen, Long, Huntsman, David, Eaves, Connie J., Hansen, Carl, Marra, Marco A., Caldas, Carlos, Shah, Sohrab P., and Aparicio, Samuel

Published
2015
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11. Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Author

Zhang, Allen W., primary, McPherson, Andrew, additional, Milne, Katy, additional, Kroeger, David R., additional, Hamilton, Phineas T., additional, Miranda, Alex, additional, Funnell, Tyler, additional, Little, Nicole, additional, de Souza, Camila P.E., additional, Laan, Sonya, additional, LeDoux, Stacey, additional, Cochrane, Dawn R., additional, Lim, Jamie L.P., additional, Yang, Winnie, additional, Roth, Andrew, additional, Smith, Maia A., additional, Ho, Julie, additional, Tse, Kane, additional, Zeng, Thomas, additional, Shlafman, Inna, additional, Mayo, Michael R., additional, Moore, Richard, additional, Failmezger, Henrik, additional, Heindl, Andreas, additional, Wang, Yi Kan, additional, Bashashati, Ali, additional, Grewal, Diljot S., additional, Brown, Scott D., additional, Lai, Daniel, additional, Wan, Adrian N.C., additional, Nielsen, Cydney B., additional, Huebner, Curtis, additional, Tessier-Cloutier, Basile, additional, Anglesio, Michael S., additional, Bouchard-Côté, Alexandre, additional, Yuan, Yinyin, additional, Wasserman, Wyeth W., additional, Gilks, C. Blake, additional, Karnezis, Anthony N., additional, Aparicio, Samuel, additional, McAlpine, Jessica N., additional, Huntsman, David G., additional, Holt, Robert A., additional, Nelson, Brad H., additional, and Shah, Sohrab P., additional

Published
2018
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14. CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

Author

Funnell, Tyler, primary, Tasaki, Shinya, additional, Oloumi, Arusha, additional, Araki, Shinsuke, additional, Kong, Esther, additional, Yap, Damian, additional, Nakayama, Yusuke, additional, Hughes, Christopher S., additional, Cheng, S.-W. Grace, additional, Tozaki, Hirokazu, additional, Iwatani, Misa, additional, Sasaki, Satoshi, additional, Ohashi, Tomohiro, additional, Miyazaki, Tohru, additional, Morishita, Nao, additional, Morishita, Daisuke, additional, Ogasawara-Shimizu, Mari, additional, Ohori, Momoko, additional, Nakao, Shoichi, additional, Karashima, Masatoshi, additional, Sano, Masaya, additional, Murai, Aiko, additional, Nomura, Toshiyuki, additional, Uchiyama, Noriko, additional, Kawamoto, Tomohiro, additional, Hara, Ryujiro, additional, Nakanishi, Osamu, additional, Shumansky, Karey, additional, Rosner, Jamie, additional, Wan, Adrian, additional, McKinney, Steven, additional, Morin, Gregg B., additional, Nakanishi, Atsushi, additional, Shah, Sohrab, additional, Toyoshiba, Hiroyoshi, additional, and Aparicio, Samuel, additional

Published
2017
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15. DELINEATING THE KEY REGIONS AND FUNCTIONS OF NUP98 CONTRIBUTING TO THE LEUKEMOGENIC ACTIVITY OF NUP98-HOX FUSIONS

Author

Yung, Eric, Sekulovic, Sanja, Argiropoulos, Bob, Lai, Courteney K., Leung, Malina, Vollett, Sarah, Chang, Vicky Chi-Dan, Wan, Adrian, Wong, Sandy, and Humphries, R. Keith

Subjects
Male, Repetitive Sequences, Amino Acid, Nucleocytoplasmic Transport Proteins, Oncogene Proteins, Fusion, Bone Marrow Cells, Kaplan-Meier Estimate, Article, Mice, Nuclear Matrix-Associated Proteins, Animals, p300-CBP Transcription Factors, Amino Acid Sequence, Myeloid Ecotropic Viral Integration Site 1 Protein, Cells, Cultured, Homeodomain Proteins, Binding Sites, Neoplasm Proteins, Mice, Inbred C57BL, Nuclear Pore Complex Proteins, Luminescent Proteins, Cell Transformation, Neoplastic, Homeobox A10 Proteins, Leukemia, Myeloid, Acute Disease, Mutation, Female, Protein Binding
Abstract

To determine the contribution of the common N-terminal truncation of NUP98 in NUP98-translocations resulting in acute myeloid leukemia, we have conducted a structure-function analysis of NUP98 in the context of NUP98-HOXA10HD, a novel, canonical NUP98-Hox fusion that significantly enhances the self-renewal capacity of hematopoietic stem cells and collaborates with Meis1 to induce AML in our mouse models Our results clearly demonstrate that the NUP98 fusion partner does not require interactions with either the nuclear pore complex (NPC) or the Rae1/anaphase promoting complex (APC), but instead, NUP98 seems to function in a transactivation manner by recruitment of CBP/p300 via its FG/GLFG repeats.

Published
2010

16. A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation

Author

Burleigh, Angela, primary, McKinney, Steven, additional, Brimhall, Jazmine, additional, Yap, Damian, additional, Eirew, Peter, additional, Poon, Steven, additional, Ng, Viola, additional, Wan, Adrian, additional, Prentice, Leah, additional, Annab, Lois, additional, Barrett, J Carl, additional, Caldas, Carlos, additional, Eaves, Connie, additional, and Aparicio, Samuel, additional

Published
2015
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17. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Author

Eirew, Peter, primary, Steif, Adi, additional, Khattra, Jaswinder, additional, Ha, Gavin, additional, Yap, Damian, additional, Farahani, Hossein, additional, Gelmon, Karen, additional, Chia, Stephen, additional, Mar, Colin, additional, Wan, Adrian, additional, Laks, Emma, additional, Biele, Justina, additional, Shumansky, Karey, additional, Rosner, Jamie, additional, McPherson, Andrew, additional, Nielsen, Cydney, additional, Roth, Andrew J. L., additional, Lefebvre, Calvin, additional, Bashashati, Ali, additional, de Souza, Camila, additional, Siu, Celia, additional, Aniba, Radhouane, additional, Brimhall, Jazmine, additional, Oloumi, Arusha, additional, Osako, Tomo, additional, Bruna, Alejandra, additional, Sandoval, Jose L., additional, Algara, Teresa, additional, Greenwood, Wendy, additional, Leung, Kaston, additional, Cheng, Hongwei, additional, Xue, Hui, additional, Wang, Yuzhuo, additional, Lin, Dong, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Zhao, Yongjun, additional, Lorette, Julie, additional, Nguyen, Long, additional, Huntsman, David, additional, Eaves, Connie J., additional, Hansen, Carl, additional, Marra, Marco A., additional, Caldas, Carlos, additional, Shah, Sohrab P., additional, and Aparicio, Samuel, additional

Published
2014
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18. The psychophysiological effects of Tai-chi and exercise in residential Schizophrenic patients: a 3-arm randomized controlled trial

Author

Ho, Rainbow Tin Hung, primary, Wan, Adrian Ho Yin, additional, Au-Yeung, Friendly So Wah, additional, Lo, Phyllis Hau Yan, additional, Siu, Pantha Joey Chung Yue, additional, Wong, Cathy Pui Ki, additional, Ng, Winnie Yuen Han, additional, Cheung, Irene Kit Man, additional, Ng, Siu Man, additional, Chan, Cecilia Lai Wan, additional, and Chen, Eric Yu Hai, additional

Published
2014
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19. Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor

Author

Sekulovic, Sanja, primary, Gasparetto, Maura, additional, Lecault, Véronique, additional, Hoesli, Corinne A., additional, Kent, David G., additional, Rosten, Patty, additional, Wan, Adrian, additional, Brookes, Christy, additional, Hansen, Carl L., additional, Piret, James M., additional, Smith, Clayton, additional, Eaves, Connie J., additional, and Humphries, R. Keith, additional

Published
2011
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24. The psychophysiological effects of Tai-chi and exercise in residential Schizophrenic patients: a 3-arm randomized controlled trial.

Author

Tin Hung Ho, Rainbow, Ho Yin Wan, Adrian, So Wah Au-Yeung, Friendly, Hau Yan Lo, Phyllis, Chung Yue Siu, Pantha Joey, Pui Ki Wong, Cathy, Yuen Han Ng, Winnie, Kit Man Cheung, Irene, Siu Man Ng, Lai Wan Chan, Cecilia, and Yu Hai Chen, Eric

Subjects
SCHIZOPHRENIA treatment, EXERCISE, CHINESE medicine, MEMORY, MOTOR ability, PSYCHOTHERAPY patients, PSYCHOLOGICAL stress, TAI chi, ACTIVITIES of daily living, RANDOMIZED controlled trials
Abstract

Background: Patients with schizophrenia are characterized by high prevalence rates and chronicity that often leads to long-term institutionalization. Under the traditional medical model, treatment usually emphasizes the management of psychotic symptoms through medication, even though anti-psychotic drugs are associated with severe side effects, which can diminish patients' physical and psychological well-being. Tai-chi, a mind-body exercise rooted in Eastern health philosophy, emphasizes the motor coordination and relaxation. With these potential benefits, a randomized controlled trial (RCT) is planned to investigate the effects of Tai-chi intervention on the cognitive and motor deficits characteristic of patients with schizophrenia. Methods/design: A 3-arm RCT with waitlist control design will be used in this study. One hundred and fifty three participants will be randomized into (i) Tai-chi, (ii) exercise or (iii) waitlist control groups. Participants in both the Tai-chi and exercise groups will receive 12-weeks of specific intervention, in addition to the standard medication and care received by the waitlist control group. The exercise group will serve as a comparison, to delineate any unique benefits of Tai-chi that are independent of moderate aerobic exercise. All three groups will undergo three assessment phases: (i) at baseline, (ii) at 12 weeks (post-intervention), and (iii) at 24 weeks (maintenance). All participants will be assessed in terms of symptom management, motor coordination, memory, daily living function, and stress levels based on self-perceived responses and a physiological marker. Discussion: Based on a promising pilot study conducted prior to this RCT, subjects in the Tai-chi intervention group are expected to be protected against deterioration of motor coordination and interpersonal functioning. They are also expected to have better symptoms management and lower stress level than the other treatment groups. Trial registration: The trail has been registered in the Clinical Trials Center of the University of Hong Kong (HKCTR-1453). [ABSTRACT FROM AUTHOR]

Published
2014
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25. The Aspergillus fumigatus Siderophore Biosynthetic Gene sidA, Encoding L-Ornithine N5-Oxygenase, Is Required for Virulence

Author

Hissen, Anna H. T., Wan, Adrian N. C., Warwas, Mark L., Pinto, Linda J., and Moore, Margo M.

Abstract

Aspergillus fumigatus is the leading cause of invasive mold infection and is a serious problem in immunocompromised populations worldwide. We have previously shown that survival of A. fumigatus in serum may be related to secretion of siderophores. In this study, we identified and characterized the sidA gene of A. fumigatus, which encodes L-ornithine N5-oxygenase, the first committed step in hydroxamate siderophore biosynthesis. A. fumigatus sidA codes for a protein of 501 amino acids with significant homology to other fungal L-ornithine N5-oxygenases. A stable ΔsidA strain was created by deletion of A. fumigatus sidA. This strain was unable to synthesize the siderophores N',N",N'''-triacetylfusarinine C (TAF) and ferricrocin. Growth of the ΔsidA strain was the same as that of the wild type in rich media; however, the ΔsidA strain was unable to grow in low-iron defined media or media containing 10% human serum unless supplemented with TAF or ferricrocin. No significant differences in ferric reduction activities were observed between the parental strain and the ΔsidA strain, indicating that blocking siderophore secretion did not result in upregulation of this pathway. Unlike the parental strain, the ΔsidA strain was unable to remove iron from human transferrin. A rescued strain (ΔsidA + sidA) was constructed; it produced siderophores and had the same growth as the wild type on iron-limited media. Unlike the wild-type and rescued strains, the ΔsidA strain was avirulent in a mouse model of invasive aspergillosis, indicating that sidA is necessary for A. fumigatus virulence.

Published
2005

26. The Aspergillus fumigatusSiderophore Biosynthetic Gene sidA, Encoding l-Ornithine N5-Oxygenase, Is Required for Virulence

Author

Hissen, Anna H. T., Wan, Adrian N. C., Warwas, Mark L., Pinto, Linda J., and Moore, Margo M.

Abstract

ABSTRACTAspergillus fumigatusis the leading cause of invasive mold infection and is a serious problem in immunocompromised populations worldwide. We have previously shown that survival of A. fumigatusin serum may be related to secretion of siderophores. In this study, we identified and characterized the sidAgene of A. fumigatus, which encodes l-ornithine N5-oxygenase, the first committed step in hydroxamate siderophore biosynthesis. A. fumigatus sidAcodes for a protein of 501 amino acids with significant homology to other fungal l-ornithine N5-oxygenases. A stable ΔsidAstrain was created by deletion of A. fumigatus sidA. This strain was unable to synthesize the siderophores N′,N",N‴-triacetylfusarinine C (TAF) and ferricrocin. Growth of the ΔsidAstrain was the same as that of the wild type in rich media; however, the ΔsidAstrain was unable to grow in low-iron defined media or media containing 10% human serum unless supplemented with TAF or ferricrocin. No significant differences in ferric reduction activities were observed between the parental strain and the ΔsidAstrain, indicating that blocking siderophore secretion did not result in upregulation of this pathway. Unlike the parental strain, the ΔsidAstrain was unable to remove iron from human transferrin. A rescued strain (ΔsidA + sidA) was constructed; it produced siderophores and had the same growth as the wild type on iron-limited media. Unlike the wild-type and rescued strains, the ΔsidAstrain was avirulent in a mouse model of invasive aspergillosis, indicating that sidAis necessary for A. fumigatusvirulence.

Published
2005
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