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To understand the audience's subjective perception of quality of service (QoS), it is important to analyze the data acquired from the logistics service logs and online evaluation system reasonably and effectively. Based on the analysis, rational improvement measures and decision suggestions can be developed to enhance the QoS. However, modern logistics service departments often face various business needs and service objects at the same time. If the evaluation subjects and their relationships are unclear in the service evaluation data, the sentiment analysis result of the text is a coarse-grained evaluation of the service as a whole. The lack of fine-grained pertinent evaluation results will hinder the improvement of specific management measures. To solve the problem, this paper designs an attention-based long short-term memory network (AT-LSTM) to divide the service reviews into ten topic relations, and then builds a deeper attention LSTM with aspect embedding (AE-DATT-LSTM). The weight-sharing bidirectional LSTM (BiLSTM) trains the topic word vectors and the text word vectors, and fuses the resulting topic features and text features. After the processing of the deep attention mechanism, the sentiment class of each evaluation topic is obtained by the classifier. Finally, several experiments were carried out on different public datasets. The results show that our approach surpasses the previous attention-based sentiment analysis models in accuracy and stability of service quality sentiment analysis. The introduction of topic features and deep attention mechanism is of great significance for the QoS-based sentiment classification b, and provides a feasible method for other fields like public opinion analysis, question answering system, and text reasoning.

Summary: Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects GBM hallmarks of immunosuppression and GSC maintenance in a paracrine and autocrine manner. Here, we expand the mechanism involved in angiogenesis, another critical GBM hallmark, as a potential basis underlying CLOCK’s pro-tumor effect in GBM. Mechanistically, CLOCK-directed olfactomedin like 3 (OLFML3) expression results in hypoxia-inducible factor 1-alpha (HIF1α)-mediated transcriptional upregulation of periostin (POSTN). As a result, secreted POSTN promotes tumor angiogenesis via activation of the TANK-binding kinase 1 (TBK1) signaling in endothelial cells. In GBM mouse and patient-derived xenograft models, blockade of the CLOCK-directed POSTN-TBK1 axis inhibits tumor progression and angiogenesis. Thus, the CLOCK-POSTN-TBK1 circuit coordinates a key tumor-endothelial cell interaction and represents an actionable therapeutic target for GBM.

Due to an error in the computer program used to summon potential jurors for service, the African-American percentage (4.17%) of jury pools was only one-half their percentage (8.25%) of the age-eligible population for about fifteen months. In June 2012, in Ambrose v. Booker, the Sixth Circuit accepted the statistical evidence as sufficient to meet the requirements for a prima facie case of unfair representation the U.S. Supreme Court established in Duren. On the same day, the Michigan S. Ct. in People v. Bryant said that the statistics were insufficient. The Michigan Court accepted a new measure, the disparity of the risk (DR), of under-representation. The DR measure is shown to be extremely stringent and an alternative measure based on the probability that a jury randomly selected from the jury pool will have fewer minorities than a jury selected from the age-eligible population is proposed. The minority fraction of individuals ultimately serving on juries also depends on the fairness of the peremptory challenges made by the parties. A method for detecting unfairness is reviewed; its effectiveness depends on the number of minorities on the venire. A reanalysis of the Michigan data shows that if the proportion of African-Americans in the jury pool equaled their proportion in the age-eligible population, prosecutors could only reduce their proportion on juries to about 80% of their proportion in the population. In contrast, the criteria for adequate representativeness based on the DR measure adopted by the Michigan Court could lead to virtually no minorities serving on actual juries as only three percent of the venires would have a sufficient number of minorities to classify a prosecutor's peremptory challenging all of them as significant. Our results indicate that when assessing statistics on the demographic mix of jury pools for legal significance, courts should consider the possible reduction in minority representation that can occur in the peremptory challenge proceedings. [ABSTRACT FROM AUTHOR]

Membrane-anchored DNA probes have been used to study molecular interactions and control cell assembly, but are not selective for different cell membranes. Here the authors develop a lipid-conjugated oligonucleotide for alkaline phosphatase-dependent cell membrane anchorage and use it to distinguish different cancer cells.