315 results on '"Vroegop A"'
Search Results
2. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice
- Author
-
Juhi Shah, Tyler Orosz, Avneet Singh, Savan Parameshwar Laxma, Rachel E. Gross, Nicholas Smith, Spencer Vroegop, Sydney Sudler, James T. Porter, Maria Colon, Lauren Jun, Jeganathan R. Babu, Minsub Shim, Thomas L. Broderick, and Layla Al-Nakkash
- Subjects
high-fat diet ,sucrose ,genistein ,exercise ,brain ,Alzheimer’s disease ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The prevalence of obesity and related consequences, including insulin resistance and Alzheimer’s-like neuropathology, has increased dramatically. Contributing to this prevalence is the shift in lifestyle preference away from wholesome foods and exercise to the Western-style diet and sedentarism. Despite advances in drug development, a healthy diet and regular exercise remain the most effective approaches to mitigating the unwanted sequelae of diet-induced obesity on brain health. In this study, we used the high-fat high-sugar (HFHS) mouse model of neurodegeneration to examine the effects of exercise training (HFHS+Ex), genistein treatment (HFHS+Gen), and combination treatment (HFHS+Ex+Gen) on proteins relating to neurodegeneration in the brain of male mice. After a period of 12 weeks, as expected, HFHS feeding increased body weight, adipose tissue weight, and systemic plasma inflammation (TNF-α) compared to lean mice fed a standard diet. HFHS feeding also increased protein expression of brain markers of insulin resistance (pGSK-3β, p-IR), apoptosis (caspase 3), early neurofibrillary tangles (CP13), and amyloid-beta precursor (CT20). Compared to HFHS mice, Ex decreased body weight, plasma TNF-α, and expression of pGSK-3β, caspase 3, CP13, amyloid-β precursor (22c11), and ADAM10. Treatment with Gen was equally protective on these markers and decreased the expression of p-IR. Combination treatment with Ex and Gen afforded the greatest overall benefits, and this group exhibited the greatest reduction in body and adipose tissue weight and all brain markers, except for 22c11 and ADAM10, which were decreased compared to mice fed an HFHS diet. In addition, levels of 4G8, which detects protein levels of amyloid-β, were decreased with combination treatment. Our results indicate that exercise training, genistein supplementation, or combination treatment provide varying degrees of neuroprotection from HFHS feeding-induced Alzheimer’s pathology. Future perspectives could include evaluating moderate exercise regimens in combination with dietary supplementation with genistein in humans to determine whether the same benefits translate clinically.
- Published
- 2024
- Full Text
- View/download PDF
3. Personalized Treatment for Obstructive Sleep Apnea: Beyond CPAP
- Author
-
Margot Van Daele, Yannick Smolders, Dorine Van Loo, Charlotte Bultynck, Johan Verbraecken, Anneclaire Vroegop, Thérèse Lapperre, Sara Op de Beeck, Marijke Dieltjens, and Olivier M. Vanderveken
- Subjects
CPAP intolerance ,obstructive sleep apnea ,alternative treatment ,personalized medicine ,Science - Abstract
Obstructive sleep apnea (OSA) is a sleep disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep. Continuous positive airway pressure (CPAP) is a method used as a first-line treatment for obstructive sleep apnea (OSA). However, intolerance and resistance to CPAP can limit its long-term effectiveness. Alternative treatments are available, such as Mandibular Advancement Devices (MADs), positional therapy, upper airway surgery, and maxillomandibular osteotomy. However, often less efficient in reducing the apnea-hypopnea index, the higher tolerance of and compliance to alternative treatment has resulted in the adequate treatment of OSA in CPAP-intolerant patients. This paper describes the protocol of a prospective single-center cohort study including adult patients with moderate to severe OSA (15 events/h ≤ apnea-hypopnea index (AHI) < 65 events/h) that failed to comply with CPAP therapy. Selected patients will be invited to the clinic to explore alternative treatment options where DISE will be a first step in further identifying upper airway collapse during sleep. By exploring alternative treatment options in CPAP-intolerant patients and systematically documenting their treatment paths, an algorithm can be defined to better guide patients towards personalized treatment for OSA. The follow-up is aimed at 5 years with an inclusion of 170 patients per year, including a drop-out rate of 15%. By leveraging a real-world database, this study aims to bridge the gap between research and clinical practice, facilitating the development of evidence-based guidelines and personalized treatment algorithms for CPAP-intolerant patients.
- Published
- 2024
- Full Text
- View/download PDF
4. Acetazolamide as an Add-on Therapy Following Barbed Reposition Pharyngoplasty in Obstructive Sleep Apnea: A Randomized Controlled Trial
- Author
-
Simon Hellemans, Eli Van de Perck, Dorine Van Loo, Johan Verbraecken, Scott A. Sands, Ali Azarbarzin, Marijke Dieltjens, Sara Op De Beeck, Anneclaire Vroegop, and Olivier M. Vanderveken
- Subjects
acetazolamide ,loop gain ,OSA ,pharmacotherapy ,pharyngoplasty ,upper airway surgery ,Science - Abstract
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP). However, predicting surgical success remains challenging, partly due to the contribution of non-anatomical factors. Therefore, combined medical treatment with acetazolamide, known to stabilize respiratory drive, may lead to superior surgical results. This double-blind, parallel-group randomized controlled trial evaluates the efficacy of acetazolamide as an add-on therapy to BRP in OSA. A total of 26 patients with moderate to severe OSA undergoing BRP were randomized to receive either acetazolamide or placebo post-surgery for 16 weeks. The group who was treated with BRP in combination with acetazolamide showed a reduction in AHI of 69.4%, significantly surpassing the 32.7% reduction of the BRP + placebo group (p < 0.01). The sleep apnea-specific hypoxic burden also decreased significantly in the group who was treated with BRP + acetazolamide (p < 0.01), but not in the group receiving BRP + placebo (p = 0.28). Based on these results, acetazolamide as an add-on therapy following BRP surgery shows promise in improving outcomes for OSA patients, addressing both anatomical and non-anatomical factors.
- Published
- 2024
- Full Text
- View/download PDF
5. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice.
- Author
-
Shah, Juhi, Orosz, Tyler, Singh, Avneet, Laxma, Savan Parameshwar, Gross, Rachel E., Smith, Nicholas, Vroegop, Spencer, Sudler, Sydney, Porter, James T., Colon, Maria, Jun, Lauren, Babu, Jeganathan R., Shim, Minsub, Broderick, Thomas L., and Al-Nakkash, Layla
- Subjects
EXERCISE physiology ,ALZHEIMER'S disease ,WESTERN diet ,HIGH-fat diet ,NEUROFIBRILLARY tangles - Abstract
The prevalence of obesity and related consequences, including insulin resistance and Alzheimer's-like neuropathology, has increased dramatically. Contributing to this prevalence is the shift in lifestyle preference away from wholesome foods and exercise to the Western-style diet and sedentarism. Despite advances in drug development, a healthy diet and regular exercise remain the most effective approaches to mitigating the unwanted sequelae of diet-induced obesity on brain health. In this study, we used the high-fat high-sugar (HFHS) mouse model of neurodegeneration to examine the effects of exercise training (HFHS+Ex), genistein treatment (HFHS+Gen), and combination treatment (HFHS+Ex+Gen) on proteins relating to neurodegeneration in the brain of male mice. After a period of 12 weeks, as expected, HFHS feeding increased body weight, adipose tissue weight, and systemic plasma inflammation (TNF-α) compared to lean mice fed a standard diet. HFHS feeding also increased protein expression of brain markers of insulin resistance (pGSK-3β, p-IR), apoptosis (caspase 3), early neurofibrillary tangles (CP13), and amyloid-beta precursor (CT20). Compared to HFHS mice, Ex decreased body weight, plasma TNF-α, and expression of pGSK-3β, caspase 3, CP13, amyloid-β precursor (22c11), and ADAM10. Treatment with Gen was equally protective on these markers and decreased the expression of p-IR. Combination treatment with Ex and Gen afforded the greatest overall benefits, and this group exhibited the greatest reduction in body and adipose tissue weight and all brain markers, except for 22c11 and ADAM10, which were decreased compared to mice fed an HFHS diet. In addition, levels of 4G8, which detects protein levels of amyloid-β, were decreased with combination treatment. Our results indicate that exercise training, genistein supplementation, or combination treatment provide varying degrees of neuroprotection from HFHS feeding-induced Alzheimer's pathology. Future perspectives could include evaluating moderate exercise regimens in combination with dietary supplementation with genistein in humans to determine whether the same benefits translate clinically. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Personalized Treatment for Obstructive Sleep Apnea: Beyond CPAP.
- Author
-
Van Daele, Margot, Smolders, Yannick, Van Loo, Dorine, Bultynck, Charlotte, Verbraecken, Johan, Vroegop, Anneclaire, Lapperre, Thérèse, Op de Beeck, Sara, Dieltjens, Marijke, and Vanderveken, Olivier M.
- Subjects
CONTINUOUS positive airway pressure ,SLEEP apnea syndromes ,PATIENT compliance ,INDIVIDUALIZED medicine ,SLEEP disorders - Abstract
Obstructive sleep apnea (OSA) is a sleep disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep. Continuous positive airway pressure (CPAP) is a method used as a first-line treatment for obstructive sleep apnea (OSA). However, intolerance and resistance to CPAP can limit its long-term effectiveness. Alternative treatments are available, such as Mandibular Advancement Devices (MADs), positional therapy, upper airway surgery, and maxillomandibular osteotomy. However, often less efficient in reducing the apnea-hypopnea index, the higher tolerance of and compliance to alternative treatment has resulted in the adequate treatment of OSA in CPAP-intolerant patients. This paper describes the protocol of a prospective single-center cohort study including adult patients with moderate to severe OSA (15 events/h ≤ apnea-hypopnea index (AHI) < 65 events/h) that failed to comply with CPAP therapy. Selected patients will be invited to the clinic to explore alternative treatment options where DISE will be a first step in further identifying upper airway collapse during sleep. By exploring alternative treatment options in CPAP-intolerant patients and systematically documenting their treatment paths, an algorithm can be defined to better guide patients towards personalized treatment for OSA. The follow-up is aimed at 5 years with an inclusion of 170 patients per year, including a drop-out rate of 15%. By leveraging a real-world database, this study aims to bridge the gap between research and clinical practice, facilitating the development of evidence-based guidelines and personalized treatment algorithms for CPAP-intolerant patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Acetazolamide as an Add-on Therapy Following Barbed Reposition Pharyngoplasty in Obstructive Sleep Apnea: A Randomized Controlled Trial.
- Author
-
Hellemans, Simon, Van de Perck, Eli, Van Loo, Dorine, Verbraecken, Johan, Sands, Scott A., Azarbarzin, Ali, Dieltjens, Marijke, Op De Beeck, Sara, Vroegop, Anneclaire, and Vanderveken, Olivier M.
- Subjects
CONTINUOUS positive airway pressure ,SLEEP apnea syndromes ,ACETAZOLAMIDE ,RANDOMIZED controlled trials ,THERAPEUTICS - Abstract
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP). However, predicting surgical success remains challenging, partly due to the contribution of non-anatomical factors. Therefore, combined medical treatment with acetazolamide, known to stabilize respiratory drive, may lead to superior surgical results. This double-blind, parallel-group randomized controlled trial evaluates the efficacy of acetazolamide as an add-on therapy to BRP in OSA. A total of 26 patients with moderate to severe OSA undergoing BRP were randomized to receive either acetazolamide or placebo post-surgery for 16 weeks. The group who was treated with BRP in combination with acetazolamide showed a reduction in AHI of 69.4%, significantly surpassing the 32.7% reduction of the BRP + placebo group (p < 0.01). The sleep apnea-specific hypoxic burden also decreased significantly in the group who was treated with BRP + acetazolamide (p < 0.01), but not in the group receiving BRP + placebo (p = 0.28). Based on these results, acetazolamide as an add-on therapy following BRP surgery shows promise in improving outcomes for OSA patients, addressing both anatomical and non-anatomical factors. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. A 6-year-old girl with an extranasopharyngeal angiofibroma of the ethmoid
- Author
-
Marie-Hélène Uwents, Mariette De Cock, Gerd Claes, Herwig Van Dijck, Anneclaire Vroegop, and Nicolien Van der Poel
- Subjects
Otorhinolaryngology ,RF1-547 - Published
- 2021
- Full Text
- View/download PDF
9. Non-CPAP therapy for obstructive sleep apnoea
- Author
-
Johan Verbraecken, Marijke Dieltjens, Sara Op de Beeck, Anneclaire Vroegop, Marc Braem, Olivier Vanderveken, and Winfried Randerath
- Subjects
Diseases of the respiratory system ,RC705-779 - Abstract
Treatment of obstructive sleep apnoea in adults is evolving, from a “one treatment fits all” to a more individualised approach. The spectrum of treatment options is broad and heterogeneous, including conservative, technological and pharmaceutical modalities. This raises the questions of which patients these modalities might be useful for, and if there are specific criteria for single or combined treatment. The most commonly used non-CPAP treatment is a mandibular advancement device. Furthermore, it appears from the available evidence that upper airway surgery, bariatric surgery, and maxillomandibular advancement can be effective in particular patient groups and should be indicated more readily in clinical practice. Technically, a tracheotomy is the most effective surgical treatment, but is not socially acceptable and is associated with major side-effects. Other treatment options are emerging, like positional therapy, hypoglossal nerve stimulation, and myofunctional exercises. Drug therapy is also promising when pathophysiological traits are considered. The range of currently available treatment options will be discussed in this review, with emphasis on the selection of appropriate patients, therapeutic efficacy and compliance, and reference to recent guidelines. In the selection process, routine application of drug-induced sleep endoscopy to assess the site(s) of collapse during sleep can increase the success rate of both surgical interventions and oral appliance therapy. Educational aims To outline recommendations concerning the proper management of obstructive sleep apnoea (OSA) patients that cannot be treated adequately with continuous positive airway pressure (CPAP) due to intolerance, poor adherence or compliance, or CPAP refusal. To provide information about the selection of appropriate patients for alternative non-CPAP treatment options. To better understand the different aspects of OSA treatment with noninvasive approaches, such as oral appliances, positional therapy, drug treatment and myofunctional therapy, including indications, contraindications, and expected short- and long-term results. To discuss the different surgical options for the treatment of OSA and to provide information on the important issue of proper patient selection for surgery, as most OSA surgical outcomes are associated with the pre-operative assessment of the level(s) of upper airway collapse.
- Published
- 2022
- Full Text
- View/download PDF
10. Impact of face masks in public spaces during COVID‐19 pandemic on daily life communication of cochlear implant users
- Author
-
Nienke C. Homans and Jantien L. Vroegop
- Subjects
cochlear implants ,Covid19 ,facemasks ,hearing loss ,quality of life ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objective/Hypothesis Investigate potential problems in the daily life communication of cochlear implant (CI) patients due to the widespread use of face masks in public places during the COVID‐19 pandemic. Study design Prospective survey study. Methods This study used an online questionnaire about the effects of face masks on daily life communication of adult CI users. The questionnaire consists of three parts: (a) A face mask questionnaire, (b) loneliness question (c) three subdomains of the Nijmegen Cochlear Implant Questionnaire to assess quality of life. The questionnaires were send out on October 20, 2020. Four hundred and seven adult CI users were invited to participate in the study. The survey inclusion was closed on November 5, 2020. The study setting was the Rotterdam Cochlear Implant Center, Erasmus MC, a tertiary referral center in The Netherlands. The loneliness question and Nijmegen Cochlear Implant Questionnaire were analyzed for possible differences between the current situation with masks and the situation before, when masks were not commonly used. Results Two hundred and twenty one adult CI users (54% female, mean age 62 years) participated in the study. The face mask questionnaire showed that face masks cause considerable problems in daily life communication of 80% of the participants. Also, CI users tend to feel more lonely and all used subdomains of the Nijmegen Cochlear Implant Questionnaire worsened due to the use of face masks. Conclusion The widespread use of face masks greatly complicates the daily life communication of CI users and reduces quality of life. Level of Evidence 3.
- Published
- 2021
- Full Text
- View/download PDF
11. Pilot study of a multidisciplinary single-day cochlear implant selection protocol
- Author
-
Homans, Nienke C., van der Toom, Hylke F.E., Pauw, Robert J., Vroegop, Jantien L., Homans, Nienke C., van der Toom, Hylke F.E., Pauw, Robert J., and Vroegop, Jantien L.
- Abstract
Purpose: This study aimed to explore and introduce the potential of a MSCS (Multidisciplinary Single-day Cochlear Implant Selection) protocol. The primary objectives of this pilot were to reduce the duration between referral and surgery, minimize hospital visits and decrease the time healthcare professionals dedicate to the cochlear implant (CI) selection process. Materials and methods: We established a pilot program at the CI center of the Erasmus MC, a tertiary referral center in the Netherlands, with the goal of improving and shorten the selection process. We evaluated our pilot, including 15 CI candidates, and conducted a retrospective analysis for time and cost savings. Results: The results showed that the pilot of the MSCS protocol significantly reduced the length of the CI selection phase (84 days vs 1; standard intake vs MSCS protocol) and the number of hospital visits (6 vs 2 visits; standard vs MSCS protocol), resulting in less travel time and lower costs for the CI candidates. The total time of professionals spend on patients was also reduced with 27 %. Conclusion: This study highlights the potential benefits of the MSCS protocol in terms of reducing the burden on patients and healthcare providers and improving the efficiency of the CI selection process.
- Published
- 2024
12. Communicating Emotion:Vocal Expression of Linguistic and Emotional Prosody in Children With Mild to Profound Hearing Loss Compared With That of Normal Hearing Peers
- Author
-
De Jong, Tjeerd J., Hakkesteegt, Marieke M., Van Der Schroeff, Marc P., Vroegop, Jantien L., De Jong, Tjeerd J., Hakkesteegt, Marieke M., Van Der Schroeff, Marc P., and Vroegop, Jantien L.
- Abstract
Objectives: Emotional prosody is known to play an important role in social communication. Research has shown that children with cochlear implants (CCIs) may face challenges in their ability to express prosody, as their expressions may have less distinct acoustic contrasts and therefore may be judged less accurately. The prosody of children with milder degrees of hearing loss, wearing hearing aids, has sparsely been investigated. More understanding of the prosodic expression by children with hearing loss, hearing aid users in particular, could create more awareness among healthcare professionals and parents on limitations in social communication, which awareness may lead to more targeted rehabilitation. This study aimed to compare the prosodic expression potential of children wearing hearing aids (CHA) with that of CCIs and children with normal hearing (CNH). Design: In this prospective experimental study, utterances of pediatric hearing aid users, cochlear implant users, and CNH containing emotional expressions (happy, sad, and angry) were recorded during a reading task. Of the utterances, three acoustic properties were calculated: fundamental frequency (F0), variance in fundamental frequency (SD of F0), and intensity. Acoustic properties of the utterances were compared within subjects and between groups. Results: A total of 75 children were included (CHA: 26, CCI: 23, and CNH: 26). Participants were between 7 and 13 years of age. The 15 CCI with congenital hearing loss had received the cochlear implant at median age of 8 months. The acoustic patterns of emotions uttered by CHA were similar to those of CCI and CNH. Only in CCI, we found no difference in F0 variation between happiness and anger, although an intensity difference was present. In addition, CCI and CHA produced poorer happy-sad contrasts than did CNH. Conclusions: The findings of this study suggest that on a fundamental, aco
- Published
- 2024
13. Patient and clinician experiences with the multidisciplinary single-day cochlear implant selection (MSCS) protocol
- Author
-
Homans, Nienke C., van der Toom, Hylke F.E., Pauw, Robert J., Vroegop, Jantien L., Homans, Nienke C., van der Toom, Hylke F.E., Pauw, Robert J., and Vroegop, Jantien L.
- Abstract
Purpose: This study assessed the MSCS (Multidisciplinary Single-day Cochlear Implant Selection) protocol with a primary focus on sustaining or enhancing patient satisfaction throughout the cochlear implant selection process. Materials and methods:Following the implementation of the new selection protocol, where all selection appointments take place on the same day, we surveyed 37 individuals who underwent the process. Twenty adhered to the standard procedure, while 17 followed the MSCS protocol. We also gathered feedback from seven out of eight involved healthcare providers. This method enabled us to evaluate the protocol's effectiveness in maintaining patient satisfaction and ensuring staff contentment with care delivery within a condensed timeframe. Results: Patient responses showed slight variations in average scores without statistical significant differences, indicating comparable satisfaction between the MSCS pathway and the standard protocol. The majority of patients preferred the MSCS protocol, with none of the MSCS participants opting for appointments spread over multiple days. Healthcare practitioners of the CI center also displayed similar or increased satisfaction levels with the MSCS protocol. Conclusion: The adoption of the MSCS in daily clinical care has led to a decrease in patient appointment times without sacrificing patient satisfaction. Additionally, the majority of individuals actively choose the MSCS protocol. Among those who have directly experienced it, there is unanimous preference for the consolidated appointments over spreading them across multiple days. Professionals within the CI team express equal satisfaction with both the new and old protocols, indicating that the reduction in patient time does not diminish overall satisfaction.
- Published
- 2024
14. A 4‐year follow‐up study of hearing acuity in a large population‐based cohort of children and adolescents
- Author
-
Danique E. Paping, Jantien L. Vroegop, Carlijn M. P. leClercq, Robert J. Baatenburg de Jong, and Marc P. van derSchroeff
- Subjects
audiometry ,children ,hearing loss ,noise ,prevalence ,Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Abstract Objectives To describe the prevalence of hearing loss among 13 year old adolescents, and to examine the change in prevalence between ages 9 and 13 years. Methods This study was embedded within Generation R, a population‐based prospective cohort study from fetal life onwards in the Netherlands. Pure‐tone thresholds were obtained at 0.5 to 8 kHz, and tympanometry was performed. Sensorineural hearing loss (SNHL) was defined as a low‐frequency and/or high‐frequency pure‐tone average of more than 15 dB HL in one of both ears. Audiometric signs suggestive of noise‐induced hearing loss (NIHL) included the presence of a notch and/or high‐frequency hearing loss. The study was conducted from April 2012 to October 2015, and April 2016 to September 2019. Results A total of 4572 adolescents with a mean age of 13 years and 7 months (SD, 5 months) were included, of whom 2334 (51.0%) were girls. Within the cohort, 6.4% (95% CI, 5.7%‐7.2%) were estimated to have SNHL, and 12.4% (95% CI, 11.5%‐13.4%) met the criteria of NIHL. In total, 3675 participants were included in the longitudinal analysis. The prevalence of SNHL decreased from 8.0% to 5.3% between ages 9 and 13 years (P
- Published
- 2021
- Full Text
- View/download PDF
15. A smartphone application to objectively monitor music listening habits in adolescents
- Author
-
Danique E. Paping, Jantien L. Vroegop, Simone P. C. Koenraads, Carlijn M.P. le Clercq, André Goedegebure, Robert J. Baatenburg de Jong, and Marc P. van der Schroeff
- Subjects
Personal listening device ,Smartphone application ,Noise-induced hearing loss ,Music ,Listening habits ,Behaviour ,Surgery ,RD1-811 - Abstract
Abstract Background Listening to music through personal listening devices (PLDs) has become more prevalent during last decades. The aim of this study was to evaluate music listening habits through PLDs in adolescents with a smartphone application, and to assess the accuracy of self-reported listening habits. Methods This study was embedded in the Generation R Study, a population-based prospective birth cohort in Rotterdam, the Netherlands. A smartphone application for Android operating systems was developed to objectively monitor music listening habits for a period of 35 days. A postal questionnaire was used to subjectively assess listening habits. The level of agreement between the objectively measured and self-reported listening habits were evaluated using weighted kappa coefficients. Data were collected from May 2017 to March 2019. Results A total of 311 adolescents aged 12 to 15 years were included, of whom 237 (76.2%) completed the postal questionnaire. The results of the smartphone application showed that the median listening frequency was 2.1 days a week (IQR 1.0–3.4), the median listening time 21.1 min a day (IQR 9.1–53.7), and the mean listening level 54.5% (SD 18.1%). There was a slight to fair agreement between the objectively measured, and self-reported listening habits according to the weighted kappa coefficients (k = 0.179 to 0.364). Conclusions The results of the current study suggest that self-reported measures of listening habits are not always accurate. We consider a smartphone application to monitor listening habits of added value in future research investigating the possible damaging effects of PLDs on hearing acuity. Graphical abstract
- Published
- 2021
- Full Text
- View/download PDF
16. Benefit of sequential bilateral cochlear implantation in children between 5 to 18 years old: A prospective cohort study.
- Author
-
W J Kleijbergen, M Sparreboom, E A M Mylanus, G de Koning, H W Helleman, P P B M Boermans, J H M Frijns, J L Vroegop, M P van der Schroeff, E E J Gelders, E L J George, M J W Lammers, W Grolman, I Stegeman, and A L Smit
- Subjects
Medicine ,Science - Abstract
ObjectiveTo determine the benefit of sequential cochlear implantation after a long inter-implantation interval in children with bilateral deafness receiving their second implant between 5 and 18 years of age.Study designProspective cohort-study.SettingTertiary multicenter.Patients85 children with bilateral deafness and unilateral implantation receiving a contralateral cochlear implant at the age of 5 to 18 years.MethodThe primary outcomes were speech recognition in quiet and noise (CVC) scores. The secondary outcomes were language outcomes and subjective hearing abilities, all measured before and 12 months after sequential bilateral cochlear implantation. Medians of the paired data were compared using the Wilcoxon signed-rank test. Univariable linear regression analyses was used to analyze associations between variables and performance outcomes.ResultsA significant benefit was found for speech recognition in quiet (96% [89-98] vs 91% [85-96]; p < 0.01) and noise (65% [57-75] vs 54% [47-71]; p = 0.01) in the bilateral CI condition compared to unilateral (n = 75, excluded 10 non-users). No benefit was seen for language outcomes. The subjective sound quality score was statistically significant higher in bilateral compared to the unilateral CI condition. Pre-operative residual hearing level in the ear of the second implant, the inter-implant interval and age at time of second implantation was not significantly associated with performance scores.ConclusionAfter 12 months of use, sequential bilateral cochlear implantation showed improved speech perception in quiet and noise and improved subjective sound quality outcomes in children despite a great inter-implantation interval (median of 8 years [range 1-16 years]).
- Published
- 2022
- Full Text
- View/download PDF
17. Correction to: A smartphone application to objectively monitor music listening habits in adolescents
- Author
-
Paping, Danique E., Vroegop, Jantien L., Koenraads, Simone P. C., le Clercq, Carlijn M. P., Goedegebure, André, Baatenburg de Jong, Robert J., and van der Schroeff, Marc P.
- Published
- 2021
- Full Text
- View/download PDF
18. A smartphone application to objectively monitor music listening habits in adolescents: Personal listening device usage and the accuracy of self-reported listening habits
- Author
-
Paping, Danique E., Vroegop, Jantien L., Koenraads, Simone P. C., le Clercq, Carlijn M.P., Goedegebure, André, Baatenburg de Jong, Robert J., and van der Schroeff, Marc P.
- Published
- 2021
- Full Text
- View/download PDF
19. An integrated end-to-end deep neural network for automated detection of discarded fish species and their weight estimation
- Author
-
Sokolova, Maria, primary, Cordova, Manuel, additional, Nap, Henk, additional, van Helmond, Aloysius, additional, Mans, Michiel, additional, Vroegop, Arjan, additional, Mencarelli, Angelo, additional, and Kootstra, Gert, additional
- Published
- 2023
- Full Text
- View/download PDF
20. Remotely controlled mandibular positioning of oral appliance therapy during polysomnography and drug-induced sleep endoscopy compared with conventional subjective titration in patients with obstructive sleep apnea: protocol for a randomized crossover trial
- Author
-
Marijke Dieltjens, Marc J. Braem, Sara Op de Beeck, Anneclaire V. M. T. Vroegop, Elahe Kazemeini, Eli Van de Perck, Jolien Beyers, Chloé Kastoer, Kristien Wouters, Marc Willemen, Johan A. Verbraecken, and Olivier M. Vanderveken
- Subjects
Mandibular advancement device ,Sleep-disordered breathing ,Apnea–hypopnea index ,Medicine (General) ,R5-920 - Abstract
Abstract Background The amount of mandibular protrusion is a key factor in optimizing the efficacy of mandibular advancement device (MAD) therapy in an individual patient diagnosed with obstructive sleep apnea. This process is called titration and is generally based on resolution of subjective symptoms like snoring and/or daytime sleepiness as a function of protrusion. An objective approach uses a remotely controlled mandibular positioner (RCMP) during a full-night polysomnography (PSG), in analogy with continuous positive airway pressure (CPAP) titration. More recently, the feasibility of RCMP use during drug-induced sleep endoscopy (DISE) titration was reported. Methods This randomized crossover trial will compare DISE-assisted titration to PSG-guided titration, as well as with the conventional subjective titration method. The primary outcome is the actual mandibular protrusive position found to be the most optimal for each tested titration procedure. Furthermore, the therapeutic efficacy will be compared among the different titration modalities using level 1 sleep studies. Discussion Currently, the optimal titration of MAD therapy is most often based on ‘trial and error’. The conventional method relies on subjective improvement in symptoms, although this may not provide the most accurate indicator for efficient titration. Therefore, relying on objective criteria in the titration process should be advantageous. In analogy with CPAP, titration of the most optimal mandibular protrusion could be performed using RCMP during an overnight titration PSG. Recently, it was shown that titration under direct visualization of upper airway patency and collapsibility is feasible using the RCMP during DISE. However, no clinical results for such a procedure are as yet available. This study is the first to compare the most optimal mandibular protrusive position according to three titration procedures, as well as to compare the therapeutic efficacy of these titration methods. Trial registration ClinicalTrials.gov, NCT03716648 . Registered on 23 October 2018.
- Published
- 2019
- Full Text
- View/download PDF
21. Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma
- Author
-
Claire A. Cox, Ilse M. Boudewijn, Sebastiaan J. Vroegop, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Judith M. Vonk, Martijn P. Farenhorst, Nick H. T. ten Hacken, Huib A. M. Kerstjens, and Maarten van den Berge
- Subjects
Borg score ,Dry powder adenosine ,AMP ,Provocation ,Dyspnea ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV1. Provocation tests only use the large airways parameter FEV1, although dyspnea is associated with both large- and small airways dysfunction. Aim of this study was to explore if adenosine 5′-monophosphate (AMP) and adenosine evoke an equal dyspnea sensation and if dyspnea associates better with large or small airways dysfunction. Methods We targeted large airways with AMP and small airways with dry powder adenosine in 59 asthmatic (ex)-smokers with ≥5 packyears, 14 ± 7 days apart. All subjects performed spirometry, impulse oscillometry (IOS), and Borg dyspnea score. In 36 subjects multiple breath nitrogen washout (MBNW) was additionally performed. We analyzed the association of the change (Δ) in Borg score with the change in large and small airways parameters, using univariate and multivariate linear regression analyses. MBNW was analyzed separately. Results Provocation with AMP and adenosine evoked similar levels of dyspnea. ΔFEV1 was not significantly associated with ΔBorg after either AMP or adenosine provocation, in both univariate and multivariate analyses. In multivariate linear regression, a decrease in FEF25–75 during adenosine provocation was independently associated with an increase in Borg. In the multivariate analyses for AMP provocation, no significant associations were found between ΔBorg and any large or small airways parameters. Conclusion AMP and adenosine induce equally severe dyspnea sensations. Our results suggest that dyspnea induced with dry powder adenosine is related to small airways involvement, while neither large nor small airways dysfunction was associated with AMP-induced dyspnea. Trail registration NCT01741285 at www.clinicaltrials.gov, first registered Dec 4th, 2012.
- Published
- 2019
- Full Text
- View/download PDF
22. Risk Factors For Hearing Decline From Childhood To Early Adolescence
- Author
-
Danique E. Paping, Berthe C. Oosterloo, Hanan El Marroun, Nienke C. Homans, Rob J. Baatenburg de Jong, Marc P. van der Schroeff, Jantien L. Vroegop, Otorhinolaryngology and Head and Neck Surgery, and Clinical Psychology
- Subjects
Otorhinolaryngology ,SDG 3 - Good Health and Well-being ,otorhinolaryngologic diseases - Abstract
Objective: To identify risk factors of hearing decline between 9 and 13 years of age. The risk factors examined included sociodemographic, health, and lifestyle-related factors. Methods: This study was embedded within a population-based prospective cohort study from fetal life onwards in the Netherlands. Pure-tone audiometry and tympanometry were performed at the age of 9 and 13 years. The hearing decline was defined as an increase in low-frequency or high-frequency pure-tone average of at least 5 dB in one of both ears. Multivariable logistic regression was performed to examine the association of possible risk factors with hearing decline. The study was conducted from April 2012 to October 2015, and from April 2016 to September 2019. Results: Of the 3,508 participants included, 7.8% demonstrated a hearing decline in the low frequencies, and 11.3% in the high frequencies. Participants who reported alcohol consumption were more likely to have a hearing decline in the low frequencies (OR 1.5, 95% CI 1.1; 2.0). Moreover, a lower educational level was associated with an increased odds of having a hearing decline in the high frequencies (OR 1.4, 95% CI 1.0; 1.8). Age, sex, household income, personal music player use, and body mass index were not associated with hearing decline. Conclusion: Educational level and risky behavior were significantly associated with hearing decline from childhood to early adolescence. The findings of the present study can help in the design of public health interventions to prevent hearing loss at a young age. Level of Evidence: 2 (prospective cohort study) Laryngoscope, 133:389–395, 2023.
- Published
- 2023
23. Correction to: A smartphone application to objectively monitor music listening habits in adolescents
- Author
-
Danique E. Paping, Jantien L. Vroegop, Simone P. C. Koenraads, Carlijn M. P. le Clercq, André Goedegebure, Robert J. Baatenburg de Jong, and Marc P. van der Schroeff
- Subjects
Surgery ,RD1-811 - Published
- 2021
- Full Text
- View/download PDF
24. Prevalence, severity and impact of chronic pain among a representative cross‐sectional study of New Zealand high school students
- Author
-
Bridget, Farrant, Simon, Denny, Paul, Vroegop, John, Fenaughty, and Terryann C, Clark
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
To report the prevalence of self-reported chronic pain and severity among young people in New Zealand and explore the relationships between pain and mental health, substance use, socialisation and school engagement.Prevalence of self-reported chronic pain frequency and severity are reported from an anonymous, representative cross-sectional self-administered health and well-being questionnaire by students aged 12-18 years in New Zealand. Multivariable models exploring chronic pain and mental health, substance use, socialisation and school engagement are reported controlling for age, sex, ethnicity, socio-economic status, disability and history of sexual abuse.Overall, 22.8% (95% confidence interval (CI) 21.2-24.5) of young people reported chronic pain for 6 months or more, with 3.2% (95% CI 3.1-4.5) reporting severe pain weekly or more often. Females and rural adolescents were more likely to report chronic and severe pain. Asian youth reported less pain than other ethnic groups. Increased severity of pain was associated more with poorer daily functioning and socialising than with frequency of pain. Severe pain occurring weekly or more often was more common among students who had a disability (2.3% 95% CI 1.8-2.7 vs. 9.8%, 95% CI 7.2-12.5) or a history of sexual abuse (2.4% 95% 1.9-2.9 vs. 8.5%, 95% CI 6.3-10.5). Those reporting chronic pain had higher proportions of self-reported significant depressive symptoms, lower well-being, lower school engagement and lower access to health care, particularly for those reporting higher levels of intensity and frequency of pain.Chronic pain is common in adolescent populations, and has a significant association with decreased daily functioning, socialising, school engagement and mental well-being. Adolescents with chronic pain report significant unmet health-care needs.
- Published
- 2022
25. Lactobacilli Have a Niche in the Human Nose
- Author
-
Ilke De Boeck, Marianne F.L. van den Broek, Camille N. Allonsius, Irina Spacova, Stijn Wittouck, Katleen Martens, Sander Wuyts, Eline Cauwenberghs, Katarina Jokicevic, Dieter Vandenheuvel, Tom Eilers, Michelle Lemarcq, Charlotte De Rudder, Sofie Thys, Jean-Pierre Timmermans, Anneclaire V. Vroegop, Alex Verplaetse, Tom Van de Wiele, Filip Kiekens, Peter W. Hellings, Olivier M. Vanderveken, and Sarah Lebeer
- Subjects
upper respiratory tract ,niche-adaptation ,microbiome ,probiotics ,sinusitis ,lactobacillus ,Biology (General) ,QH301-705.5 - Abstract
Summary: Although an increasing number of beneficial microbiome members are characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from the beneficial Lactobacillus genus complex are more prevalent in the healthy URT than in patients with chronic rhinosinusitis (CRS). Several URT-specific isolates are cultured, characterized, and further explored for their genetic and functional properties related to adaptation to the URT. Catalase genes are found in the identified lactobacilli, which is a unique feature within this mostly facultative anaerobic genus. Moreover, one of our isolated strains, Lactobacillus casei AMBR2, contains fimbriae that enable strong adherence to URT epithelium, inhibit the growth and virulence of several URT pathogens, and successfully colonize nasal epithelium of healthy volunteers. This study thus demonstrates that specific lactobacilli are adapted to the URT and could have a beneficial keystone function in this habitat.
- Published
- 2020
- Full Text
- View/download PDF
26. Architecture and Dynamics of the Jasmonic Acid Gene Regulatory Network
- Author
-
Hickman, Richard, Van Verk, Marcel C., Van Dijken, Anja J.H., Mendes, Marciel Pereira, Vroegop-Vos, Irene A., Caarls, Lotte, Steenbergen, Merel, Van der Nagel, Ivo, Wesselink, Gert Jan, Jironkin, Aleksey, Talbot, Adam, Rhodes, Johanna, De Vries, Michel, Schuurink, Robert C., Denby, Katherine, Pieterse, Corné M.J., and Van Wees, Saskia C.M.
- Published
- 2017
27. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression
- Author
-
Ilse M. Boudewijn, Alen Faiz, Katrina Steiling, Erica van der Wiel, Eef D. Telenga, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Corry-Anke Brandsma, Huib A. M. Kerstjens, Wim Timens, Irene H. Heijink, Marnix R. Jonker, Harold G. de Bruin, J. Sebastiaan Vroegop, Henk R. Pasma, Wim G. Boersma, Pascal Wielders, Frank van den Elshout, Khaled Mansour, Avrum Spira, Marc E. Lenburg, Victor Guryev, Dirkje S. Postma, and Maarten van den Berge
- Subjects
COPD ,Nasal epithelium ,Bronchial epithelium ,Genome wide gene expression ,Microarray ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigated whether this COPD-associated gene expression profile in nasal epithelium is comparable with the profile observed in bronchial epithelium. Methods Genome wide gene expression analysis was performed on nasal epithelial brushes of 31 severe COPD patients and 22 controls, all current smokers, using Affymetrix Human Gene 1.0 ST Arrays. We repeated the gene expression analysis on bronchial epithelial brushes in 2 independent cohorts of mild-to-moderate COPD patients and controls. Results In nasal epithelium, 135 genes were significantly differentially expressed between severe COPD patients and controls, 21 being up- and 114 downregulated in COPD (false discovery rate
- Published
- 2017
- Full Text
- View/download PDF
28. Extrafine compared to non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma
- Author
-
Cox, Claire A., Boudewijn, Ilse M., Vroegop, Sebastiaan J., Schokker, Siebrig, Lexmond, Anne J., Frijlink, Henderik W., Hagedoorn, Paul, Vonk, Judith M., Farenhorst, Martijn P., Ten Hacken, Nick H.T., Kerstjens, Huib A.M., Postma, Dirkje S., and van den Berge, Maarten
- Published
- 2017
- Full Text
- View/download PDF
29. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD
- Author
-
Faiz, Alen, Imkamp, Kai, van der Wiel, Erica, Boudewijn, Ilse M., Koppelman, Gerard H., Brandsma, Corry-Anke, Kerstjens, Huib A. M., Timens, Wim, Vroegop, Sebastiaan, Pasma, Henk R., Boersma, Wim G., Wielders, Pascal, van den Elshout, Frank, Mansour, Khaled, Steiling, Katrina, Spira, Avrum, Lenburg, Marc E., Heijink, Irene H., Postma, Dirkje S., and van den Berge, Maarten
- Published
- 2020
- Full Text
- View/download PDF
30. Correction to: Remotely controlled mandibular positioning of oral appliance therapy during polysomnography and drug-induced sleep endoscopy compared with conventional subjective titration in patients with obstructive sleep apnea: protocol for a randomized crossover trial
- Author
-
Dieltjens, Marijke, Braem, Marc J., Op de Beeck, Sara, Vroegop, Anneclaire V. M. T., Kazemeini, Elahe, Van de Perck, Eli, Beyers, Jolien, Kastoer, Chloé, Wouters, Kristien, Willemen, Marc, Verbraecken, Johan A., and Vanderveken, Olivier M.
- Published
- 2020
- Full Text
- View/download PDF
31. Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma
- Author
-
Cox, Claire A., Boudewijn, Ilse M., Vroegop, Sebastiaan J., Schokker, Siebrig, Lexmond, Anne J., Frijlink, Henderik W., Hagedoorn, Paul, Vonk, Judith M., Farenhorst, Martijn P., ten Hacken, Nick H. T., Kerstjens, Huib A. M., and van den Berge, Maarten
- Published
- 2019
- Full Text
- View/download PDF
32. Automatic Phenotyping of Tomatoes in Production Greenhouses Using Robotics and Computer Vision: From Theory to Practice
- Author
-
Hubert Fonteijn, Manya Afonso, Dick Lensink, Marcel Mooij, Nanne Faber, Arjan Vroegop, Gerrit Polder, and Ron Wehrens
- Subjects
phenotyping ,robotics ,computer vision ,deep learning ,tomato ,greenhouse ,Agriculture - Abstract
High-throughput phenotyping is playing an increasingly important role in many areas of agriculture. Breeders will use it to obtain values for the traits of interest so that they can estimate genetic value and select promising varieties; growers may be interested in having predictions of yield well in advance of the actual harvest. In most phenotyping applications, image analysis plays an important role, drastically reducing the dependence on manual labor while being non-destructive. An automatic phenotyping system combines a reliable acquisition system, a high-performance segmentation algorithm for detecting fruits in individual images, and a registration algorithm that brings the images (and the corresponding detected plants or plant components) into a coherent spatial reference frame. Recently, significant advances have been made in the fields of robotics, image registration, and especially image segmentation, which each individually have improved the prospect of developing a fully integrated automatic phenotyping system. However, so far no complete phenotyping systems have been reported for routine use in a production environment. This work catalogs the outstanding issues that remain to be resolved by describing a prototype phenotyping system for a production tomato greenhouse, for many reasons a challenging environment.
- Published
- 2021
- Full Text
- View/download PDF
33. Emotion perception in children with cochlear implants and with hearing aids
- Author
-
Başkent, Deniz, primary, Babaoğlu, Gizem, additional, Yazgan, Başak, additional, Ertürk, Pınar, additional, Gaudrain, Etienne, additional, Nagels, Leanne, additional, Jong, Tjeerd, additional, Launer, Stefan, additional, Singh, Gurjit, additional, Derleth, R. Peter, additional, Coster, Francien, additional, Chatterjee, Monita, additional, Vickers, Debi, additional, Hendriks, Petra, additional, Yücel, Esra, additional, Sennaroğlu, Gonca, additional, Schroeff, Marc, additional, Vroegop, Jantien, additional, Maat, Bert, additional, Free, Rolien, additional, Benard, Ruben, additional, Dirks, Evelien, additional, and Rachman, Laura, additional
- Published
- 2023
- Full Text
- View/download PDF
34. Correction to: Remotely controlled mandibular positioning of oral appliance therapy during polysomnography and drug-induced sleep endoscopy compared with conventional subjective titration in patients with obstructive sleep apnea: protocol for a randomized crossover trial
- Author
-
Marijke Dieltjens, Marc J. Braem, Sara Op de Beeck, Anneclaire V. M. T. Vroegop, Elahe Kazemeini, Eli Van de Perck, Jolien Beyers, Chloé Kastoer, Kristien Wouters, Marc Willemen, Johan A. Verbraecken, and Olivier M. Vanderveken
- Subjects
Medicine (General) ,R5-920 - Abstract
Following publication of the original article [1], the authors reported that Fig. 1 had not been corrected based on the reviewer’s comments. The correct Fig. 1 is presented below.
- Published
- 2020
- Full Text
- View/download PDF
35. A systematic review on the impact of auditory functioning and language proficiency on psychosocial difficulties in children and adolescents with hearing loss
- Author
-
de Jong, Tjeerd J., van der Schroeff, Marc P., Stapersma, Luuk, Vroegop, Jantien L., de Jong, Tjeerd J., van der Schroeff, Marc P., Stapersma, Luuk, and Vroegop, Jantien L.
- Abstract
Objective: Approximately 20% to 40% of children with hearing loss encounter psychosocial difficulties. This prevalence may be outdated, given the advancements in hearing technology and rehabilitation efforts to enhance the psychosocial well-being of these children. A systematic review of up-to-date literature can help to identify factors that may contribute to the children’s psychosocial well-being. Design/Study sample: A systematic review was conducted. Original articles were identified through systematic searches in Embase, Medline, PsychINFO, and Web of Science Core Collection. The quality of the papers was assessed using the Newcastle-Ottawa Quality Assessment Scale and custom Reviewers’ Criteria. Results: A search was performed on 20 October 2022. A total of 1561 articles were identified, and 36 were included for review. Critical appraisal led to 24 good to fair quality articles, and 12 poor quality articles. Conclusion: Children with hearing loss have a twofold risk of experiencing psychosocial difficulties compared to normal hearing peers. Estimates for functioning in social interactions, like speech perception (in noise) or language proficiency, have proven to be more adequate predictors for psychosocial difficulties than the degree of hearing loss. Our findings can be useful for identifying children at risk for difficulties and offering them earlier and more elaborate psychological interventions.
- Published
- 2023
36. Data underlying the publication: An integrated end-to-end deep neural network for automated detection of discarded fish species and their weight estimation.
- Author
-
Sokolova, Maria, Cordova Neira, Manuel, Nap, Henk, van Helmond, Edwin, Mans, Michiel, Vroegop, Arjan, Mencarelli, Angelo, Kootstra, Gert, Sokolova, Maria, Cordova Neira, Manuel, Nap, Henk, van Helmond, Edwin, Mans, Michiel, Vroegop, Arjan, Mencarelli, Angelo, and Kootstra, Gert
- Abstract
The dataset contains images of the discarded fish on the conveyor belt and annotations. Annotations are prepared in YOLO format, i.e. separate text files, containing fish species label, object bounding box annotation, weight and occlusion level. Annotation per individual fish is written in a separate row of the file. Additionally, we provide weight file (.pt) for the best performing Detection-Weight2 model.
- Published
- 2023
37. An integrated end-to-end deep neural network for automated detection of discarded fish species and their weight estimation
- Author
-
Sokolova, Maria, Cordova, Manuel, Nap, Henk, van Helmond, Aloysius, Mans, Michiel, Vroegop, Arjan, Mencarelli, Angelo, Kootstra, Gert, Sokolova, Maria, Cordova, Manuel, Nap, Henk, van Helmond, Aloysius, Mans, Michiel, Vroegop, Arjan, Mencarelli, Angelo, and Kootstra, Gert
- Abstract
Sustainable management of aquatic resources requires efficient acquisition and processing of vast amounts of information to check the compliance of fishing activities with the regulations. Recent implementation of the European Common Fisheries Policy Landing Obligation implies the declaration of all listed species and sizes at the harbour. To comply with such regulation, fishers need to collect and store all discards onboard the vessel, which results in additional processing time, labour demands, and costs. In this study, we presented a system that allowed image-based documentation of discards on the conveyor belt. We presented a novel integrated end-to-end simultaneous detection and weight prediction pipeline based on the state-of-the-art deep convolutional neural network. The performance of the network was evaluated per species and under different occlusion levels. The resulting model was able to detect discards with a macro F1-score of 94.10% and a weighted F1-score of 93.88%. Weight of the fish could be predicted with mean absolute error, mean absolute percentage error, and root squared error of 29.74 (g), 23.78%, and 44.69 (g), respectively. Additionally, we presented a new dataset containing images of fish, which, unlike common object detection datasets, also contains weight measurements and occlusion level per individual fish.
- Published
- 2023
38. First results of the Strengths and Difficulties Questionnaire, applied as a screening tool for psychosocial difficulties in pediatric audiology
- Author
-
de Jong, Tjeerd J., van der Schroeff, Marc P., Achterkamp, Marieke D., Vroegop, Jantien L., de Jong, Tjeerd J., van der Schroeff, Marc P., Achterkamp, Marieke D., and Vroegop, Jantien L.
- Abstract
Purpose: Despite major improvements in rehabilitation possibilities, children with sensorineural hearing loss are at risk for psychosocial difficulties. These difficulties can impact their educational and career achievements and may be two to three times more common in children with hearing loss compared to those with normal hearing. Early identification of psychosocial difficulties can be facilitated using the Strengths and Difficulties Questionnaire (SDQ) and may improve outcomes and quality of life. We implemented the SDQ into the clinical follow-up of children with hearing loss in a tertiary referral hospital. With this, prevalence and severity of difficulties in specific psychosocial domains and several predictors were investigated. Methods: A retrospective, cross-sectional investigation was performed of the following factors in association with the SDQ results: type of hearing device, type and degree of hearing loss, speech perception in quiet and in noise, and type of schooling. Results: Between June 2020 and January 2022, parents of 312 children (age 4–18) completed the SDQ. An additional 113 child-reports were completed. The response rate of the parents was 69%. Problems with peer relationships and prosocial behavior were the most affected areas with clinically elevated scores in 22% of the children. Psychosocial difficulties were distributed similarly across types of hearing device, nature and degrees of hearing loss, and educational settings. Better speech perception in quiet was significantly associated with fewer parent-reported conduct problems. Conclusion: The results of the present study suggest that children with hearing loss may be at risk of experiencing challenges with social interactions and attachment in social contexts. Using the SDQ in clinical follow-up may improve the chances for early psychological assessment and intervention. In addition, the study found that children’s mental health may be impacted by their communication abilities.
- Published
- 2023
39. Risk Factors For Hearing Decline From Childhood To Early Adolescence
- Author
-
Paping, Danique E., Oosterloo, Berthe C., El Marroun, Hanan, Homans, Nienke C., Baatenburg de Jong, Rob J., van der Schroeff, Marc P., Vroegop, Jantien L., Paping, Danique E., Oosterloo, Berthe C., El Marroun, Hanan, Homans, Nienke C., Baatenburg de Jong, Rob J., van der Schroeff, Marc P., and Vroegop, Jantien L.
- Abstract
Objective: To identify risk factors of hearing decline between 9 and 13 years of age. The risk factors examined included sociodemographic, health, and lifestyle-related factors. Methods: This study was embedded within a population-based prospective cohort study from fetal life onwards in the Netherlands. Pure-tone audiometry and tympanometry were performed at the age of 9 and 13 years. The hearing decline was defined as an increase in low-frequency or high-frequency pure-tone average of at least 5 dB in one of both ears. Multivariable logistic regression was performed to examine the association of possible risk factors with hearing decline. The study was conducted from April 2012 to October 2015, and from April 2016 to September 2019. Results: Of the 3,508 participants included, 7.8% demonstrated a hearing decline in the low frequencies, and 11.3% in the high frequencies. Participants who reported alcohol consumption were more likely to have a hearing decline in the low frequencies (OR 1.5, 95% CI 1.1; 2.0). Moreover, a lower educational level was associated with an increased odds of having a hearing decline in the high frequencies (OR 1.4, 95% CI 1.0; 1.8). Age, sex, household income, personal music player use, and body mass index were not associated with hearing decline. Conclusion: Educational level and risky behavior were significantly associated with hearing decline from childhood to early adolescence. The findings of the present study can help in the design of public health interventions to prevent hearing loss at a young age. Level of Evidence: 2 (prospective cohort study) Laryngoscope, 133:389–395, 2023.
- Published
- 2023
40. The association of sociodemographic factors and risk behavior with unsafe use of personal listening devices in adolescents
- Author
-
Paping, Danique E., Vroegop, Jantien L., El Marroun, Hanan, Baatenburg de Jong, Robert J., van der Schroeff, Marc P., Paping, Danique E., Vroegop, Jantien L., El Marroun, Hanan, Baatenburg de Jong, Robert J., and van der Schroeff, Marc P.
- Abstract
Many young people are potentially at risk of noise-induced hearing loss due to unsafe use of personal listening devices. The aim of this cross-sectional study was to examine the association of sociodemographic factors and risk behavior with unsafe use of personal listening devices in adolescents to identify a target group for prevention. A smartphone application was developed to objectively measure music listening habits among 314 adolescents with a mean age of 13 years and 7 months (SD ±5 months). Listening habits were characterized as safe or unsafe based on the weekly noise dose. Data on sociodemographic factors and traditional health risk behaviors were obtained by questionnaires. Within the study group, 10.5% of the participants exceeded the 50%, and 4.8% the 100% recommended weekly noise dose. Adolescents with a lower socioeconomic status were more likely to engage in unsafe listening habits as compared to adolescents with a higher socioeconomic status. Additionally, risk behavior was associated with higher odds of having unsafe listening habits as compared to no risk behavior. Age, sex and educational levels were not significantly associated with unsafe listening habits. The findings of the present study indicate that interventions to promote safe listening habits should target adolescents with a lower socioeconomic status and higher risk behavior. Future research is needed to investigate how these adolescents can be motivated to adopt safe listening habits.
- Published
- 2023
41. Translation and validation of the speech, spatial, and qualities of hearing scale (SSQ) and the hearing environments and reflection on quality of life (HEAR-QL) questionnaire for children and adolescents in Dutch
- Author
-
Batthyany, Christina, Schut, Anne Rose, van der Schroeff, Marc, Vroegop, Jantien, Batthyany, Christina, Schut, Anne Rose, van der Schroeff, Marc, and Vroegop, Jantien
- Abstract
Objective: To date, no hearing-specific self-report tool is available in Dutch to give insight into how deficits in auditory skills are experienced by a child in daily life or to examine the impact of hearing loss on children’s quality of life. Therefore, we aimed to translate and validate the Speech, Spatial, and Qualities of Hearing Scale (SSQ) and the Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for children and adolescents into Dutch. Design: Translation of the questionnaires into Dutch was conducted by means of the forward-backward procedure. Participants were invited to complete the questionnaires digitally. We examined discriminant validity, internal consistency, and test-retest reliability. Study sample: A total of 121 subjects between 7 and 18 years old were included, of which 54 normal hearing and 67 bilaterally hearing-impaired subjects. Hearing-impaired subjects were fitted with hearing aids, bone conductive devices and/or cochlear implants. Results: All questionnaires were shown to significantly discriminate between the normal hearing and the hearing-impaired group. Satisfying internal consistency and good test-retest reliability were found. Conclusions: The Dutch SSQ and HEAR-QL questionnaires for children and adolescents appear to be valid and reliable self-report tools for management and follow-up of those with hearing loss.
- Published
- 2023
42. First results of the Strengths and Difficulties Questionnaire, applied as a screening tool for psychosocial difficulties in pediatric audiology
- Author
-
Tjeerd J. de Jong, Marc P. van der Schroeff, Marieke D. Achterkamp, Jantien L. Vroegop, Otorhinolaryngology and Head and Neck Surgery, and Child and Adolescent Psychiatry / Psychology
- Subjects
Otorhinolaryngology ,SDG 3 - Good Health and Well-being ,General Medicine - Abstract
Purpose Despite major improvements in rehabilitation possibilities, children with sensorineural hearing loss are at risk for psychosocial difficulties. These difficulties can impact their educational and career achievements and may be two to three times more common in children with hearing loss compared to those with normal hearing. Early identification of psychosocial difficulties can be facilitated using the Strengths and Difficulties Questionnaire (SDQ) and may improve outcomes and quality of life. We implemented the SDQ into the clinical follow-up of children with hearing loss in a tertiary referral hospital. With this, prevalence and severity of difficulties in specific psychosocial domains and several predictors were investigated. Methods A retrospective, cross-sectional investigation was performed of the following factors in association with the SDQ results: type of hearing device, type and degree of hearing loss, speech perception in quiet and in noise, and type of schooling. Results Between June 2020 and January 2022, parents of 312 children (age 4–18) completed the SDQ. An additional 113 child-reports were completed. The response rate of the parents was 69%. Problems with peer relationships and prosocial behavior were the most affected areas with clinically elevated scores in 22% of the children. Psychosocial difficulties were distributed similarly across types of hearing device, nature and degrees of hearing loss, and educational settings. Better speech perception in quiet was significantly associated with fewer parent-reported conduct problems. Conclusion The results of the present study suggest that children with hearing loss may be at risk of experiencing challenges with social interactions and attachment in social contexts. Using the SDQ in clinical follow-up may improve the chances for early psychological assessment and intervention. In addition, the study found that children’s mental health may be impacted by their communication abilities.
- Published
- 2023
43. Objective Measurement of Listening Device Use and Its Relation to Hearing Acuity
- Author
-
Simone P. C. Koenraads, Geert Geleijnse, Danique E. Paping, Carlijn M. P. le Clercq, Marc P. van der Schroeff, Jantien L. Vroegop, and Otorhinolaryngology and Head and Neck Surgery
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Relation (database) ,Audiology ,Smartphone application ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Noise exposure ,Hearing ,medicine ,Humans ,Active listening ,Prospective Studies ,030212 general & internal medicine ,030223 otorhinolaryngology ,business.industry ,Objective measurement ,MP3-Player ,Device use ,Noise ,Cross-Sectional Studies ,Hearing Loss, Noise-Induced ,Otorhinolaryngology ,Hearing acuity ,Female ,Surgery ,business ,Music - Abstract
Objectives: To examine whether adolescents exceed recommended noise exposure limits when using personal listening devices (PLDs) and to investigate the relationship between objectively measured PLD use and hearing thresholds Study Design: Cross-sectional study. Setting: This study was embedded within an ongoing prospective birth cohort study in Rotterdam, the Netherlands. Data were collected from May 2017 to September 2019. Methods: A smartphone application was developed to measure daily noise exposure from PLDs. Listening habits were monitored among 314 adolescents with a mean age of 13 years 7 months (SD, 5 months), of whom 51.6% were male. Hearing acuity was measured by pure tone audiometry, and tympanometry was performed in both ears. Results: Within the study group, 2.2% adolescents exceeded the recommended daily noise dose (85 dBA as an 8-hour time-weighted average) among all days when the application was active and 9.9% when among only the listening days. No significant correlation was found between the daily noise dose from PLDs and pure tone thresholds. Conclusions: The majority of adolescents exhibited listening habits that could be considered safe. As noise-induced hearing loss develops slowly over time, it could be that the effects of PLD use on hearing are not evident yet in this young population with a relatively short duration of PLD use.
- Published
- 2022
44. Remotely controlled mandibular positioning of oral appliance therapy during polysomnography and drug-induced sleep endoscopy compared with conventional subjective titration in patients with obstructive sleep apnea: protocol for a randomized crossover trial
- Author
-
Dieltjens, Marijke, Braem, Marc J., Op de Beeck, Sara, Vroegop, Anneclaire V. M. T., Kazemeini, Elahe, Van de Perck, Eli, Beyers, Jolien, Kastoer, Chloé, Wouters, Kristien, Willemen, Marc, Verbraecken, Johan A., and Vanderveken, Olivier M.
- Published
- 2019
- Full Text
- View/download PDF
45. Translation and validation of the speech, spatial, and qualities of hearing scale (SSQ) and the hearing environments and reflection on quality of life (HEAR-QL) questionnaire for children and adolescents in Dutch
- Author
-
Christina, Batthyany, Anne-Rose, Schut, Marc, van der Schroeff, Jantien, Vroegop, Otorhinolaryngology and Head and Neck Surgery, and Surgery
- Subjects
Speech and Hearing ,Linguistics and Language ,SDG 3 - Good Health and Well-being ,otorhinolaryngologic diseases ,Language and Linguistics - Abstract
Objective: To date, no hearing-specific self-report tool is available in Dutch to give insight into how deficits in auditory skills are experienced by a child in daily life or to examine the impact of hearing loss on children’s quality of life. Therefore, we aimed to translate and validate the Speech, Spatial, and Qualities of Hearing Scale (SSQ) and the Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for children and adolescents into Dutch. Design: Translation of the questionnaires into Dutch was conducted by means of the forward-backward procedure. Participants were invited to complete the questionnaires digitally. We examined discriminant validity, internal consistency, and test-retest reliability. Study sample: A total of 121 subjects between 7 and 18 years old were included, of which 54 normal hearing and 67 bilaterally hearing-impaired subjects. Hearing-impaired subjects were fitted with hearing aids, bone conductive devices and/or cochlear implants. Results: All questionnaires were shown to significantly discriminate between the normal hearing and the hearing-impaired group. Satisfying internal consistency and good test-retest reliability were found. Conclusions: The Dutch SSQ and HEAR-QL questionnaires for children and adolescents appear to be valid and reliable self-report tools for management and follow-up of those with hearing loss.
- Published
- 2022
46. A pilot study on comparison of subjective titration versus remotely controlled mandibular positioning during polysomnography and drug-induced sleep endoscopy, to determine the effective protrusive position for mandibular advancement device therapy
- Author
-
Elahe Kazemeini, Sara Op de Beeck, Anneclaire Vroegop, Dorine Van Loo, Marc Willemen, Johan Verbraecken, Marc J. Braem, Olivier M. Vanderveken, and Marijke Dieltjens
- Subjects
Cross-Over Studies ,Treatment Outcome ,Otorhinolaryngology ,Polysomnography ,Humans ,Occlusal Splints ,Pilot Projects ,Endoscopy ,Human medicine ,Neurology (clinical) ,Sleep ,Mandibular Advancement - Abstract
Study objectives The aim of this pilot study was to evaluate the clinical effectiveness of subjective titration versus objectively guided titration during polysomnography (PSG) and drug-induced sleep endoscopy (DISE) in mandibular advancement device (MAD) therapy for patients with obstructive sleep apnea (OSA). Methods In this pilot cross-over study, patients underwent three titration procedures in randomized order: (1) subjective titration, (2) PSG-guided titration using a remotely controlled mandibular positioner (RCMP) and (3) DISE-assisted titration using RCMP. After each titration procedure, patients used the MAD for 1 month at the targeted protrusion obtained according to the preceding titration procedure. For each procedure, a follow-up PSG was performed after 1 month of MAD use in order to evaluate the efficacy of the MAD. Results Ten patients were included in the study. Overall, no significant differences in targeted optimal protrusion compared to maximal comfortable protrusion among the three titration methods were observed. There was no significant difference in reduction in AHI. In this study, PSG titration correctly classified 50% of patients as ‘responder’. A higher predictive accuracy was found for DISE titration with a sensitivity of 83.3% and a specificity of 100%. Conclusions This pilot randomized cross-over trial showed no differences in optimal mandibular positioning and corresponding efficacy of MAD between subjective titration, DISE titration or PSG titration.
- Published
- 2022
47. Revision surgery for chronically discharging mastoid cavities: mastoid obliteration with canal wall reconstruction versus non-obliteration surgery
- Author
-
Anne van Linge, Tim L. Molenaar, Mick Metselaar, Jantien L. Vroegop, Marc P. van der Schroeff, Hylke F. E. van der Toom, Robert Jan Pauw, and Otorhinolaryngology and Head and Neck Surgery
- Subjects
Surgical results ,medicine.medical_specialty ,business.industry ,Cholesteatoma ,Retrospective cohort study ,General Medicine ,medicine.disease ,Surgery ,Otitis ,Otorhinolaryngology ,Canal wall down ,medicine ,otorhinolaryngologic diseases ,Outpatient clinic ,Canal wall ,medicine.symptom ,Mastoid obliteration ,business - Abstract
Purpose To evaluate the surgical results of revision canal wall down (CWD) surgery for chronically discharging mastoid cavities and to compare the non-obliteration approach to mastoid obliteration with canal wall reconstruction. Methods This is a retrospective cohort study. All adult patients (≥ 18 years) who underwent revision surgery for chronically draining mastoid cavities between January 2013 and January 2020 were included. Primary outcome measures included the dry ear rate, complications and postoperative hearing. Results 79 ears were included; 56 ears received revision CWD with mastoid obliteration and posterior canal wall reconstruction and 23 ears received CWD without mastoid obliteration. The dry ear rate at the most recent outpatient clinic visit (median 28.0 months postoperative) was significantly higher in the obliteration group with 96.4% compared to 73.9% for the non-obliteration group (p = .002). There were no differences in audiological outcome and incidence of complications between the two techniques. Conclusion We show that in our study population revision CWD surgery with mastoid obliteration and posterior canal wall reconstruction is superior to revision CWD surgery without mastoid obliteration in the management of chronically discharging mastoid cavities. In the obliteration group, a dry ear was achieved in 96.4% as this was 73.9% in the non-obliteration group. We found no differences in audiological outcome and in incidence of complications between the two techniques.
- Published
- 2022
48. Non-CPAP therapy for obstructive sleep apnoea
- Author
-
Verbraecken, Johan, primary, Dieltjens, Marijke, additional, Op de Beeck, Sara, additional, Vroegop, Anneclaire, additional, Braem, Marc, additional, Vanderveken, Olivier, additional, and Randerath, Winfried, additional
- Published
- 2022
- Full Text
- View/download PDF
49. Bronchial Provocation Testing Can Be Improved by Using Dry Powder Adenosine Instead of Nebulized Adenosine Monophosphate
- Author
-
Lexmond, Anne J., Boudewijn, Ilse M., Hagedoorn, Paul, Schokker, Siebrig, Cox, Claire A., Vonk, Judith M., ten Hacken, Nick H. T., Frijlink, Henderik W., Vroegop, Sebastiaan J., and van den Berge, Maarten
- Published
- 2018
- Full Text
- View/download PDF
50. Impact of face masks in public spaces during <scp>COVID</scp> ‐19 pandemic on daily life communication of cochlear implant users
- Author
-
Nienke C. Homans, Jantien L. Vroegop, and Otorhinolaryngology and Head and Neck Surgery
- Subjects
medicine.medical_specialty ,RD1-811 ,OTOLOGY, NEUROTOLOGY, AND NEUROSCIENCE ,Hearing loss ,medicine.medical_treatment ,Face (sociological concept) ,Computer-assisted web interviewing ,Quality of life (healthcare) ,cochlear implants ,Cochlear implant ,medicine ,Original Research ,hearing loss ,Covid19 ,Loneliness ,General Medicine ,quality of life ,Otorhinolaryngology ,RF1-547 ,Family medicine ,facemasks ,Surgery ,medicine.symptom ,Psychology ,Inclusion (education) - Abstract
Objective/Hypothesis Investigate potential problems in the daily life communication of cochlear implant (CI) patients due to the widespread use of face masks in public places during the COVID‐19 pandemic. Study design Prospective survey study. Methods This study used an online questionnaire about the effects of face masks on daily life communication of adult CI users. The questionnaire consists of three parts: (a) A face mask questionnaire, (b) loneliness question (c) three subdomains of the Nijmegen Cochlear Implant Questionnaire to assess quality of life. The questionnaires were send out on October 20, 2020. Four hundred and seven adult CI users were invited to participate in the study. The survey inclusion was closed on November 5, 2020. The study setting was the Rotterdam Cochlear Implant Center, Erasmus MC, a tertiary referral center in The Netherlands. The loneliness question and Nijmegen Cochlear Implant Questionnaire were analyzed for possible differences between the current situation with masks and the situation before, when masks were not commonly used. Results Two hundred and twenty one adult CI users (54% female, mean age 62 years) participated in the study. The face mask questionnaire showed that face masks cause considerable problems in daily life communication of 80% of the participants. Also, CI users tend to feel more lonely and all used subdomains of the Nijmegen Cochlear Implant Questionnaire worsened due to the use of face masks. Conclusion The widespread use of face masks greatly complicates the daily life communication of CI users and reduces quality of life. Level of Evidence 3., During the COVID‐19 pandemic, the use of face masks is generally mandatory. The effects of the face masks on the daily communication of patients have not yet been studied.Our study shows that face masks have a major influence on the daily communication of cochlear implant users. Patients feel more lonely and the quality of life deteriorates.
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.