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The article presents a case of diagnosis and treatment of Wolff-Parkinson-White syndrome combined with early ventricular repolarization syndrome in a 19-year-old patient. The clinical presentation was characterized by a rarer variant of tachycardia involving the manifest atrioventricular accessory pathway – antidromic atrioventricular reentrant tachycardia accompanied by syncope. The risk of sudden cardiac death was estimated based on the concomitant pathology. The indications for radiofrequency ablation of accessory pathway are presented and the method of carrying out ablation in the above patient is described.